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  1. Article ; Online: Vascular smooth muscle cells display another colour of Cezanne's palette.

    Lehoux, Stephanie

    Cardiovascular research

    2021  Volume 118, Issue 2, Page(s) 355–356

    MeSH term(s) Color ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle
    Language English
    Publishing date 2021-12-22
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab365
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    Zs.A 565: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Adventures in the Adventitia.

    Lehoux, Stephanie

    Hypertension (Dallas, Tex. : 1979)

    2016  Volume 67, Issue 5, Page(s) 836–838

    MeSH term(s) Adventitia ; Humans
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.116.06375
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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  3. Article: Molecular Interactions Between Vascular Smooth Muscle Cells and Macrophages in Atherosclerosis.

    Beck-Joseph, Jahnic / Lehoux, Stephanie

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 737934

    Abstract: Atherosclerosis is the largest contributor toward life-threatening cardiovascular events. Cellular activity and cholesterol accumulation lead to vascular remodeling and the formation of fatty plaques. Complications arise from blood clots, forming at ... ...

    Abstract Atherosclerosis is the largest contributor toward life-threatening cardiovascular events. Cellular activity and cholesterol accumulation lead to vascular remodeling and the formation of fatty plaques. Complications arise from blood clots, forming at sites of plaque development, which may detach and result in thrombotic occlusions. Vascular smooth muscle cells and macrophages play dominant roles in atherosclerosis. A firm understanding of how these cells influence and modulate each other is pivotal for a better understanding of the disease and the development of novel therapeutics. Recent studies have investigated molecular interactions between both cell types and their impact on disease progression. Here we aim to review the current knowledge. Intercellular communications through soluble factors, physical contact, and extracellular vesicles are discussed. We also present relevant background on scientific methods used to study the disease, the general pathophysiology and intracellular factors involved in phenotypic modulation of vascular smooth muscle cells. We conclude this review with a discussion of the current state, shortcomings and potential future directions of the field.
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.737934
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  4. Article ; Online: Design and development of Branched Poly(ß-aminoester) nanoparticles for Interleukin-10 gene delivery in a mouse model of atherosclerosis.

    Distasio, Nicholas / Dierick, France / Ebrahimian, Talin / Tabrizian, Maryam / Lehoux, Stephanie

    Acta biomaterialia

    2022  Volume 143, Page(s) 356–371

    Abstract: Atherosclerosis progression is a result of chronic and non-resolving inflammation, effective treatments for which still remain to be developed. We designed and developed branched poly(ß-amino ester) nanoparticles (NPs) containing plasmid DNA encoding IL- ... ...

    Abstract Atherosclerosis progression is a result of chronic and non-resolving inflammation, effective treatments for which still remain to be developed. We designed and developed branched poly(ß-amino ester) nanoparticles (NPs) containing plasmid DNA encoding IL-10, a potent anti-inflammatory cytokine to atherosclerosis. The NPs (NP-VHPK) are functionalized with a targeting peptide (VHPK) specific for VCAM-1, which is overexpressed by endothelial cells at sites of atherosclerotic plaque. The anionic coating affords NP-VHPK with significantly lower toxicity than uncoated NPs in both endothelial cells and red blood cells (RBCs). Following injection of NP-VHPK in ApoE
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Atherosclerosis/drug therapy ; Atherosclerosis/therapy ; Disease Models, Animal ; Endothelial Cells/metabolism ; Inflammation/drug therapy ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Mice ; Nanoparticles ; Plaque, Atherosclerotic/metabolism ; Vascular Cell Adhesion Molecule-1/genetics ; Vascular Cell Adhesion Molecule-1/metabolism ; Vascular Cell Adhesion Molecule-1/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Vascular Cell Adhesion Molecule-1 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2022-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.02.043
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  5. Article ; Online: B cell-specific knockout of AID protects against atherosclerosis.

    Ebrahimian, Talin / Dierick, France / Ta, Vincent / Kotsiopriftis, Maria / O'Connor Miranda, Jonathan / Mann, Koren K / Orthwein, Alexandre / Lehoux, Stephanie

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8723

    Abstract: Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would thus be ... ...

    Abstract Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would thus be expected to foster atherosclerosis. Yet, AID also plays a major role in the establishment of B cell tolerance. We sought to define whether AID affects atherosclerotic plaque formation. We generated Ldlr
    MeSH term(s) Animals ; Mice ; Atherosclerosis/genetics ; Atherosclerosis/prevention & control ; Atherosclerosis/metabolism ; B-Lymphocytes ; Cell Differentiation ; Hydrolases/metabolism ; Immunoglobulin M/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Plaque, Atherosclerotic/genetics ; Plaque, Atherosclerotic/metabolism ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Cytidine Deaminase/genetics
    Chemical Substances Hydrolases (EC 3.-) ; Immunoglobulin M ; Receptors, LDL ; AICDA (activation-induced cytidine deaminase) (EC 3.5.4.-) ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35980-1
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  6. Article ; Online: B cell-specific knockout of AID protects against atherosclerosis

    Talin Ebrahimian / France Dierick / Vincent Ta / Maria Kotsiopriftis / Jonathan O’Connor Miranda / Koren K. Mann / Alexandre Orthwein / Stephanie Lehoux

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would ... ...

    Abstract Abstract Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would thus be expected to foster atherosclerosis. Yet, AID also plays a major role in the establishment of B cell tolerance. We sought to define whether AID affects atherosclerotic plaque formation. We generated Ldlr -/- chimeras transplanted with bone marrow from Aicda -/- or wild-type (WT) mice, fed a HFD for 14 weeks. Decreased B cell maturation in Ldlr -/- Aicda -/- mice was demonstrated by 50% reduction in splenic and aortic BAFFR expression, a key signaling component of B2 cell maturation. This was associated with increased plasma IgM in Ldlr –/- Aicda -/- compared with Ldlr -/- WT animals. Importantly, Ldlr -/- Aicda -/- mice had reduced atherosclerotic lesion area (0.20 ± 0.03mm2) compared with Ldlr -/- WT (0.30 ± 0.04mm2, P < 0.05), although no differences in plaque composition were noted between groups. In addition, immunofluorescence analysis revealed increased splenic B and T cell areas independent of cell number. AID depletion directly inhibits atherosclerotic plaque formation.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Shear stress, arterial identity and atherosclerosis.

    Lehoux, Stephanie / Jones, Elizabeth A

    Thrombosis and haemostasis

    2016  Volume 115, Issue 3, Page(s) 467–473

    Abstract: In the developing embryo, the vasculature first takes the form of a web-like network called the vascular plexus. Arterial and venous differentiation is subsequently guided by the specific expression of genes in the endothelial cells that provide spatial ... ...

    Abstract In the developing embryo, the vasculature first takes the form of a web-like network called the vascular plexus. Arterial and venous differentiation is subsequently guided by the specific expression of genes in the endothelial cells that provide spatial and temporal cues for development. Notch1/4, Notch ligand delta-like 4 (Dll4), and Notch downstream effectors are typically expressed in arterial cells along with EphrinB2, whereas chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and EphB4 characterise vein endothelial cells. Haemodynamic forces (blood pressure and blood flow) also contribute importantly to vascular remodelling. Early arteriovenous differentiation and local blood flow may hold the key to future inflammatory diseases. Indeed, despite the fact that atherosclerosis risk factors such as smoking, hypertension, hypercholesterolaemia, and diabetes all induce endothelial cell dysfunction throughout the vasculature, plaques develop only in arteries, and they localise essentially in vessel branch points, curvatures and bifurcations, where blood flow (and consequently shear stress) is low or oscillatory. Arterial segments exposed to high blood flow (and high laminar shear stress) tend to remain plaque-free. These observations have led many to investigate what particular properties of arterial or venous endothelial cells confer susceptibility or protection from plaque formation, and how that might interact with a particular shear stress environment.
    MeSH term(s) Animals ; Arteries/physiology ; Atherosclerosis/metabolism ; Cell Differentiation ; Endothelial Cells/cytology ; Endothelium, Vascular/metabolism ; Ephrin-B2/metabolism ; Humans ; Inflammation ; Intercellular Signaling Peptides and Proteins/metabolism ; Mice ; Phenotype ; Receptor, Notch1/metabolism ; Shear Strength ; Signal Transduction/physiology ; Stress, Mechanical
    Chemical Substances DLL4 protein, human ; Ephrin-B2 ; Intercellular Signaling Peptides and Proteins ; NOTCH1 protein, human ; Receptor, Notch1
    Language English
    Publishing date 2016-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    DOI 10.1160/TH15-10-0791
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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  8. Article: Endothelial strain and stress in atherosclerosis.

    Lehoux, Stephanie

    Clinical hemorheology and microcirculation

    2007  Volume 37, Issue 1-2, Page(s) 47–55

    MeSH term(s) Animals ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Biomechanical Phenomena ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelial Cells/physiology ; Endothelium, Vascular/pathology ; Humans ; Reactive Oxygen Species/metabolism ; Stress, Mechanical
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2007
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1381750-4
    ISSN 1386-0291
    ISSN 1386-0291
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    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Redox signalling in vascular responses to shear and stretch.

    Lehoux, Stephanie

    Cardiovascular research

    2006  Volume 71, Issue 2, Page(s) 269–279

    Abstract: Blood vessels are permanently exposed to stretch and shear stress due to blood pressure and blood flow. Significant variations in the mechanical environment, of physiological or pathophysiological nature, occur in vivo. These trigger acute changes in ... ...

    Abstract Blood vessels are permanently exposed to stretch and shear stress due to blood pressure and blood flow. Significant variations in the mechanical environment, of physiological or pathophysiological nature, occur in vivo. These trigger acute changes in vessel diameter that tend to restore basal levels of tensile and shear stress. However, when altered mechanical conditions persist, they lead to compensatory phenotypical modulation of the endothelial and vascular smooth muscle cells, producing structural and functional modifications of the arterial wall. Such vascular remodelling is a fundamental basis of normal vessel growth and adaptation. However, when the vascular environment changes, due to humoral, metabolic or surgical alterations, for example, mechanical factors may actually exacerbate the underlying conditions and contribute significantly to disease progression. Several studies have demonstrated that reactive oxygen species are induced in the vascular response to changes in shear stress or stretch. It appears that the balance between oxidant and antioxidant generation, which is directly determined by the nature of the mechanical stimulus, can greatly influence the process of vascular remodelling, contributing to both transient and more prolonged adaptations.
    MeSH term(s) Animals ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Humans ; Hyperplasia/metabolism ; Mechanotransduction, Cellular/physiology ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Stress, Mechanical
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2006-07-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1016/j.cardiores.2006.05.008
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    Zs.A 565: Show issues Location:
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  10. Article ; Online: IL-10 Gene Transfection in Primary Endothelial Cells via Linear and Branched Poly(β-amino ester) Nanoparticles Attenuates Inflammation in Stimulated Macrophages.

    DiStasio, Nicholas / Arts, Marloes / Lehoux, Stephanie / Tabrizian, Maryam

    ACS applied bio materials

    2018  Volume 1, Issue 3, Page(s) 917–927

    Abstract: Poly(β-amino esters) or PBAEs are highly efficient synthetic polymers optimized for gene delivery, a complicated process dependent on polymer properties such as hydrophobicity, charge, and degradability. The modular design of PBAEs has allowed for the ... ...

    Abstract Poly(β-amino esters) or PBAEs are highly efficient synthetic polymers optimized for gene delivery, a complicated process dependent on polymer properties such as hydrophobicity, charge, and degradability. The modular design of PBAEs has allowed for the identification of which polymer and nanoparticle properties significantly affect gene delivery efficiency in various cell types. However, these investigations need to be extended to more difficult-to-transfect cells such as primary endothelial cells, which hold enormous potential for atherosclerosis. Here a small library of 6 different PBAEs were screened for efficacy and safety in two types of primary endothelial cells (ECs). Nearly all polymers were more efficient than commercial transfection reagents (
    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.8b00342
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