LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene.

    Myant, Nicolas B

    Proceedings. Biological sciences

    2009  Volume 277, Issue 1680, Page(s) 345–351

    Abstract: In the mature cerebral cortex of higher vertebrates, neurons are arranged in layers, each layer containing neurons of the same functional class. The cortical layering pattern is laid down during development by migration of young post-mitotic neurons ... ...

    Abstract In the mature cerebral cortex of higher vertebrates, neurons are arranged in layers, each layer containing neurons of the same functional class. The cortical layering pattern is laid down during development by migration of young post-mitotic neurons along glial fibres to their correct positions in the cortical plate. The mechanics of whole-cell movement are well understood, but there is still uncertainty as to how a migrating neuron is instructed to leave its glial support when it reaches its destination. An intraneuronal signalling pathway initiated by reelin and containing apolipoprotein E receptor 2 (apoER2) is essential for normal cortical layering, and there is strong evidence that detachment of a migrating neuron is brought about by reelin-dependent downregulation of alpha3 integrin. But there remains the problem of how the reelin signal is switched on at a position in the cortex appropriate for each class of neuron. ApoER2 of placental mammals contains an amino acid sequence that is encoded in a separate exon in the apoER2 gene and is required for normal memory and spatial learning. The separate exon is not present in marsupials, birds or reptiles. The addition of this exon to the evolving apoER2 gene may have contributed to the success of placental mammals.
    MeSH term(s) Animals ; Brain/embryology ; Brain/metabolism ; Cell Adhesion Molecules, Neuronal/genetics ; Cell Adhesion Molecules, Neuronal/metabolism ; Cerebral Cortex/embryology ; Cerebral Cortex/metabolism ; Evolution, Molecular ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; LDL-Receptor Related Proteins ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Receptors, Lipoprotein/genetics ; Receptors, Lipoprotein/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism
    Chemical Substances Cell Adhesion Molecules, Neuronal ; Extracellular Matrix Proteins ; LDL-Receptor Related Proteins ; Nerve Tissue Proteins ; Receptors, Lipoprotein ; low density lipoprotein receptor-related protein 8 ; Serine Endopeptidases (EC 3.4.21.-) ; reelin protein (EC 3.4.21.-)
    Language English
    Publishing date 2009-10-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2009.1412
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia homozygotes.

    Thompson, Gilbert R / Seed, Mary / Naoumova, Rossi P / Neuwirth, Clare / Walji, Shahenaz / Aitman, Timothy J / Scott, James / Myant, Nicolas B / Soutar, Anne K

    Atherosclerosis

    2015  Volume 243, Issue 1, Page(s) 328–333

    Abstract: Background and aims: There is a paucity of data concerning the influence of lipid-lowering therapy on cardiovascular (CV) outcomes in patients with homozygous familial hypercholesterolaemia (FH). To redress this a retrospective analysis was undertaken ... ...

    Abstract Background and aims: There is a paucity of data concerning the influence of lipid-lowering therapy on cardiovascular (CV) outcomes in patients with homozygous familial hypercholesterolaemia (FH). To redress this a retrospective analysis was undertaken of the demographic features, lipid levels, low density lipoprotein receptor and Autosomal Recessive Hypercholesterolaemia gene mutations, CV outcomes and vital status of 44 FH homozygotes referred to a single centre in the UK between 1964 and 2014.
    Methods: Data were obtained from past publications, case records and death certificates. Differences in categorical and continuous variables between living and dead patients were analysed using Fisher's exact test and an independent t-test respectively.
    Results: During the 50 years covered by this survey 13 patients have died, 30 are still alive and 1 was lost to follow up. The mean age of Alive patients was 32.6 ± 11.5 versus 28.3 ± 14.9 years in Dead ones (P = 0.31) and they were born 18 years later (P = 0.0001). Pre-treatment serum total cholesterol (TC) was similar in Alive and Dead (20.2 ± 5.1 v 21.3 ± 4.4 mmol/l, P = 0.52) but on-treatment TC was lower in Alive than Dead (8.1 ± 2.8 v 14.5 ± 6.0 mmol/l, P = 0.0001) and CV adverse events were far less frequent (eg aortic stenosis, 33% v 77%, P = 0.02).
    Conclusions: The lower on-treatment TC and fewer CV adverse events in FH homozygotes still living reflect advances in apheresis and drug therapy since the 1990s. Further improvements in prognosis can be expected with the impending introduction of novel lipid-lowering agents.
    MeSH term(s) Adolescent ; Adult ; Anticholesteremic Agents/therapeutic use ; Aortic Valve Stenosis/drug therapy ; Blood Component Removal ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/therapy ; Cholesterol, LDL/blood ; Cohort Studies ; Female ; Homozygote ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hyperlipoproteinemia Type II/complications ; Hyperlipoproteinemia Type II/genetics ; Hyperlipoproteinemia Type II/therapy ; Male ; Middle Aged ; Models, Statistical ; Mutation ; Receptors, LDL/blood ; Receptors, LDL/genetics ; Retrospective Studies ; United Kingdom ; Young Adult
    Chemical Substances Anticholesteremic Agents ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Receptors, LDL
    Language English
    Publishing date 2015-09-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2015.09.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top