LIVIVO - Search results -

Search results

Result 1 - 10 of total 78

Search options

Article ; Online: Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.

Jones, Benjamin T / Han, Jaeil / Zhang, He / Hammer, Robert E / Evers, Bret M / Rakheja, Dinesh / Acharya, Asha / Mendell, Joshua T

Genes & development

2023 Volume 37, Issue 13-14, Page(s) 661–674

Abstract: MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets with extensive ... ...

Abstract	MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets with extensive complementarity are rapidly decayed, has emerged as a potent mechanism of controlling miRNA levels. Nevertheless, the biological role and scope of miRNA regulation by TDMD in mammals remains poorly understood. To address these questions, we generated mice with constitutive or conditional deletion of
MeSH term(s)	Mice ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mammals/genetics ; Base Sequence
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.350906.123
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.

Jones, Benjamin T / Han, Jaeil / Zhang, He / Hammer, Robert E / Evers, Bret M / Rakheja, Dinesh / Acharya, Asha / Mendell, Joshua T

bioRxiv : the preprint server for biology

2023

Abstract	MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets with extensive complementarity are rapidly decayed, has emerged as a potent mechanism of controlling miRNA levels. Nevertheless, the biological role and scope of miRNA regulation by TDMD in mammals remains poorly understood. To address these questions, we generated mice with constitutive or conditional deletion of
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.26.546601
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Anxiety among the General Population of Himalayan District during the COVID-19 Pandemic: A Descriptive Cross-sectional Study.

Pandit, Sanjib / Thapa, Niresh / Sharma, Asha / Pokhrel, Bishal / Bham, Gajendra / Acharya, Nandaraj

JNMA; journal of the Nepal Medical Association

2022 Volume 60, Issue 246, Page(s) 132–136

Abstract: Introduction: COVID-19 pandemic and subsequent measures taken by the government to control the situation have imposed adverse impacts on the mental health and wellbeing of the general population. We conducted a study to determine the prevalence of ... ...

Abstract	Introduction: COVID-19 pandemic and subsequent measures taken by the government to control the situation have imposed adverse impacts on the mental health and wellbeing of the general population. We conducted a study to determine the prevalence of anxiety among general population of a Himalayan district during the COVID-19 pandemic. Methods: A descriptive cross-sectional study was conducted in rural communities of the Himalayan district during the early stage of the pandemic using the Hospital Anxiety and Depression Scale. Data was collected for a period of one month from 13th April 2020 to 13th May 2020. Ethical approval was sought from the Institutional Review Committee of Karnali Academy of Health Sciences (Reference number: 2076/2077/07). All the participants of age 18 or above were included in the study excluding those with known mental illness. Convenience sampling method was used. A total of 427 participants were included in the study. Data were analyzed using the Statistical Package for the Social Sciences version 20. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence rate of anxiety was 196 (45.9%) (41.15-50.64 at 95% Confidence Interval). Anxiety was more prevalent among farmers, illiterate, widowed, and old aged. Conclusions: The study indicates a higher prevalence of anxiety amidst the COVID-19 pandemic compared to reported studies and highlights the need for a strategic intervention to promote awareness and wellbeing at mental health level.
MeSH term(s)	Adolescent ; Aged ; Anxiety/epidemiology ; COVID-19 ; Cross-Sectional Studies ; Depression/epidemiology ; Humans ; Middle Aged ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-02-15
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
DOI	10.31729/jnma.6553
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anxiety among the General Population of Himalayan District during the COVID-19 Pandemic

Sanjib Pandit / Niresh Thapa / Asha Sharma / Bishal Pokhrel / Gajendra Bham / Nandaraj Acharya

Journal of Nepal Medical Association, Vol 60, Iss

A Descriptive Cross-sectional Study

2022 Volume 246

Abstract	Introduction: COVID-19 pandemic and subsequent measures taken by the government to control the situation have imposed adverse impacts on the mental health and wellbeing of the general population. We conducted a study to determine the prevalence of anxiety among general population of a Himalayan district during the COVID-19 pandemic. Methods: A descriptive cross-sectional study was conducted in rural communities of the Himalayan district during the early stage of the pandemic using the Hospital Anxiety and Depression Scale. Data was collected for a period of one month from 13th April 2020 to 13th May 2020. Ethical approval was sought from the Institutional Review Committee of Karnali Academy of Health Sciences (Reference number: 2076/2077/07). All the participants of age 18 or above were included in the study excluding those with known mental illness. Convenience sampling method was used. A total of 427 participants were included in the study. Data were analyzed using the Statistical Package for the Social Sciences version 20. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence rate of anxiety was 196 (45.9%) (41.15-50.64 at 95% Confidence Interval). Anxiety was more prevalent among farmers, illiterate, widowed, and old aged. Conclusions: The study indicates a higher prevalence of anxiety amidst the COVID-19 pandemic compared to reported studies and highlights the need for a strategic intervention to promote awareness and wellbeing at mental health level.
Keywords	anxiety ; COVID-19 ; mental health ; pandemic ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nepal Medical Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Anxiety among the General Population of Himalayan District during the COVID-19 Pandemic

Sanjib Pandit / Niresh Thapa / Asha Sharma / Bishal Pokhrel / Gajendra Bham / Nandaraj Acharya

Journal of Nepal Medical Association, Vol 60, Iss

A Descriptive Cross-sectional Study

2022 Volume 246

Abstract	Introduction: COVID-19 pandemic and subsequent measures taken by the government to control the situation have imposed adverse impacts on the mental health and wellbeing of the general population. We conducted a study to determine the prevalence of anxiety among general population of a Himalayan district during the COVID-19 pandemic. Methods: A descriptive cross-sectional study was conducted in rural communities of the Himalayan district during the early stage of the pandemic using the Hospital Anxiety and Depression Scale. Data was collected for a period of one month from 13th April 2020 to 13th May 2020. Ethical approval was sought from the Institutional Review Committee of Karnali Academy of Health Sciences (Reference number: 2076/2077/07). All the participants of age 18 or above were included in the study excluding those with known mental illness. Convenience sampling method was used. A total of 427 participants were included in the study. Data were analyzed using the Statistical Package for the Social Sciences version 20. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence rate of anxiety was 196 (45.9%) (41.15-50.64 at 95% Confidence Interval). Anxiety was more prevalent among farmers, illiterate, widowed, and old aged. Conclusions: The study indicates a higher prevalence of anxiety amidst the COVID-19 pandemic compared to reported studies and highlights the need for a strategic intervention to promote awareness and wellbeing at mental health level.
Keywords	anxiety ; COVID-19 ; mental health ; pandemic ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nepal Medical Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Indications for Caesarean Section and its Fetal and Maternal Outcome in a Teaching Hospital, Province Five, Nepal

Asha Panth / Sarswoti Kumari Gautam / Sunita Acharya

Journal of Karnali Academy of Health Sciences, Vol 3, Iss

2020 Volume 1

Abstract: Introduction: Cesarean section (CS) is an operative technique by which a fetus is delivered through an abdominal and uterine incision and is effective in saving maternal and infant lives but caesarean section rates higher than 10% are not associated with ...

Abstract	Introduction: Cesarean section (CS) is an operative technique by which a fetus is delivered through an abdominal and uterine incision and is effective in saving maternal and infant lives but caesarean section rates higher than 10% are not associated with reductions in maternal and newborn mortality rates. The objective of the study was to find out the indications for caesarean section and its fetal and maternal outcomes in a Teaching Hospital, Province Five, Nepal. Methods: A descriptive, cross-sectional study was conducted in a teaching hospital, Nepal. A total of 150 purposively selected postnatal mothers after caesarean section were interviewed by face to face technique using a structured interview schedule. Analysis and interpretation of the findings were done with the help of descriptive and inferential statistics. Results: The study showed that the majority (93.3%) of mothers had undergone an emergency caesarean section and the majority (92%) had maternal indications for caesarean section. Among them, one third had previous caesarean section followed by 14.5% obstructed labour. Fetal indications include breach (44.4%), fetal distress (29.6%), big baby (11.1) and twins and triplets (3.7%). Only (10.7%) had an unfavorable fetal outcome which includes the need for Neonatal Intensive Care Unit (NICU) (31.2%) followed by neonatal death (25%). Only three mothers (2%) had unfavorable maternal outcome which includes Post-Partum Hemorrhage (PPH); need for blood transfusion and fever respectively. There was no statistically significant association between socio demographic characteristics and type of caesarean section. There was statistically significant association between the previous history of caesarean section and type of caesarean section (P= .005). Conclusions: Previous caesarean section was the most common indication for caesarean section. Unfavorable outcome after caesarean section was considerably present which need to be addressed.
Keywords	Caesarean Section ; Indications ; Maternal Outcome ; Fetal Outcome ; Nepal ; Medicine (General) ; R5-920
Subject code	900
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Karnali Academy of Health Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Patients' Preference to Bedside Teaching Encounters in Four Major Wards in a Tertiary Care Centre.

Ghimire, Calvin / Acharya, Sajan / Thapa, Abhiskar / Shrestha, Asha / Basnet, Deep / Rajak, Kripa

JNMA; journal of the Nepal Medical Association

2020 Volume 57, Issue 220, Page(s) 429–431

Abstract: Introduction: Patient interaction is a vital aspect of medical education. Bedside teaching encounters involve clinicians, medical students, and patients, and comprise a formative and focused activity. Patients' willingness to cooperate and contribute to ...

Abstract	Introduction: Patient interaction is a vital aspect of medical education. Bedside teaching encounters involve clinicians, medical students, and patients, and comprise a formative and focused activity. Patients' willingness to cooperate and contribute to the education and training of medical students provide better teaching opportunities. The study aims to find the patients' preference to bedside teaching encounters in four major wards in a tertiary care center in Nepal. Methods: This descriptive cross-sectional study was performed in four major wards in a tertary care centre from June 3, 2015 to July 3, 2015 after receiving ethical approval. Convenient sampling was done. Data was collected in Microsoft Excel and analyzed in Statistical Package for Social Sciences 13.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Subgroup analysis was done on the basis of demographic variables. Results: Seventy-eight (77.2%) patients preferred bedside teaching encounters among 101 participants (77.12-77.28%) at 95% Confidence Interval. Among which, females, age ranging from 16 to 32 years, education below secondary school and with hospital stay<4 days were most common. Conclusions: The results showed that most of the patients preferred bedside teaching encounters which was congruent with the other national and international studies.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Attitude to Health ; Cross-Sectional Studies ; Educational Status ; Female ; Humans ; Male ; Middle Aged ; Nepal ; Patient Preference ; Quality of Health Care ; Sex Factors ; Teaching Rounds ; Tertiary Care Centers ; Young Adult
Language	English
Publishing date	2020-04-25
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Micro-Raman spectroscopy study of optically trapped erythrocytes in malaria, dengue and leptospirosis infections.

Jacob, Sanu Susan / Lukose, Jijo / Bankapur, Aseefhali / Mithun, N / Vani Lakshmi, R / Acharya, Mahendra / Rao, Pragna / Kamath, Asha / Baby, Prathap M / Rao, Raghavendra K / Chidangil, Santhosh

Frontiers in medicine

2022 Volume 9, Page(s) 858776

Abstract: Malaria, dengue and leptospirosis are three tropical infectious diseases that present with severe hematological derangement causing significant morbidity and mortality, especially during the seasonal monsoons. During the course of these infectious ... ...

Abstract	Malaria, dengue and leptospirosis are three tropical infectious diseases that present with severe hematological derangement causing significant morbidity and mortality, especially during the seasonal monsoons. During the course of these infectious diseases, circulating red blood cells are imperiled to the direct ill-effects of the infectious pathogen in the body as well as to the pro-inflammatory cytokines generated as a consequence of the infection. RBCs when exposed to such inflammatory and/or pathogenic milieu are susceptible to injuries such as RBC programmed
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.858776
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Signalling through chromatin modifications and protein-protein interactions.

Acharya, Asha / Kuo, Min-Hao

Biotechnology & genetic engineering reviews

2012 Volume 23, Page(s) 105–127

MeSH term(s)	Chromatin Assembly and Disassembly/genetics ; DNA-Binding Proteins/genetics ; Histones/genetics ; Models, Genetic ; Protein Binding ; Signal Transduction/genetics
Chemical Substances	DNA-Binding Proteins ; Histones
Language	English
Publishing date	2012-04-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	49457-4
ISSN	0264-8725
ISSN	0264-8725
DOI	10.1080/02648725.2006.10648081
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1012: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Artificial intelligence in differentiating tropical infections: A step ahead.

Shenoy, Shreelaxmi / Rajan, Asha K / Rashid, Muhammed / Chandran, Viji Pulikkel / Poojari, Pooja Gopal / Kunhikatta, Vijayanarayana / Acharya, Dinesh / Nair, Sreedharan / Varma, Muralidhar / Thunga, Girish

PLoS neglected tropical diseases

2022 Volume 16, Issue 6, Page(s) e0010455

Abstract: Background and objective: Differentiating tropical infections are difficult due to its homogenous nature of clinical and laboratorial presentations among them. Sophisticated differential tests and prediction tools are better ways to tackle this issue. ... ...

Abstract	Background and objective: Differentiating tropical infections are difficult due to its homogenous nature of clinical and laboratorial presentations among them. Sophisticated differential tests and prediction tools are better ways to tackle this issue. Here, we aimed to develop a clinician assisted decision making tool to differentiate the common tropical infections. Methodology: A cross sectional study through 9 item self-administered questionnaire were performed to understand the need of developing a decision making tool and its parameters. The most significant differential parameters among the identified infections were measured through a retrospective study and decision tree was developed. Based on the parameters identified, a multinomial logistic regression model and a machine learning model were developed which could better differentiate the infection. Results: A total of 40 physicians involved in the management of tropical infections were included for need analysis. Dengue, malaria, leptospirosis and scrub typhus were the common tropical infections in our settings. Sodium, total bilirubin, albumin, lymphocytes and platelets were the laboratory parameters; and abdominal pain, arthralgia, myalgia and urine output were the clinical presentation identified as better predictors. In multinomial logistic regression analysis with dengue as a reference revealed a predictability of 60.7%, 62.5% and 66% for dengue, malaria and leptospirosis, respectively, whereas, scrub typhus showed only 38% of predictability. The multi classification machine learning model observed to have an overall predictability of 55-60%, whereas a binary classification machine learning algorithms showed an average of 79-84% for one vs other and 69-88% for one vs one disease category. Conclusion: This is a first of its kind study where both statistical and machine learning approaches were explored simultaneously for differentiating tropical infections. Machine learning techniques in healthcare sectors will aid in early detection and better patient care.
MeSH term(s)	Artificial Intelligence ; Cross-Sectional Studies ; Dengue/diagnosis ; Humans ; Leptospirosis/diagnosis ; Malaria/diagnosis ; Retrospective Studies ; Scrub Typhus/diagnosis
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010455
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito