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  1. Article ; Online: The Evolution of Ketamine in Severe Pediatric Traumatic Brain Injury, From Contraband to Promising Neuroprotectant?

    Kochanek, Patrick M / Herrmann, Jeremy R / Bleck, Thomas P

    Critical care medicine

    2023  Volume 51, Issue 5, Page(s) 677–680

    MeSH term(s) Humans ; Child ; Ketamine/therapeutic use ; Neuroprotective Agents/therapeutic use ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries/drug therapy
    Chemical Substances Ketamine (690G0D6V8H) ; Neuroprotective Agents
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005826
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    Zs.A 1261: Show issues Location:
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  2. Article ; Online: How Critical Illness Affects the Brain…and Vice Versa.

    Bleck, Thomas P

    Critical care medicine

    2018  Volume 46, Issue 3, Page(s) 465–470

    MeSH term(s) Brain/physiopathology ; Brain Diseases/etiology ; Brain Diseases/physiopathology ; Critical Illness ; Humans
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002944
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  3. Article ; Online: Dopamine Antagonists in ICU Delirium.

    Bleck, Thomas P

    The New England journal of medicine

    2018  Volume 379, Issue 26, Page(s) 2569–2570

    MeSH term(s) Critical Illness ; Delirium ; Dopamine Antagonists ; Haloperidol ; Humans ; Intensive Care Units ; Piperazines ; Thiazoles
    Chemical Substances Dopamine Antagonists ; Piperazines ; Thiazoles ; ziprasidone (6UKA5VEJ6X) ; Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2018-10-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1813382
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  4. Article ; Online: Delirium in Cardiac and Cardiovascular Surgical Intensive Care Units.

    Breit, Hannah / Bleck, Thomas P / Koffman, Lauren

    Seminars in neurology

    2021  Volume 41, Issue 4, Page(s) 453–462

    Abstract: Delirium is a common occurrence in cardiac and cardiovascular surgical intensive care units. Due to multiple confounding factors, this diagnosis remains challenging for medical professionals. Multiple theories exist regarding the pathophysiology of ... ...

    Abstract Delirium is a common occurrence in cardiac and cardiovascular surgical intensive care units. Due to multiple confounding factors, this diagnosis remains challenging for medical professionals. Multiple theories exist regarding the pathophysiology of delirium, which include disruption of neurotransmitters as well as inflammation. Delirium has been associated with prolonged hospitalizations and an increase in mortality. Although there are widely used screening tools for delirium, none have been validated in this particular patient population. Limited treatments exist for delirium, so: both pharmacologic and nonpharmacologic preventative measures should be employed in this patient population.
    MeSH term(s) Critical Care ; Delirium/diagnosis ; Delirium/etiology ; Delirium/therapy ; Humans ; Intensive Care Units
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0041-1726283
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    Zs.A 1737: Show issues Location:
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  5. Book ; Audio / Video: Central nervous system and eye infections

    Bleck, Thomas P.

    medline linked

    (Atlas of infectious diseases ; 3)

    1996  

    Author's details ed. Thomas P. Bleck
    Series title Atlas of infectious diseases ; 3
    Collection
    Language English
    Size 1 CD-ROM ; 12 cm
    Publisher Current Med
    Publishing place Philadelphia
    Publishing country United States
    Document type Book ; Audio / Video
    Accompanying material Begleith. (28 S.)
    HBZ-ID HT010722866
    ISBN 1-57340-071-8 ; 978-1-57340-071-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 MO 89 -3- order for loan Magazin

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  6. Article ; Online: Comment on "Can Quantitative Pupillometry be used to Screen for Elevated Intracranial Pressure? A Retrospective Cohort Study".

    Maas, Matthew B / Naidech, Andrew M / Batra, Ayush / Chou, Sherry H-Y / Bleck, Thomas P

    Neurocritical care

    2022  Volume 37, Issue 2, Page(s) 597–598

    MeSH term(s) Humans ; Intracranial Hypertension/diagnosis ; Intracranial Pressure ; Retrospective Studies
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-022-01549-5
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  7. Article ; Online: Letter re: Diagnosis of ventriculostomy-related infection: Is cerebrospinal fluid lactate measurement a useful tool?

    Busl, Katharina M / Bleck, Thomas P

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2018  Volume 48, Page(s) 246

    MeSH term(s) Cerebrospinal Fluid ; Humans ; Hydrocephalus/surgery ; Lactates ; Third Ventricle/surgery ; Ventriculostomy
    Chemical Substances Lactates
    Language English
    Publishing date 2018
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2017.11.017
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    Zs.A 3999: Show issues Location:
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  8. Book: Central nervous system and eye infections

    Bleck, Thomas P.

    (Atlas of infectious diseases ; 3)

    1995  

    Author's details ed. Thomas P. Bleck
    Series title Atlas of infectious diseases ; 3
    Collection
    Keywords Central Nervous System Diseases / diagnosis / atlases ; Central Nervous System Diseases / microbiology / atlases ; Eye Infections / diagnosis / atlases
    Language English
    Size Getr. Zählung : zahlr. Ill., graph. Darst., Kt.
    Publisher Current Med
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    HBZ-ID HT006822239
    ISBN 0-443-07700-2 ; 978-0-443-07700-5
    Database Catalogue ZB MED Medicine, Health

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    2012 C 80 order for loan Magazin
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  9. Article: Thermoregulation in epilepsy.

    Pollandt, Sebastian / Bleck, Thomas P

    Handbook of clinical neurology

    2018  Volume 157, Page(s) 737–747

    Abstract: Several aspects of thermoregulation play a role in epilepsy. Circuitries involved in thermoregulation are affected by seizures and epilepsy, hyperthermia may be both cause and result of seizures, and hypothermia may prevent or abort seizures. Autonomic ... ...

    Abstract Several aspects of thermoregulation play a role in epilepsy. Circuitries involved in thermoregulation are affected by seizures and epilepsy, hyperthermia may be both cause and result of seizures, and hypothermia may prevent or abort seizures. Autonomic manifestations of seizures including thermoregulatory disturbances are common in a variety of clinical epilepsy syndromes. Experimental hyperthermia has been studied extensively, predominantly to investigate febrile seizures of childhood. In particular prolonged or complex febrile seizures have been associated with the later development of epilepsy in adulthood and the pathophysiology of how febrile seizures cause epilepsy is of tremendous interest. Febrile seizures represent an opportunity to potentially intervene early in life in susceptible individuals and affect epileptogenesis. The pathophysiologic underpinnings of how hyperthermia induces seizures and how this in turn results in epilepsy are controversial, but likely involve multiple factors. Both glutamatergic and GABAergic neurotransmission is affected, and numerous mutations in genes encoding ion channels have been identified. Cytokines such as interleukin-1β have been implicated in febrile seizures as well as susceptibility to provoked seizures later in life. Hyperthermia is a common feature of generalized convulsive status epilepticus, but may also be seen with nonconvulsive seizures, indicating involvement of thermoregulatory centers.
    MeSH term(s) Animals ; Body Temperature Regulation/physiology ; Epilepsy/physiopathology ; Humans
    Language English
    Publishing date 2018-11-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-64074-1.00045-8
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  10. Article ; Online: Inattentional blindness to DWI lesions in spontaneous intracerebral hemorrhage.

    Garg, Rajeev K / Ouyang, Bichun / Kocak, Mehmet / Bhabad, Sudeep / Bleck, Thomas P / Jhaveri, Miral

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 7, Page(s) 4355–4361

    Abstract: ... Both were significantly different (p < 0.05) from the sensitivity of the "official read.": Conclusions ...

    Abstract Purpose: Inattentional blindness refers to when an individual fails to recognize an event or object due to their awareness being engaged in a different task and has been described in radiology. The purpose of this study is to determine whether the sensitivity of detecting diffusion-weighted imaging (DWI) lesions in spontaneous intracerebral hemorrhage (sICH) is reduced due to inattentional blindness.
    Methods: Using a prospective observational cohort, select sICH patients received an MRI scan within 72 h of admission. The scans were subject to an "official read" that occurred as part of the routine workflow. Separately, each scan underwent two "preliminary research reads" with task-specific instructions to detect DWI lesions. A "final research read" via three-party adjudication was used to calculate sensitivity and specificity for detecting these lesions. Board-certified neuroradiologists blinded to the clinical history of the patients reviewed all imaging.
    Results: Amongst 121 sICH participants with research MRI scans, 49.6% (n = 60) scans were noted to have DWI lesion on their "final research read." The "official read" detected these DWI lesions with a sensitivity of 65% (95% CI, 52-77%). In contrast, the "preliminary research read" sensitivity for readers 1 and 2 was 98% (CI 95%, 91 to 100%) and 87% (CI 95%, 75 to 94%), respectively. Both were significantly different (p < 0.05) from the sensitivity of the "official read."
    Conclusions: Given the increased sensitivity with task-specific instructions, our results suggest that inattentional blindness may be leading to the decreased detection of DWI lesions in patients with concomitant sICH.
    MeSH term(s) Blindness ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Magnetic Resonance Imaging ; Sensitivity and Specificity
    Language English
    Publishing date 2022-03-09
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-05992-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1877: Show issues Location:
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