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Article ; Online: Novel Magnetic Elastic Phase-Change Nanodroplets as Dual Mode Contrast Agent for Ultrasound and Magnetic Resonance Imaging.

Riaz, Ramish / Waqar, Hira / Ahmad, Nasir M / Abbas, Shah Rukh

2022 Volume 14, Issue 14

Abstract: Recently, dual-mode imaging systems merging magnetic resonance imaging (MRI) and ultrasound (US) have been developed. Designing a dual-mode contrast agent is complex due to different mechanisms of enhancement. Herein, we describe novel phase change ... ...

Abstract	Recently, dual-mode imaging systems merging magnetic resonance imaging (MRI) and ultrasound (US) have been developed. Designing a dual-mode contrast agent is complex due to different mechanisms of enhancement. Herein, we describe novel phase change nanodroplets (PCNDs) with perfluoropentane encapsulated in a pre-polyglycerol sebacate (pre-PGS) shell loaded with polyethylene glycol (PEG)-coated iron oxide nanoparticles as having a dual-mode contrast agent effect. Iron oxide nanoparticles were prepared via the chemical co-precipitation method and PCNDs were prepared via the solvent displacement technique. PCNDs showed excellent enhancement in the in vitro US much more than Sonovue
Language	English
Publishing date	2022-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14142915
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Contrast enhanced sonothrombolysis using streptokinase loaded phase change nano-droplets for potential treatment of deep venous thrombosis.

Masood, Usama / Riaz, Ramish / Shah, Saeed Ullah / Majeed, Ayesha Isani / Abbas, Shah Rukh

RSC advances

2022 Volume 12, Issue 41, Page(s) 26665–26672

Abstract: Current thrombolytic therapies for deep venous thrombosis are limited due to the wide side effect profile. Contrast mediated sonothrombolysis is a promising approach for thrombus treatment. The current study examines the effectiveness ... ...

Abstract	Current thrombolytic therapies for deep venous thrombosis are limited due to the wide side effect profile. Contrast mediated sonothrombolysis is a promising approach for thrombus treatment. The current study examines the effectiveness of
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra04467f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Novel Magnetic Elastic Phase-Change Nanodroplets as Dual Mode Contrast Agent for Ultrasound and Magnetic Resonance Imaging

Ramish Riaz / Hira Waqar / Nasir M. Ahmad / Shah Rukh Abbas

Polymers, Vol 14, Iss 14, p

2022 Volume 2915

Abstract	Recently, dual-mode imaging systems merging magnetic resonance imaging (MRI) and ultrasound (US) have been developed. Designing a dual-mode contrast agent is complex due to different mechanisms of enhancement. Herein, we describe novel phase change nanodroplets (PCNDs) with perfluoropentane encapsulated in a pre-polyglycerol sebacate (pre-PGS) shell loaded with polyethylene glycol (PEG)-coated iron oxide nanoparticles as having a dual-mode contrast agent effect. Iron oxide nanoparticles were prepared via the chemical co-precipitation method and PCNDs were prepared via the solvent displacement technique. PCNDs showed excellent enhancement in the in vitro US much more than Sonovue ® microbubbles. Furthermore, they caused a susceptibility effect resulting in a reduction of signal intensity on MRI. An increase in the concentration of nanoparticles caused an increase in the MR contrast effect but a reduction in US intensity. The concentration of nanoparticles in a shell of PCNDs was optimized to obtain a dual-mode contrast effect. Biocompatibility, hemocompatibility, and immunogenicity assays showed that PCNDs were safe and non-immunogenic. Another finding was the dual-mode potential of unloaded PCNDs as T1 MR and US contrast agents. Results suggest the excellent potential of these PCNDs for use as dual-mode contrast agents for both MRI and US.
Keywords	dual-mode contrast agent ; magnetic resonance imaging ; ultrasound ; iron oxide nanoparticles ; PCNDs ; poly glycerol sebacate ; Organic chemistry ; QD241-441
Subject code	500
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Precochlear Implant Assessment: Clinical Profile and Family History of Children with Severe Bilateral Prelingual Hearing Loss.

Raza, Syed Hashim / Waris, Rehmana / Akhtar, Samina / Riaz, Ramish

International archives of otorhinolaryngology

2020 Volume 24, Issue 4, Page(s) e457–e461

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2020-02-07
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0039-3402442
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monodisperse magnetic lecithin-PFP submicron bubbles as dual imaging contrast agents for ultrasound (US) and MRI.

Waqar, Hira / Riaz, Ramish / Ahmed, Nasir M / Majeed, Ayesha Isani / Abbas, Shah Rukh

RSC advances

2022 Volume 12, Issue 17, Page(s) 10504–10513

Abstract: Multimodal imaging is a recent idea of combining two or more imaging methods synergistically to overcome the weakness of individual imaging modalities and utilizing complementary benefits. Ultrasound (US) and magnetic resonance imaging (MRI) are widely ... ...

Abstract	Multimodal imaging is a recent idea of combining two or more imaging methods synergistically to overcome the weakness of individual imaging modalities and utilizing complementary benefits. Ultrasound (US) and magnetic resonance imaging (MRI) are widely used imaging techniques in healthcare and to fully utilize the potential of fusion imaging, dual-modal contrast agents are necessary to improve disease diagnosis by enhancing contrast resolution and reducing health risks associated with the dual dosage of contrast agents. In this study, magnetic microbubbles were synthesized by incorporating oleic acid stabilized superparamagnetic iron oxide nanoparticles (OA-SPIONs) into lecithin microbubbles, encapsulating the perfluoropentane (PFP) core. The magnetic microbubbles were characterized by FTIR, SEM, MFM, zeta potential,
Language	English
Publishing date	2022-04-05
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra01542k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Breast Hemangioma: Unique Presentation in a Patient with Klippel- Trenaunay-syndrome.

Siddiqui, Ayesha Shamim / Zafar, Ibtesam / Majeed, Ayesha Isani / Riaz, Ramish

Current medical imaging

2021 Volume 18, Issue 7, Page(s) 764–767

Abstract: Background: Klippel-Trénaunay-Syndrome (KTS) is characterized by a triad of varicose veins, port-wine stain and soft tissue or bony hypertrophy, and the diagnosis of KTS can be made if any two of these three features are present. Hemangiomas in various ... ...

Abstract	Background: Klippel-Trénaunay-Syndrome (KTS) is characterized by a triad of varicose veins, port-wine stain and soft tissue or bony hypertrophy, and the diagnosis of KTS can be made if any two of these three features are present. Hemangiomas in various locations, e.g., skull, brain, epidural and vertebral hemangioma, mediastinal, colonic hemangioma, intraneural/intramuscular hemangiomas, are reported with KTS. Case presentation: Benign vascular tumors may rarely develop malignant transformation as Bugarin- Estrada et al. reported breast angiosarcoma in a patient diagnosed as Klippel-Trenaunay-Syndrome. We reported a case of a 40-year-old female with a known case of Klipple-Trenaunay-Syndrome with left leg varicosities, cutaneous nevus, as well as unfortunate development of deep venous thrombosis and markedly enlarged right breast hemangioma. Due to low incidence or lack of early detection of breast hemangioma, its diagnosis is challenging. Conclusion: The history of the patient and multi-modality imaging utilization can help in early and accurate diagnosis of diseases leading to better prognosis.
MeSH term(s)	Adult ; Breast Neoplasms/complications ; Breast Neoplasms/diagnostic imaging ; Female ; Hemangioma/complications ; Hemangioma/diagnostic imaging ; Hemangiosarcoma ; Humans ; Klippel-Trenaunay-Weber Syndrome/complications ; Klippel-Trenaunay-Weber Syndrome/diagnostic imaging ; Spine
Language	English
Publishing date	2021-09-24
Publishing country	United Arab Emirates
Document type	Case Reports
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/1871529X21666210924150832
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multimodality Imaging in Acute Ischemic Stroke.

Zameer, Shahla / Siddiqui, Ayesha Shamim / Riaz, Ramish

Current medical imaging

2020 Volume 17, Issue 5, Page(s) 567–577

Abstract: Stroke is the most common cause of mortality and morbidity worldwide. The prognosis of stroke depends upon the area affected and its early treatment. Time is of the essence in the care of stroke patients as it is estimated that approximately 1.9 million ... ...

Abstract	Stroke is the most common cause of mortality and morbidity worldwide. The prognosis of stroke depends upon the area affected and its early treatment. Time is of the essence in the care of stroke patients as it is estimated that approximately 1.9 million neurons, 14 billion synapses, and 12 km myelinated nerve fibers are lost per minute. Therefore, early diagnosis and prompt treatment are necessary. The primary goal of imaging in acute stroke is to diagnose the underlying cause, estimate the area affected, predict response towards thrombolytic therapy and to exclude the conditions mimicking stroke. With advancements in radiology, multiple imaging modalities are available for diagnosis and predicting prognosis. None of them is considered alone to be perfect. In this era of multimodality imaging, the decision of choosing appropriate techniques depends upon purpose and availability. Non-Contrast Computed Tomography is time effective, and helps in excluding other causes, Trans Cranial Doppler is time-effective and cost-effective with wide availability, however, is operator dependent and less sensitive. It holds a great future in sonothrombolysis. Magnetic Resonance Imaging is so far considered to be the most superior one in terms of early diagnosis, planning for interventional treatment and predicting the response of treatment. However, it is limited due to high cost and lack of availability. The current review gives a detailed account of all imaging modalities available for imaging stroke and their associated pros and cons.
MeSH term(s)	Brain Ischemia/diagnostic imaging ; Humans ; Ischemic Stroke ; Magnetic Resonance Imaging ; Stroke/diagnostic imaging ; Thrombolytic Therapy
Language	English
Publishing date	2020-12-13
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/1573405616666201130094948
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment Of Carpal Tunnel Syndrome With Ultrasonography.

Ahmed, Aliya / Malik, Ghazala / Imtiaz, Hassan / Riaz, Ramish / Badshah, Mazhar / Zameer, Shahla

Journal of Ayub Medical College, Abbottabad : JAMC

2022 Volume 34, Issue 2, Page(s) 295–299

Abstract: Background: Carpal tunnel syndrome (CTS) is the most common nerve entrapment neuropathy caused by compression of median nerve at wrist as it passes through Osseo fibrous canal known as carpal tunnel. Epidemiological statistics shows one in every ten ... ...

Abstract	Background: Carpal tunnel syndrome (CTS) is the most common nerve entrapment neuropathy caused by compression of median nerve at wrist as it passes through Osseo fibrous canal known as carpal tunnel. Epidemiological statistics shows one in every ten people develops the disease at any stage of life. CTS mostly affect females than males with mean age of 50. Clinical features are considered to be enough for establishing the diagnosis of carpal tunnel syndrome. However, nerve conduction studies give quantitative information regarding median nerve function therefore good at predicting outcome of intervention. Ultrasound being easily available, cost effective and real time is a promising modality for diagnosis and grading carpal tunnel syndrome. Methods: This correlational study was conducted in collaboration of Neurology and Radiology Department of Pakistan Institute of Medical Sciences, Islamabad from January 2018 to January 2019. Total 50 patients with 85 wrists involved were included in the study. All patients with positive nerve conduction study were included. Patient with history of wrist trauma were not included. Detailed history and clinical features were recorded. All patients with positive result on nerve conduction studies underwent ultrasound examinations. Fifty control wrists were also included to establish the normal median nerve cross sectional area value in our study population. Results were recorded. Data was analyzed and appropriate statistical tests were applied by using SPSS v20. Results: Mean cross sectional area of median nerve for controls was 6.34±1.23. Mean cross sectional area of median nerve for mild CTS was 8.05±1.72, moderate CTS was 11.15±2.32, severe was 17.49±4.93. Strong correlation was found between (r=0.76, p-value <0.0001) between increased cross-sectional area on Ultrasonography and severity of CTS on NCS. Other finding on Ultrasonography included flattening in 4 and fluid in 10 affected wrists. Conclusions: Increased cross-sectional area on Ultrasonography and severity of carpal tunnel syndrome on nerve conduction studies are very strongly correlated.
MeSH term(s)	Carpal Tunnel Syndrome/diagnostic imaging ; Carpal Tunnel Syndrome/epidemiology ; Female ; Humans ; Male ; Median Nerve/diagnostic imaging ; Middle Aged ; Neural Conduction/physiology ; Ultrasonography/methods ; Wrist/diagnostic imaging
Language	English
Publishing date	2022-05-01
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-02-9892
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Case-Control Study on Fetal Outcomes in Isolated Oligohydramnios in Third Trimester

Iram Iqbal / Sajida Asghar / Khairun Nisa / Fouzia Rashid / Kashif Khurshid Quredhi / Ramish Riaz

Journal of Rawalpindi Medical College, Vol 26, Iss

2022 Volume 1

Abstract: Background: Oligohydramnios is defined as a condition with low volume of amniotic fluid relative to gestational age. Long-term oligohydramnios can result in pulmonary hypoplasia, intra uterine growth retardation, Potter’s syndrome, club hand & foot and ... ...

Abstract	Background: Oligohydramnios is defined as a condition with low volume of amniotic fluid relative to gestational age. Long-term oligohydramnios can result in pulmonary hypoplasia, intra uterine growth retardation, Potter’s syndrome, club hand & foot and dislocation of hip. This study was conducted to assess feto-maternal outcome in isolated oligohydramnios and factors associated with poor outcome. Methodology: This case-control study was conducted from January to December 2020 in the Gynecology & Obstetrics and Radiology departments of HBS General Hospital, Islamabad. Total 300 patients with isolated oligohydramnios fulfilling the criterion were included. For cases, patients with singleton intrauterine pregnancy with AFI <5, of any age or parity with gestational age of more than 34 weeks were included. 300 controls were also taken. Patients with increased amount of amniotic fluid, diabetics, hypertensive and cardiac patients were excluded. Patient were followed up till delivery. Mode of delivery was checked out. Fetal APGAR score at 1 minute and at 5 minutes were observed. New born weight and NICU admissions were recorded. Data was analyzed via SPSS v26. Results: Forty six percent (n=138) patients underwent caesarean section while fifty four percent (n=162) had normal vaginal delivery. Significant association (OR=1.85, P<0.001) was found between caesarean section in mothers with oligohydramnios compared to controls. Thirty eight percent (n=114) of neonates among cases had low APGAR score. Significant association (OR=3.29, P<0.001) was found between low APGAR score and mothers with oligohydramnios compare3d to controls. Thirty percent (n=90) required NICU admission. There were 6 still births. Mother’s with oligohydramnios have double risk of still birth and NICU admission compared to women with normal fluid levels. Conclusion: Neonate born with mothers having oligohydramnios have low birth weight, lower APGAR scores and high rate of NICU admissions. Delivery at 37-39 weeks in oligohydramnios is ...
Keywords	Oligohydramnios ; Feto-maternal Outcomes ; Caesarean section ; APGAR Score ; Still Births ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Rawalpindi Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Monodisperse magnetic lecithin-PFP submicron bubbles as dual imaging contrast agents for ultrasound (US) and MRI

Waqar, Hira / Riaz, Ramish / Ahmed, Nasir M. / Majeed, Ayesha Isani / Abbas, Shah Rukh

RSC advances. 2022 Apr. 05, v. 12, no. 17

2022

Abstract	Multimodal imaging is a recent idea of combining two or more imaging methods synergistically to overcome the weakness of individual imaging modalities and utilizing complementary benefits. Ultrasound (US) and magnetic resonance imaging (MRI) are widely used imaging techniques in healthcare and to fully utilize the potential of fusion imaging, dual-modal contrast agents are necessary to improve disease diagnosis by enhancing contrast resolution and reducing health risks associated with the dual dosage of contrast agents. In this study, magnetic microbubbles were synthesized by incorporating oleic acid stabilized superparamagnetic iron oxide nanoparticles (OA-SPIONs) into lecithin microbubbles, encapsulating the perfluoropentane (PFP) core. The magnetic microbubbles were characterized by FTIR, SEM, MFM, zeta potential, in vitro MRI, and ultrasound. Upon in vitro MRI, magnetic microbubbles showed a negative contrast effect by producing darker T2 weighted images. Magnetic microbubbles showed concentration-dependent response with a decrease in signal intensity with an increase in the concentration of OA-IONP in microbubbles. However, a decrease in acoustic enhancement was also observed with an increase in OA-IONP concentration, therefore concentration was optimized to achieve the best effect on both modalities. The magnetic lecithin microbubble with 10 mg SPIONs provided the best contrast on both US and MR imaging. The hemocompatibility testing resulted in hemolysis less than 7% with plasma recalcification time and thrombin time of 240 s and 6 s corresponding to excellent hemocompatibility. Thus the magnetic microbubbles with a phase convertible PFP core encapsulated by a lecithin shell loaded with OA-SPIONs can serve as a potential bimodal contrast agent for both US and MRI imaging.
Keywords	acoustics ; biocompatibility ; disease diagnosis ; health services ; hemolysis ; iron oxides ; lecithins ; magnetism ; microbubbles ; oleic acid ; thrombin ; ultrasonics ; zeta potential
Language	English
Dates of publication	2022-0405
Size	p. 10504-10513.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d2ra01542k
Database	NAL-Catalogue (AGRICOLA)

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