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  1. Article ; Online: Influence of perfluorohexyloctane (Evotears®) on higher order aberrations.

    Saad, Amr / Frings, Andreas

    International ophthalmology

    2023  Volume 43, Issue 12, Page(s) 5025–5030

    Abstract: Purpose: To prospectively assess the effect of regular application of perfluorohexyloctane (F6H8; Evotears®) on the tear film lipid layer, higher order aberrations (HOA) and the repeatability of measurements in healthy eyes.: Methods: This ... ...

    Abstract Purpose: To prospectively assess the effect of regular application of perfluorohexyloctane (F6H8; Evotears®) on the tear film lipid layer, higher order aberrations (HOA) and the repeatability of measurements in healthy eyes.
    Methods: This prospective clinical study included 104 eyes treated with F6H8 four times daily for four weeks (group A) and 101 eyes that served as controls (group B). Measurements were performed with the WASCA aberrometer (Carl Zeiss Meditec GmbH, Jena, Germany). Main outcome measurement in addition to subjective refraction were the root mean square values of HOA measured before and after the intervention.
    Results: Regular use of F6H8 over a period of four weeks significantly increases HOA in healthy eyes (p < 0.05). In addition, the repeatability of measurement increases after the application of F6H8.
    Conclusion: F6H8 may be a suitable treatment option to improve the accuracy of refractive assessment, although it increases HOA. Further studies are needed to confirm the effect on HOA and the repeatability of measurement.
    MeSH term(s) Humans ; Cornea ; Prospective Studies ; Refraction, Ocular ; Fluorocarbons/pharmacology
    Chemical Substances perfluorohexyl-octan (7VYX4ELWQM) ; Fluorocarbons
    Language English
    Publishing date 2023-10-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02905-w
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  2. Article ; Online: Praktische Tipps für ein Fellowship in London.

    Frings, Andreas

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2019  Volume 116, Issue 3, Page(s) 291–292

    Title translation Praktische Tipps für ein Fellowship in London.
    MeSH term(s) Fellowships and Scholarships ; London
    Language German
    Publishing date 2019-01-07
    Publishing country Germany
    Document type News
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-018-0842-6
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  3. Article ; Online: Influence of the patient's age on the safety, efficacy, and prediction accuracy of the microkeratome in laser-assisted in situ keratomileusis.

    Benabidi, Safiya / Frings, Andreas / Druchkiv, Vasyl / Katz, Toam

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1972

    Abstract: The purpose of this retrospective pseudonymised data analysis was to determine whether the patient's age has an influence on the safety, efficacy, and prediction accuracy of laser in situ keratomileusis (LASIK) treatment of myopic and hyperopic eyes. ... ...

    Abstract The purpose of this retrospective pseudonymised data analysis was to determine whether the patient's age has an influence on the safety, efficacy, and prediction accuracy of laser in situ keratomileusis (LASIK) treatment of myopic and hyperopic eyes. This study was performed at CARE Vision GmbH (Düsseldorf, Germany) and included two patient cohorts: an older group with patients > 55 years old and a younger group with patients 30-40 years old. Each patient had a single LASIK treatment. The safety, efficacy, and prediction accuracy of the refractive results were analysed. In total, 682 patients were analysed, with 341 patients in each patient group (one eye per patient). There were 570 myopic eyes and 112 hyperopic eyes. In myopic eyes, the efficacy was significantly influenced by the patient's age but only in myopic eyes (myopic: p ≤ 0.05; hyperopic: p = 0.085), while safety was not significantly influenced by the patient's age in hyperopic or myopic eyes (p = 0.204). We found that LASIK treatment at an older age (> 55 years) resulted in almost the same safety outcomes as a LASIK treatment at a younger age (30-40 years) but with a lower efficacy; the efficacy correlated with the patient's age. If the patient was hyperopic, their age did not influence safety or efficacy.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Keratomileusis, Laser In Situ ; Retrospective Studies ; Eye ; Myopia ; Hyperopia ; Lasers
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50985-6
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  4. Article ; Online: Refractive results of photorefractive keratectomy comparing trans-PRK and PTK-PRK for correction of myopia and myopic astigmatism.

    Saad, Ahmed / Saad, Amr / Frings, Andreas

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 111

    Abstract: Purpose: To compare refractive outcomes after transepithelial photorefractive keratectomy (tPRK) and combined phototherapeutic keratectomy (PTK-PRK) procedure using two different excimer laser platforms for correction of myopia and myopic astigmatism.!## ...

    Abstract Purpose: To compare refractive outcomes after transepithelial photorefractive keratectomy (tPRK) and combined phototherapeutic keratectomy (PTK-PRK) procedure using two different excimer laser platforms for correction of myopia and myopic astigmatism.
    Methods: In this retrospective multicenter study, we compared the results of two different PRK methods. The first group received a tPRK treatment with the Amaris750 excimer laser (Schwind eye-tech solutions). The second group received a combined PTK-PRK treatment with the MEL90 excimer laser (Carl Zeiss). Only healthy eyes with no previous surgery and a spherical equivalent (SE) of -1 to -8 diopters (D) were included. Preoperative spherical equivalent (SE), age, and sex were matched among the two groups. All treatments were performed by the same surgeon in different clinics. This study was approved by the local Ethics Committee (No. 2022-1980).
    Results: We included 154 eyes of 86 patients in our study. There was no difference in predictability of SE between the two groups. Efficacy and safety indices were equally high in both groups. Similarly, no significant differences were seen in change of higher order aberrations (HOA) between the two groups (p > 0.05). No complications occurred.
    Conclusion: Both investigated methods provide safe and effective refractive results. The combination of PTK with PRK may be a suitable option to the already used one-step tPRK for the correction of myopia.
    MeSH term(s) Humans ; Photorefractive Keratectomy/methods ; Astigmatism/surgery ; Astigmatism/complications ; Visual Acuity ; Refraction, Ocular ; Lasers, Excimer/therapeutic use ; Myopia/surgery ; Myopia/complications ; Cornea/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2024-02-25
    Publishing country Netherlands
    Document type Multicenter Study ; Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-02999-w
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: In Reply.

    Frings, Andreas

    Deutsches Arzteblatt international

    2017  Volume 114, Issue 38, Page(s) 642

    Language English
    Publishing date 2017-09-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2017.0642b
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  6. Article ; Online: Repeatability of pupil diameter measurements using three different topography devices.

    Saad, Amr / Steinberg, Johannes / Frings, Andreas

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0290417

    Abstract: Purpose: To evaluate the intra- and inter-device repeatability of pupil diameter measurements using three different devices in patients prior to corneal refractive surgery.: Methods: We examined preoperative measurements from a total of 204 eyes (102 ...

    Abstract Purpose: To evaluate the intra- and inter-device repeatability of pupil diameter measurements using three different devices in patients prior to corneal refractive surgery.
    Methods: We examined preoperative measurements from a total of 204 eyes (102 patients) scheduled for corneal refractive surgery at two private centers between July and December 2021. Three consecutive scans were performed with three different devices (Sirius anterior segment analyzer, Pentacam HR, IOLMaster 500) in the same session by the same examiner under standardized conditions. To assess the intra- and inter-device repeatability, we calculated the Intraclass Correlation Coefficient (ICC) and demonstrated results using Bland-Altman plots.
    Results: The measurement accuracy (intra-device repeatability) of Sirius and IOLMaster was comparable (ICC = 0.64 and 0.61, respectively), with almost no statistically significant differences. Sirius showed the highest measurement accuracy among the three devices. Pentacam measurements resulted in lower precision, with an ICC of 0.09. The agreement between the pairs of devices (inter-device repeatability) was low (wide LoA ranges, Table 5).
    Conclusion: In this study, the intra-device repeatability of Sirius and IOLMaster was higher than that of the Pentacam, although it did not achieve an optimal level across all three devices. The three devices examined cannot be used interchangeably.
    MeSH term(s) Humans ; Pupil ; Cornea ; Interior Design and Furnishings ; Ophthalmology
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290417
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  7. Article ; Online: Pre- and postoperative angle kappa in MIOL patients after touch-up LASIK.

    Saad, Amr / Frings, Andreas / Druchkiv, Vasyl / Katz, Toam

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0283578

    Abstract: Purpose: To study the influence of angle kappa (κ) on visual acuity after implantation of a multifocal intraocular lens (MIOL) and consecutive "touch-up" corneal refractive surgery with Laser-in-situ-Keratomileusis (LASIK).: Methods: This ... ...

    Abstract Purpose: To study the influence of angle kappa (κ) on visual acuity after implantation of a multifocal intraocular lens (MIOL) and consecutive "touch-up" corneal refractive surgery with Laser-in-situ-Keratomileusis (LASIK).
    Methods: This retrospective multicenter study included patients who underwent MIOL surgery and consecutive LASIK (= Bioptics) in the period from 2016 to 2020 at Care Vision Refractive Centers in Germany. Our study was approved by the local ethics committee at the University in Duesseldorf (approval date: 23.04.2021) and conducted according to the tenets of the Declaration of Helsinki and Good Clinical Practices Guidelines. The pre- and post-operative κ of 548 eyes were measured using a Scheimpflug-based imaging system. Corrected distance visual acuity (CDVA) and the safety index (SI) were analyzed in relation with κ. For a more detailed analysis, the cohort was divided into pre-operative hyperopic and myopic patients to show group-specific differences.
    Results: There was a significant decrease (p<0.001) in the magnitude of κ after MIOL implantation and Bioptics. However, there was almost no significant correlation of κ on CDVA and SI, pre- and postoperatively.
    Conclusion: A large κ is not a significant risk factor for poor visual acuity. Therefore, it is not a suitable clinical predictor of postoperative outcomes after a Bioptic procedure.
    MeSH term(s) Humans ; Cornea/surgery ; Keratomileusis, Laser In Situ/methods ; Multifocal Intraocular Lenses ; Refraction, Ocular ; Retrospective Studies
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283578
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  8. Article ; Online: Registered Report 2.0: The PCI RR Initiative.

    Eder, Andreas B / Frings, Christian

    Experimental psychology

    2021  Volume 68, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Percutaneous Coronary Intervention ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2021-06-14
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2071412-9
    ISSN 2190-5142 ; 1618-3169
    ISSN (online) 2190-5142
    ISSN 1618-3169
    DOI 10.1027/1618-3169/a000512
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  9. Conference proceedings: Refraktive Hornhautchirurgie trotz systemischer Kontraindikation?

    Frings, Andreas

    2019  , Page(s) 19rwa003

    Event/congress 181. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte; Aachen; Verein Rheinisch-Westfälischer Augenärzte; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-02-12
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19rwa003
    Database German Medical Science

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  10. Conference proceedings: Evidenzniveau gegenwärtiger Kontraindikationen für korneal-refraktive Verfahren

    Frings, Andreas

    2019  , Page(s) 19dgii037

    Event/congress 33. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII); Berlin; Deutschsprachige Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-03-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19dgii037
    Database German Medical Science

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