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Article ; Online: NNDB: An Expanded Database of Nearest Neighbor Parameters for Predicting Stability of Nucleic Acid Secondary Structures.

Mittal, Abhinav / Turner, Douglas H / Mathews, David H

2024 , Page(s) 168549

Abstract: Nearest neighbor thermodynamic parameters are widely used for RNA and DNA secondary structure prediction and to model thermodynamic ensembles of secondary structures. The Nearest Neighbor Database (NNDB) is a freely available web resource (https://rna ... ...

Abstract	Nearest neighbor thermodynamic parameters are widely used for RNA and DNA secondary structure prediction and to model thermodynamic ensembles of secondary structures. The Nearest Neighbor Database (NNDB) is a freely available web resource (https://rna.urmc.rochester.edu/NNDB) that provides the functional forms, parameter values, and example calculations. The NNDB provides the 1999 and 2004 set of RNA folding nearest neighbor parameters. We expanded the database to include a set of DNA parameters and a set of RNA parameters that includes m
Language	English
Publishing date	2024-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2024.168549
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Article ; Online: Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers.

Abhinav, Verma / Mittal, Rishabh / Navaneethakannan, Mathiyazhagan / Singh, Ahirwar Sonu / Sukhes, Mukherjee / Ashwin, Kotnis

Current molecular medicine

2024

Abstract: Non-alcoholic fatty liver disease is a globally prevalent disorder that can rapidly progress if not detected early. Currently, no accepted markers exist for early diagnosis and prognosis of NAFLD. This review describes derangement in major metabolic ... ...

Abstract	Non-alcoholic fatty liver disease is a globally prevalent disorder that can rapidly progress if not detected early. Currently, no accepted markers exist for early diagnosis and prognosis of NAFLD. This review describes derangement in major metabolic pathways of lipid, carbohydrate, and amino acids in NAFLD. It suggests that measuring levels of thrombospondin, TyG index, asymmetric dimethylarginine, LAL-A, GLP-1, FGF-21, and GSG index are potential markers for early diagnosis of NAFLD. A single marker may not indicate early NAFLD, and further large-scale studies on correlating levels of Thrombospondin-2, triglyceride-glucose index, and FGF-21 with NAFLD are warranted.
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/0115665240269082240213115711
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Zs.A 5580: Show issues

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Article ; Online: Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis Treatment: A Comprehensive Review.

Mittal, Vishnu / Barak, Ashima / Sharma, Anjali / Singhal, Abhinav

Current rheumatology reviews

2024

Abstract: Rheumatoid Arthritis (RA) is an inflammatory disease that causes severe joint destruction and persistent inflammation. This review aims to evaluate the efficacy, safety, and mechanisms of action of various herbal interventions in managing RA, providing ... ...

Abstract	Rheumatoid Arthritis (RA) is an inflammatory disease that causes severe joint destruction and persistent inflammation. This review aims to evaluate the efficacy, safety, and mechanisms of action of various herbal interventions in managing RA, providing valuable insights for patients and healthcare practitioners. To investigate the anti-inflammatory and antioxidant properties of selected herbal interventions, including turmeric, ginger, Boswellia serrata (frankincense), green tea, and Ashwagandha, to assess their potential as complementary treatments for RA, a comprehensive analysis is performed on the anti-inflammatory mechanisms and antioxidant effects of selected herbs. Emphasis is placed on the modulation of key inflammatory pathways and their ability to counteract oxidative stress, which are crucial factors in RA progression. Safety profiles and potential adverse effects of herbal remedies are also scrutinized. The review reveals promising evidence supporting the efficacy of turmeric and ginger in alleviating RA symptoms by modulating inflammatory pathways. Additionally, Boswellia serrata shows potential as an adjunct therapy for joint health and inflammation. The antioxidant-rich properties of green tea and Ashwagandha are highlighted, suggesting their role in counteracting oxidative stress associated with RA. In conclusion, while herbal remedies like turmeric, ginger, Boswellia serrata, green tea, and Ashwagandha offer potential complementary treatments for RA, their safety profiles and adverse effects warrant careful consideration. Rigorous clinical trials are needed to confirm their efficacy and safety, highlighting the necessity for further research in this area. These findings are crucial for patients and healthcare providers in making informed decisions about incorporating herbal interventions into RA treatment strategies.
Language	English
Publishing date	2024-04-25
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/0115733971294467240326074155
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Article ; Online: RNA Secondary Structure Analysis Using RNAstructure.

Ali, Sara E / Mittal, Abhinav / Mathews, David H

Current protocols

2023 Volume 3, Issue 7, Page(s) e846

Abstract: RNAstructure is a user-friendly program for the prediction and analysis of RNA secondary structure. It is available as a web server, a program with a graphical user interface, or a set of command line tools. The programs are available for Microsoft ... ...

Abstract	RNAstructure is a user-friendly program for the prediction and analysis of RNA secondary structure. It is available as a web server, a program with a graphical user interface, or a set of command line tools. The programs are available for Microsoft Windows, macOS, or Linux. This article provides protocols for prediction of RNA secondary structure (using the web server, the graphical user interface, or the command line) and high-affinity oligonucleotide binding sites to a structured RNA target (using the graphical user interface). © 2023 Wiley Periodicals LLC. Basic Protocol 1: Predicting RNA secondary structure using the RNAstructure web server Alternate Protocol 1: Predicting secondary structure and base pair probabilities using the RNAstructure graphical user interface Alternate Protocol 2: Predicting secondary structure and base pair probabilities using the RNAstructure command line interface Basic Protocol 2: Predicting binding affinities of oligonucleotides complementary to an RNA target using OligoWalk.
MeSH term(s)	Binding Sites ; Oligonucleotides ; Probability ; Protein Structure, Secondary ; RNA
Chemical Substances	Oligonucleotides ; RNA (63231-63-0)
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.846
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Article: Mycotic Pseudoaneurysm of the Internal Mammary Artery: An Unusual Complication of Tuberculosis—Managed with Percutaneous Glue Embolization

Mittal, Payal / Ganesan, Prem Kumar / Vats, Abhinav / Parakh, Ankit

Journal of Clinical Interventional Radiology ISVIR

2024

Abstract: Tuberculosis is still an endemic in many parts of the world. Vascular complications have been described in patients with tuberculosis and in aggressive chest infections such as actinomycoses. Etiology of internal mammary artery pseudoaneurysms includes ... ...

Abstract	Tuberculosis is still an endemic in many parts of the world. Vascular complications have been described in patients with tuberculosis and in aggressive chest infections such as actinomycoses. Etiology of internal mammary artery pseudoaneurysms includes iatrogenic causes or a complication of infection (mycotic aneurysm). Early diagnosis and treatment of these aneurysms are key to prevent complications such as hemorrhage, hemothorax, and hemorrhagic shock. In this case report, we describe the presentation and management of a 11-year-old patient with tuberculosis, who developed an internal mammary artery pseudoaneurysm during the course of treatment. We describe the case of a 11-year-old girl with known tuberculosis who developed a left internal mammary artery pseudoaneurysm, and treated with percutaneous ultrasound-guided glue embolization.
Keywords	mycotic pseudoaneurysm ; internal mammary artery ; percutaneous glue embolization
Language	English
Publishing date	2024-01-05
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2904139-9
ISSN	2456-4869 ; 2456-4869
ISSN (online)	2456-4869
ISSN	2456-4869
DOI	10.1055/s-0043-1777847
Database	Thieme publisher's database

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Book ; Online: Agree To Disagree

Raghuvanshi, Abhinav / Pawar, Siddhesh / Mittal, Anirudh

2023

Abstract: How frequently do individuals thoroughly review terms and conditions before proceeding to register for a service, install software, or access a website? The majority of internet users do not engage in this practice. This trend is not surprising, given ... ...

Abstract	How frequently do individuals thoroughly review terms and conditions before proceeding to register for a service, install software, or access a website? The majority of internet users do not engage in this practice. This trend is not surprising, given that terms and conditions typically consist of lengthy documents replete with intricate legal terminology and convoluted sentences. In this paper, we introduce a Machine Learning-powered approach designed to automatically parse and summarize critical information in a user-friendly manner. This technology focuses on distilling the pertinent details that users should contemplate before committing to an agreement.
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Publishing date	2023-09-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of three different

Tiwari, Nidhi / Jaimini, Abhinav / Jain, Gaurav Kumar / Aggarwal, Geeta / Mittal, Gaurav

Journal of pharmacological and toxicological methods

2023 Volume 122, Page(s) 107280

Abstract: Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a 'priority neglected tropical disease' and stressing for a need to develop novel therapeutic strategies to reduce death and ... ...

Abstract	Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a 'priority neglected tropical disease' and stressing for a need to develop novel therapeutic strategies to reduce death and disability rate by end of 2030. Since a major component of venom; the high molecular weight (HMw) toxins enter the bloodstream through lymphatic system, research is focusing on modulating the lymphatic flow rate after topical application of suitable drug candidates. Present study compared the suitability of three radiopharmaceutical agents, namely
MeSH term(s)	Humans ; Animals ; Rats ; Lymphoscintigraphy ; Radiopharmaceuticals/pharmacology ; Technetium Tc 99m Sulfur Colloid ; Venoms ; Snake Bites/diagnostic imaging ; Rats, Sprague-Dawley ; Lymph Nodes ; Sulfur Compounds
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Sulfur Colloid (556Q0P6PB1) ; Venoms ; Sulfur Compounds
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105919-9
ISSN	1873-488X ; 1056-8719
ISSN (online)	1873-488X
ISSN	1056-8719
DOI	10.1016/j.vascn.2023.107280
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Zs.A 1440: Show issues

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Article: Trends and Practices in Limb Lengthening: An 11-year US Database Study.

Mittal, Ashish / Allahabadi, Sachin / Jayaram, Rishab / Nalluri, Abhinav / Callahan, Matt / Sabharwal, Sanjeev

Strategies in trauma and limb reconstruction

2023 Volume 18, Issue 1, Page(s) 21–31

Abstract: ... to cite this article: Mittal A, Allahabadi S, Jayaram R, ...

Abstract	Aim: Over the past couple of decades, limb lengthening has evolved to encompass various implants and techniques. The purpose of this study was to (1) determine trends in the utilisation of various limb lengthening techniques for the femur and tibia in the United States, (2) determine trends in 1-year readmission rate following limb lengthening procedures and (3) to study the relationship of limb lengthening implant used and payment method used with the underlying diagnosis associated with limb shortening. Materials and methods: Inpatient data were acquired using the Healthcare Cost and Utilisation Project (HCUP) database from 2005 to 2015 from seven states in the United States. Patients with an International Classification of Diseases (ICD)-9 code for limb lengthening of the femur or tibia were included. A total of 2,563 patients were included. Data were analysed using descriptive statistics, and chi-square test was used for comparison of subcategories. Linear regression analysis was used to examine trends over time. Results: There was a strong linear trend towards increasing proportional use of internal lengthening of the femur from 2011 to 2015 ( Conclusion: There was increasing use of internal lengthening techniques from 2011 to 2015. Patients with short stature had higher use of internal lengthening technique and self-pay for payment method. Clinical significance: Intramedullary devices have seen increasing use for limb lengthening procedures. Lengthening technique and payment method may differ by underlying diagnosis. How to cite this article: Mittal A, Allahabadi S, Jayaram R,
Language	English
Publishing date	2023-09-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2387508-2
ISSN	1828-8928 ; 1828-8936
ISSN (online)	1828-8928
ISSN	1828-8936
DOI	10.5005/jp-journals-10080-1574
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Article ; Online: Robotic bronchoscopy and future directions of interventional pulmonology.

Folch, Erik / Mittal, Abhinav / Oberg, Catherine

Current opinion in pulmonary medicine

2021 Volume 28, Issue 1, Page(s) 37–44

Abstract: Purpose of review: To describe the emerging field of robotic bronchoscopy within advanced diagnostic bronchoscopy. We review the literature available for these two novel platforms to highlight their differences and discuss the impact on future ... ...

Abstract	Purpose of review: To describe the emerging field of robotic bronchoscopy within advanced diagnostic bronchoscopy. We review the literature available for these two novel platforms to highlight their differences and discuss the impact on future directions. Recent findings: There are two distinct technologies both known as robotic bronchoscopy. The Monarch robotic-assisted bronchoscopy is based on electromagnetic guidance whereas the Ion robotic-assisted bronchoscopy is founded on shape sensing technology. Although there is ongoing work to explore the capabilities of these systems, studies have shown that both are safe modalities. Furthermore, both hold promise to improve diagnostic yield and may eventually pave the way for therapeutic bronchoscopic ablation in the future. Summary: Although both platforms fall under the umbrella term of robotic-assisted bronchoscopy, the Monarch and Ion systems are quite unique in their technology. Thus far, both have demonstrated safety, and early data shows promising results for improved diagnostic yield compared to previously advanced bronchoscopy modalities, especially when combined with advanced confirmatory imaging. Future directions may include bronchoscopic ablation of peripheral lesions given the stability and reach of these platforms.
MeSH term(s)	Bronchoscopy ; Humans ; Lung Neoplasms ; Pulmonary Medicine ; Robotic Surgical Procedures
Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1285505-4
ISSN	1531-6971 ; 1070-5287 ; 1078-1641
ISSN (online)	1531-6971
ISSN	1070-5287 ; 1078-1641
DOI	10.1097/MCP.0000000000000849
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Article: Design and Implementation of a Quantitative Network Health Monitoring and Recovery System.

Gujral, Harshit / Sharma, Abhinav / Jain, Pulkit / Juneja, Shriya / Mittal, Sangeeta

Wireless personal communications

2022 Volume 125, Issue 1, Page(s) 367–397

Abstract: A network health monitoring system focuses on the quantification of the network's health by taking into account various security flaws, leaks, and vulnerabilities. A plethora of propriety tools and patents are available for network health quantification. ...

Abstract	A network health monitoring system focuses on the quantification of the network's health by taking into account various security flaws, leaks, and vulnerabilities. A plethora of propriety tools and patents are available for network health quantification. However, there is a paucity of available research and literature in this field. Thus, in this study, we present an architectural design of a network health monitoring system. The design focuses on the quantification of the network health of each end-user as well as the entire network. The network health score for each end-user is quantified by identifying (1) illicit egress-ingress traffic, (2) anomalous fingerprints, and (3) system-network vulnerabilities based on the NVD-CVSS (National Vulnerability Database, Common Vulnerability Severity Score) standards. An overall network-health score is produced, along with a prevention and recovery mechanism that is triggered upon the detection of an anomaly. The proposed system is implemented in a local area network and has demonstrated to protect the network against various threats successfully. The study is concluded by comparing the proposed tool with the popular propriety tools available in the field. The results outline that the proposed system garners features of open-source tools and enriches them by introducing a state-of-the-art architecture coupled with multiple novel features like exhaustive identification of vulnerability and detection of network aberrations using timers.
Language	English
Publishing date	2022-03-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1479327-1
ISSN	1572-834X ; 0929-6212
ISSN (online)	1572-834X
ISSN	0929-6212
DOI	10.1007/s11277-022-09554-9
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