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Article ; Online: Clinical Proteomics: A Promise Becoming Reality.

Gillette, Michael A / Jimenez, Connie R / Carr, Steven A

2024 Volume 23, Issue 2, Page(s) 100688

MeSH term(s)	Proteomics
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Editorial
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2023.100688
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Article ; Online: Perioperative Antiplatelet Bridging With Cangrelor: A Cohort Study and Narrative Review.

Salgia, Alok / Krueger, Chelsea K / Gillette, Michael A

The Annals of pharmacotherapy

2022 Volume 57, Issue 5, Page(s) 544–552

Abstract: ... procedures in a veteran population.: Methods: Retrospective cohort of patients from Michael E. DeBakey VA ...

Abstract	Background: In patients who received a cardiac stent, practice guidelines recommend dual antiplatelet therapy (DAPT). However, an urgent procedure may be required necessitating interruption of DAPT. Intravenous cangrelor was previously shown to be an alternative due its short-half life and quick onset/offset. Objective: To determine the safety and effectiveness of cangrelor bridging for patients undergoing invasive procedures in a veteran population. Methods: Retrospective cohort of patients from Michael E. DeBakey VA Medical Center and the VA North Texas Health Care Systems who underwent perioperative cangrelor bridging. The primary outcome was the incidence of bleeding using the Bleeding Academic Research Consortium (BARC) criteria. The secondary outcome was a composite of nonfatal stroke, myocardial infarction (MI), mortality, and unplanned revascularization within 30 days. A narrative review was also performed to summarize cangrelor bridging for noncardiac invasive procedure. Results: There were 41 patients that met the eligibility criteria. Patients were predominantly Caucasian (57.5%) men with a median age of 70 years. The median duration on cangrelor bridging was 2.6 days with 11 and 30 patients undergoing cardiac and noncardiac invasive procedures, respectively. Nine patients (22%) had a bleeding event of which 8 were minor. One was severe due to significant iliopsoas hematoma following drain placement. All bleeding events occurred postoperatively except for 2 perioperative events that occurred during orthopedic procedures. Ischemic events up to 30 days occurred in 3 patients (7.3%) which consisted of 1 (2.4%) nonfatal MI requiring revascularization and 2 (4.9%) deaths, 1 of which was sudden cardiac. Conclusion and relevance: This study suggests that cangrelor bridging may be a reasonable alternative to holding oral P2Y12 inhibitors in patients requiring interruption of antiplatelet therapy for an urgent surgery/invasive procedure.
MeSH term(s)	Male ; Humans ; Aged ; Female ; Platelet Aggregation Inhibitors/adverse effects ; Cohort Studies ; Retrospective Studies ; Myocardial Infarction/chemically induced ; Myocardial Infarction/epidemiology ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors ; cangrelor (6AQ1Y404U7)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/10600280221120310
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Article ; Online: Ins and Outs: Perspectives of Inpatient Prescribing for Sacubitril/Valsartan.

Gillette, Michael / Bozkurt, Biykem

The Annals of pharmacotherapy

2020 Volume 55, Issue 6, Page(s) 805–813

Abstract: Heart failure is a major public health concern with a rising prevalence and significant financial detriment. Although sacubitril/valsartan was shown to reduce the risk of death and hospitalization from heart failure in a contemporary cohort, it continues ...

Abstract	Heart failure is a major public health concern with a rising prevalence and significant financial detriment. Although sacubitril/valsartan was shown to reduce the risk of death and hospitalization from heart failure in a contemporary cohort, it continues to remain substantially underutilized. A recent article in the
MeSH term(s)	Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Biphenyl Compounds ; Drug Combinations ; Heart Failure/drug therapy ; Humans ; Inpatients ; Stroke Volume ; Tetrazoles/therapeutic use ; Valsartan
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Drug Combinations ; Tetrazoles ; Valsartan (80M03YXJ7I) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/1060028020964923
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Article ; Online: Fungal profile, levels of aflatoxin M1, exposure, and the risk characterization of local cheese '

Kortei, Nii Korley / Gillette, Valentina Sylvia / Wiafe-Kwagyan, Michael / Ansah, Leslie Owusu / Kyei-Baffour, Vincent / Odamtten, George Tawia

Toxicology reports

2024 Volume 12, Page(s) 186–199

Abstract: ... ...

Abstract	Wagashi
Language	English
Publishing date	2024-01-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2024.01.009
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Article ; Online: Antibiotics reduce Pocillopora coral-associated bacteria diversity, decrease holobiont oxygen consumption and activate immune gene expression.

Connelly, Michael T / Snyder, Grace / Palacio-Castro, Ana M / Gillette, Phillip R / Baker, Andrew C / Traylor-Knowles, Nikki

Molecular ecology

2023 Volume 32, Issue 16, Page(s) 4677–4694

Abstract: Corals are important models for understanding invertebrate host-microbe interactions; however, to fully discern mechanisms involved in these relationships, experimental approaches for manipulating coral-bacteria associations are needed. Coral-associated ... ...

Abstract	Corals are important models for understanding invertebrate host-microbe interactions; however, to fully discern mechanisms involved in these relationships, experimental approaches for manipulating coral-bacteria associations are needed. Coral-associated bacteria affect holobiont health via nutrient cycling, metabolic exchanges and pathogen exclusion, yet it is not fully understood how bacterial community shifts affect holobiont health and physiology. In this study, a combination of antibiotics (ampicillin, streptomycin and ciprofloxacin) was used to disrupt the bacterial communities of 14 colonies of the reef framework-building corals Pocillopora meandrina and P. verrucosa, originally collected from Panama and hosting diverse algal symbionts (family Symbiodiniaceae). Symbiodiniaceae photochemical efficiencies and holobiont oxygen consumption (as proxies for coral health) were measured throughout a 5-day exposure. Antibiotics altered bacterial community composition and reduced alpha and beta diversity, however, several bacteria persisted, leading to the hypothesis that these bacteria are either antibiotics resistant or occupy internal niches that are shielded from antibiotics. While antibiotics did not affect Symbiodiniaceae photochemical efficiency, antibiotics-treated corals had lower oxygen consumption rates. RNAseq revealed that antibiotics increased expression of Pocillopora immunity and stress response genes at the expense of cellular maintenance and metabolism functions. Together, these results reveal that antibiotic disruption of corals' native bacteria negatively impacts holobiont health by decreasing oxygen consumption and activating host immunity without directly impairing Symbiodiniaceae photosynthesis, underscoring the critical role of coral-associated bacteria in holobiont health. They also provide a baseline for future experiments that manipulate Pocillopora corals' symbioses by first reducing the diversity and complexity of coral-associated bacteria.
MeSH term(s)	Animals ; Anthozoa/genetics ; Anthozoa/microbiology ; Anti-Bacterial Agents/pharmacology ; Microbiota/genetics ; Symbiosis/genetics ; Bacteria/genetics ; Oxygen Consumption ; Dinoflagellida/genetics ; Gene Expression ; Coral Reefs
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.17049
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Article ; Online: Comparison of Self and Caregiver Reports of Antiretroviral Treatment Adherence among Children and Adolescents Living with HIV in Western Kenya.

Gillette, Emma / Nyandiko, Winstone / Baum, Aaron / Chory, Ashley / Aluoch, Josephine / Ashimosi, Celestine / Lidweye, Janet / Njorge, Tabitha / Sang, Festus / Nyagaya, Jack / Scanlon, Michael / Vreeman, Rachel

Journal of the International Association of Providers of AIDS Care

2024 Volume 23, Page(s) 23259582241242335

Abstract: Background: Youth living with HIV with perinatal infection spend a lifetime taking antiretroviral treatment (ART) to suppress the virus, and face significant challenges to successfully maintaining ART adherence. Tools to measure adherence include self- ... ...

Abstract	Background: Youth living with HIV with perinatal infection spend a lifetime taking antiretroviral treatment (ART) to suppress the virus, and face significant challenges to successfully maintaining ART adherence. Tools to measure adherence include self-report, medication event monitoring system (MEMS) pill bottle caps, pill counts, and plasma or hair drug levels; however, the inter-rater agreement between child and caregiver self-report has not been validated in an African setting. This study aims to assess inter-rater agreement between child and caregiver self-reports, compared to reporting from MEMS pill bottle caps. Methods: This was a secondary analysis of a cluster-randomized trial to evaluate an intervention for children living with HIV, conducted at the Academic Model Providing Access to Healthcare in western Kenya. We analyzed data from 285 child-caregiver dyads to compare adherence self-reported by children and their caregivers, and subsequently compared all self-reports to adherence reported by MEMS pill bottle caps to determine whether child or caregiver self-reports aligned more closely with adherence measured by MEMS. Results: Children and their caregivers reported similar levels of adherence and numbers of missed doses in the past month, and both reports were similarly associated with adherence reported by MEMS pill bottle caps. Children with a caregiver that was not a biological parent were significantly more likely to report more missed doses than their caregiver. The correlation coefficient for the relationship between the child and caregiver self-reports was 0.71; for the relationship between child report and MEMS was 0.23; and for the relationship between caregiver report and MEMS was 0.20. Both children and caregivers under-reported non-adherence compared to MEMS data. Conclusion: Children and caregiver self-reports were generally similar in reporting adherence and were not highly correlated with MEMS reports of adherence, with children and caregivers reporting higher level of adherence than the MEMS data. This may indicate that children and caregiver reports are similarly inaccurate or biased; however, further research with larger sample sizes is required to further understand the differences in these reports.
MeSH term(s)	Adolescent ; Humans ; Anti-Retroviral Agents/therapeutic use ; Caregivers ; HIV Infections/drug therapy ; Kenya/epidemiology ; Medication Adherence
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2709037-1
ISSN	2325-9582 ; 2325-9574
ISSN (online)	2325-9582
ISSN	2325-9574
DOI	10.1177/23259582241242335
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Article ; Online: Reflections of the Angiotensin Receptor Blocker Recall by the FDA and Repercussions on Healthcare.

Gillette, Michael / Taylor, Addison / Butulija, Djenita / Kadiyala, Himabindu / Jneid, Hani

Cardiovascular drugs and therapy

2020 Volume 34, Issue 4, Page(s) 579–584

Abstract: Purpose: Beginning in July of 2018, the FDA issued a voluntary recall regarding the presence of a contaminant found in the manufacturing of valsartan. What would ensue has become a largely unprecedented sequence of alarming events since the FDA began ... ...

Abstract	Purpose: Beginning in July of 2018, the FDA issued a voluntary recall regarding the presence of a contaminant found in the manufacturing of valsartan. What would ensue has become a largely unprecedented sequence of alarming events since the FDA began reporting public recalls, withdrawals and safety alerts on their website in 2016. Since then, the United States has been significantly impacted by drug recalls affecting angiotensin receptor blockers. This report arms clinicians with additional guidance and provides a framework for responding appropriately to future similar incidents and includes an overview of the angiotensin receptor blockers, and their effects and safety profiles. Methods: This report includes a review of data from all pertinent clinical and scientific sources including information from the FDA's inspection documents and recall website. Additional information is provided on the specific bottles including all lot numbers, expiration dates, etc. RESULTS: The recalls/withdrawals are attributable to the presence of cancer-causing contaminants identified during the manufacturing process from drug manufacturers abroad. The root causes behind the recalls and subsequent shortage appear multifactorial, and stem to a certain extent from the outsourcing of medication manufacturing overseas and lack of quality checks and appropriate oversight. Conclusions: This inherent issue is not likely to resolve soon and has eroded the public trust of/in the healthcare system and the pharmaceutical industry. Patients and healthcare providers are significantly affected and should have a full understanding of the matter in order to guide appropriate response and actions.
MeSH term(s)	Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/analysis ; Carcinogens/analysis ; Drug Approval ; Drug Contamination ; Drug Industry/standards ; Drug Recalls ; Humans ; Patient Safety ; Quality Control ; Risk Assessment ; Risk Factors ; United States ; United States Food and Drug Administration/standards
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Carcinogens
Keywords	covid19
Language	English
Publishing date	2020-04-21
Publishing country	United States
Document type	Editorial ; Review
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-020-06976-0
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Article: Variation in incubation length and hatching asynchrony in Eastern Kingbirds: Weather eclipses female effects

Gillette, Samantha M. / Klehr, Amanda L. / Murphy, Michael T.

The auk. 2021 May 18, v. 138, no. 3

2021

Abstract: Incubation length and hatching asynchrony are integral elements of the evolved reproductive strategies of birds. We examined intra- and interpopulation variation in both traits for Eastern Kingbird (Tyrannus tyrannus) populations from New York (NY), ... ...

Title translation	Variación en la duración de la incubación y asincronía de la eclosión en Tyrannus tyrannus: el clima eclipsa los efectos de la hembra
Abstract	Incubation length and hatching asynchrony are integral elements of the evolved reproductive strategies of birds. We examined intra- and interpopulation variation in both traits for Eastern Kingbird (Tyrannus tyrannus) populations from New York (NY), Kansas (KS), and Oregon (OR) and found that both incubation length and hatching asynchrony were not repeatable among females, after controlling for a repeatable trait, clutch size. Instead, incubation length and clutch size were influenced by ambient temperature and precipitation. Incubation length exhibited the same median (15 days) and range (13–17 days) at all sites. Model selection results indicated that incubation periods for the smallest and largest clutches were longer in NY than KS when rain was frequent throughout incubation, in replacement nests, and likely when ambient temperatures were low during egg-laying. Full hatching usually required 2 days (but up to 3), with synchronous hatching associated with small clutch sizes, short incubation periods, frequent rain during the egg-laying period, and low ambient temperatures during the first half of incubation. Nestling starvation was uncommon (5–9% of nestlings monitored) and not associated with greater hatching asynchrony. These results indicate that while clutch size, a repeatable female trait, contributed to variation in incubation length and hatching asynchrony in Eastern Kingbirds, weather was a greater source of variation, especially for incubation length. LAY SUMMARY The length of time that eggs remain in a nest exposed to causes of mortality has important influences on the reproductive success of birds. We collected data on incubation length, the length of time elapsed between the hatching of the first and last egg (called hatching asynchrony), and probability of nestling starvation in Eastern Kingbirds breeding at 3 locations (Kansas, New York, and Oregon). Incubation length and hatching asynchrony varied considerably within, but also among sites. Incubation length and hatching asynchrony were both greater in nests with more eggs. However, most other variation was likely due to environmental effects. Cool and wet conditions were associated with long incubation periods while greater hatching asynchrony was found during periods when it was warm and dry. Starvation of nestlings was infrequent, and nests with a greater range of nestling ages (caused by high hatching asynchrony) did not experience greater starvation of young. Nestling starvation was thus not a cost of high-hatching asynchrony. Our research demonstrates that environmental temperature and frequency of precipitation have greater effects on incubation period compared to clutch size.
Keywords	Oregon ; Tyrannus tyrannus ; ambient temperature ; clutch size ; eggs ; females ; mortality ; nests ; oviposition ; probability ; rain ; reproductive success ; starvation ; Kansas ; New York
Language	English
Dates of publication	2021-0518
Size	p. 1-15.
Publishing place	University of California Press
Document type	Article
ISSN	2732-4613
DOI	10.1093/ornithology/ukab031
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Screening tool for identification of hip fractures in the prehospital setting.

Gillette, Danielle M / Cheng, Olivia / Wilson, Alghin / Mantero, Rogerio / Chisholm, Douglas / Feldman, Michael

OTA international : the open access journal of orthopaedic trauma

2021 Volume 4, Issue 4, Page(s) e157

Abstract: Objectives: This study aims to develop a screening tool that will help first responders identify patients with proximal femur fractures, commonly referred to as hip fractures, on site and direct these patients to hospitals with orthopaedic surgery ... ...

Abstract	Objectives: This study aims to develop a screening tool that will help first responders identify patients with proximal femur fractures, commonly referred to as hip fractures, on site and direct these patients to hospitals with orthopaedic surgery services. Study design: Prospective survey. Methods: Literature and expert opinion defined parameters for the Collingwood Hip Fracture Rule (CHFR) which predict a patient's likelihood of hip fracture. The study population included adults presenting to Collingwood General and Marine Hospital with lower extremity injuries between December 1, 2019 and March 10, 2020. Excluded patients had previous hip replacement, previous hip fracture on the side of the injury, or a high energy mechanism of injury. Patients were assessed with the CHFR before receiving x-ray imaging. The parameters were scored based on their predictive powers and analyzed by a receiver operating characteristic curve. Results: The study included 101 patients (mean age 66.3 years), and 25.7% had a hip fracture confirmed on imaging. The sensitivity, specificity, positive predictive value, and negative predictive value helped score each parameter. Factors receiving 1 point are: age 65 to 79 years, female, mechanical fall, unable to weight-bear, knee pain. Factors receiving 2 points are: bruising at greater trochanter, age >80 years. Factors receiving 3 points are: pain with hip rotation, leg shortened and externally rotated. Score is the summation of all the factors' points. The receiver operating characteristic curve (0.953; Conclusion: The CHFR screening tool score of 7 can be used by first responders in the prehospital setting to identify patients who sustain a hip fracture and make appropriate triage decisions. This will improve patient outcomes and decrease institutional costs.
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article
ISSN	2574-2167
ISSN (online)	2574-2167
DOI	10.1097/OI9.0000000000000157
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Article ; Online: HIV-Related Stigma Shapes Research Participation for Youth Living With HIV in Kenya.

Gillette, Emma / Naanyu, Violet / Nyandiko, Winstone / Chory, Ashley / Scanlon, Michael / Aluoch, Josephine / Koros, Hillary / Ashimosi, Celestine / Beigon, Whitney / Munyoro, Dennis / Lidweye, Janet / Nyagaya, Jack / DeLong, Allison / Kantor, Rami / Vreeman, Rachel

Journal of the International Association of Providers of AIDS Care

2023 Volume 22, Page(s) 23259582231170732

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Adolescent ; HIV Infections/drug therapy ; HIV Infections/psychology ; HIV ; Kenya ; Social Stigma ; Medication Adherence
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2709037-1
ISSN	2325-9582 ; 2325-9574
ISSN (online)	2325-9582
ISSN	2325-9574
DOI	10.1177/23259582231170732
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