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  1. Book ; Online: The Comprehensive Cancer Center : Development, Integration, and Implementation

    Aljurf, Mahmoud / Majhail, Navneet S. / Koh, Mickey B.C. / Kharfan-Dabaja, Mohamed A. / Chao, Nelson J.

    2022  

    Keywords Oncology ; Medical administration & management ; Palliative medicine ; Inpatient Unit ; Radiation Therapy Facility ; Palliative Care ; Infusion Center ; Blood Bank ; Open Access
    Size 1 electronic resource (193 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229784
    ISBN 9783030820527 ; 3030820521
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: How to Perform Hematopoietic Stem Cell Transplantation.

    Majhail, Navneet S

    JACC. CardioOncology

    2021  Volume 3, Issue 5, Page(s) 742–746

    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2021.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Not So Young at Heart: Long-Term Cardiac Dysfunction in Young Adult Hematopoietic Cell Transplantation Survivors.

    Majhail, Navneet S / Bhatt, Neel S

    JACC. CardioOncology

    2020  Volume 2, Issue 3, Page(s) 472–474

    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2020.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Increasing access to allotransplants in the United States: the impact of race, geography, and socioeconomics.

    Hong, Sanghee / Majhail, Navneet S

    Hematology. American Society of Hematology. Education Program

    2021  Volume 2021, Issue 1, Page(s) 275–280

    Abstract: Allogeneic hematopoietic cell transplantation (HCT) is particularly susceptible to racial, socioeconomic, and geographic disparities in access and outcomes given its specialized nature and its availability in select centers in the United States. Nearly ... ...

    Abstract Allogeneic hematopoietic cell transplantation (HCT) is particularly susceptible to racial, socioeconomic, and geographic disparities in access and outcomes given its specialized nature and its availability in select centers in the United States. Nearly all patients who need HCT have a potential donor in the current era, but racial minority populations are less likely to have an optimal donor and often rely on alternative donor sources. Furthermore, prevalent health care disparity factors are further accentuated and can be barriers to access and referral to a transplant center. Research has primarily focused on defining and quantifying a variety of social determinants of health and their association with access to allogeneic HCT, with a focus on race/ethnicity and socioeconomic status. However, research on interventions is lacking and is an urgent unmet need. We discuss the role of racial, socioeconomic, and geographic disparities in access to allogeneic HCT, along with policy changes to address and mitigate them and opportunities for future research.
    MeSH term(s) Ethnic and Racial Minorities ; Health Services Accessibility/economics ; Healthcare Disparities/economics ; Hematopoietic Stem Cell Transplantation/economics ; Humans ; Socioeconomic Factors ; Transplantation, Homologous/economics ; United States
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2021000259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Race colors transplantation utilization for multiple myeloma.

    Majhail, Navneet S

    Cancer

    2017  Volume 123, Issue 16, Page(s) 3005–3006

    MeSH term(s) Color ; Hematopoietic Stem Cell Transplantation ; Hispanic Americans ; Humans ; Multiple Myeloma ; Stem Cell Transplantation ; Transplantation, Autologous ; United States
    Language English
    Publishing date 2017-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.30750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Chimeric Antigen Receptor T-Cell Therapy for Hematologic Malignancies: A Practical Review.

    Strati, Paolo / Gregory, Tara / Majhail, Navneet S / Jain, Nitin

    JCO oncology practice

    2023  Volume 19, Issue 9, Page(s) 706–713

    Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy has become an established therapeutic approach for the treatment of hematologic malignancies. The field continues to evolve rapidly and newer-generation constructs are being designed to enhance ... ...

    Abstract Chimeric antigen receptor T-cell (CAR-T) therapy has become an established therapeutic approach for the treatment of hematologic malignancies. The field continues to evolve rapidly and newer-generation constructs are being designed to enhance proliferative capacity, and achieve long-term persistence and greater efficacy with an overall lower incidence of toxicity. Initial clinical application of CAR-T therapies has focused on relapsed and/or refractory hematologic malignancies, and Food and Drug Administration-approved CAR-T products targeting CD19 are available for B-cell acute lymphoblastic leukemia and low- and high-grade B-cell non-Hodgkin lymphoma, and targeting B-cell maturation antigen are available for multiple myeloma. Cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome have been recognized as class specific toxicities associated with these novel therapies. In this review, we focus on the clinical application of CAR-T therapies in adult patients with hematologic malignancies, including access issues, outpatient administration, and appropriate timing for referring a patient to a CAR-T treatment center.
    MeSH term(s) United States ; Adult ; Humans ; Receptors, Chimeric Antigen/therapeutic use ; Receptors, Antigen, T-Cell/therapeutic use ; Hematologic Neoplasms/drug therapy ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen ; cell-associated neurotoxicity ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7198: Show issues Location:
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  7. Article: Long-term complications after hematopoietic cell transplantation.

    Majhail, Navneet S

    Hematology/oncology and stem cell therapy

    2017  Volume 10, Issue 4, Page(s) 220–227

    Abstract: The prevalence of autologous and allogeneic hematopoietic cell transplantation (HCT) survivors continues to increase. Among patients whose disease remains in remission for the first 2-5years after transplantation, it is estimated that approximately 80-90% ...

    Abstract The prevalence of autologous and allogeneic hematopoietic cell transplantation (HCT) survivors continues to increase. Among patients whose disease remains in remission for the first 2-5years after transplantation, it is estimated that approximately 80-90% will be alive over the subsequent 10years. However, the relative mortality rates of such patients continue to remain higher than those of their general population peers, with late complications contributing to significant long-term morbidity and mortality. Late effects in HCT survivors include secondary cancers, organ specific complications, late infections, quality of life impairments, psychosocial issues, sexual and fertility concerns, financial toxicity, and issues around return to work/school. A patient-centric and multidisciplinary approach to HCT survivorship care with collaborative and coordinated care from transplant centers and community healthcare providers is necessary to ensure their long-term health. Lifelong follow-up of HCT survivors is recommended, with established guidelines serving as the template for providing screening and preventive care based on patient-specific exposures. This review discussed common late complications, models for care delivery, and gaps and priorities for future research in the field of HCT survivorship.
    MeSH term(s) Allografts ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Mortality ; Quality of Life ; Survivors ; Time Factors
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2651893-4
    ISSN 1658-3876
    ISSN 1658-3876
    DOI 10.1016/j.hemonc.2017.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6950: Show issues Location:
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  8. Article ; Online: Treatment and disease-related complications in multiple myeloma: Implications for survivorship.

    Chakraborty, Rajshekhar / Majhail, Navneet S

    American journal of hematology

    2020  Volume 95, Issue 6, Page(s) 672–690

    Abstract: New treatments have transformed multiple myeloma into a chronic disease. Hence, optimal management of treatment and disease-related complications remains a critical component of survivorship care. Survivorship care model in cancers requiring a fixed- ... ...

    Abstract New treatments have transformed multiple myeloma into a chronic disease. Hence, optimal management of treatment and disease-related complications remains a critical component of survivorship care. Survivorship care model in cancers requiring a fixed-duration therapy may not be applicable to myeloma, since patients are exposed to multiple lines of continuous therapy along the disease trajectory. The two most common therapy-related causes of death, which require special consideration, are infection and second cancers. Identifying patients at a high risk of toxicities will facilitate individualized treatment selection and designing clinical trials for protective strategies targeting those patients. For example, prophylactic antibiotic or immunoglobulin replacement can be tested for primary prevention of infections in high-risk patients. Long-term follow up of ongoing trials and epidemiologic data will help identify the nature and trajectory of rare toxicities with a long latency, such as secondary cancers. Patients who are frail, have persistent renal insufficiency, and refractory to multiple lines of therapy need special attention regarding treatment toxicity and quality of life. In this review, we discuss the incidence, risk-factors, and management of treatment and disease-related complications in myeloma, discuss knowledge gaps and research priorities in this area, and propose a survivorship care model to improve health-care delivery to a growing pool of myeloma survivors.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Clinical Trials as Topic ; Humans ; Models, Biological ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy ; Quality of Life ; Renal Insufficiency/chemically induced ; Renal Insufficiency/mortality
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Conditioning regimens for refractory acute myeloid leukaemia.

    Majhail, Navneet S

    The Lancet. Haematology

    2015  Volume 2, Issue 9, Page(s) e354–5

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute ; Transplantation Conditioning
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(15)00154-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prognostic Impact of Adiposity in Hematological Malignancies: A Systematic Review and Meta-analysis.

    Aleixo, Gabriel F P / Sheu, Michael / Mirzai, Saeid / Majhail, Navneet S

    Clinical lymphoma, myeloma & leukemia

    2022  Volume 22, Issue 10, Page(s) 726–734

    Abstract: It has been proposed that direct measurement of adiposity has a greater accuracy as a prognostic factor in various malignancies than anthropometric measures such as BMI. We evaluated the association of visceral and subcutaneous adiposity with outcomes in ...

    Abstract It has been proposed that direct measurement of adiposity has a greater accuracy as a prognostic factor in various malignancies than anthropometric measures such as BMI. We evaluated the association of visceral and subcutaneous adiposity with outcomes in patients with hematological malignancies with a systematic review and meta-analysis. This systematic review included patients with hematological malignancies who had the analysis of overall mortality and progression-free survival according to their adiposity status. We identified 3137 articles, of which we included seven studies. Patients with visceral low visceral adiposity had 2 times greater mortality risk (HR 2.02, P = .0004) and 80% higher risk of death or disease progression (HR 2.98, P = 0.0002), than patients with normal visceral obesity. Patients classified with subcutaneous adipopenia had almost 3 times greater mortality risk. In conclusion, hematological malignancy patients having low adiposity (subcutaneous or visceral) have worse outcomes.
    MeSH term(s) Adiposity ; Body Mass Index ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/pathology ; Humans ; Intra-Abdominal Fat/pathology ; Obesity/complications ; Prognosis
    Language English
    Publishing date 2022-05-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5903: Show issues Location:
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