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Article ; Online: Analysis of Concentrated COVID-19 Outbreaks in Elderly Facilities in Suita City, Osaka Prefecture, Japan.

Shibata, Toshiyuki / Okano, Sawa / Onozuka, Daisuke / Ohta, Etsuko / Kutsuna, Satoshi

International journal of environmental research and public health

2023 Volume 20, Issue 20

Abstract: There are several types of facilities for elderly individuals in Japan. Infection control efforts, such as care provision and medical care access, differ according to the type of facility. Elderly individuals at these facilities who were infected with ... ...

Abstract	There are several types of facilities for elderly individuals in Japan. Infection control efforts, such as care provision and medical care access, differ according to the type of facility. Elderly individuals at these facilities who were infected with coronavirus disease 2019 (COVID-19) experienced severe illness and mortality. This study aimed to determine the characteristics of concentrated COVID-19 outbreaks that occurred in nursing homes and care facilities in Suita City. During this study, twenty-five elderly facilities in Suita City with a capacity of 40 or more individuals where an outbreak occurred during the sixth or seventh wave of infection were included. We investigated whether there was a difference in the COVID-19 incidence and the percentage of positive cases according to the type of facility. We also investigated the relationship between the facility capacity and positive case rate and that between the number of positive cases and outbreak duration. The incidence rate of COVID-19 was significantly different according to the facility type (
MeSH term(s)	Humans ; Aged ; COVID-19/epidemiology ; Japan/epidemiology ; Nursing Homes ; Infection Control ; Disease Outbreaks
Language	English
Publishing date	2023-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20206926
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cross-sectional surveillance study of long COVID in Toyonaka city, Osaka prefecture, Japan.

Kutsuna, Satoshi / Onozuka, Daisuke / Asano, Kento / Matsunami, Katsura / Matsuoka, Taro

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 30, Issue 6, Page(s) 511–515

Abstract: Background: As the COVID-19 epidemic continues, concerns about long-term health impacts, specifically long COVID, persist. While the prevalence and symptomatology of long COVID have been explored in various global contexts, large-scale cohort studies in ...

Abstract	Background: As the COVID-19 epidemic continues, concerns about long-term health impacts, specifically long COVID, persist. While the prevalence and symptomatology of long COVID have been explored in various global contexts, large-scale cohort studies in Japan remain limited, especially after the advent of the Omicron variant. Methods: In this observational study, 4,047 residents with a history of COVID-19 living in Toyonaka City, Osaka Prefecture, were assessed for long COVID symptoms using the VOICE mobile application and a paper survey. Respondents provided demographic and health information, as well as information regarding COVID-19 infection and subsequent symptoms. A Cox proportional hazard regression model was used to estimate the multivariable-adjusted hazard ratios and 95 % confidence intervals for overall morbidity of long COVID symptoms. Results: The survey found that 5.2 % of participants reported the persistence of one or more symptoms at 30 days post-onset. Fatigue was the most commonly reported symptom (1.75 %), followed by hair loss (1.41 %), and cough (1.28 %). Factors associated with an increased risk of experiencing long COVID symptoms included BMI, severe illness during the acute phase, and infection with certain COVID-19 variant strains, including Alpha, Delta, and Omicron. However, the incidence rate of long COVID appears to be decreasing with the dominance of the Omicron variant. Conclusions: This large-scale study from Toyonaka City suggests a 5.2 % prevalence rate for persistent COVID-19 symptoms 4 weeks post-infection, potentially indicating a lower prevalence of long COVID in Japanese populations after the rise of the Omicron variant.
MeSH term(s)	Humans ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; Japan/epidemiology ; SARS-CoV-2 ; Cross-Sectional Studies
Language	English
Publishing date	2023-12-14
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.12.006
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Zs.A 5236: Show issues

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Article ; Online: Effect of non-stationary climate on infectious gastroenteritis transmission in Japan.

Onozuka, Daisuke

Scientific reports

2014 Volume 4, Page(s) 5157

Abstract: Local weather factors are widely considered to influence the transmission of infectious gastroenteritis. Few studies, however, have examined the non-stationary relationships between global climatic factors and transmission of infectious gastroenteritis. ... ...

Abstract	Local weather factors are widely considered to influence the transmission of infectious gastroenteritis. Few studies, however, have examined the non-stationary relationships between global climatic factors and transmission of infectious gastroenteritis. We analyzed monthly data for cases of infectious gastroenteritis in Fukuoka, Japan from 2000 to 2012 using cross-wavelet coherency analysis to assess the pattern of associations between indices for the Indian Ocean Dipole (IOD) and El Niño Southern Oscillation (ENSO). Infectious gastroenteritis cases were non-stationary and significantly associated with the IOD and ENSO (Multivariate ENSO Index [MEI], Niño 1 + 2, Niño 3, Niño 4, and Niño 3.4) for a period of approximately 1 to 2 years. This association was non-stationary and appeared to have a major influence on the synchrony of infectious gastroenteritis transmission. Our results suggest that non-stationary patterns of association between global climate factors and incidence of infectious gastroenteritis should be considered when developing early warning systems for epidemics of infectious gastroenteritis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Infections/epidemiology ; Bacterial Infections/transmission ; Child ; Child, Preschool ; Climate ; Climate Change/statistics & numerical data ; Computer Simulation ; Disease Outbreaks/statistics & numerical data ; Female ; Gastroenteritis/epidemiology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Japan/epidemiology ; Male ; Middle Aged ; Models, Statistical ; Risk Assessment ; Statistics as Topic ; Young Adult
Language	English
Publishing date	2014-06-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep05157
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Article: Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins: A competing risk analysis among Yusho patients

Onozuka, Daisuke / Nakamura, Yuko / Tsuji, Gaku / Furue, Masutaka

Environment international. 2021 Feb., v. 147

2021

Abstract: In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in Yusho patients ...

Abstract	In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in Yusho patients exposed to polychlorinated biphenyls (PCBs) and dioxin-related compounds has not been estimated.We identified vital status and cause of death for Yusho patients between 1968 and 2017. Risk of cancer- and noncancer-specific mortality was estimated using a flexible hazards-based regression model, with accounting for competing events.In total, 1664 Yusho patients with 63,566 person-years of follow-up were included in the analysis. 50-year cumulative incidence of cancer mortality was 12.4% (95% confidence interval [CI], 10.5–14.7) in males and 4.7% (95% CI, 3.5–6.4) in females (difference, 7.7 percentage points [95% CI, 5.2–10.2]; adjusted hazard ratio for males, 2.61 [95% CI, 1.93–3.52]). For noncancer, the 50-year cumulative incidence of mortality was 35.4% (95% CI, 32.8–38.3) in males and 35.6% (95% CI, 33.3–38.1) in females (difference, −0.2 percentage points [95% CI, −3.5 to 3.1]; adjusted hazard ratio for males, 1.51 [95% CI, 1.26–1.82]).These findings confirm that male Yusho patients have a significantly higher risk of cumulative incidence of cancer-specific mortality than female Yusho patients. Our findings might be useful in providing Yusho patients with more accurate information on cancer prognosis and survivorship and help determine more appropriate disease management.
Keywords	confidence interval ; cumulative risk ; death ; disease control ; environment ; females ; hazard ratio ; males ; polychlorinated biphenyls ; prognosis ; regression analysis ; risk analysis ; survival rate
Language	English
Dates of publication	2021-02
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2020.106320
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Extreme influenza epidemics and out-of-hospital cardiac arrest.

Onozuka, Daisuke / Hagihara, Akihito

International journal of cardiology

2018 Volume 263, Page(s) 158–162

Abstract: Introduction: There is compelling evidence for an association between influenza epidemics and major adverse cardiovascular events. However, the role of extreme influenza epidemics as a trigger of out-of-hospital cardiac arrest (OHCA) is unclear. Thus, ... ...

Abstract	Introduction: There is compelling evidence for an association between influenza epidemics and major adverse cardiovascular events. However, the role of extreme influenza epidemics as a trigger of out-of-hospital cardiac arrest (OHCA) is unclear. Thus, we evaluated the potential association between extreme influenza epidemics and incidence of OHCA. Methods: We used a quasi-experimental design with time-series analysis of national registry data for cases of OHCA from all 47 prefectures of Japan during influenza seasons between 2005 and 2014. A Poisson regression time-series model with a distributed lag non-linear model was used to estimate prefecture-specific effects of influenza epidemics on OHCA. A multivariate meta-analysis was conducted for nationally pooled estimates. Results: In total, 481,516 OHCAs of presumed cardiac origin were reported during the study period. The minimum morbidity percentile (MMP) was estimated as the 0th percentile for influenza incidence. The overall cumulative relative risk versus the MMP was 1.25 (95% confidence interval, 1.16-1.34) for extreme influenza epidemics (at the 99th percentile of influenza incidence). The effect of extreme influenza epidemics was significant for lag periods of 1.5-7.1 and 17.9-21 days. Multivariate random-effects meta-analysis indicated significant spatial heterogeneity among prefectures (Cochran Q test, p = 0.011; I Conclusion: Extreme influenza epidemics are associated with higher risk of OHCA. Our findings suggest that several weeks' prevention for extreme influenza infections should be implemented to reduce the risk of OHCA.
MeSH term(s)	Aged ; Epidemics/prevention & control ; Female ; Humans ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Japan/epidemiology ; Male ; Middle Aged ; Out-of-Hospital Cardiac Arrest/diagnosis ; Out-of-Hospital Cardiac Arrest/epidemiology ; Registries ; Risk Factors
Language	English
Publishing date	2018-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.02.028
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Article ; Online: Out-of-Hospital Cardiac Arrests During the Japanese Professional Baseball Championship Series.

Onozuka, Daisuke / Hagihara, Akihito

The American journal of cardiology

2018 Volume 121, Issue 12, Page(s) 1471–1476

Abstract: Because the Japan Professional Baseball Championship Series (Japan Series) is a stressful sports event, it is possible that watching Japan Series matches may increase the risk of cardiovascular events. Therefore, we investigated the potential association ...

Abstract	Because the Japan Professional Baseball Championship Series (Japan Series) is a stressful sports event, it is possible that watching Japan Series matches may increase the risk of cardiovascular events. Therefore, we investigated the potential association between the Japan Series and the incidence of out-of-hospital cardiac arrest (OHCA) events. National registry data for all cases of OHCA between 2005 and 2014 from 47 prefectures of Japan were obtained. We used a time-stratified case-crossover design with a conditional Poisson regression model to compare OHCA events during the Japan Series with those events that occurred during the periods except for dates of the Japan Series. The estimated associations for each prefecture were pooled at the nationwide level using a random-effects meta-analysis. In total, 666,020 OHCAs of presumed cardiac origin were reported during the study period. On days of Japan Series matches, the pooled relative risk of OHCA was 1.033 (95% confidence interval 1.012 to 1.055; p = 0.002; I
MeSH term(s)	Adolescent ; Adult ; Aged ; Baseball/psychology ; Female ; Humans ; Incidence ; Japan/epidemiology ; Male ; Middle Aged ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/psychology ; Registries ; Regression Analysis ; Sex Distribution ; Stress, Psychological/psychology ; Young Adult
Language	English
Publishing date	2018-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2018.02.038
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Article ; Online: Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins

Daisuke Onozuka / Yuko Nakamura / Gaku Tsuji / Masutaka Furue

Environment International, Vol 147, Iss , Pp 106320- (2021)

A competing risk analysis among Yusho patients

2021

Abstract: Background: In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in ... ...

Abstract	Background: In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in Yusho patients exposed to polychlorinated biphenyls (PCBs) and dioxin-related compounds has not been estimated. Methods: We identified vital status and cause of death for Yusho patients between 1968 and 2017. Risk of cancer- and noncancer-specific mortality was estimated using a flexible hazards-based regression model, with accounting for competing events. Results: In total, 1664 Yusho patients with 63,566 person-years of follow-up were included in the analysis. 50-year cumulative incidence of cancer mortality was 12.4% (95% confidence interval [CI], 10.5–14.7) in males and 4.7% (95% CI, 3.5–6.4) in females (difference, 7.7 percentage points [95% CI, 5.2–10.2]; adjusted hazard ratio for males, 2.61 [95% CI, 1.93–3.52]). For noncancer, the 50-year cumulative incidence of mortality was 35.4% (95% CI, 32.8–38.3) in males and 35.6% (95% CI, 33.3–38.1) in females (difference, −0.2 percentage points [95% CI, −3.5 to 3.1]; adjusted hazard ratio for males, 1.51 [95% CI, 1.26–1.82]). Conclusions: These findings confirm that male Yusho patients have a significantly higher risk of cumulative incidence of cancer-specific mortality than female Yusho patients. Our findings might be useful in providing Yusho patients with more accurate information on cancer prognosis and survivorship and help determine more appropriate disease management.
Keywords	Cancer ; Competing risk ; Cumulative incidence function ; Polychlorinated biphenyls ; Yusho ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: a 50-year retrospective cohort study.

Onozuka, Daisuke / Nakamura, Yuko / Tsuji, Gaku / Furue, Masutaka

Environmental health : a global access science source

2020 Volume 19, Issue 1, Page(s) 119

Abstract: Background: In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients.: Methods: ... ...

Abstract	Background: In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients. Methods: We obtained updated cohort data for all Yusho patients for the period 1968-2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan. Results: A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR: 1.22, 95% confidence interval [CI]: 1.02 to 1.45) and lung cancer (SMR: 1.59, 95% CI: 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR: 2.05, 95% CI: 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population. Conclusions: Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Chemical Hazard Release/mortality ; Dibenzofurans, Polychlorinated/toxicity ; Dietary Exposure/adverse effects ; Environmental Pollutants/toxicity ; Female ; Food Contamination ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Neoplasms/mortality ; Polychlorinated Biphenyls/toxicity ; Porphyrias/chemically induced ; Porphyrias/mortality ; Retrospective Studies ; Young Adult
Chemical Substances	Dibenzofurans, Polychlorinated ; Environmental Pollutants ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1476-069X
ISSN (online)	1476-069X
DOI	10.1186/s12940-020-00680-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins: A competing risk analysis among Yusho patients.

Onozuka, Daisuke / Nakamura, Yuko / Tsuji, Gaku / Furue, Masutaka

Environment international

2020 Volume 147, Page(s) 106320

Abstract	Background: In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in Yusho patients exposed to polychlorinated biphenyls (PCBs) and dioxin-related compounds has not been estimated. Methods: We identified vital status and cause of death for Yusho patients between 1968 and 2017. Risk of cancer- and noncancer-specific mortality was estimated using a flexible hazards-based regression model, with accounting for competing events. Results: In total, 1664 Yusho patients with 63,566 person-years of follow-up were included in the analysis. 50-year cumulative incidence of cancer mortality was 12.4% (95% confidence interval [CI], 10.5-14.7) in males and 4.7% (95% CI, 3.5-6.4) in females (difference, 7.7 percentage points [95% CI, 5.2-10.2]; adjusted hazard ratio for males, 2.61 [95% CI, 1.93-3.52]). For noncancer, the 50-year cumulative incidence of mortality was 35.4% (95% CI, 32.8-38.3) in males and 35.6% (95% CI, 33.3-38.1) in females (difference, -0.2 percentage points [95% CI, -3.5 to 3.1]; adjusted hazard ratio for males, 1.51 [95% CI, 1.26-1.82]). Conclusions: These findings confirm that male Yusho patients have a significantly higher risk of cumulative incidence of cancer-specific mortality than female Yusho patients. Our findings might be useful in providing Yusho patients with more accurate information on cancer prognosis and survivorship and help determine more appropriate disease management.
MeSH term(s)	Dibenzofurans, Polychlorinated ; Dioxins/toxicity ; Female ; Food Contamination ; Humans ; Incidence ; Japan ; Male ; Neoplasms ; Polychlorinated Biphenyls/toxicity ; Risk Assessment
Chemical Substances	Dibenzofurans, Polychlorinated ; Dioxins ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2020-12-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2020.106320
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Article ; Online: Using novel micropore technology combined with artificial intelligence to differentiate Staphylococcus aureus and Staphylococcus epidermidis.

Morimura, Ayumi / Taniguchi, Masateru / Takei, Hiroyasu / Sakamoto, Osamu / Naono, Norihiko / Akeda, Yukihiro / Onozuka, Daisuke / Yoshimura, Jumpei / Tomono, Kazunori / Kutsuna, Satoshi / Hamaguchi, Shigeto

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6994

Abstract: Methods for identifying bacterial pathogens are broadly categorised into conventional culture-based microbiology, nucleic acid-based tests, and mass spectrometry. The conventional method requires several days to isolate and identify bacteria. Nucleic ... ...

Abstract	Methods for identifying bacterial pathogens are broadly categorised into conventional culture-based microbiology, nucleic acid-based tests, and mass spectrometry. The conventional method requires several days to isolate and identify bacteria. Nucleic acid-based tests and mass spectrometry are relatively rapid and reliable, but they require trained technicians. Moreover, mass spectrometry requires expensive equipment. The development of a novel, inexpensive, and simple technique for identifying bacterial pathogens is needed. Through combining micropore technology and assembly machine learning, we developed a novel classifier whose receiver operating characteristic (ROC) curve showed an area under the ROC curve of 0.94, which rapidly differentiated between Staphylococcus aureus and Staphylococcus epidermidis in this proof-of-concept study. Morphologically similar bacteria belonging to an identical genus can be distinguished using our method, which requires no specific training, and may facilitate the diagnosis and treatment of patients with bacterial infections in remote areas and in developing countries.
MeSH term(s)	Humans ; Staphylococcus aureus ; Staphylococcus epidermidis ; Artificial Intelligence ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Nucleic Acids
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55773-4
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