LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article ; Online: Blood Pressure and Cardiovascular Risk in the Dialysis Patient: How Low Can You Go?

Tudorancea, Ionut / Iliescu, Radu

Hypertension (Dallas, Tex. : 1979)

2017 Volume 70, Issue 2, Page(s) 255–256

Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Editorial
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.117.09237
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1488: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives.

Tanase, Daniela Maria / Apostol, Alina Georgiana / Costea, Claudia Florida / Tarniceriu, Claudia Cristina / Tudorancea, Ionut / Maranduca, Minela Aida / Floria, Mariana / Serban, Ionela Lacramioara

Pharmaceutics

2022 Volume 14, Issue 3

Abstract: Arterial hypertension (HTN) is one of the most prevalent entities globally, characterized by increased incidence and heterogeneous pathophysiology. Among possible etiologies, oxidative stress (OS) is currently extensively studied, with emerging evidence ... ...

Abstract	Arterial hypertension (HTN) is one of the most prevalent entities globally, characterized by increased incidence and heterogeneous pathophysiology. Among possible etiologies, oxidative stress (OS) is currently extensively studied, with emerging evidence showing its involvement in endothelial dysfunction and in different cardiovascular diseases (CVD) such as HTN, as well as its potential as a therapeutic target. While there is a clear physiological equilibrium between reactive oxygen species (ROS) and antioxidants essential for many cellular functions, excessive levels of ROS lead to vascular cell impairment with decreased nitric oxide (NO) availability and vasoconstriction, which promotes HTN. On the other hand, transcription factors such as nuclear factor erythroid factor 2-related factor 2 (Nrf2) mediate antioxidant response pathways and maintain cellular reduction-oxidation homeostasis, exerting protective effects. In this review, we describe the relationship between OS and hypertension-induced endothelial dysfunction and the involvement and therapeutic potential of Nrf2 in HTN.
Language	English
Publishing date	2022-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14030534
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Brugada Syndrome: From Molecular Mechanisms and Genetics to Risk Stratification.

Popa, Irene Paula / Șerban, Dragomir N / Mărănducă, Minela Aida / Șerban, Ionela Lăcrămioara / Tamba, Bogdan Ionel / Tudorancea, Ionuț

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) in young adults. BrS is a complex entity in terms of mechanisms, ... ...

Abstract	Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) in young adults. BrS is a complex entity in terms of mechanisms, genetics, diagnosis, arrhythmia risk stratification, and management. The main electrophysiological mechanism of BrS requires further research, with prevailing theories centered on aberrant repolarization, depolarization, and current-load match. Computational modelling, pre-clinical, and clinical research show that BrS molecular anomalies result in excitation wavelength (k) modifications, which eventually increase the risk of arrhythmia. Although a mutation in the
MeSH term(s)	Young Adult ; Humans ; Brugada Syndrome/genetics ; Mutation ; Arrhythmias, Cardiac ; Risk Factors ; Risk Assessment ; NAV1.5 Voltage-Gated Sodium Channel/genetics ; Electrocardiography/methods
Chemical Substances	NAV1.5 Voltage-Gated Sodium Channel
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043328
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation.

Tudorancea, Ionut / Lohmeier, Thomas E / Alexander, Barbara T / Pieptu, Dragos / Serban, Dragomir N / Iliescu, Radu

Frontiers in physiology

2018 Volume 9, Page(s) 455

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2018-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.00455
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Contribution of Oxidative Stress (OS) in Calcific Aortic Valve Disease (CAVD): From Pathophysiology to Therapeutic Targets.

Tanase, Daniela Maria / Valasciuc, Emilia / Gosav, Evelina Maria / Floria, Mariana / Costea, Claudia Florida / Dima, Nicoleta / Tudorancea, Ionut / Maranduca, Minela Aida / Serban, Ionela Lacramioara

Cells

2022 Volume 11, Issue 17

Abstract: Calcific aortic valve disease (CAVD) is a major cause of cardiovascular mortality and morbidity, with increased prevalence and incidence. The underlying mechanisms behind CAVD are complex, and are mainly illustrated by inflammation, mechanical stress ( ... ...

Abstract	Calcific aortic valve disease (CAVD) is a major cause of cardiovascular mortality and morbidity, with increased prevalence and incidence. The underlying mechanisms behind CAVD are complex, and are mainly illustrated by inflammation, mechanical stress (which induces prolonged aortic valve endothelial dysfunction), increased oxidative stress (OS) (which trigger fibrosis), and calcification of valve leaflets. To date, besides aortic valve replacement, there are no specific pharmacological treatments for CAVD. In this review, we describe the mechanisms behind aortic valvular disease, the involvement of OS as a fundamental element in disease progression with predilection in AS, and its two most frequent etiologies (calcific aortic valve disease and bicuspid aortic valve); moreover, we highlight the potential of OS as a future therapeutic target.
MeSH term(s)	Aortic Valve/pathology ; Aortic Valve Stenosis ; Calcinosis/drug therapy ; Humans ; Oxidative Stress
Language	English
Publishing date	2022-08-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11172663
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: MicroRNAs (miRNAs) in Cardiovascular Complications of Rheumatoid Arthritis (RA): What Is New?

Tanase, Daniela Maria / Gosav, Evelina Maria / Petrov, Daniela / Teodorescu, Dan-Stefan / Buliga-Finis, Oana Nicoleta / Ouatu, Anca / Tudorancea, Ionut / Rezus, Elena / Rezus, Ciprian

International journal of molecular sciences

2022 Volume 23, Issue 9

Abstract: Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains ... ...

Abstract	Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by a combination between genetic susceptibility, and environmental triggers, which result in an auto-perpetuating process. The subsequently, systemic inflammation associated with RA is linked with a variety of extra-articular comorbidities, including cardiovascular disease (CVD), resulting in increased mortality and morbidity. Hitherto, vast evidence demonstrated the key role of non-coding RNAs such as microRNAs (miRNAs) in RA, and in RA-CVD related complications. In this descriptive review, we aim to highlight the specific role of miRNAs in autoimmune processes, explicitly on their regulatory roles in the pathogenesis of RA, and its CV consequences, their main role as novel biomarkers, and their possible role as therapeutic targets.
MeSH term(s)	Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Biomarkers/metabolism ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/genetics ; Heart Diseases/complications ; Humans ; Inflammation/complications ; Inflammation/genetics ; MicroRNAs/metabolism
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2022-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23095254
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The RAAS Axis and SARS-CoV-2: From Oral to Systemic Manifestations.

Maranduca, Minela Aida / Vamesu, Calin George / Tanase, Daniela Maria / Clim, Andreea / Drochioi, Ilie Cristian / Pinzariu, Alin Constantin / Filip, Nina / Dima, Nicoleta / Tudorancea, Ionut / Serban, Dragomir Nicolae / Serban, Ionela Lacramioara

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 12

Abstract: One of the essential regulators of arterial blood pressure, the renin-angiotensin-aldosterone system (RAAS) seems to be one of the most complex mechanisms in the human body. Since the discovery of its key components and their actions, new substances and ... ...

Abstract	One of the essential regulators of arterial blood pressure, the renin-angiotensin-aldosterone system (RAAS) seems to be one of the most complex mechanisms in the human body. Since the discovery of its key components and their actions, new substances and functions are still being unraveled. The main pathway begins with the secretion of renin in the kidney and culminates with the synthesis of angiotensin II (Ang II)-a strong vasoconstrictor-thanks to the angiotensin-converting enzyme (ACE). Research conducted in 2000 identified another enzyme, named ACE2, that converts Ang II into Ang-(1-7), a heptapeptide with opposing effects to those of Ang II: vasodilation and anti-inflammatory properties. This particular enzyme became of paramount importance during the last two decades, as a result of the confrontation of the human race with life-threatening epidemics. Multiple studies have been performed in order to uncover the link between ACE2 and human coronaviruses, the results of which we systemized in order to create an overview of the pathogenic mechanism. Human coronaviruses, such as SARS-CoV and SARS-CoV-2, attach to ACE2 via their spike proteins (S), causing the destruction of the enzyme. Because ACE2 limits the production of Ang II (by converting it into Ang-(1-7)), its destruction leads to a dysregulated inflammatory response. The purpose of this review is to decipher the complex pathophysiological mechanisms underlying the multiorgan complications (oral, cardiac, pulmonary, systemic) that appear as a result of the interaction of the SARS CoV-2 virus with the angiotensin-converting enzyme type 2.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58121717
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6270: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Pulmonary Embolism Risk Assessment Using Blood Copeptin Concentration and Pulmonary Arteries Thrombotic Burden Evaluated by Computer Tomography.

Haba, Mihai Ștefan Cristian / Tudorancea, Ionut / Miftode, Radu Ștefan / Popa, Irene Paula / Mitu, Ovidiu / Mihai, Cosmin Teodor / Haba, Raluca Maria / Onofrei, Viviana Aursulesei / Petris, Antoniu Octavian / Costache, Irina Iuliana / Haba, Danisia / Șorodoc, Laurentiu

Journal of personalized medicine

2022 Volume 12, Issue 12

Abstract: 1) Background: Pulmonary embolism (PE) represents the third most important cardiovascular cause of death after myocardial infarction and stroke. The proper management of this condition is dependent on adequate risk stratification, due to the life- ... ...

Abstract	(1) Background: Pulmonary embolism (PE) represents the third most important cardiovascular cause of death after myocardial infarction and stroke. The proper management of this condition is dependent on adequate risk stratification, due to the life-threatening complications of more aggressive therapies such as thrombolysis. Copeptin is a surrogate marker of vasopressin which is found increased in several cardiovascular conditions. The Mastora score is an imagistic evaluation of the degree of pulmonary arteries thrombotic burden based on computed tomography angiography. In this study, we aimed to evaluate the diagnostic and prognostic role of copeptin in patients with acute PE. Furthermore, we analyzed the relationship between copeptin and Mastora score and their role in PE risk profiling. (2) Methods: We conducted a single center prospective study that included 112 patients with PE and 53 healthy volunteers. Clinical and paraclinical parameters, together with plasma levels of copeptin and the Mastora score, were evaluated in all patients after admission. (3) Results: Copeptin levels were significantly increased in PE patients compared with the general population (26.05 vs. 9.5 pmol/L, p < 0.001), while receiver operating characteristic (ROC) analysis revealed an AUC of 0.800 (95% CI 0.728−0.873, p < 0.001). Copeptin directly correlated with the Mastora score (r = 0.535, p = 0.011) and both parameters were strong predictors for adverse clinical events and death. Receiver operating characteristic (ROC) analysis for death within 30 days revealed a copeptin cut-off of 38.36 pmol/L, which presented a specificity of 79.6% and a sensitivity of 88.9%, and a Mastora score cut-off of 82 points, which presented a specificity of 74.8% and a sensitivity of 77.8%. (4) Conclusions: Our results showed that copeptin and the Mastora score are both correlated with adverse cardiovascular events and mortality in PE patients, and this may pave the way for their use in clinical practice, helping physicians to select the best therapeutical management.
Language	English
Publishing date	2022-12-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12122084
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases.

Tudorancea, Ivona Maria / Ciorpac, Mitică / Stanciu, Gabriela Dumitrița / Caratașu, Cătălin / Săcărescu, Alina / Ignat, Bogdan / Burlui, Alexandra / Rezuș, Elena / Creangă, Ioana / Alexa-Stratulat, Teodora / Tudorancea, Ionuț / Tamba, Bogdan Ionel

Biomedicines

2022 Volume 10, Issue 10

Abstract: The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability ... ...

Abstract	The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furthermore, cannabinoids, as components of the cannabinoid system (CS), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. In this comprehensive review, we aimed to describe the complex interaction between CS and most common age-related diseases such as neuro-degenerative, oncological, skeletal, and cardiovascular disorders, together with the potential of various cannabinoids to ameliorate the progression of these disorders. Since chronic inflammation is postulated as the pillar of all the above-mentioned medical conditions, we also discuss in this paper the potential of CS to ameliorate aging-associated immune system dysregulation.
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10102492
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Contribution of Oxidative Stress (OS) in Calcific Aortic Valve Disease (CAVD)

Daniela Maria Tanase / Emilia Valasciuc / Evelina Maria Gosav / Mariana Floria / Claudia Florida Costea / Nicoleta Dima / Ionut Tudorancea / Minela Aida Maranduca / Ionela Lacramioara Serban

Cells, Vol 11, Iss 2663, p

From Pathophysiology to Therapeutic Targets

2022 Volume 2663

Abstract	Calcific aortic valve disease (CAVD) is a major cause of cardiovascular mortality and morbidity, with increased prevalence and incidence. The underlying mechanisms behind CAVD are complex, and are mainly illustrated by inflammation, mechanical stress (which induces prolonged aortic valve endothelial dysfunction), increased oxidative stress (OS) (which trigger fibrosis), and calcification of valve leaflets. To date, besides aortic valve replacement, there are no specific pharmacological treatments for CAVD. In this review, we describe the mechanisms behind aortic valvular disease, the involvement of OS as a fundamental element in disease progression with predilection in AS, and its two most frequent etiologies (calcific aortic valve disease and bicuspid aortic valve); moreover, we highlight the potential of OS as a future therapeutic target.
Keywords	oxidative stress ; calcific aortic valve disease ; bicuspid aortic valve ; valvular interstitial cells ; antioxidants ; therapeutic targets ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED