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  1. Book ; Online: Advances in Craniofacial and Dental Materials Through Nanotechnology and Tissue Engineering

    Orsini, Giovanna / Putignano, Angelo / Mitsiadis, Thimios A.

    2019  

    Keywords Science: general issues ; Physiology ; signalling pathways ; Tooth ; enamel ; Palate ; Calvaria ; Craniofacial ; Stem Cells ; Tissue Regeneration
    Size 1 electronic resource (125 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230045
    ISBN 9782889458585 ; 288945858X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Emerging Trends and Promises in Orofacial Cancers.

    Mitsiadis, Thimios A

    Frontiers in physiology

    2019  Volume 10, Page(s) 679

    Language English
    Publishing date 2019-05-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2019.00679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kidney capsule transplantation of chemically treated embryonic murine tooth germs.

    Jimenez-Rojo, Lucia / Mitsiadis, Thimios A

    STAR protocols

    2023  Volume 4, Issue 3, Page(s) 102377

    Abstract: Subcapsular transplantation of developing tissues and organs into the richly vascularized murine kidney provides the necessary trophic support, thus ensuring proper completion of their growth. ...

    Abstract Subcapsular transplantation of developing tissues and organs into the richly vascularized murine kidney provides the necessary trophic support, thus ensuring proper completion of their growth.
    MeSH term(s) Animals ; Mice ; Tooth Germ ; Tooth/surgery ; Kidney/surgery ; Epithelium
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kidney capsule transplantation of chemically treated embryonic murine tooth germs

    Lucia Jimenez-Rojo / Thimios A. Mitsiadis

    STAR Protocols, Vol 4, Iss 3, Pp 102377- (2023)

    2023  

    Abstract: ... to Mitsiadis et al.4 : Publisher’s note: Undertaking any experimental protocol requires adherence to local ...

    Abstract Summary: Subcapsular transplantation of developing tissues and organs into the richly vascularized murine kidney provides the necessary trophic support, thus ensuring proper completion of their growth.1,2,3 Here, we provide a protocol for kidney capsule transplantation that allows the full differentiation of embryonic teeth previously exposed to chemicals. We describe steps for dissection and in vitro culture of embryonic teeth, followed by transplantation of tooth germs. We then detail harvesting of kidneys for further analysis.For complete details on the use and execution of this protocol, please refer to Mitsiadis et al.4 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Cell Culture ; Developmental Biology ; Model Organisms ; Cell Differentiation ; Science (General) ; Q1-390
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas.

    Porcheri, Cristina / Mitsiadis, Thimios A

    Cancers

    2021  Volume 13, Issue 21

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infection. Oral squamous cell carcinoma, as other head and neck cancers, presents a high degree of intratumor heterogeneity, which makes their treatment difficult, and directly correlates with drug resistance. Since the classical treatments for HNSCC oftentimes do not resolve the clinical picture, there is great need for novel therapeutic approaches, models for drug testing, and new drug delivery systems.
    Language English
    Publishing date 2021-11-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13215515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Versatile Roles of Nerve Growth Factor in Neuronal Attraction, Odontoblast Differentiation, and Mineral Deposition in Human Teeth.

    Mitsiadis, Thimios A / Pagella, Pierfrancesco

    Advances in experimental medicine and biology

    2021  Volume 1331, Page(s) 65–75

    Abstract: Nerve growth factor (NGF) is an important molecule for the development and differentiation of neuronal and non-neuronal cells. Here we analyze by immunohistochemistry the distribution of NGF in the dental pulp mesenchyme of embryonic and functional human ...

    Abstract Nerve growth factor (NGF) is an important molecule for the development and differentiation of neuronal and non-neuronal cells. Here we analyze by immunohistochemistry the distribution of NGF in the dental pulp mesenchyme of embryonic and functional human teeth. In the dental pulp of both embryonic and healthy functional teeth, NGF is mainly expressed in the odontoblasts that are responsible for dentine formation, while in functional teeth NGF is also expressed in nerve fibers innervating the dental pulp. In injured teeth, NGF is expressed in the newly formed odontoblastic-like cells, which replace the dying odontoblasts. In these teeth, NGF expression is also upregulated in the intact odontoblasts, suggesting a role for this molecule in dental tissue repair. Similarly, in cultures of human dental pulp cells, NGF expression is strongly upregulated during their differentiation into odontoblasts as well as during the mineralization process. In microfluidic devices, release of NGF from cultured human dental pulp cells induced neuronal growth from trigeminal ganglia toward the NGF secreting cells. These results show that NGF is closely linked to the various functions of odontoblasts, including secretory and neuronal attraction processes.
    MeSH term(s) Cell Differentiation ; Dental Pulp ; Humans ; Minerals ; Nerve Growth Factor/genetics ; Odontoblasts ; Tooth
    Chemical Substances Minerals ; Nerve Growth Factor (9061-61-4)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-74046-7_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model.

    Mitsiadis, Thimios A / Pagella, Pierfrancesco / Capellini, Terence D / Smith, Moya Meredith

    Cellular and molecular life sciences : CMLS

    2023  Volume 80, Issue 7, Page(s) 182

    Abstract: The Notch pathway is an ancient, evolutionary conserved intercellular signaling mechanism that is involved in cell fate specification and proper embryonic development. The Jagged2 gene, which encodes a ligand for the Notch family of receptors, is ... ...

    Abstract The Notch pathway is an ancient, evolutionary conserved intercellular signaling mechanism that is involved in cell fate specification and proper embryonic development. The Jagged2 gene, which encodes a ligand for the Notch family of receptors, is expressed from the earliest stages of odontogenesis in epithelial cells that will later generate the enamel-producing ameloblasts. Homozygous Jagged2 mutant mice exhibit abnormal tooth morphology and impaired enamel deposition. Enamel composition and structure in mammals are tightly linked to the enamel organ that represents an evolutionary unit formed by distinct dental epithelial cell types. The physical cooperativity between Notch ligands and receptors suggests that Jagged2 deletion could alter the expression profile of Notch receptors, thus modifying the whole Notch signaling cascade in cells within the enamel organ. Indeed, both Notch1 and Notch2 expression are severely disturbed in the enamel organ of Jagged2 mutant teeth. It appears that the deregulation of the Notch signaling cascade reverts the evolutionary path generating dental structures more reminiscent of the enameloid of fishes rather than of mammalian enamel. Loss of interactions between Notch and Jagged proteins may initiate the suppression of complementary dental epithelial cell fates acquired during evolution. We propose that the increased number of Notch homologues in metazoa enabled incipient sister cell types to form and maintain distinctive cell fates within organs and tissues along evolution.
    MeSH term(s) Pregnancy ; Female ; Mice ; Animals ; Cell Lineage/genetics ; Membrane Proteins/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Serrate-Jagged Proteins/metabolism ; Cell Differentiation/physiology ; Carrier Proteins ; Mammals/metabolism
    Chemical Substances Membrane Proteins ; Receptors, Notch ; Serrate-Jagged Proteins ; Carrier Proteins
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-04831-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Analysis of Tooth Innervation in Microfluidic Coculture Devices.

    Pagella, Pierfrancesco / Mitsiadis, Thimios A

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2155, Page(s) 99–106

    Abstract: Innervation plays a key role in the development, homeostasis, and regeneration of organs and tissues. However, the mechanisms underlying these phenomena are not well understood yet. In particular, the role of innervation in tooth development and ... ...

    Abstract Innervation plays a key role in the development, homeostasis, and regeneration of organs and tissues. However, the mechanisms underlying these phenomena are not well understood yet. In particular, the role of innervation in tooth development and regeneration is neglected. Cocultures constitute a valuable method to investigate and manipulate the interactions between nerve fibers and teeth in a controlled and isolated environment. Microfluidic systems for allow cocultures of neurons and different cell types in their appropriate culture media, while permitting the passage of axons from one compartment to the other. Here we describe how to isolate and coculture developing trigeminal ganglia and tooth germs in a microfluidic coculture system. This protocol describes a simple and flexible way to coculture ganglia/nerves and their target tissues and to study the roles of specific molecules on such interactions in a controlled and isolated environment.
    MeSH term(s) Animals ; Cell Culture Techniques ; Coculture Techniques ; Embryo, Mammalian ; Lab-On-A-Chip Devices ; Mice ; Microdissection ; Microfluidics/instrumentation ; Microfluidics/methods ; Tooth/innervation
    Language English
    Publishing date 2020-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0655-1_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Notch in Head and Neck Cancer.

    Porcheri, Cristina / Mitsiadis, Thimios A

    Advances in experimental medicine and biology

    2020  Volume 1287, Page(s) 81–103

    Abstract: Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is ... ...

    Abstract Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. The Notch signaling is involved in a variety of tumorigenic mechanisms, such as regulation of the tumor microenvironment, aberrant intercellular communication, and altered metabolism. Here, we provide an up-to-date review of the role of Notch in head and neck cancer and draw parallels with other types of solid tumors where the Notch pathway plays a crucial role in emergence, maintenance, and progression of the disease. We therefore give a perspective view on the importance of the pathway in neoplastic development in order to define future lines of research and novel therapeutic approaches.
    MeSH term(s) Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/therapy ; Humans ; Receptors, Notch ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-55031-8_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Isolation of dental pulp and periodontal cells from human teeth for single-cell RNA sequencing.

    Pagella, Pierfrancesco / Stadlinger, Bernd / Mitsiadis, Thimios A

    STAR protocols

    2021  Volume 2, Issue 4, Page(s) 100953

    Abstract: Teeth and the surrounding periodontal tissues are affected by many pathologies that compromise their integrity and significantly affect life quality. The study of the main dental tissues, the dental pulp and periodontium, is made arduous by their close ... ...

    Abstract Teeth and the surrounding periodontal tissues are affected by many pathologies that compromise their integrity and significantly affect life quality. The study of the main dental tissues, the dental pulp and periodontium, is made arduous by their close association with highly mineralized tissues (dentin, cementum, and alveolar bone). Here we describe a protocol to isolate all cells composing human dental pulp and periodontium for single-cell RNA sequencing analysis. For complete details on the use and execution of this protocol, please refer to Pagella et al. (2021).
    MeSH term(s) Cell Culture Techniques ; Cell Separation/methods ; Cells, Cultured ; Dental Pulp/cytology ; Humans ; Periodontium/cytology ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods ; Tooth/cytology
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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