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Article: Facile and Sustainable Synthesis of Commendamide and its Analogues.

Villano, Rosaria / Tinto, Francesco / Di Marzo, Vincenzo

2022 Volume 10, Page(s) 858854

Abstract: Commendamide, or N-(3-hydroxypalmitoyl)- ... ...

Abstract	Commendamide, or N-(3-hydroxypalmitoyl)-glycine
Language	English
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.858854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regarding "Understanding the 'Scope' of the Problem: Why Laparoscopy Is Considered Safe during the COVID-19 Pandemic".

Di Marzo, Francesco / Cardi, Maurizio

Journal of minimally invasive gynecology

2020 Volume 27, Issue 6, Page(s) 1424

Keywords	covid19
Language	English
Publishing date	2020-04-25
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2020.04.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Facile and Sustainable Synthesis of Commendamide and its Analogues

Rosaria Villano / Francesco Tinto / Vincenzo Di Marzo

Frontiers in Chemistry, Vol

2022 Volume 10

Abstract: Commendamide, or N-(3-hydroxypalmitoyl)-glycine 1a, is a gut microbiota-derived bioactive metabolite, structurally similar to long-chain N-acyl-amino acids which belong to the complex lipid signaling system known as endocannabinoidome and play important ... ...

Abstract	Commendamide, or N-(3-hydroxypalmitoyl)-glycine 1a, is a gut microbiota-derived bioactive metabolite, structurally similar to long-chain N-acyl-amino acids which belong to the complex lipid signaling system known as endocannabinoidome and play important roles in mammals through activation of, inter alia, G-protein-coupled receptors (GPCRs). In this work, we describe a simple, green and economic method for the preparation of commendamide 1a, a GPCR G2A/132 agonist. The developed protocol is general and could also be applied to the synthesis of deuterated commendamide 1b, as well as to other minor microbiota-derived metabolites, such as the analog 2.
Keywords	commendamide ; microbiota ; endocannabinoidome ; green chemistry ; organic synthesis ; drug discovery ; Chemistry ; QD1-999
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (

Suriano, Francesco / Manca, Claudia / Flamand, Nicolas / Van Hul, Matthias / Delzenne, Nathalie M / Silvestri, Cristoforo / Cani, Patrice D / Di Marzo, Vincenzo

Cells

2023 Volume 12, Issue 3

Abstract: Obesity is associated with a cluster of metabolic disorders, chronic low-grade inflammation, altered gut microbiota, increased intestinal permeability, and alterations of the lipid mediators of the expanded endocannabinoid (eCB) signaling system, or ... ...

Abstract	Obesity is associated with a cluster of metabolic disorders, chronic low-grade inflammation, altered gut microbiota, increased intestinal permeability, and alterations of the lipid mediators of the expanded endocannabinoid (eCB) signaling system, or endocannabinoidome (eCBome). In the present study, we characterized the profile of the eCBome and related oxylipins in the small and large intestines of genetically obese (
MeSH term(s)	Mice ; Animals ; Oxylipins ; Gastrointestinal Microbiome ; Transcriptome/genetics ; Lipidomics ; Obesity/metabolism ; Diabetes Mellitus ; Inflammation/complications ; Mice, Inbred Strains ; Intestines
Chemical Substances	Oxylipins
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12030411
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Article: From Chaos to Opportunity: Decoding Cancer Heterogeneity for Enhanced Treatment Strategies.

Ottaiano, Alessandro / Ianniello, Monica / Santorsola, Mariachiara / Ruggiero, Raffaella / Sirica, Roberto / Sabbatino, Francesco / Perri, Francesco / Cascella, Marco / Di Marzo, Massimiliano / Berretta, Massimiliano / Caraglia, Michele / Nasti, Guglielmo / Savarese, Giovanni

Biology

2023 Volume 12, Issue 9

Abstract: Cancer manifests as a multifaceted disease, characterized by aberrant cellular proliferation, survival, migration, and invasion. Tumors exhibit variances across diverse dimensions, encompassing genetic, epigenetic, and transcriptional realms. This ... ...

Abstract	Cancer manifests as a multifaceted disease, characterized by aberrant cellular proliferation, survival, migration, and invasion. Tumors exhibit variances across diverse dimensions, encompassing genetic, epigenetic, and transcriptional realms. This heterogeneity poses significant challenges in prognosis and treatment, affording tumors advantages through an increased propensity to accumulate mutations linked to immune system evasion and drug resistance. In this review, we offer insights into tumor heterogeneity as a crucial characteristic of cancer, exploring the difficulties associated with measuring and quantifying such heterogeneity from clinical and biological perspectives. By emphasizing the critical nature of understanding tumor heterogeneity, this work contributes to raising awareness about the importance of developing effective cancer therapies that target this distinct and elusive trait of cancer.
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12091183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Regarding 'Understanding the "Scope" of the Problem: Why Laparoscopy is Considered Safe During the COVID-19 Pandemic.'

Di Marzo, Francesco / Cardi, Maurizio

J Minim Invasive Gynecol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #162805
Database	COVID19

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Article ; Online: Regarding “Understanding the ‘Scope’ of the Problem

Di Marzo, Francesco / Cardi, Maurizio

Journal of Minimally Invasive Gynecology

Why Laparoscopy Is Considered Safe during the COVID-19 Pandemic”

2020 Volume 27, Issue 6, Page(s) 1424

Keywords	Obstetrics and Gynaecology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2020.04.027
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 4205: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Prostate Imaging for Local Recurrence Reporting and Data System for Biparametric Magnetic Resonance Imaging: A Proposal.

Scialpi, Michele / Martorana, Eugenio / Trippa, Fabio / Di Marzo, Alessandro / Scalera, Giovanni Battista / Aisa, Maria Cristina / D'Andrea, Alfredo / Mancioli, Francesco Maria / Nicola, Refky / Scialpi, Pietro / Di Blasi, Aldo

Urology research & practice

2023 Volume 49, Issue 4, Page(s) 233–240

Abstract: We investigated a novel dedicated Prostate Imaging for Local Recurrence Reporting and Data System (PI-RRADS) in biochemical recurrence after radiotherapy (RT) and rad- ical prostatectomy (RP) evaluating biparametric magnetic resonance imaging (bpMRI) ... ...

Abstract	We investigated a novel dedicated Prostate Imaging for Local Recurrence Reporting and Data System (PI-RRADS) in biochemical recurrence after radiotherapy (RT) and rad- ical prostatectomy (RP) evaluating biparametric magnetic resonance imaging (bpMRI) exams, at 3T MRI of 55 patients. Associating bpMRI and biochemical recurrence data, we calculated bpMRI diagnostic accuracy. Four probability categories, from 1 (very low) to 4 (very high), were distinguished. In 20 patients with radiotherapy, 25% and 75% of lesions were reported as PI-RRADS 3, and 4, respectively. In 35 patients with radi- cal prostatectomy, 7.7% of lesions were included in PI-RRADS 1-2, whereas 40.4% and 51.9% in PI-RRADS 3 and 4 categories, respectively. Excellent agreement and significant correlation between bpMRI and biochemical recurrence were found. BpMRI showed sensitivity, specificity, positive predictive value, negative predictive value, false-posi- tive value, false-negative value, and total diagnostic accuracy of 96.15%, 86.7%, 97.4 %, 81.25%, 13.3%, 3.8% and 94.6%, respectively. BpMRI-based PI-RRADS allows the detection and localization local recurrence in biochemical recurrence after RT and RP contributing in clinical management and treatment.
Language	English
Publishing date	2023-10-25
Publishing country	Turkey
Document type	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22228
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: From Chaos to Opportunity

Alessandro Ottaiano / Monica Ianniello / Mariachiara Santorsola / Raffaella Ruggiero / Roberto Sirica / Francesco Sabbatino / Francesco Perri / Marco Cascella / Massimiliano Di Marzo / Massimiliano Berretta / Michele Caraglia / Guglielmo Nasti / Giovanni Savarese

Biology, Vol 12, Iss 1183, p

Decoding Cancer Heterogeneity for Enhanced Treatment Strategies

2023 Volume 1183

Abstract	Cancer manifests as a multifaceted disease, characterized by aberrant cellular proliferation, survival, migration, and invasion. Tumors exhibit variances across diverse dimensions, encompassing genetic, epigenetic, and transcriptional realms. This heterogeneity poses significant challenges in prognosis and treatment, affording tumors advantages through an increased propensity to accumulate mutations linked to immune system evasion and drug resistance. In this review, we offer insights into tumor heterogeneity as a crucial characteristic of cancer, exploring the difficulties associated with measuring and quantifying such heterogeneity from clinical and biological perspectives. By emphasizing the critical nature of understanding tumor heterogeneity, this work contributes to raising awareness about the importance of developing effective cancer therapies that target this distinct and elusive trait of cancer.
Keywords	cancer heterogeneity ; genetics ; epigenetics ; mutations ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese ( ob/ob ) and Diabetic ( db/db ) Mice

Francesco Suriano / Claudia Manca / Nicolas Flamand / Matthias Van Hul / Nathalie M. Delzenne / Cristoforo Silvestri / Patrice D. Cani / Vincenzo Di Marzo

Cells, Vol 12, Iss 411, p

Links with Inflammation and Gut Microbiota

2023 Volume 411

Abstract	Obesity is associated with a cluster of metabolic disorders, chronic low-grade inflammation, altered gut microbiota, increased intestinal permeability, and alterations of the lipid mediators of the expanded endocannabinoid (eCB) signaling system, or endocannabinoidome (eCBome). In the present study, we characterized the profile of the eCBome and related oxylipins in the small and large intestines of genetically obese ( ob/ob ) and diabetic ( db/db ) mice to decipher possible correlations between these mediators and intestinal inflammation and gut microbiota composition. Basal lipid and gene expression profiles, measured by LC/MS-MS-based targeted lipidomics and qPCR transcriptomics, respectively, highlighted a differentially altered intestinal eCBome and oxylipin tone, possibly linked to increased mRNA levels of inflammatory markers in db/db mice. In particular, the duodenal levels of several 2-monoacylglycerols and N -acylethanolamines were increased and decreased, respectively, in db/db mice, which displayed more pronounced intestinal inflammation. To a little extent, these differences were explained by changes in the expression of the corresponding metabolic enzymes. Correlation analyses suggested possible interactions between eCBome/oxylipin mediators, cytokines, and bacterial components and bacterial taxa closely related to intestinal inflammation. Collectively, this study reveals that db/db mice present a higher inflammatory state in the intestine as compared to ob/ob mice, and that this difference is associated with profound and potentially adaptive or maladaptive, and partly intestinal segment-specific alterations in eCBome and oxylipin signaling. This study opens the way to future investigations on the biological role of several poorly investigated eCBome mediators and oxylipins in the context of obesity and diabetes-induced gut dysbiosis and inflammation.
Keywords	lipidomics ; transcriptomics ; endocannabinoids ; enzymes ; intestine ; obesity ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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