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Article ; Online: Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years.

Demirci, Ufuk / Umit, Elif Gulsum / Baysal, Mehmet / Demir, Ahmet Muzaffer

2023 Volume 10, Issue 4, Page(s) 477–783

Abstract: Objective: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the ... ...

Abstract	Objective: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the pathogenesis. Methods: In our study, we evaluated the features of 33 patients with ITP, over 80 years of age. Results: The median age of the patients was 90, 15 patients were female (45.4%). The mean platelet count of the patients was 39×10 Conclusion: Morphologic observations suggesting dysplasia including micromegakaryocytes and a non-dysplastic but dysmegakaryopoietic finding, multiple segmented nuclei may be related to the degree of thrombocytopenia and response to treatment. Likewise, nondysplastic features including immature forms, emperipolesis, bare nucleus, hypolobulation, and hypersegmented nucleus were related to the degree of thrombocytopenia.
Language	English
Publishing date	2023-08-09
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2022.57124
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Article ; Online: Recommendation in the Age of Digital Communication

Barış Uçar / Goca Solak / Yaşar Göçer / Nevzat Arslan / Ufuk Demirci / Vecihi Demirci / Ümit Atabek

Journal of Human Resource Management, Vol 25, Iss 2, Pp 1-

a Proposal for Business, Education, Social, Private Life Recommendation Scale (BESP-L) for Human Resources Communication

2023 Volume 12

Abstract: Purpose - Communication is an important aspect of recommendation practices in all industries across the world. This study explores the communication components of recommendation culture in the digital age. Aim – This study pursuits the possibility of a ... ...

Abstract	Purpose - Communication is an important aspect of recommendation practices in all industries across the world. This study explores the communication components of recommendation culture in the digital age. Aim – This study pursuits the possibility of a digital recommendation system suitable for the business organizations. Methodology - A sample of N=1002 is surveyed in order to analyze how people evaluate certain practices of recommendation in Turkey. Sampling and surveying procedures are conducted on a blockchain-based system. Additionally, decision tree analysis is applied to the data. Findings - It is found that duration of acquaintance with the recommender is the most essential element for the credibility of the letters of recommendation, while recommendation from social media sources is found to be the least credible. The importance of the recommendation from a person acquainted in the business life domain is perceived to be the highest. The study also revealed that credibility of references that are printed with original signature is not much higher than the online references that are digitally signed. Furthermore, the credibility of references over distance connection tools are even higher than the references through oral communication. These findings suggest that a digital recommendation culture is emerging in parallel with the rapid development of digital communication tools in organizations. Limitations of the study – The study is a cross-sectional study, and based on data from only one country. Practical implications - The paper suggests a recommendation system based on Business, Education, Social, Private Life Recommendation Scale (BESP-L) which is developed from a decision tree analysis. Originality/Value - It is a proposal in the pursuit of an advanced HR systems in the digital age.
Keywords	recommendation ; reference ; online recommendation ; online recruitment systems ; digital communication ; Social sciences (General) ; H1-99
Subject code	650
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Comenius University in Bratislava, Faculty of Management
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Increased Risk of e-Thrombosis in e-Life Era.

Demirci, Ufuk / Ümit, Elif Gülsüm / Demir, Ahmet Muzaffer

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2021 Volume 27, Page(s) 10760296211028282

MeSH term(s)	COVID-19/complications ; Female ; Humans ; Male ; Risk Factors ; SARS-CoV-2 ; Telemedicine/methods ; Thrombosis/etiology
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Letter
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/10760296211028282
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Article ; Online: Quantitative computed tomography assessment for systemic sclerosis-related interstitial lung disease: comparison of different methods.

Ufuk, Furkan / Demirci, Mahmut / Altinisik, Goksel

European radiology

2020 Volume 30, Issue 8, Page(s) 4369–4380

Abstract: Objectives: To compare the previously defined six different histogram-based quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) in patients with systemic sclerosis (SSc)-related interstitial lung disease (ILD).: Methods: The HRCT ... ...

Abstract	Objectives: To compare the previously defined six different histogram-based quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) in patients with systemic sclerosis (SSc)-related interstitial lung disease (ILD). Methods: The HRCT images of SSc patients with ILD were reviewed, and the visual ILD score (semiquantitative) and the severity of ILD (limited or extensive) were calculated. The QLA score of ILD was evaluated using the previously defined six different methods and parameters (different lung attenuation ranges, skewness, kurtosis, mean lung attenuation, and standard deviation [SD]). Pulmonary function tests (PFTs) were also performed on all patients. Relationships among variables were evaluated using Spearman's correlation coefficient (r). Diagnostic performance of quantitative methods for the ability to differentiate the limited from extensive ILD was calculated using ROC analysis. Results: Fifty-five patients were included in the study. There was a significant correlation between all quantitative and semiquantitative measurement results (p < 0.0001). The QLA scores revealed a significant correlation with PFT results. The kurtosis value of the voxels between - 200 and - 1024 Hounsfield unit (HU) (Method-5) showed the best correlation with semiquantitative evaluation (r = - 0.740, p < 0.0001). The ROC analysis demonstrated the best performance of SD of the voxels between - 400 and - 950 HU (Method-6) for histogram analysis method and Method-3 (voxels between - 260 and - 600 HU were calculated as ILD) for CT density cutoff methods. Conclusions: All the QLA methods are applicable in assessing the ILD score in SSc patients and have potential importance to differentiate limited from extensive ILD. Key points: • Quantitative interstitial lung disease assessment helps clinicians to assess systemic sclerosis patients with interstitial lung disease. • Quantitative lung assessment methods are applicable in assessing the interstitial lung disease score in systemic sclerosis patients. • Quantitative lung assessment methods have potential importance in the management of patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Forced Expiratory Volume ; Humans ; Lung/diagnostic imaging ; Lung/physiopathology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/physiopathology ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; ROC Curve ; Respiratory Function Tests ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Scleroderma, Systemic/physiopathology ; Severity of Illness Index ; Tomography, X-Ray Computed/methods ; Vital Capacity
Language	English
Publishing date	2020-03-19
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-06772-2
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Article ; Online: Quantitative analysis of Sjogren's syndrome related interstitial lung disease with different methods.

Ufuk, Furkan / Demirci, Mahmut / Altinisik, Goksel / Karasu, Ugur

European journal of radiology

2020 Volume 128, Page(s) 109030

Abstract: Purpose: To investigate the success of different quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) to assess the severity of Sjogren's syndrome (SjS) related interstitial lung disease (ILD).: Method: Consecutive SjS patients who ...

Abstract	Purpose: To investigate the success of different quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) to assess the severity of Sjogren's syndrome (SjS) related interstitial lung disease (ILD). Method: Consecutive SjS patients who underwent both thin-section HRCT and pulmonary function tests (PFTs) were investigated. The QLA was obtained using two different DICOM (digital imaging and communications in medicine) viewer with three different methods and lung histogram values. HRCT images were semiquantitatively (SQLA) evaluated in consensus by two radiologists using the Goh score and, two groups were established: limited (< 20%), extensive (> 20%) ILD. Spearman's correlation test was used to assess the correlation between variables. ROC curve analysis was performed to determine the ability of QLA methods to distinguish ILD groups. Results: Thirty-four patients were included, and SQLA revealed limited ILD in 22 patients (64.7%). PFT values were significantly lower in the extensive ILD group. The QLA scores showed a significant difference between limited and extensive ILD groups, and all QLA indices showed a significant correlation with SQLA and PFTs. ROC analysis showed that mean lung attenuation and Method-1 (ILD: voxels between -200 and -700 HU) were the best to distinguish the ILD severity by 0.93 (CI 95 0.83 -1%) and 0.84 (CI 95 0.71-0.97%), respectively. Conclusion: The QLA methods are a promising alternative to the Goh score in the objective evaluation of SjS-related ILD. The QLA methods are capable of distinguishing extensive (which is responsible for poor prognosis in SjS patients) from limited ILD.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Evaluation Studies as Topic ; Female ; Humans ; Lung/diagnostic imaging ; Lung/physiopathology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/physiopathology ; Male ; Middle Aged ; ROC Curve ; Reproducibility of Results ; Respiratory Function Tests ; Retrospective Studies ; Severity of Illness Index ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/physiopathology ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2020-05-07
Publishing country	Ireland
Document type	Evaluation Study ; Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2020.109030
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Article: An Unusual Complication of Urinary Stone Disease: Spontaneous Perirenal Hematoma.

Ufuk, Furkan / Demirci, Mahmut / Özlülerden, Yusuf / Çelen, Sinan

The Journal of emergency medicine

2019 Volume 57, Issue 6, Page(s) e191–e192

MeSH term(s)	Adult ; Hematoma/complications ; Hematoma/etiology ; Hematoma/physiopathology ; Humans ; Kidney/abnormalities ; Kidney/physiopathology ; Male ; Nephrolithiasis/complications ; Nephrolithiasis/physiopathology ; Paraplegia/complications ; Paraplegia/physiopathology ; Tomography, X-Ray Computed/methods ; Ultrasonography/methods
Language	English
Publishing date	2019-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	605559-x
ISSN	0736-4679
ISSN	0736-4679
DOI	10.1016/j.jemermed.2019.08.006
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Article ; Online: A comment on "a prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia" by Zhou et al.

Demirci, Ufuk / Umit, Elif G / Demir, Ahmet Muzaffer

American journal of hematology

2020 Volume 95, Issue 4, Page(s) E103–E104

MeSH term(s)	Adult ; Antimetabolites, Antineoplastic/therapeutic use ; Azacitidine/therapeutic use ; Decitabine/therapeutic use ; Humans ; Prospective Studies ; Purpura, Thrombocytopenic, Idiopathic/drug therapy
Chemical Substances	Antimetabolites, Antineoplastic ; Decitabine (776B62CQ27) ; Azacitidine (M801H13NRU)
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.25740
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Article ; Online: Improving Care of Older Patients with Hemophilia During COVID-19 Pandemic, Reducing the Risk of Venous Thrombosis with Home Exercises.

Demirci, Ufuk / Umit, Elif G / Ozdemir, Hande / Demirbag Kabayel, Derya / Demir, Ahmet Muzaffer

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2022 Volume 28, Page(s) 10760296221087223

MeSH term(s)	COVID-19 ; Hemophilia A/complications ; Hemophilia A/therapy ; Humans ; Pandemics ; Quality Improvement ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Letter
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/10760296221087223
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Article: Successful pregnancy and delivery management in a patient with Bernard Soulier Syndrome.

Demirci, Ufuk / Erbilen, Esra Altan / Ümit, Elif Gülsüm / İnan, Cihan / Sayın, N Cenk / Demir, Ahmet Muzaffer

Obstetric medicine

2022 Volume 16, Issue 3, Page(s) 203–205

Abstract: Bernard Soulier Syndrome (BSS) is an inherited bleeding disorder characterized by macrothrombocytopenia and absence of ristocetin-induced platelet aggregation. Clinical findings vary from person to person. Most of the patients are diagnosed with muco- ... ...

Abstract	Bernard Soulier Syndrome (BSS) is an inherited bleeding disorder characterized by macrothrombocytopenia and absence of ristocetin-induced platelet aggregation. Clinical findings vary from person to person. Most of the patients are diagnosed with muco-cutaneous bleeding such as purpura, epistaxis and gingival bleeding in early childhood. Few pregnant women with BSS are described in the literature. Management of thrombocytopenia during pregnancy and delivery requires a multidisciplinary approach. The family should be warned about the potentially life-threatening bleeding during pregnancy and the delivery and the decision about mode of delivery should be individualised, involving discussion with patient and multidisciplinary team.
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2612229-7
ISSN	1753-4968 ; 1753-495X
ISSN (online)	1753-4968
ISSN	1753-495X
DOI	10.1177/1753495X211067119
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Article ; Online: Evaluation of disease severity with quantitative chest CT in COVID-19 patients.

Ufuk, Furkan / Demirci, Mahmut / Uğurlu, Erhan / Çetin, Nazlı / Yiğit, Nilüfer / Sarı, Tuğba

Diagnostic and interventional radiology (Ankara, Turkey)

2021 Volume 27, Issue 2, Page(s) 164–171

Abstract: Purpose: We aimed to assess the severity of coronavirus disease 2019 (COVID-19) pneumonia on computed tomography (CT) using quantitative (QCT) and semiquantitative (SCT) assessments and compare with the clinical findings.: Methods: Two observers ... ...

Abstract	Purpose: We aimed to assess the severity of coronavirus disease 2019 (COVID-19) pneumonia on computed tomography (CT) using quantitative (QCT) and semiquantitative (SCT) assessments and compare with the clinical findings. Methods: Two observers independently examined the CT images of COVID-19 patients, and the SCT severity score was calculated. The SCT score was calculated as the sum of values ranging from 0 to 4, according to the volumetric rate of involvement for each lung lobe. In quantitative assessment, total lung volume (TLV) was automatically calculated from CT density values between -200 and -950 HU. Besides, healthy lung volume (HLV) was calculated from voxels between -800 and -950 HU. The QCT score was calculated with the following formula: (TLV - HLV / TLV) ×100. All patients were clinically divided into four groups: mild, common, severe, and critical. Interobserver agreement for SCT assessment was investigated using the Cohen's Kappa statistics (κ). Pearson's correlation coefficient was used for the relationship between continuous data. The diagnostic accuracy of SCT and QCT in the differentiation of clinically limited (mild, common) and extensive (severe, critical) disease was investigated using ROC analysis. Results: Seventy-six patients with a diagnosis of COVID-19 were included. There was good agreement between the two observers in the SCT evaluation of pulmonary disease severity (κ = 0.796; 95% CI, 0.751-0.841). A significant correlation was found between QCT and SCT scores (p < 0.001, r = 0.661). Both QCT and SCT scores showed a significant correlation with clinical severity score (p < 0.001, r = 0.620 and p = 0.004, r = 0.529, respectively). The ROC analysis revealed the AUC of QCT and SCT for differentiation of limited and extensive disease as 0.873 (95% CI, 0.774-0.972) and 0.816 (95% CI, 0.673-0.959), respectively. Conclusion: The QCT assessment is an objective method in the evaluation of COVID-19 severity and is more successful than semiquantitative CT assessment to discriminate extensive from limited disease.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnostic imaging ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
Keywords	covid19
Language	English
Publishing date	2021-01-20
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3612
ISSN (online)	1305-3612
ISSN	1305-3612
DOI	10.5152/dir.2020.20281
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