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  1. Article ; Online: Enzymatic and non-enzymatic transnitrosylation: "SCAN"ning the SNO-proteome.

    Nakamura, Tomohiro / Lipton, Stuart A

    Molecular cell

    2024  Volume 84, Issue 2, Page(s) 191–193

    Abstract: In a recent study in Cell, Zhou et al. ...

    Abstract In a recent study in Cell, Zhou et al.
    MeSH term(s) Proteome ; Nitric Oxide/metabolism ; Signal Transduction ; Proteomics
    Chemical Substances Proteome ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Synergistic Illusions: Enhancing Perceptual Effects of Pseudo-Attraction Force by Kinesthetic Illusory Hand Movement.

    Noto, Takuya / Nakamura, Takuto / Amemiya, Tomohiro

    IEEE transactions on haptics

    2024  Volume PP

    Abstract: We investigated the enhancement of the perceived force strength in force feedback devices by combining the pulling illusion with kinesthetic illusions. The pulling illusion (i.e., a sensation of being pulled or pushed) is induced by asymmetric vibrations ...

    Abstract We investigated the enhancement of the perceived force strength in force feedback devices by combining the pulling illusion with kinesthetic illusions. The pulling illusion (i.e., a sensation of being pulled or pushed) is induced by asymmetric vibrations applied to the fingertips, enabling the implementation of small, lightweight, and ungrounded force feedback devices. However, the perceived force intensity is limited. We focused on the kinesthetic illusion, a phenomenon in which the movement of a limb in the direction of muscle extension is illusively perceived by presenting vibrations to tendons or muscles as an illusion that could enhance the perceived strength of the pulling illusion. Moreover, we investigated the perceptual characteristics of force sensation by combining a kinesthetic illusion induced by wrist tendon vibration stimulation with a pulling illusion. The findings demonstrate that the direction of the pulling illusion was accurately perceived, even with simultaneous wrist tendon vibration stimuli. Importantly, the results suggest that tendon vibration on the wrist, rather than cutaneous vibration on the wrist, enhances the perceived force intensity of the pulling illusion at the fingertips. These findings indicate the potential for expanding the expressive capability of the pulling illusion.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4051
    ISSN (online) 2329-4051
    DOI 10.1109/TOH.2024.3386199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Redistribution of knee and ankle joint work with different midsole thicknesses in non-rearfoot strikers during running: a cross-sectional study.

    Miyazaki, Tomohiro / Aimi, Takayuki / Nakamura, Yasuo

    Acta of bioengineering and biomechanics

    2024  Volume 25, Issue 1, Page(s) 79–90

    Abstract: Purpose: The aim of this work was to i nvestigate the effects of midsole thickness on non-rearfoot strike runners' redistributions of knee and ankle joint negative and positive work.: Methods: Fourteen healthy male runners wore minimalist, ... ...

    Abstract Purpose: The aim of this work was to i nvestigate the effects of midsole thickness on non-rearfoot strike runners' redistributions of knee and ankle joint negative and positive work.
    Methods: Fourteen healthy male runners wore minimalist, traditional and maximalist shoes and ran in a straight line in each shoe in the laboratory at a speed of 15 km/h, with a ±5% difference being allowed. Whole-body kinematics and ground reaction forces were recorded, and the data of eleven non-rearfoot strikers were used for the analysis. Ankle and knee joint negative and positive work was calculated by integrating each joint's torque power. Friedman test was used for statistical comparisons.
    Results: Running in minimalist shoes induced significantly greater ankle joint negative and positive work than in other shoes. Running in maximalist shoes induced significantly lower ankle joint positive work and greater knee joint negative work than in other shoes, and significantly greater knee joint positive work than in minimalist shoes.
    Conclusions: Our results indicated that nonrearfoot strikers redistributed joint negative and positive work from the knee to the ankle when using minimalist shoes or from the ankle to the knee when using maximalist shoes. It is recommended that future research employs more rigorous study designs, such as randomised controlled trials and longitudinal studies, to provide a more accurate assessment of the effect of these shoes on in.
    MeSH term(s) Male ; Humans ; Ankle Joint ; Cross-Sectional Studies ; Lower Extremity ; Knee Joint ; Running ; Shoes ; Biomechanical Phenomena
    Language English
    Publishing date 2024-02-05
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2559094-7
    ISSN 1509-409X
    ISSN 1509-409X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fitness Trade-Offs between Phage and Antibiotic Sensitivity in Phage-Resistant Variants: Molecular Action and Insights into Clinical Applications for Phage Therapy.

    Fujiki, Jumpei / Nakamura, Keisuke / Nakamura, Tomohiro / Iwano, Hidetomo

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although ... ...

    Abstract In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although bacterial resistance to phages has been reported in clinical cases, recent studies on the fitness trade-offs between phage and antibiotic resistance have revealed new avenues in the field of phage therapy. This strategy aims to restore the antibiotic susceptibility of antimicrobial-resistant bacteria, even if phage-resistant variants develop. Here, we summarize the basic virological properties of phages and their applications within the context of antimicrobial resistance. In addition, we review the occurrence of phage resistance in clinical cases, and examine fitness trade-offs between phage and antibiotic sensitivity, exploring the potential of an evolutionary fitness cost as a countermeasure against phage resistance in therapy. Finally, we discuss future strategies and directions for phage-based therapy from the aspect of fitness trade-offs. This approach is expected to provide robust options when combined with antibiotics in this era of phage 're'-discovery.
    MeSH term(s) Humans ; Bacteriophages/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Phage Therapy/methods ; Bacterial Infections/therapy ; Bacteria
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115628
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  5. Article ; Online: The remaining parameters of patellar instability could be affected for osteoarthritic change after medial patellofemoral ligament reconstruction with or without anteromedialization of the tibial tubercle osteotomy for patellar instability: a retrospective cohort study.

    Hashimoto, Yusuke / Nishino, Kazuya / Tomohiro, Tomihara / Tsumoto, Shuko / Nakamura, Hiroaki

    BMC musculoskeletal disorders

    2023  Volume 24, Issue 1, Page(s) 56

    Abstract: Background: In literature, studies evaluating the factors associated the postoperative progression of patellofemoral (PF) osteoarthritis (OA) following patellar stabilization surgery are limited. This study aimed to compare the clinical outcomes after ... ...

    Abstract Background: In literature, studies evaluating the factors associated the postoperative progression of patellofemoral (PF) osteoarthritis (OA) following patellar stabilization surgery are limited. This study aimed to compare the clinical outcomes after medial patellofemoral ligament reconstruction (MPFLR) as an isolated procedure (iMPFLR) and in combination with anteromedialization (AMZ) of the tibial tubercle osteotomy (TTO) and investigate the factors related to the postoperative progression of PFOA after patellar stabilization surgery.
    Methods: Between 2009 and 2020, 30 knees of 23 consecutive patients underwent MPFLR with or without AMZ, using an autologous semitendinosus tendon graft; they were followed up for more than 2 years in the retrospective nature of the study. iMPFLR was performed in cases of recurrent patellar dislocation with normal tibial tubercle-trochlear groove (TT-TG) distance and no PFOA, and MPFLR+AMZ was performed for cases of excessive TT-TG distance, preoperative PFOA of recurrent patellar dislocation, or habitual patellar dislocation. Clinical findings and radiographs of the PF joint were evaluated pre- and postoperatively with PF alignment parameters and PFOA and were compared between surgical procedures. Factors for the postoperative progression of PFOA were compared between the OA progression and non-progression groups.
    Results: Postoperative clinical score, radiographic parameters except for sulcus angle, TT-TG distance, and progression of PFOA were not significantly different between the iMPFLR and MPFLR+AMZ groups. Postoperative lateral patellar displacement (p = 0.001) and congruence angle (p = 0.017) were significantly different between the OA progression and non-progression groups.
    Conclusion: Similar to MPFLR for recurrent cases, MPFLR with AMZ can improve the clinical and radiographic outcomes in severe cases. The remaining parameters of patellar instability could be affected in the postoperative progression of PFOA after MPFL reconstruction with or without AMZ of TTO for patellar instability.
    MeSH term(s) Humans ; Patellar Dislocation/diagnostic imaging ; Patellar Dislocation/surgery ; Patellofemoral Joint/diagnostic imaging ; Patellofemoral Joint/surgery ; Retrospective Studies ; Joint Instability/diagnostic imaging ; Joint Instability/etiology ; Joint Instability/surgery ; Recurrence ; Ligaments, Articular/surgery ; Tibia/diagnostic imaging ; Tibia/surgery ; Joint Dislocations ; Osteotomy/methods ; Bone Diseases ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-022-06100-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fitness Trade-Offs between Phage and Antibiotic Sensitivity in Phage-Resistant Variants

    Jumpei Fujiki / Keisuke Nakamura / Tomohiro Nakamura / Hidetomo Iwano

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    Molecular Action and Insights into Clinical Applications for Phage Therapy

    2023  Volume 15628

    Abstract: In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although ... ...

    Abstract In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although bacterial resistance to phages has been reported in clinical cases, recent studies on the fitness trade-offs between phage and antibiotic resistance have revealed new avenues in the field of phage therapy. This strategy aims to restore the antibiotic susceptibility of antimicrobial-resistant bacteria, even if phage-resistant variants develop. Here, we summarize the basic virological properties of phages and their applications within the context of antimicrobial resistance. In addition, we review the occurrence of phage resistance in clinical cases, and examine fitness trade-offs between phage and antibiotic sensitivity, exploring the potential of an evolutionary fitness cost as a countermeasure against phage resistance in therapy. Finally, we discuss future strategies and directions for phage-based therapy from the aspect of fitness trade-offs. This approach is expected to provide robust options when combined with antibiotics in this era of phage ‘re’-discovery.
    Keywords bacteriophage ; antimicrobial resistance (AMR) ; fitness cost ; phage cocktail ; engineered phage ; infectious disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: [Ⅳ. Recent Development and Foresight in Minimally Invasive Surgery for Lung Cancer].

    Haruki, Tomohiro / Nakamura, Hiroshige

    Gan to kagaku ryoho. Cancer & chemotherapy

    2021  Volume 48, Issue 8, Page(s) 1033–1036

    MeSH term(s) Humans ; Lung Neoplasms/surgery ; Minimally Invasive Surgical Procedures ; Pneumonectomy
    Language Japanese
    Publishing date 2021-08-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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  8. Article ; Online: Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer's disease: Mechanistic insights and potential therapies.

    Ghatak, Swagata / Nakamura, Tomohiro / Lipton, Stuart A

    Frontiers in neural circuits

    2023  Volume 17, Page(s) 1099467

    Abstract: Alzheimer's disease (AD) is arguably the most common cause of dementia in the elderly and is marked by progressive synaptic degeneration, which in turn leads to cognitive decline. Studies in patients and in various AD models have shown that one of the ... ...

    Abstract Alzheimer's disease (AD) is arguably the most common cause of dementia in the elderly and is marked by progressive synaptic degeneration, which in turn leads to cognitive decline. Studies in patients and in various AD models have shown that one of the early signatures of AD is neuronal hyperactivity. This excessive electrical activity contributes to dysregulated neural network function and synaptic damage. Mechanistically, evidence suggests that hyperexcitability accelerates production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that contribute to neural network impairment and synapse loss. This review focuses on the pathways and molecular changes that cause hyperexcitability and how RNS-dependent posttranslational modifications, represented predominantly by protein S-nitrosylation, mediate, at least in part, the deleterious effects of hyperexcitability on single neurons and the neural network, resulting in synaptic loss in AD.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease ; Protein S ; Neurons/physiology ; Reactive Nitrogen Species
    Chemical Substances Protein S ; Reactive Nitrogen Species
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2452968-0
    ISSN 1662-5110 ; 1662-5110
    ISSN (online) 1662-5110
    ISSN 1662-5110
    DOI 10.3389/fncir.2023.1099467
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  9. Article: Effects of acute cervical stretching on arterial wall elastic properties.

    Ikebe, Harumi / Oi, Naoya / Makino, Akitoshi / Kume, Daisuke / Ishido, Minenori / Nakamura, Tomohiro / Nishiwaki, Masato

    Frontiers in physiology

    2023  Volume 14, Page(s) 1198152

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1198152
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  10. Article ; Online: A concise synthesis of thioaurones

    Nakamura, Akira / Rao, Fei / Ukiya, Kazuchika / Matsunaga, Riko / Ohira, Shin-Ichiro / Maegawa, Tomohiro

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 6, Page(s) 1134–1137

    Abstract: A mild and efficient approach for the synthesis of ... ...

    Abstract A mild and efficient approach for the synthesis of thioaurones
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01995g
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