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  1. Article: Hormetic Nutrition and Redox Regulation in Gut-Brain Axis Disorders.

    Scuto, Maria / Rampulla, Francesco / Reali, Giuseppe Maria / Spanò, Sestina Maria / Trovato Salinaro, Angela / Calabrese, Vittorio

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest for preventing and therapeutically ... ...

    Abstract The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics have shown to improve gut bioavailability and blood-brain barrier (BBB) permeability, thus inhibiting the oxidative stress, metabolic dysfunction and inflammation linked to gut dysbiosis and ultimately the onset and progression of central nervous system (CNS) disorders. In accordance with hormesis, polyphenols display biphasic dose-response effects by activating at a low dose the Nrf2 pathway resulting in the upregulation of antioxidant
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040484
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  2. Article ; Online: Agro-industrial wastes as potential carriers for enzyme immobilization: A review.

    Girelli, Anna Maria / Astolfi, Maria Luisa / Scuto, Francesca Romana

    Chemosphere

    2019  Volume 244, Page(s) 125368

    Abstract: This review provides a general overview of the suitability of different agro-industrial wastes for enzyme immobilization. For the purposes of this literary study, the support materials are divided into two main groups, called lignocellulosic (coconut ... ...

    Abstract This review provides a general overview of the suitability of different agro-industrial wastes for enzyme immobilization. For the purposes of this literary study, the support materials are divided into two main groups, called lignocellulosic (coconut fiber, corn cob, spent grain, spent coffee, husk, husk ash, and straw rice, soybean and wheat bran) and not lignocellulosic by-products (eggshell and eggshell membranes). The study pointed out that all of these wastes are materials of great potentiality for enzyme immobilization even if coconut fiber is preferred. This result is of significant interest due to the low cost and great availability of such wastes, which actually are underused and cause significant environmental problems for improper storage. In addition, the development of economic biocatalysts more sustainable, besides reduce environmental impacts, improve the application of enzymatic technology in industry. Therefore, the enzyme immobilization reaction and the application of biocatalysts are reviewed and discussed.
    MeSH term(s) Agriculture ; Edible Grain ; Environmental Restoration and Remediation/methods ; Industrial Waste ; Industry ; Oryza
    Chemical Substances Industrial Waste
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2019.125368
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  3. Article ; Online: Blood-Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients.

    Cosentino, Alessia / Agafonova, Aleksandra / Modafferi, Sergio / Trovato Salinaro, Angela / Scuto, Maria / Maiolino, Luigi / Fritsch, Tilman / Calabrese, Edward J / Lupo, Gabriella / Anfuso, Carmelina Daniela / Calabrese, Vittorio

    Antioxidants & redox signaling

    2023  Volume 40, Issue 7-9, Page(s) 542–563

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Endothelial Cells ; Ear, Inner ; Cochlea ; Hearing Loss ; Pericytes
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0251
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  4. Article ; Online: Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols.

    Bucciantini, Monica / Leri, Manuela / Scuto, Maria / Ontario, Marialaura / Trovato Salinaro, Angela / Calabrese, Edward J / Calabrese, Vittorio / Stefani, Massimo

    Mechanisms of ageing and development

    2022  Volume 202, Page(s) 111620

    Abstract: The paper provides a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health. This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity ... ...

    Abstract The paper provides a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health. This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease. It is proposed that olive polyphenol-induced anti-inflammatory protective effects are mediated in large part via the activation of AMPK and the upregulation of Nrf2 pathway. Consistently, herein we also review the importance of the modulation of Nrf2-related stress responsive vitagenes by olive polyphenols, which at low concentration according to the hormesis theory activates this neuroprotective cascade to preserve brain health and its potential use in the prevention and therapy against aging and age-related cognitive disorders in humans.
    MeSH term(s) Aging/metabolism ; Hormesis ; Humans ; Neurodegenerative Diseases/prevention & control ; Olea ; Polyphenols/pharmacology
    Chemical Substances Polyphenols
    Language English
    Publishing date 2022-01-13
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111620
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  5. Article: Moringa oleifera

    Amara, Ines / Ontario, Maria Laura / Scuto, Maria / Lo Dico, Gianluigi Maria / Sciuto, Sebastiano / Greco, Valentina / Abid-Essefi, Salwa / Signorile, Anna / Salinaro, Angela Trovato / Calabrese, Vittorio

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 4

    Abstract: ... Moringa ... ...

    Abstract Moringa oleifera
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10040532
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  6. Article ; Online: Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox.

    Ontario, Maria Laura / Siracusa, Rosalba / Modafferi, Sergio / Scuto, Maria / Sciuto, Sebastiano / Greco, Valentina / Bertuccio, Maria Paola / Trovato Salinaro, Angela / Crea, Roberto / Calabrese, Edward J / Di Paola, Rosanna / Calabrese, Vittorio

    Mechanisms of ageing and development

    2022  Volume 203, Page(s) 111637

    Abstract: Most chronic illnesses are caused by the biological reaction to an injury, rather than the initial injury or the injurious agent itselves as in neurodegeneration. With respect to this, notable attention is emerging on the therapeutic effects of dietary ... ...

    Abstract Most chronic illnesses are caused by the biological reaction to an injury, rather than the initial injury or the injurious agent itselves as in neurodegeneration. With respect to this, notable attention is emerging on the therapeutic effects of dietary polyphenols for human health, able to counteract and neutralize oxidative stress and inflammatory processes involved in the etiopathogenesis of major neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. The acquired concept that cellular stress at low doses induces neuroprotective responses against degenerative processes is a frontier area of the neurobiological research focusing on the development of novel preventive and therapeutic interventions for neurodegenerative disorders. Notably, basal levels of prooxidant species are essential to promote adaptive redox cellular responses including vitagenes, tightly correlated to cell survival against age-related diseases. In this paper we discuss the concept of cellular stress response and hormesis and its applications to the field of neuroprotection and the potential therapeutic support provided by olive polyphenols, in particular hydroxytyrosol (HT)-rich aqueous olive pulp extract (Hidrox), as a pivotal activator of Nrf2 pathway and related vitagenes, and inhibitor of Keap1-Nrf2 interaction.Olive polyphenols are considered potential pharmacological modulators of neuroinflammation by upregulation of the Keap1/Nfr2/ARE pathway thus providing a strong rationale for treating neurodegenerative disorders.
    MeSH term(s) Biological Products/therapeutic use ; Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/prevention & control ; Olea/metabolism ; Oxidative Stress ; Polyphenols/pharmacology ; Polyphenols/therapeutic use
    Chemical Substances Biological Products ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Polyphenols ; olive extract
    Language English
    Publishing date 2022-02-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111637
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    Zs.A 1012: Show issues Location:
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  7. Article ; Online: A new laccase-mediator system facing the biodegradation challenge: Insight into the NSAIDs removal.

    Apriceno, Azzurra / Astolfi, Maria Luisa / Girelli, Anna Maria / Scuto, Francesca Romana

    Chemosphere

    2018  Volume 215, Page(s) 535–542

    Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely found pollutants in the aquatic environment and the currently available treatments for their removal are usually associated with some drawbacks. The aim of this research was to apply a laccase- ... ...

    Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely found pollutants in the aquatic environment and the currently available treatments for their removal are usually associated with some drawbacks. The aim of this research was to apply a laccase-mediator system for the degradation of some commonly used NSAIDs, namely diclofenac (DCF), naproxen (NAP) and ketoprofen (KP). The biocatalyst was obtained by direct immobilization on chitosan beads of a periodate-oxided laccase from Trametes versicolor. A preliminary study aimed to optimize DCF degradation in the presence of 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonicacid) diammonium salt (ABTS) as mediator. It turned out that pH 3 and a 1:1 M ratio for ABTS:drug were the best experimental conditions under which DCF was degraded at 90% after 3 h. In addition, an efficient reuse of the biocatalyst for up to 5 cycles emerged. DCF was further mixed with naproxen and ketoprofen to test whether laccase was still able to eliminate DCF and eventually act on the other compounds. At just 0.02 U of laccase activity, diclofenac was completely degraded within 3 h, while an almost complete removal for naproxen (∼90%) and a partial removal for ketoprofen (30%) occurred in 7 d when drugs were added at high concentrations (78.5 μM, 98 μM and 108 μM, respectively). After 7 d of degradation, transformation products of diclofenac, identified as hydroxylated compounds, disappeared. Naproxen products were, instead, reduced to very small amounts.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Biodegradation, Environmental ; Diclofenac/chemistry ; Hydroxylation ; Ketoprofen/chemistry ; Laccase/chemistry ; Naproxen/chemistry ; Trametes/metabolism
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Diclofenac (144O8QL0L1) ; Naproxen (57Y76R9ATQ) ; Ketoprofen (90Y4QC304K) ; Laccase (EC 1.10.3.2)
    Language English
    Publishing date 2018-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2018.10.086
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  8. Article ; Online: Antioxidants, Hormetic Nutrition, and Autism.

    Modafferi, Sergio / Lupo, Gabriella / Tomasello, Mario / Rampulla, Francesco / Ontario, Marialaura / Scuto, Maria / Salinaro, Angela Trovato / Arcidiacono, Antonio / Anfuso, Carmelina Daniela / Legmouz, Maria / Azzaoui, Fatima-Zahra / Palmeri, Agostino / Spano, Sestina / Biamonte, Francesca / Cammilleri, Gaetano / Fritsch, Tilman / Sidenkova, Alena / Calabrese, Edward / Wenzel, Uwe /
    Calabrese, Vittorio

    Current neuropharmacology

    2023  Volume 22, Issue 7, Page(s) 1156–1168

    Abstract: Autism spectrum disorder (ASD) includes a heterogeneous group of complex neurodevelopmental disorders characterized by atypical behaviors with two core pathological manifestations: deficits in social interaction/communication and repetitive behaviors, ... ...

    Abstract Autism spectrum disorder (ASD) includes a heterogeneous group of complex neurodevelopmental disorders characterized by atypical behaviors with two core pathological manifestations: deficits in social interaction/communication and repetitive behaviors, which are associated with disturbed redox homeostasis. Modulation of cellular resilience mechanisms induced by low levels of stressors represents a novel approach for the development of therapeutic strategies, and in this context, neuroprotective effects of a wide range of polyphenol compounds have been demonstrated in several in vitro and in vivo studies and thoroughly reviewed. Mushrooms have been used in traditional medicine for many years and have been associated with a long list of therapeutic properties, including antitumor, immunomodulatory, antioxidant, antiviral, antibacterial, and hepatoprotective effects. Our recent studies have strikingly indicated the presence of polyphenols in nutritional mushrooms and demonstrated their protective effects in different models of neurodegenerative disorders in humans and rats. Although their therapeutic effects are exerted through multiple mechanisms, increasing attention is focusing on their capacity to induce endogenous defense systems by modulating cellular signaling processes such as nuclear factor erythroid 2 related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) pathways. Here we discuss the protective role of hormesis and its modulation by hormetic nutrients in ASD.
    MeSH term(s) Humans ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Hormesis/drug effects ; Autistic Disorder/drug therapy ; Agaricales/chemistry ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/metabolism ; Polyphenols/pharmacology ; Polyphenols/therapeutic use
    Chemical Substances Antioxidants ; Polyphenols
    Language English
    Publishing date 2023-08-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X21666230817085811
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  9. Article: Hidrox

    Cordaro, Marika / Trovato Salinaro, Angela / Siracusa, Rosalba / D'Amico, Ramona / Impellizzeri, Daniela / Scuto, Maria / Ontario, Maria Laura / Interdonato, Livia / Crea, Roberto / Fusco, Roberta / Cuzzocrea, Salvatore / Di Paola, Rosanna / Calabrese, Vittorio

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: Endometriosis is a gynecological and painful condition affecting women of reproductive age. It is characterized by dysfunctional endometrium-like implants outside of the uterine cavity. The purpose of this study was to evaluate the effects of ... ...

    Abstract Endometriosis is a gynecological and painful condition affecting women of reproductive age. It is characterized by dysfunctional endometrium-like implants outside of the uterine cavity. The purpose of this study was to evaluate the effects of Hidrox
    Language English
    Publishing date 2021-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10050720
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  10. Article: Key Mechanisms and Potential Implications of

    Cordaro, Marika / Salinaro, Angela Trovato / Siracusa, Rosalba / D'Amico, Ramona / Impellizzeri, Daniela / Scuto, Maria / Ontario, Maria Laura / Cuzzocrea, Salvatore / Di Paola, Rosanna / Fusco, Roberta / Calabrese, Vittorio

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases with age. Altered antioxidant systems and inflammation have an important role in the etiology of neurodegenerative disorders. In this study, we evaluated the effects ...

    Abstract Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases with age. Altered antioxidant systems and inflammation have an important role in the etiology of neurodegenerative disorders. In this study, we evaluated the effects of
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111664
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