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Article: Faux positifs en sérologie infectieuse : un problème rare à ne pas ignorer.

Dumoulin, Alexis

2023 Volume 19, Issue 845, Page(s) 1830–1834

Abstract: Although rare, false-positive results from infectious serology tests can mislead the practitioner and have harmful consequences for the patient. The causes are not always clear, but there are certain principles that are important to be aware of, and that ...

Title translation	False positives in infectious serology : a rare issue that should not be ignored.
Abstract	Although rare, false-positive results from infectious serology tests can mislead the practitioner and have harmful consequences for the patient. The causes are not always clear, but there are certain principles that are important to be aware of, and that help to interpret these diagnostic puzzles correctly. Similarities between different families of pathogens, the technical characteristics of the tests used, the use of therapeutic human immunoglobulins, the detection of vaccine-induced antibodies or even the detection of vaccine antigens themselves can cause non-specific reactions. This article uses examples from routine laboratory practice to illustrate the problem and draw the attention of the treating physician to this issue.
MeSH term(s)	Humans ; False Positive Reactions ; Serologic Tests/methods ; Hematologic Tests ; Laboratories ; Vaccines
Chemical Substances	Vaccines
Language	French
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2023.19.845.1830
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Article ; Online: Looking for Guidance - Models and Methods to Study Axonal Navigation.

Dumoulin, Alexandre / Stoeckli, Esther T

Neuroscience

2022 Volume 508, Page(s) 30–39

Abstract: The molecular mechanisms of neural circuit formation have been of interest to Santiago Ramón y Cajal and thousands of neuroscientists sharing his passion for neural circuits ever since. Cajal was a brilliant observer and taught us about the connections ... ...

Abstract	The molecular mechanisms of neural circuit formation have been of interest to Santiago Ramón y Cajal and thousands of neuroscientists sharing his passion for neural circuits ever since. Cajal was a brilliant observer and taught us about the connections and the morphology of neurons in the adult and developing nervous system. Clearly, we will not learn about molecular mechanisms by just looking at brain sections or cells in culture. Technically, we had to come a long way to today's possibilities that allow us to perturb target gene expression and watch the consequences of our manipulations on navigating axons in situ. In this review, we summarize landmark steps towards modern live-imaging approaches used to study the molecular basis of axon guidance.
MeSH term(s)	Axons/metabolism ; Neurons/physiology ; Axon Guidance/physiology ; Brain
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2022.08.005
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Book ; Online: L’armée belge face au Covid-19

Dumoulin, André

Revue Défense Nationale, N 831, 6, 2020-06-23, pp.131-136

le choix de la sémantique

2020

Abstract: ... À la différence de la France, le vocabulaire a été moins « guerrier » dans un pays complexe et divisé ...

Abstract	Face à la pandémie, les forces armées belges ont apporté leur contribution aux dispositifs de santé. À la différence de la France, le vocabulaire a été moins « guerrier » dans un pays complexe et divisé politiquement. Cependant, le constat reste identique quant à sa capacité de résilience, qu’il faudra réexaminer demain. In the face of the pandemic, the Belgian armed forces have made their contribution to the health system. Compared with that used in France, the vocabulary has been less war-like in this complex and politically divided country. For all that, the results have been the same regarding the country’s capacity for resilience—and they will need future examination.
Keywords	Belgique ; résilience ; capacités ; service de santé ; covid19
Language	French
Publishing country	fr
Document type	Book ; Online
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Article ; Online: Metabolic flexibility in Trypanosoma cruzi amastigotes: implications for persistence and drug sensitivity.

Dumoulin, Peter C / Burleigh, Barbara A

Current opinion in microbiology

2021 Volume 63, Page(s) 244–249

Abstract: Throughout their life cycle, parasitic organisms experience a variety of environmental conditions. To ensure persistence and transmission, some protozoan parasites are capable of adjusting their replication or converting to distinct life cycle stages. ... ...

Abstract	Throughout their life cycle, parasitic organisms experience a variety of environmental conditions. To ensure persistence and transmission, some protozoan parasites are capable of adjusting their replication or converting to distinct life cycle stages. Trypanosoma cruzi is a 'generalist' parasite that is competent to infect various insect (triatomine) vectors and mammalian hosts. Within the mammalian host, T. cruzi replicates intracellularly as amastigotes and can persist for the lifetime of the host. The persistence of the parasites in tissues can lead to the development of Chagas disease. Recent work has identified growth plasticity and metabolic flexibility as aspects of amastigote biology that are important determinants of persistence in varied growth conditions and under drug pressure. A better understanding of the link between amastigote and host/tissue metabolism will aid in the development of new drugs or therapies that can limit disease pathology.
MeSH term(s)	Animals ; Chagas Disease ; Life Cycle Stages ; Parasites ; Pharmaceutical Preparations ; Trypanosoma cruzi/genetics
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2021-08-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1418474-6
ISSN	1879-0364 ; 1369-5274
ISSN (online)	1879-0364
ISSN	1369-5274
DOI	10.1016/j.mib.2021.07.017
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Article ; Online: Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening.

Gouhier, Arthur / Dumoulin-Gagnon, Justine / Lapointe-Roberge, Vincent / Harris, Juliette / Balsalobre, Aurelio / Drouin, Jacques

Nature structural & molecular biology

2024 Volume 31, Issue 1, Page(s) 92–101

Abstract: Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, although pioneers ... ...

Abstract	Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, although pioneers have been shown to interact with nucleosomal target DNA and with some chromatin-remodeling complexes. We now define the sequence of events that enables the pioneer Pax7 with its unique abilities. Chromatin condensation exerted by linker histone H1 is the first constraint on Pax7 recruitment, and this establishes the initial speed of chromatin remodeling. The first step of pioneer action involves recruitment of the KDM1A (LSD1) H3K9me2 demethylase for removal of this repressive mark, as well as recruitment of the MLL complex for deposition of the activating H3K4me1 mark. Further progression of pioneer action requires passage through cell division, and this involves dissociation of pioneer targets from perinuclear lamin B. Only then are the SWI-SNF remodeling complex and the coactivator p300 recruited, leading to nucleosome displacement and enhancer activation. Thus, the unique features of pioneer actions are those occurring in the lamin-associated compartment of the nucleus. This model is consistent with previous work that showed a dependence on cell division for establishment of new cell fates.
MeSH term(s)	Chromatin ; Nucleosomes ; Cell Differentiation/genetics ; Cell Cycle ; Cell Division ; Chromatin Assembly and Disassembly
Chemical Substances	Chromatin ; Nucleosomes
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-023-01152-y
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Article ; Online: Pharmacovigilance of nephrotoxic drugs in neonates: the Pottel method for acute kidney injury detection in ELBW neonates.

Dumoulin, Mathilde / Pottel, Hans / Mekahli, Djalila / Laenen, Annouschka / Smits, Anne / Allegaert, Karel

Pediatric nephrology (Berlin, Germany)

2024

Abstract: Background: Extremely low birth weight (ELBW) neonates (birth weight ≤ 1000 g) are at high risk to develop drug-induced acute kidney injury (AKI). However, we lack a pragmatic detection tool to capture their time-dependent (patho)physiologic serum ... ...

Abstract	Background: Extremely low birth weight (ELBW) neonates (birth weight ≤ 1000 g) are at high risk to develop drug-induced acute kidney injury (AKI). However, we lack a pragmatic detection tool to capture their time-dependent (patho)physiologic serum creatinine (Scr) patterns. Pottel et al. suggested rescaling Scr by dividing Scr with the mean Scr value of the age- and sex-specific reference population. We explored if this Pottel method can detect drug-related nephrotoxicity in ELBW neonates. Methods: A previously reported dataset on Scr changes in ELBW neonates exposed to ibuprofen, amikacin, or vancomycin was updated to calculate Pottel scores for every available Scr value in the first 28 postnatal days. We hereby used previously published postnatal age-specific 50 Results: Serum creatinine (n = 3231) observations in 201 ELBW neonates were collected. A statistically significant rise of Pottel scores was observed with ibuprofen starting from postnatal day 4. In addition, a cumulative effect of treatment with mean Pottel scores on day 0 of 1.020 and on day 3 during treatment of 1.106 (95% CI 1.068-1.145, p < 0.001) was observed, corrected for effect of antibiotics. Antibiotic administrations showed a small but statistically significant difference up to postnatal day 5. Conclusions: As rescaled Scr biomarker, the Pottel method showed a clear association with ibuprofen-exposed ELBW neonates, suggesting its applicability as a pragmatic bedside alternative tool to assess nephrotoxicity.
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06335-3
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Article: [

Dumoulin, Alexis

Revue medicale suisse

2016 Volume 12, Issue 534, Page(s) 1694–1697

Abstract: Mycoplasma pneumoniae is a frequent cause of community acquired pneumonia, especially in children. Discovered by Eaton in the 1940s, it has long been considered as a virus, in part because of its difficult growth in cultures. M. pneumoniae can cause many ...

Title translation	Mycoplasma pneumoniae
Abstract	Mycoplasma pneumoniae is a frequent cause of community acquired pneumonia, especially in children. Discovered by Eaton in the 1940s, it has long been considered as a virus, in part because of its difficult growth in cultures. M. pneumoniae can cause many complications, some of which are severe such as dermatological lesions or affections of the central nervous system. The laboratory diagnosis of M. pneumoniae is difficult, notably because of the fastidious growth conditions, the persistence of IgM antibody after acute infection and the debated existence of asymptomatic carriers. In recent years, the spread of mutants resistant to macrolides caused an additional challenge linked to this pathogen.
Language	French
Publishing date	2016-10-12
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Massive Größenprogredienz und maligne Transformation einer muzinös-zystischen Neoplasie des Pankreas in der Schwangerschaft – ein Fallbericht.

Scheyda-Yoo, Katharina / Hofer, Ulrich / Várnai-Händel, Alinda / Maus, Martin K-H / Dumoulin, Franz Ludwig

Zeitschrift fur Gastroenterologie

2024

Abstract: Background: Mucinous-cystic neoplasms (MCN) account for 10% of all pancreatic cystic lesions. They are found almost exclusively in females. MCN have an ovarian-like stroma and often estrogen and progesterone receptors. During pregnancy, they can ... ...

Title translation	Rapid growth and malignant transformation of a mucinous cystic neoplasm during pregnancy - a case report.
Abstract	Background: Mucinous-cystic neoplasms (MCN) account for 10% of all pancreatic cystic lesions. They are found almost exclusively in females. MCN have an ovarian-like stroma and often estrogen and progesterone receptors. During pregnancy, they can massively increase in size and transform into malignancy. Case report: We report on a 29-year-old woman in whom a 35mm cyst in the pancreatic tail had been diagnosed several years ago. After workup the lesions had been classified as a pseudocyst. During pregnancy, the cyst massively increased in size and finally was resected. Histology showed a mucinous-cystic neoplasia with focal malignant transformation. Conclusion: Cystic neoplasms of the pancreas require a differentiated management. While overtreatment should be avoided, malignant transformation always merits consideration - in particular if the cystic lesion is located in the pancreatic tail. Women with suspected MCN or cystic pancreatic lesions of uncertain etiology should be informed about the (rare) risk of a malignant transformation of an MCN and should be closely monitored during pregnancy.
Language	German
Publishing date	2024-04-24
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2239-7898
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Article ; Online: Mid-term results of total elbow arthroplasties in the treatment of geriatric distal humerus fractures.

Dumoulin, Arthur / Chivot, Matthieu / Dobelle, Emile / Argenson, Jean-Noël / Lami, Damien

Orthopaedics & traumatology, surgery & research : OTSR

2024 , Page(s) 103887

Abstract: Background: While double plate fixation is the gold standard treatment for distal humerus fractures in the general population, it is the source of many complications in the elderly. Total elbow arthroplasty (TEA) has been proposed as an alternative ... ...

Abstract	Background: While double plate fixation is the gold standard treatment for distal humerus fractures in the general population, it is the source of many complications in the elderly. Total elbow arthroplasty (TEA) has been proposed as an alternative treatment, with satisfactory short-term functional outcomes. However, little is known about the longevity of the implant and the mid- and long-term complications of this procedure. Materials and methods: A total of 58 TEAs were performed in 57 patients with comminuted distal humerus fractures between September 2008 and September 2019. All patients were clinically (ranges of motion, Mayo Elbow Performance Score [MEPS] and Disabilities of the Arm, Shoulder and Hand [QuickDASH] functional scores) and radiographically assessed. The minimum follow-up was 2years, and the mean follow-up was 4.7years. Results: The overall complication rate was 20.7%, with ulnar nerve damage, complex regional pain syndrome, and severe stiffness being the main complications. The mean MEPS was 85.3, and the mean QuickDASH was 28.1. The mean flexion was 122°, and the mean extension was -23.5°. There were no prosthetic revisions. Of these patients, 17% had radiolucent lines, and 13% had bushing wear at the last follow-up. Discussion: TEA is an effective technique for treating comminuted distal humerus fractures in the geriatric population. The prosthesis's mid-term survivorship was highly satisfactory, with a complication rate that remained low and was generally lower than that of osteosynthesis, with identical functional outcomes. TEAs are indicated in elderly patients, for whom maintaining the fullest possible autonomy is paramount. Our findings suggest that TEAs have sufficient longevity to guarantee a functional, pain-free elbow with no need for reoperation. Level of evidence: IV; case series.
Language	English
Publishing date	2024-04-12
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2024.103887
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Article ; Online: Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance.

Zuñiga, Nikole R / Dumoulin, Alexandre / Vaccaro, Giuseppe / Stoeckli, Esther T

Development (Cambridge, England)

2023 Volume 150, Issue 19

Abstract: During neural circuit formation, axons navigate from one intermediate target to the next, until they reach their final target. At intermediate targets, axons switch from being attracted to being repelled by changing the guidance receptors on the growth ... ...

Abstract	During neural circuit formation, axons navigate from one intermediate target to the next, until they reach their final target. At intermediate targets, axons switch from being attracted to being repelled by changing the guidance receptors on the growth cone surface. For smooth navigation of the intermediate target and the continuation of their journey, the switch in receptor expression has to be orchestrated in a precisely timed manner. As an alternative to changes in expression, receptor function could be regulated by phosphorylation of receptors or components of signaling pathways. We identified Cables1 as a linker between floor-plate exit of commissural axons, regulated by Slit/Robo signaling, and the rostral turn of post-crossing axons, regulated by Wnt/Frizzled signaling. Cables1 localizes β-catenin, phosphorylated at tyrosine 489 by Abelson kinase, to the distal axon, which in turn is necessary for the correct navigation of post-crossing commissural axons in the developing chicken spinal cord.
MeSH term(s)	Axon Guidance/physiology ; Axons/metabolism ; Growth Cones ; Spinal Cord/metabolism ; Wnt Signaling Pathway ; Animals ; Chickens
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.201671
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