LIVIVO - Search results -

Search results

Result 1 - 10 of total 5102

Search options

Book: Oxford textbook of heart failure

Clark, Andrew L. / Gardner, Roy S. / McDonagh, Theresa A.

(Oxford textbooks in cardiology)

2022

Title variant	Textbook of heart failure ; Heart failure
Author's details	edited by Andrew Clark, Roy Gardner, Theresa McDonagh
Series title	Oxford textbooks in cardiology
Keywords	Heart failure ; Akutes Herzversagen
Subject code	616.129
Language	English
Size	xv, 873 Seiten, Illustrationen, 28 cm
Edition	Second edition
Publisher	Oxford University Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT021370118
ISBN	978-0-19-876622-3 ; 0-19-876622-X
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2022 A 641	available for loan (reading room)	Lesesaal EG

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.

Venkatraman, Shankar / Lebsack, Alec D / Alves, Kenneth / Gardner, Michael F / James, Joyce / Lingham, Russell B / Maniar, Salony / Mumford, Richard A / Si, Qian / Stock, Nicholas / Treonze, Kelly M / Wang, Bowei / Zunic, Jasmine / Munoz, Benito

Bioorganic & medicinal chemistry letters

2009 Volume 19, Issue 19, Page(s) 5803–5806

Abstract: A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline ...

Abstract	A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline 4-position with cyclic amines was evaluated as VLA-4 antagonists. The ring size and presence or absence of fluorine affected potency and receptor occupancy. The analog with 3,3-difluoropiperidine at the proline 4-position (13) was the most potent compound and had very good duration of receptor occupancy in vitro. The ethyl ester prodrug of 13 demonstrated excellent receptor occupancy after oral dosing in rats.
MeSH term(s)	Administration, Oral ; Animals ; Dipeptides/administration & dosage ; Dipeptides/chemical synthesis ; Dipeptides/chemistry ; Drug Discovery ; Integrin alpha4beta1/antagonists & inhibitors ; Integrin alpha4beta1/metabolism ; Phenylalanine/administration & dosage ; Phenylalanine/analogs & derivatives ; Phenylalanine/chemical synthesis ; Prodrugs/administration & dosage ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Rats
Chemical Substances	Dipeptides ; Integrin alpha4beta1 ; N-(N-((3-cyanobenzene)sulfonyl)-4-(3,3-difluoropiperidin-1-yl)prolyl)-4-((3',5'-dichloroisonicotinoyl)amino)-phenylalanine ; Prodrugs ; Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2009-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2009.07.111
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3203: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Gastrointestinal Helminths of Opossums (Mammalia: Didelphidae) From Bolivia.

Jiménez, F Agustín / Campbell, Mariel L / Byles, Beth / Scheibel, R Philip / Gardner, Scott L

Parasitology

2024 , Page(s) 1–53

Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182024000490
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.220: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multimodal analgesia in a Southern White Rhinoceros (Ceratotherium simum) with pentosan polysulfate, gabapentin, amantadine and phenylbutazone to manage chronic pain.

Gardner, B R / Rourke, N L

Australian veterinary journal

2021 Volume 99, Issue 3, Page(s) 86–88

Abstract: A 38-year-old white rhinoceros bull (Ceratotherium simum) was treated with phenylbutazone over a period of four years for chronic osteoarthritic and neuropathic pain of the thoracic limbs. Initially the lameness was sporadic and responded well to ... ...

Abstract	A 38-year-old white rhinoceros bull (Ceratotherium simum) was treated with phenylbutazone over a period of four years for chronic osteoarthritic and neuropathic pain of the thoracic limbs. Initially the lameness was sporadic and responded well to phenylbutazone (4 mg/kg PO SID). The lameness increased in severity during the winter months. Four years after treatment was initiated, there was an increase in the severity and incidence of the lameness. Analgesia was augmented by the addition of non-conventional analgesic drugs. Pentosan polysulfate was administered IM at 3 mg/kg once a week for two treatments and thereafter monthly when possible. Gabapentin was used at 8 mg/kg but produced ataxia and anorexia. The dose was reduced to 4-5 mg/kg PO SID. Amantadine (3 mg/kg PO BID) was added to the multimodal analgesia and produced a significant improvement in the clinical lameness. Chronic inflammation was monitored using both automated and manual fibrinogen methods. Eventually the rhinoceros was euthanized on humane grounds when treatment was unable to produce suitable clinical relief.
MeSH term(s)	Amantadine/therapeutic use ; Analgesia/veterinary ; Animals ; Cattle ; Chronic Pain/veterinary ; Euthanasia, Animal ; Gabapentin/therapeutic use ; Male ; Pentosan Sulfuric Polyester ; Perissodactyla ; Phenylbutazone
Chemical Substances	Pentosan Sulfuric Polyester (37300-21-3) ; Gabapentin (6CW7F3G59X) ; Amantadine (BF4C9Z1J53) ; Phenylbutazone (GN5P7K3T8S)
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	41542-x
ISSN	1751-0813 ; 0005-0423
ISSN (online)	1751-0813
ISSN	0005-0423
DOI	10.1111/avj.13043
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 550: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: In vivo imaging in transgenic songbirds reveals superdiffusive neuron migration in the adult brain.

Shvedov, Naomi R / Analoui, Sina / Dafalias, Theresia / Bedell, Brooke L / Gardner, Timothy J / Scott, Benjamin B

Cell reports

2024 Volume 43, Issue 2, Page(s) 113759

Abstract: Neuron migration is a key phase of neurogenesis, critical for the assembly and function of neuronal circuits. In songbirds, this process continues throughout life, but how these newborn neurons disperse through the adult brain is unclear. We address this ...

Abstract	Neuron migration is a key phase of neurogenesis, critical for the assembly and function of neuronal circuits. In songbirds, this process continues throughout life, but how these newborn neurons disperse through the adult brain is unclear. We address this question using in vivo two-photon imaging in transgenic zebra finches that express GFP in young neurons and other cell types. In juvenile and adult birds, migratory cells are present at a high density, travel in all directions, and make frequent course changes. Notably, these dynamic migration patterns are well fit by a superdiffusive model. Simulations reveal that these superdiffusive dynamics are sufficient to disperse new neurons throughout the song nucleus HVC. These results suggest that superdiffusive migration may underlie the formation and maintenance of nuclear brain structures in the postnatal brain and indicate that transgenic songbirds are a useful resource for future studies into the mechanisms of adult neurogenesis.
MeSH term(s)	Animals ; Songbirds/physiology ; Vocalization, Animal/physiology ; Brain/metabolism ; Animals, Genetically Modified ; Neurons/metabolism ; Neurogenesis/physiology
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113759
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Pine needle abortions in cattle due to consumption of Pinus ponderosa in Argentina: Case reports.

Martinez, A / Apostolo, R / Herrera, R / Gardner, D / Borrelli, L / Zabaleta, G / Robles, C / Ferrería, J

Toxicon : official journal of the International Society on Toxinology

2024 Volume 242, Page(s) 107712

Abstract: Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuquén provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, ...

Abstract	Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuquén provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, the dams were in the last third of gestation, and, due to a period of cold, snow and lack of available forage, they gained access to Pinus ponderosa and Pinus contorta forests. No pathological lesions, serological, molecular, or microbiological evidence of infectious causes were observed in any of the six fetuses analyzed. Microhistological analysis of feces confirmed higher presence of fragments of Pinus spp. needles in the diet of affected dams than in that of non-affected ones (12.2 vs 3.0%). Moreover, toxicological analysis showed higher tetrahydroagathic acid in the sera of affected dams than in that of non-affected ones (10.05 vs 2.81 ppm). In addition, this acid was detected in different fetal fluids (3.6-8.1 ppm) of the six fetuses analyzed. Interestingly, isocupressic acid was detected only in needles of P. ponderosa, and its content was lower than that found in other areas of the world (0.31 and 0.5% in Chubut and Neuquén respectively). These results confirm that the consumption of P. ponderosa by dams could have been the cause of these abortion outbreaks, a fact that should be considered as differential diagnosis in abortions of cattle, especially in silvopastoral systems of Argentina.
MeSH term(s)	Cattle ; Animals ; Argentina/epidemiology ; Female ; Cattle Diseases/epidemiology ; Abortion, Veterinary/epidemiology ; Pregnancy ; Pinus ponderosa ; Plant Leaves ; Plant Poisoning/veterinary ; Plant Poisoning/epidemiology ; Disease Outbreaks/veterinary
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article ; Case Reports
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2024.107712
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 501: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Effects of Blue-Light Filtering Intraocular Implants on Glare Geometry.

Hammond, Billy R / Gardner, Colin R / Renzi-Hammond, Lisa

Current eye research

2023 Volume 48, Issue 7, Page(s) 639–644

Abstract: Purpose: One common complaint with natural opacified lenses is the deleterious effects of higher-order ocular aberrations and intraocular scatter, such as halos and starbursts, which are not always remedied with surgery and intraocular lens (IOL) ... ...

Abstract	Purpose: One common complaint with natural opacified lenses is the deleterious effects of higher-order ocular aberrations and intraocular scatter, such as halos and starbursts, which are not always remedied with surgery and intraocular lens (IOL) implantation. Blue-light filtering (BLF) IOL filter scatter-prone short-wave light. Here, we determine whether BLF IOL reduce halo and starburst size. Methods: This study was a case-control design, between- and within-subjects (contralateral implantation). Sixty-nine participants with either the BLF IOL ( Results: A case-control analysis. Halo size was significantly larger ( Conclusions: BLF IOL filter short-wave light and mimic retinal screening by the young, natural crystalline lens. Such filtering can reduce some deleterious effects of bright light by decreasing ocular diffusion/halos and starbursts.
MeSH term(s)	Humans ; Lenses, Intraocular ; Glare ; Lens Implantation, Intraocular ; Contrast Sensitivity ; Light ; Prosthesis Design ; Phacoemulsification
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2023.2192446
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1775: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Practical Guidance on [177Lu]Lu-PSMA-617 Treatment, Including Radiation Safety, Adverse Event Monitoring, and Patient Counseling.

Spitz, Avery / Floyd, Rebecca / Sutton, Jennifer / Gardner, Linda

Clinical journal of oncology nursing

2023 Volume 27, Issue 5, Page(s) 539–547

Abstract: Background: The approval of the prostate-specific membrane antigen (PSMA)-targeted radio-ligand therapy [177Lu]Lu-PSMA-617 represents a shift toward precision medicine-based treatments for metastatic castration-resistant prostate cancer.: Objectives: ...

Abstract	Background: The approval of the prostate-specific membrane antigen (PSMA)-targeted radio-ligand therapy [177Lu]Lu-PSMA-617 represents a shift toward precision medicine-based treatments for metastatic castration-resistant prostate cancer. Objectives: This review aims to provide practical advice and clinical considerations for working with [177Lu]Lu-PSMA-617; particularly, regarding the role of nurses in managing radiation safety, monitoring and reporting of adverse events, and counseling patients receiving this therapy. Methods: Clinical data, protocols, and guidelines are summarized alongside real-world insights to provide practical recommendations for nurses caring for patients treated with [177Lu]Lu-PSMA-617. Findings: Nurses coordinate safe care for patients receiving [177Lu]Lu-PSMA-617 by facilitating communication among physicians, managing logistic concerns, monitoring for adverse events related to treatment, providing education, and counseling patients and caregivers throughout treatment.
MeSH term(s)	Male ; Humans ; Lutetium ; Radioisotopes ; Counseling
Chemical Substances	PSMA-617 ; Lutetium-177 (BRH40Y9V1Q) ; Lutetium (5H0DOZ21UJ) ; Radioisotopes
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2014665-6
ISSN	1538-067X ; 1092-1095
ISSN (online)	1538-067X
ISSN	1092-1095
DOI	10.1188/23.CJON.539-547
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5229: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 390: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Overcoming the Barriers to Teaching Teamwork to Undergraduates in STEM.

Goldsmith, Gregory R / Aiken, Miranda L / Camarillo-Abad, Hector M / Diki, Kamal / Gardner, Daniel L / Stipčić, Mario / Espeleta, Javier F

CBE life sciences education

2024 Volume 23, Issue 2, Page(s) es2

Abstract: There is widespread recognition that undergraduate students in the life sciences must learn how to work in teams. However, instructors who wish to incorporate teamwork into their classrooms rarely have formal training in how to teach teamwork. This is ... ...

Abstract	There is widespread recognition that undergraduate students in the life sciences must learn how to work in teams. However, instructors who wish to incorporate teamwork into their classrooms rarely have formal training in how to teach teamwork. This is further complicated by the application of synonymous and often ambiguous terminology regarding teamwork that is found in literature spread among many different disciplines. There are significant barriers for instructors wishing to identify and implement best practices. We synthesize key concepts in teamwork by considering the knowledge, skills, and attitudes (KSAs) necessary for success, the pedagogies and curricula for teaching those KSAs, and the instruments available for evaluating and assessing success. There are only a limited number of studies on teamwork in higher education that present an intervention with a control group and a formal evaluation or assessment. Moreover, these studies are almost exclusively outside STEM disciplines, raising questions about their extensibility. We conclude by considering how to build an evidence base for instruction that will empower students with the KSAs necessary for participating in a lifetime of equitable and inclusive teamwork.
MeSH term(s)	Humans ; Students ; Curriculum ; Learning ; Biological Science Disciplines ; Knowledge
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2465176-X
ISSN	1931-7913 ; 1931-7913
ISSN (online)	1931-7913
ISSN	1931-7913
DOI	10.1187/cbe.23-07-0128
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Active Mutual Conjoint Estimation of Multiple Contrast Sensitivity Functions.

Marticorena, Dom Cp / Wong, Quinn Wai / Browning, Jake / Wilbur, Ken / Davey, Pinakin / Seitz, Aaron R / Gardner, Jacob R / Barbour, Dennis L

medRxiv : the preprint server for health sciences

2024

Abstract: Recent advances in nonparametric Contrast Sensitivity Function (CSF) estimation have yielded a new tradeoff between accuracy and efficiency not available to classical parametric estimators. An additional advantage of this new framework is the ability to ... ...

Abstract	Recent advances in nonparametric Contrast Sensitivity Function (CSF) estimation have yielded a new tradeoff between accuracy and efficiency not available to classical parametric estimators. An additional advantage of this new framework is the ability to independently tune multiple aspects of the estimator to seek further improvements. Machine Learning CSF (MLCSF) estimation with Gaussian processes allows for design optimization in the kernel, acquisition function and underlying task representation, to name a few. This paper describes a novel kernel for psychometric function estimation that is more flexible than a kernel based on signal detection theory. Despite being more flexible, it can result in a more efficient estimator. Further, trial selection for data acquisition that is generalized beyond pure information gain can also improve estimator quality. Finally, introducing latent variable representations underlying general CSF shapes can enable simultaneous estimation of multiple CSFs, such as from different eyes, eccentricities or luminances. The conditions under which the new procedures perform better than previous nonparametric estimation procedures are presented and quantified.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.12.24302700
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Inter-library loan at ZB MED