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  1. Book ; Online: Advances in Steroid-Responsive Encephalopathy

    Tian, Xin / Wang, Xuefeng / Kwan, Patrick

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; steroid-responsive encephalopathy ; mechanism ; diagnosis ; treatment ; prognosis
    Size 1 electronic resource (115 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230631
    ISBN 9782889660421 ; 2889660427
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Neuroepidemiology in Resource-Limited Areas

    Ding, Ding / Wang, Wenzhi / Kwan, Patrick

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; Epidemiology ; prevalence ; population-based study ; risk factors ; neurological disorders
    Size 1 electronic resource (134 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231283
    ISBN 9782889637331 ; 2889637336
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Commentary on "Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?"

    Kwan, Patrick

    Epilepsia

    2019  Volume 60, Issue 6, Page(s) 1124–1125

    MeSH term(s) Adult ; Anticonvulsants ; Drug Resistance ; Epilepsies, Partial ; Humans ; Neurologists
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2019-05-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.14886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 517: Show issues Location:
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    Zs.MO 475: Show issues

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  4. Article ; Online: Editorial: Epidemiology of epilepsy and seizures.

    Chen, Zhibin / Brodie, Martin J / Ding, Ding / Kwan, Patrick

    Frontiers in epidemiology

    2023  Volume 3, Page(s) 1273163

    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Editorial
    ISSN 2674-1199
    ISSN (online) 2674-1199
    DOI 10.3389/fepid.2023.1273163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of machine learning in the management of epilepsy: a systematic review protocol.

    Chang, Richard Shek-Kwan / Nguyen, Shani / Chen, Zhibin / Foster, Emma / Kwan, Patrick

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e079785

    Abstract: Introduction: Machine learning is a rapidly expanding field and is already incorporated into many aspects of medicine including diagnostics, prognostication and clinical decision-support tools. Epilepsy is a common and disabling neurological disorder, ... ...

    Abstract Introduction: Machine learning is a rapidly expanding field and is already incorporated into many aspects of medicine including diagnostics, prognostication and clinical decision-support tools. Epilepsy is a common and disabling neurological disorder, however, management remains challenging in many cases, despite expanding therapeutic options. We present a systematic review protocol to explore the role of machine learning in the management of epilepsy.
    Methods and analysis: This protocol has been drafted with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for Protocols. A literature search will be conducted in databases including MEDLINE, Embase, Scopus and Web of Science. A PRISMA flow chart will be constructed to summarise the study workflow. As the scope of this review is the clinical application of machine learning, the selection of papers will be focused on studies directly related to clinical decision-making in management of epilepsy, specifically the prediction of response to antiseizure medications, development of drug-resistant epilepsy, and epilepsy surgery and neuromodulation outcomes. Data will be extracted following the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies checklist. Prediction model Risk Of Bias ASsessment Tool will be used for the quality assessment of the included studies. Syntheses of quantitative data will be presented in narrative format.
    Ethics and dissemination: As this study is a systematic review which does not involve patients or animals, ethics approval is not required. The results of the systematic review will be submitted to peer-review journals for publication and presented in academic conferences.
    Prospero registration number: CRD42023442156.
    MeSH term(s) Humans ; Research Design ; Systematic Reviews as Topic ; Epilepsy/diagnosis ; Epilepsy/therapy ; Machine Learning ; Review Literature as Topic
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-079785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anxiety and depressive symptoms in adults with new-onset seizures: A scoping review.

    Cronin, William / Kwan, Patrick / Foster, Emma

    Epilepsia open

    2023  Volume 8, Issue 3, Page(s) 758–772

    Abstract: Objective: Anxiety and depression are common comorbidities in people living with epilepsy. Emerging research suggests that these conditions may even predate epilepsy onset. This review aimed to summarize the prevalence of clinically significant anxiety ... ...

    Abstract Objective: Anxiety and depression are common comorbidities in people living with epilepsy. Emerging research suggests that these conditions may even predate epilepsy onset. This review aimed to summarize the prevalence of clinically significant anxiety and depressive symptoms in people with first seizures and newly diagnosed epilepsy, as well as clinicodemographic factors associated with these symptoms.
    Methods: A scoping literature review was performed. OVID Medline and Embase were searched from January 1, 2000, through May 1, 2022. Articles of interest were selected based on predetermined inclusion and exclusion criteria.
    Results: From 1836 studies identified on screening, 16 met eligibility criteria and were included in the review. Clinically significant anxiety and depressive symptoms, as determined by validated cutoff scores for anxiety and depression screening instruments, were common in people with first seizures (range 13-28%) and newly diagnosed epilepsy (range 11-45%). They were associated with a range of clinicodemographic factors including past psychiatric history and trauma, personality traits, self-esteem, and stigma profiles.
    Significance: There is substantial evidence that clinically significant anxiety and depressive symptoms are often present at the time and shortly following the first seizure or epilepsy diagnosis. Future research is needed to better understand the complex interactions between these common psychiatric comorbidities, new-onset seizure disorders, and certain clinicodemographic characteristics. This knowledge may inform targeted and holistic treatment approaches.
    MeSH term(s) Humans ; Adult ; Depression/epidemiology ; Depression/diagnosis ; Epilepsy/complications ; Anxiety/epidemiology ; Anxiety Disorders/complications ; Anxiety Disorders/diagnosis ; Comorbidity
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Experience of waiting for seizure freedom and perception of machine learning technologies to support treatment decision: A qualitative study in adults with recent onset epilepsy.

    Reeder, Sandra / Foster, Emma / Vishwanath, Swarna / Kwan, Patrick

    Epilepsy research

    2023  Volume 190, Page(s) 107096

    Abstract: Purpose: With no reliable surrogate biomarkers for treatment response, people with epilepsy currently await the passage of time to determine whether prescribed treatments are effective. Few studies have examined the issues faced by people with epilepsy ... ...

    Abstract Purpose: With no reliable surrogate biomarkers for treatment response, people with epilepsy currently await the passage of time to determine whether prescribed treatments are effective. Few studies have examined the issues faced by people with epilepsy during this waiting period. We aim to explore the experiences of people with recently diagnosed epilepsy as they wait to achieve seizure freedom.
    Methods: We purposively sampled adults of working age who had been diagnosed and treated for epilepsy for less than four years. Semi-structured interviews were undertaken between July and September 2021. A thematic analysis using a framework approach was performed.
    Results: We recruited 15 patients. Results revealed four main themes: 1) Impact on mental health, as people with newly diagnosed epilepsy described waiting for seizure freedom as a time of vulnerability, uncertainty, and confusion. 2) Participants described their life as "on hold", prior to achieving effective seizure control 3) Difficulty navigating health systems to find and understand information about epilepsy, tests, and medications, and to find the 'right' health professional to address their needs. 4) Technology systems that support clinician decision making with selecting effective medications early after diagnosis were cautiously welcomed by participants.
    Conclusion: Interventions are needed to reduce the negative impacts experienced by people who are newly diagnosed with epilepsy while waiting for effective seizure control. Technology systems that support clinician decision making were acceptable, as people with epilepsy sought accessible and effective solutions to restore a sense of control in their lives.
    MeSH term(s) Humans ; Adult ; Child, Preschool ; Epilepsy/drug therapy ; Epilepsy/diagnosis ; Seizures/drug therapy ; Qualitative Research ; Perception ; Freedom
    Language English
    Publishing date 2023-01-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2023.107096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2193: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Book ; Online: Fast Facts : Epilepsy

    Brodie, Martin J. / Schachter, Steven C. / Kwan, Patrick

    (Fast facts)

    2012  

    Abstract: This is a succinct and practical aid to diagnosis and treatment of a wide range of seizure disorders. The contents cover the diagnostic essentials, the principles of drug selection and therapy withdrawal, an up-to-date overview of all the antiepileptic ... ...

    Author's details Martin J. Brodie, Steven C. Schachter, Patrick Kwan
    Series title Fast facts
    Abstract This is a succinct and practical aid to diagnosis and treatment of a wide range of seizure disorders. The contents cover the diagnostic essentials, the principles of drug selection and therapy withdrawal, an up-to-date overview of all the antiepileptic drugs on the market, and much more.
    Keywords Epilepsy ; Epilepsy/Treatment
    Subject code 616.853
    Language English
    Size 1 online resource (144 pages) ;, color illustrations
    Edition 5th edition
    Publisher Health Press Ltd
    Publishing place Oxford
    Document type Book ; Online
    Note English ; Previous edition: 2009.
    ISBN 1-280-12943-3 ; 9786613533319 ; 1-908541-19-9 ; 1-908541-12-1 ; 978-1-280-12943-8 ; 6613533319 ; 978-1-908541-19-2 ; 978-1-908541-12-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: One step closer towards personalized epilepsy management.

    Chen, Zhibin / Anderson, Alison / Ge, Zongyuan / Kwan, Patrick

    Brain : a journal of neurology

    2021  Volume 144, Issue 6, Page(s) 1624–1626

    Language English
    Publishing date 2021-06-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awab199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.26: Show issues Location:
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  10. Article ; Online: Pharmacological treatment for older adults with epilepsy and comorbid neurodegenerative disorders.

    O'Dwyer, Rebecca / Foster, Emma / Leppik, Ilo / Kwan, Patrick

    Current opinion in neurology

    2023  Volume 36, Issue 2, Page(s) 117–123

    Abstract: Purpose of review: An increased interest in epilepsy in older adults has emerged as the global population ages. The purpose of this article is to review the literature regarding the pharmacological treatment of epilepsy in older adults, highlighting ... ...

    Abstract Purpose of review: An increased interest in epilepsy in older adults has emerged as the global population ages. The purpose of this article is to review the literature regarding the pharmacological treatment of epilepsy in older adults, highlighting issues specifically pertinent to those living with comorbid neurodegenerative disorders.
    Recent findings: Although new original research remains sparse, in the last 5 years, there has been a growing number of studies addressing the relationship between epilepsy and neurodegenerative disorders. Accurate diagnosis is incredibly challenging with electroencephalogram findings often requiring circumspect interpretation. Older individuals are often excluded from or under-represented in clinical trials, and there are sparse guidelines offered on the management of these patients, with even less available in reference to those with neurodegenerative comorbidities.
    Summary: We propose that seizures occurring earlier in the neurodegenerative process should be treated aggressively, with the goal to inhibit neuro-excitotoxicity and the associated neuronal loss. By strategically choosing newer antiseizure medications with less adverse effects and a holistic approach to treatment, a patient's time living independently can be conserved. In addition, we advocate for original, multinational collaborative research efforts.
    MeSH term(s) Humans ; Aged ; Anticonvulsants/therapeutic use ; Epilepsy/complications ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Seizures/drug therapy ; Comorbidity ; Neurodegenerative Diseases/complications ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/epidemiology
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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