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Article ; Online: An exploration of how adolescents experience and reason their parents' comments on their weight, shape, and eating.

Dahill, Lucy M / Morrison, Natalie M V / Touyz, Stephen / Mitchison, Deborah / Bussey, Kay / Mannan, Haider / Hay, Phillipa

Journal of adolescence

2023 Volume 95, Issue 7, Page(s) 1488–1504

Abstract: Introduction: Disordered eating among adolescents is of increasing concern given associated physical and mental health sequelae. Cognitions underlying disordered eating are formed in childhood and adolescence. Parents are a significant presence during ... ...

Abstract	Introduction: Disordered eating among adolescents is of increasing concern given associated physical and mental health sequelae. Cognitions underlying disordered eating are formed in childhood and adolescence. Parents are a significant presence during this period, so it is critical to understand how they influence their adolescent's eating cognitions and behaviors. Methods: Qualitative analysis using interpretative phenomenological analysis (IPA) methodology was employed to consider the lived experiences of 10 Australian adolescents (14-19 years), 60% female, as they engaged with their parents in a range of weight, shape, and eating communications. Results: Our inductive IPA revealed three key themes representing adolescents' experiences and meaning-making: Parents as Influencers-adolescents acknowledged parents are influencers (objects) within a wider context of community and cultural norms (symbols) and can be protective for peer influence on body image ideals; Expression and Perception-the "what" (weight-talk as an object) and the "how" (objects as independent influences) of gendered parental communication related to health and fitness ideals and illustrated diverse interpretations of both verbal and non-verbal expression; and Fertile Soil and Maturity-the adolescent's characteristics and context influence perceptions of communication, a fear of deviating from norms, and an overarching focus on being "healthy" yet not always knowing what that was. Perception of bidirectional communication also offered valuable insights into potential dangers through family loyalty and in-group permissions. Conclusions: Findings highlight implications for the nuanced influence of parental communication and illustrate the pivotal role of parents within the bioecosystem of adolescent development.
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	303529-3
ISSN	1095-9254 ; 0140-1971
ISSN (online)	1095-9254
ISSN	0140-1971
DOI	10.1002/jad.12221
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Article ; Online: Associations between Parents' Body Weight/Shape Comments and Disordered Eating Amongst Adolescents over Time-A Longitudinal Study.

Dahill, Lucy M / Hay, Phillipa / Morrison, Natalie M V / Touyz, Stephen / Mitchison, Deborah / Bussey, Kay / Mannan, Haider

Nutrients

2023 Volume 15, Issue 6

Abstract: Parents are key influencers of adolescents' attitudes on weight, shape, and eating, and make more positive than negative comments, with negative comments most impactful. This study examined prospective unique associations of parental positive and ... ...

Abstract	Parents are key influencers of adolescents' attitudes on weight, shape, and eating, and make more positive than negative comments, with negative comments most impactful. This study examined prospective unique associations of parental positive and negative comments in a community sample of adolescents with paediatric psychosocial quality of life (PED-QoL), Eating Disorder Weight/Shape Cognitions (EDEQ-WS), BMI percentile, and Psychological Distress (K10) scales. Data were from 2056 adolescents from the EveryBODY study cohort. Multiple regressions were conducted for the impacts of parental positive and negative comments on four dependent variables at one year after controlling for their stage of adolescence (early, middle, late). Multiple imputation and bootstrapping were used for handling missing data and violations of normality. Results indicated that positive maternal comments on eating were associated with increased EDCs and better quality of life at one year. Paternal positive weight shape comments were associated with a decrease in psychological distress, but positive eating comments saw a decrease in quality of life. Findings highlight the nuances of parental comments and how these are perceived and interpreted, and could alert health care workers and family practitioners who have weight, shape, and eating conversations to be aware of the potential influence of their communication.
MeSH term(s)	Humans ; Adolescent ; Child ; Longitudinal Studies ; Quality of Life ; Prospective Studies ; Parents/psychology ; Feeding and Eating Disorders ; Body Weight
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061419
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Article ; Online: Correction: Dahill et al. Associations between Parents' Body Weight/Shape Comments and Disordered Eating Amongst Adolescents over Time-A Longitudinal Study.

Dahill, Lucy M / Hay, Phillipa / Morrison, Natalie M V / Touyz, Stephen / Mitchison, Deborah / Bussey, Kay / Mannan, Haider

Nutrients

2023 Volume 15, Issue 18

Abstract: There was an error in the original publication [ ... ]. ...

Abstract	There was an error in the original publication [...].
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15183993
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Article ; Online: NCEPOD and alcohol-related liver disease, what are the views of those who deliver the service? A survey of consultants and trainees in North Eastern England.

Mitchison, H / Saksena, S / Hudson, M

The journal of the Royal College of Physicians of Edinburgh

2018 Volume 48, Issue 4, Page(s) 293–298

Abstract: Background: National Confidential Enquiry into Patient Outcome and Death (NCEPOD) 'Measuring the Units' (June 2013) identified significant organisational and attitudinal deficits in hospital care of patients with alcohol-related liver disease (ARLD), ... ...

Abstract	Background: National Confidential Enquiry into Patient Outcome and Death (NCEPOD) 'Measuring the Units' (June 2013) identified significant organisational and attitudinal deficits in hospital care of patients with alcohol-related liver disease (ARLD), care being recognised as good in less than 50% of patients. Method: We surveyed over 700 consultants and trainees in acute medical and intensive therapy specialties to examine their perceptions of the NCEPOD findings. Results: A total of 178 responded. In keeping with the NCEPOD findings, their perception was of lack of 24-hour access to specialty advice for patients with liver disease and inequity of access to high-dependency units. Their explanations include lack of resources, therapeutic nihilism and prejudicial judgements that would not be made of other patient groups. Conclusion: There is an urgent need for robust mechanisms to ensure equity of access to specialist liver advice and intensive therapy unit resources, and to counter negative and prejudicial attitudes to these patients.
MeSH term(s)	Attitude of Health Personnel ; Critical Care ; England ; Gastroenterology ; Health Resources ; Health Services Accessibility ; Humans ; Internship and Residency ; Liver Diseases, Alcoholic/therapy ; Medical Futility ; Physicians/psychology ; Prejudice ; Referral and Consultation ; Surveys and Questionnaires
Language	English
Publishing date	2018-11-29
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2018.402
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Article ; Online: Cell biology: How cilia beat.

Mitchison, T J / Mitchison, H M

Nature

2010 Volume 463, Issue 7279, Page(s) 308–309

MeSH term(s)	Axoneme/physiology ; Cilia/pathology ; Cilia/physiology ; Ciliary Motility Disorders/metabolism ; Ciliary Motility Disorders/pathology ; Dyneins/metabolism ; Flagella/physiology ; Humans ; Models, Biological ; Movement/physiology ; Periodicity
Chemical Substances	Dyneins (EC 3.6.4.2)
Language	English
Publishing date	2010-01-20
Publishing country	England
Document type	News
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/463308a
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Exploring associations between positive and negative valanced parental comments about adolescents' bodies and eating and eating problems: a community study.

Dahill, Lucy M / Morrison, Natalie M V / Mannan, Haider / Mitchison, Deborah / Touyz, Stephen / Bussey, Kay / Trompeter, Nora / Hay, Phillipa

Journal of eating disorders

2022 Volume 10, Issue 1, Page(s) 43

Abstract: Background: Adolescence is a time of rapid emotional and physical development when foundational self-concepts (including beliefs about one's weight and shape) are established. Parents are key influencers of adolescent beliefs and behaviours. This study ... ...

Abstract	Background: Adolescence is a time of rapid emotional and physical development when foundational self-concepts (including beliefs about one's weight and shape) are established. Parents are key influencers of adolescent beliefs and behaviours. This study aimed to investigate associations between perceived positive and negative parental comments on weight/shape and eating, with sons' and daughters' psychological distress and eating disorder cognitions (EDCs). Methods: A representative mixed-sex sample of 2204 Australian adolescents (12-19 years) from the EveryBODY Study completed an online survey exploring eating behaviours, psychological wellbeing and experiences of parental comments regarding weight, shape and eating behaviours. Results: Correlation analyses revealed that adolescents' reports of perceived positive parental comments on shape/weight were significantly associated with lower psychological distress and EDCs only for daughters. All perceived negative parental comments on shape/weight or eating were associated with greater psychological distress and EDCs for both sons and daughters. In the final model of the regression analysis, only perceived parental negative shape/weight and maternal negative eating comments, adolescent stage and biological sex were significantly associated with EDCs. When known contributors such as BMI percentile and psychological distress were included in the regression model, adolescent stage and perceived negative paternal comments were no longer significantly associated with EDCs. Conclusions: Overall, results show perceived negative comments were associated with poorer adolescent mental health, both their specific EDCs and general distress. Findings highlight the importance of raising awareness of potential negative impacts within family systems of comments around weight/shape and eating in these key formative years. Trial Registration The study was approved by the Macquarie University Human Research Ethics Committee (HREC 5201600312) and the New South Wales Department of Education.
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-022-00561-6
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Article ; Online: Associations between Adverse Childhood Experiences and Performance-Enhancing Substance Use among Young Adults.

Ganson, Kyle T / Murray, Stuart B / Mitchison, Deborah / Hawkins, Misty A W / Layman, Harley / Tabler, Jennifer / Nagata, Jason M

Substance use & misuse

2021 Volume 56, Issue 6, Page(s) 854–860

Abstract: Background and objective: Adverse childhood experiences (ACEs) are associated with negative health outcomes, yet their associations with performance-enhancing substance (PES) use are unclear. This study aimed to determine whether ACEs predict greater ... ...

Abstract	Background and objective: Adverse childhood experiences (ACEs) are associated with negative health outcomes, yet their associations with performance-enhancing substance (PES) use are unclear. This study aimed to determine whether ACEs predict greater use of legal and illegal PES in young adults. Methods: We analyzed data from the National Longitudinal Study of Adolescent to Adult Health ( Results: Sexual abuse had the greatest effect and predicted higher odds of legal PES use (men: adjusted odds ratio [AOR] 1.66, 95% confidence interval [CI] 1.06-2.59; women: AOR 3.74, 95% CI 1.63-8.59) and AAS use (men: AOR 8.89, 95% CI 5.37-14.72; women: AOR 5.73, 95% CI 2.31-14.18). Among men, a history of physical abuse (AOR 3.04, 95% CI 2.05-4.52), being left alone by a parent/guardian (AOR 2.33, 95% CI 1.50-3.60), and basic needs not being met (AOR 3.47, 95% CI 2.30-5.23) predicted higher odds of AAS use. Among women, basic needs not being met (AOR 2.94, 95% CI 1.43-6.04) predicted higher odds of AAS use. Among both men and women, greater number of cumulative ACEs predicted higher odds of both legal and illegal PES use. Conclusions: ACEs predict greater PES use among young adults. Clinicians should monitor for PES use among those who have experienced ACEs and provide psychoeducation on the adverse effects associated with PES use.
MeSH term(s)	Adolescent ; Adverse Childhood Experiences ; Child ; Child Abuse ; Female ; Humans ; Longitudinal Studies ; Male ; Odds Ratio ; Performance-Enhancing Substances ; Sex Offenses ; Young Adult
Chemical Substances	Performance-Enhancing Substances
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2021.1899230
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Article ; Online: In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.

Luthria, Gaurav / Li, Ran / Wang, Stephanie / Prytyskach, Mark / Kohler, Rainer H / Lauffenburger, Douglas A / Mitchison, Timothy J / Weissleder, Ralph / Miller, Miles A

Nature communications

2020 Volume 11, Issue 1, Page(s) 3521

Abstract: Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-end ... ...

Abstract	Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quantify MT dynamics in live xenograft tumor models. Among analyzed features, cancer cells in vivo displayed higher coherent orientation of MT dynamics along their cell major axes compared with 2D in vitro cultures, and distinct from 3D collagen gel cultures. This in vivo MT phenotype was reproduced in vitro when cells were co-cultured with IL4-polarized MΦ. MΦ depletion, MT disruption, targeted kinase inhibition, and altered MΦ polarization via IL10R blockade all reduced MT coherence and/or tumor cell elongation. We show that MT coherence is a defining feature for in vivo tumor cell dynamics and migration, modulated by local signaling from pro-tumor macrophages.
MeSH term(s)	Animals ; Cell Cycle/genetics ; Cell Cycle/physiology ; Cell Movement/genetics ; Cell Movement/physiology ; Female ; Humans ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Microtubules/metabolism ; Mitosis/genetics ; Mitosis/physiology ; Principal Component Analysis ; RAW 264.7 Cells
Chemical Substances	Microtubule-Associated Proteins
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-17147-y
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Article ; Online: The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.

Kuhn, Hallie / Sopko, Richelle / Coughlin, Margaret / Perrimon, Norbert / Mitchison, Tim

Development (Cambridge, England)

2015 Volume 142, Issue 22, Page(s) 3869–3878

Abstract: Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by ... ...

Abstract	Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome.
MeSH term(s)	Animals ; Autophagy-Related Protein-1 Homolog ; Blotting, Western ; Drosophila/embryology ; Drosophila Proteins/metabolism ; Egg Yolk/metabolism ; In Situ Nick-End Labeling ; Microscopy, Electron ; Protein-Serine-Threonine Kinases/metabolism ; Real-Time Polymerase Chain Reaction ; Rosaniline Dyes ; Signal Transduction/genetics ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Drosophila Proteins ; Rosaniline Dyes ; Coomassie blue (78642-64-5) ; target of rapamycin protein, Drosophila (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Atg1 protein, Drosophila (EC 2.7.11.1) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2015-11-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.125419
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Article ; Online: Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.

Fu, S / Thompson, C L / Ali, A / Wang, W / Chapple, J P / Mitchison, H M / Beales, P L / Wann, A K T / Knight, M M

Osteoarthritis and cartilage

2019 Volume 27, Issue 7, Page(s) 1064–1074

Abstract: Objective: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and ... ...

Abstract	Objective: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and associated intraflagellar transport (IFT) in the mechanical regulation of interleukin-1β (IL-1β) signalling. Design: Isolated chondrocytes and cartilage explants were subjected to cyclic mechanical loading in the presence and absence of the cytokine IL-1β. Nitric oxide (NO) and prostaglandin E Results: Mechanical loading suppressed NO and PGE Conclusions: This study reveals that mechanical loading suppresses inflammatory signalling, partially dependent on IFT, by activation of HDAC6 and post transcriptional modulation of tubulin.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Blotting, Western ; Cartilage, Articular/metabolism ; Cattle ; Cells, Cultured ; Chondrocytes/metabolism ; Cilia/metabolism ; Dinoprostone/metabolism ; Histone Deacetylase 6/metabolism ; Humans ; Interleukin-1beta/metabolism ; Microscopy, Confocal ; Nitric Oxide/metabolism ; Sensitivity and Specificity ; Signal Transduction ; Stress, Mechanical ; Tubulin/metabolism
Chemical Substances	Biomarkers ; IL1B protein, human ; Interleukin-1beta ; Tubulin ; Nitric Oxide (31C4KY9ESH) ; HDAC6 protein, human (EC 3.5.1.98) ; Histone Deacetylase 6 (EC 3.5.1.98) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2019-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2019.03.003
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