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  1. Article ; Online: Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity.

    Phucharoenrak, Pakkapong / Trachootham, Dunyaporn

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: Bergaptol (5-hydroxypsoralen or 5-hydroxyfuranocoumarin) is a naturally occurring furanocoumarin widely found in citrus fruits, which has multiple health benefits. Nonetheless, no specific review articles on bergaptol have been published. Compiling ... ...

    Abstract Bergaptol (5-hydroxypsoralen or 5-hydroxyfuranocoumarin) is a naturally occurring furanocoumarin widely found in citrus fruits, which has multiple health benefits. Nonetheless, no specific review articles on bergaptol have been published. Compiling updated information on bergaptol is crucial in guiding future research direction and application. The present review focuses on the research evidence related to the pharmacological properties and toxicity of bergaptol. Bergaptol has anti-inflammatory, antioxidant, anti-cancer, anti-osteoporosis, anti-microbial, and anti-lipidemic effects. It can inhibit the activities of cytochrome P450s (CYP), especially CYP2C9 and CYP3A4, thereby affecting the metabolism and concentrations of some drugs and toxins. Compared with other coumarins, bergaptol has the least potency to inhibit CYP3A4 in cancer cells. Instead, it can suppress drug efflux transporters, such as P-glycoprotein, thereby overcoming chemotherapeutic drug resistance. Furthermore, bergaptol has antimicrobial effects with a high potential for inhibition of quorum sensing. In vivo, bergaptol can be retained in plasma for longer than other coumarins. Nevertheless, its toxicity has not been clearly reported. In vitro study suggests that, unlike most furocoumarins, bergaptol is not phototoxic or photomutagenic. Existing research on bergaptol has mostly been conducted in vitro. Further in vivo and clinical studies are warranted to identify the safe and effective doses of bergaptol for its multimodal application.
    MeSH term(s) Citrus ; Cytochrome P-450 CYP3A ; Furocoumarins/pharmacology ; Coumarins/pharmacology
    Chemical Substances bergaptol (KTC8ANI30F) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Furocoumarins ; Coumarins
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030713
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    Zs.MO 81: Show issues

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  2. Article ; Online: An Individuality of Response to Cannabinoids: Challenges in Safety and Efficacy of Cannabis Products.

    Kitdumrongthum, Sarunya / Trachootham, Dunyaporn

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral ... ...

    Abstract Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral consumption of cannabis transports much less hazardous chemicals than smoking. Nevertheless, the response to cannabis is biphasically dose-dependent (hormesis; a low-dose stimulation and a high-dose inhibition) with wide individuality in responses. Thus, the exact same dose and preparation of cannabis may be beneficial for some but toxic to others. The purpose of this review is to highlight the concept of individual variations in response to cannabinoids, which leads to the challenge of establishing standard safe doses of cannabis products for the general population. The mechanisms of actions, acute and chronic toxicities, and factors affecting responses to cannabis products are updated. Based on the literature review, we found that the response to cannabis products depends on exposure factors (delivery route, duration, frequency, and interactions with food and drugs), individual factors (age, sex), and susceptibility factors (genetic polymorphisms of cannabinoid receptor gene, N-acylethanolamine-hydrolyzing enzymes, THC-metabolizing enzymes, and epigenetic regulations). Owing to the individuality of responses, the safest way to use cannabis-containing food products is to start low, go slow, and stay low.
    MeSH term(s) Humans ; Cannabinoids/pharmacology ; Cannabis/chemistry ; Dronabinol/adverse effects ; Cannabidiol/pharmacology ; Hallucinogens ; Cannabinoid Receptor Agonists
    Chemical Substances Cannabinoids ; Dronabinol (7J8897W37S) ; Cannabidiol (19GBJ60SN5) ; Hallucinogens ; Cannabinoid Receptor Agonists
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062791
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  3. Article: Cooking Methods for Preserving Isothiocyanates and Reducing Goitrin in

    Panduang, Thanaporn / Phucharoenrak, Pakkapong / Karnpanit, Weeraya / Trachootham, Dunyaporn

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 19

    Abstract: Glucosinolates ... ...

    Abstract Glucosinolates in
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12193647
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  4. Article ; Online: An Individuality of Response to Cannabinoids

    Sarunya Kitdumrongthum / Dunyaporn Trachootham

    Molecules, Vol 28, Iss 2791, p

    Challenges in Safety and Efficacy of Cannabis Products

    2023  Volume 2791

    Abstract: Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral ... ...

    Abstract Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral consumption of cannabis transports much less hazardous chemicals than smoking. Nevertheless, the response to cannabis is biphasically dose-dependent (hormesis; a low-dose stimulation and a high-dose inhibition) with wide individuality in responses. Thus, the exact same dose and preparation of cannabis may be beneficial for some but toxic to others. The purpose of this review is to highlight the concept of individual variations in response to cannabinoids, which leads to the challenge of establishing standard safe doses of cannabis products for the general population. The mechanisms of actions, acute and chronic toxicities, and factors affecting responses to cannabis products are updated. Based on the literature review, we found that the response to cannabis products depends on exposure factors (delivery route, duration, frequency, and interactions with food and drugs), individual factors (age, sex), and susceptibility factors (genetic polymorphisms of cannabinoid receptor gene, N-acylethanolamine-hydrolyzing enzymes, THC-metabolizing enzymes, and epigenetic regulations). Owing to the individuality of responses, the safest way to use cannabis-containing food products is to start low, go slow, and stay low.
    Keywords cannabis ; toxicity ; individual variation ; response ; genetic polymorphism ; hormesis ; Organic chemistry ; QD241-441
    Subject code 590
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers.

    Rungraung, Numphung / Muangpracha, Niramol / Trachootham, Dunyaporn

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: Coffee cherry pulp, a major waste product from coffee manufacturing, contains polyphenols with antioxidant activity. However, its clinical safety and health benefits are unclear. This randomized, double-blinded, placebo-controlled trial evaluated the ... ...

    Abstract Coffee cherry pulp, a major waste product from coffee manufacturing, contains polyphenols with antioxidant activity. However, its clinical safety and health benefits are unclear. This randomized, double-blinded, placebo-controlled trial evaluated the safety and potential efficacy of coffee cherry pulp juice concentrate. A total of 61 participants were randomly divided into a study group (
    MeSH term(s) Humans ; Healthy Volunteers ; Fruit and Vegetable Juices ; Antioxidants ; Body Weight ; Lipids ; Double-Blind Method
    Chemical Substances Antioxidants ; Lipids
    Language English
    Publishing date 2023-03-25
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071602
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  6. Article ; Online: Metabolomic Analysis of Phytochemical Compounds from Ethanolic Extract of Lime (

    Phucharoenrak, Pakkapong / Muangnoi, Chawanphat / Trachootham, Dunyaporn

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich lime peel extract. This study aimed to identify the metabolomics profile of phytochemicals and the anti- ...

    Abstract Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich lime peel extract. This study aimed to identify the metabolomics profile of phytochemicals and the anti-cancer effects of ethanolic extract of lime (
    MeSH term(s) Humans ; Hesperidin/chemistry ; Carcinoma, Hepatocellular/drug therapy ; Limonins/pharmacology ; Limonins/analysis ; Food ; Liver Neoplasms/drug therapy ; Refuse Disposal ; Citrus/chemistry ; Plant Extracts/chemistry
    Chemical Substances Hesperidin (E750O06Y6O) ; limonin (L0F260866S) ; Limonins ; lime (C7X2M0VVNH) ; Plant Extracts
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28072965
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  7. Article ; Online: Metabolomic Analysis of Phytochemical Compounds from Ethanolic Extract of Lime ( Citrus aurantifolia ) Peel and Its Anti-Cancer Effects against Human Hepatocellular Carcinoma Cells

    Pakkapong Phucharoenrak / Chawanphat Muangnoi / Dunyaporn Trachootham

    Molecules, Vol 28, Iss 2965, p

    2023  Volume 2965

    Abstract: Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich lime peel extract. This study aimed to identify the metabolomics profile of phytochemicals and the anti- ...

    Abstract Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich lime peel extract. This study aimed to identify the metabolomics profile of phytochemicals and the anti-cancer effects of ethanolic extract of lime ( Citrus aurantifolia ) peel against liver cancer cells PLC/PRF/5. The extract’s metabolomics profile was analyzed by using LC-qTOF/MS and GC-HRMS. The anti-cancer effects were studied by using MTT assay, Annexin-PI assay, and Transwell-invasion assay. Results show that the average IC 50 (s) of hesperidin, limonin, and the extract on cancer cells’ viability were 165.615, 188.073, and 503.004 µg/mL, respectively. At the IC 50 levels, the extract induced more apoptosis than those of pure compounds when incubating for 24 and 48 h ( p < 0.0001). A combination of limonin and hesperidin showed a synergistic effect on apoptosis induction ( p < 0.001), but the effect of the combination was still less than that of the extract at 48 h. Furthermore, the extract significantly inhibited cancer cell invasion better than limonin but equal to hesperidin. At the IC 50 level, the extract contains many folds lower amounts of hesperidin and limonin than the IC 50 doses of the pure compounds. Besides limonin and hesperidin, there were another 60 and 22 compounds detected from the LCMS and GCMS analyses, respectively. Taken altogether, the superior effect of the ethanolic extract against liver cancer cells compared to pure compound likely results from the combinatorial effects of limonin, hesperidin, and other phytochemical components in the extract.
    Keywords food waste ; citrus ; anti-cancer ; PLC/PRF/5 cells ; LC-qTOF/MS ; GC-MS ; Organic chemistry ; QD241-441
    Subject code 500
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (

    Phucharoenrak, Pakkapong / Muangnoi, Chawanphat / Trachootham, Dunyaporn

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: Green extraction is aimed at reducing energy consumption by using renewable plant sources and environmentally friendly bio-solvents. Lime ( ...

    Abstract Green extraction is aimed at reducing energy consumption by using renewable plant sources and environmentally friendly bio-solvents. Lime (
    MeSH term(s) Chemical Fractionation ; Citrus/chemistry ; Hesperidin/isolation & purification ; Limonins/isolation & purification ; Plant Extracts/isolation & purification ; Powders ; Solvents ; Temperature
    Chemical Substances Limonins ; Plant Extracts ; Powders ; Solvents ; Hesperidin (E750O06Y6O) ; limonin (L0F260866S)
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27030820
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  9. Article ; Online: Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer.

    Trachootham, Dunyaporn / Khoonin, Watcharapol

    Cancer communications (London, England)

    2019  Volume 39, Issue 1, Page(s) 9

    MeSH term(s) Colonic Neoplasms ; Colorectal Neoplasms ; Homeostasis ; Humans ; Oxidation-Reduction
    Language English
    Publishing date 2019-03-12
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1186/s40880-019-0355-y
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  10. Article ; Online: Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial.

    Lam-Ubol, Aroonwan / Sukhaboon, Jirasak / Rasio, Withee / Tupwongse, Peerawitch / Tangshewinsirikul, Thapana / Trachootham, Dunyaporn

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: ... ...

    Abstract TP53
    MeSH term(s) Humans ; Tumor Suppressor Protein p53/genetics ; Progression-Free Survival ; Quality of Life ; Cytochromes c ; Oropharyngeal Neoplasms/drug therapy
    Chemical Substances phenethyl isothiocyanate (6U7TFK75KV) ; Tumor Suppressor Protein p53 ; Cytochromes c (9007-43-6)
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097824
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