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  1. Book: The delivery of regenerative medicines and their impact on healthcare

    Prescott, Catherine D. / Polak, Julia M.

    2011  

    Author's details ed. by Catherine Prescott ; Julia Polak
    Keywords Regenerative Medicine ; Health Care Sector
    Language English
    Size XVI, 400 S. : Ill., 24 cm
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016996486
    ISBN 978-1-4398-3606-4 ; 1-4398-3606-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 4149 order for loan Magazin

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  2. Article ; Online: Characteristics and Outcomes of Clinic Visits Immediately Preceding Sepsis Hospitalization.

    Miller, H Catherine / Liu, Vincent X / Prescott, Hallie C

    American journal of critical care : an official publication, American Association of Critical-Care Nurses

    2021  Volume 30, Issue 2, Page(s) 135–139

    Abstract: Background: Existing sepsis quality improvement initiatives focus on recognition and treatment of sepsis upon hospital admission. Yet many patients are evaluated in the clinic within 1 day of sepsis hospitalization.: Objectives: To determine the ... ...

    Abstract Background: Existing sepsis quality improvement initiatives focus on recognition and treatment of sepsis upon hospital admission. Yet many patients are evaluated in the clinic within 1 day of sepsis hospitalization.
    Objectives: To determine the circumstances of clinic visits that precede sepsis hospitalization, including illness severity, whether patients are referred to the hospital, and time lapse and change in illness severity between clinic and hospital evaluation.
    Methods: In a retrospective cohort study at a tertiary academic medical center, data from electronic medical records were collected for all adult patients evaluated in an outpatient clinic within 1 day of sepsis hospitalization in 2017.
    Results: Of 1450 patients hospitalized with sepsis, 118 had an established outpatient provider and a clinic visit within 1 day of admission and thus were included. During the clinic visit, 47 patients (39.8%) had a quick Sequential Organ Failure Assessment (qSOFA) score ≥1, and 59 (50.0%) had vital sign abnormalities. Most (74, 62.7%) were sent directly to the emergency department or hospital. Upon emergency department/hospital presentation, 62 patients (52.5%) had a worsening qSOFA score and/ or vital signs and 27 (22.9%) had worsening of multiple parameters. Median time lapse from clinic to emergency department/hospital evaluation was 3.2 hours.
    Conclusions: One in 10 patients hospitalized for sepsis had been evaluated in a clinic within 1 day of admission. At that clinic visit, most patients had an elevated qSOFA score or abnormal vital signs and a majority were sent directly to the emergency department/hospital. Half experienced clinical deterioration between the clinic visit and arrival in the emergency department/hospital.
    MeSH term(s) Adult ; Ambulatory Care ; Ambulatory Care Facilities ; Emergency Service, Hospital ; Hospital Mortality ; Hospitalization ; Humans ; Prognosis ; ROC Curve ; Retrospective Studies ; Sepsis/diagnosis ; Sepsis/epidemiology ; Sepsis/therapy ; Severity of Illness Index
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1130987-8
    ISSN 1937-710X ; 1062-3264
    ISSN (online) 1937-710X
    ISSN 1062-3264
    DOI 10.4037/ajcc2021456
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  3. Article ; Online: The business of exploiting induced pluripotent stem cells.

    Prescott, Catherine

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2011  Volume 366, Issue 1575, Page(s) 2323–2328

    Abstract: Induced pluripotent stem cells (iPS cells) can be exploited for both research and clinical applications. The first part of this review seeks to provide an understanding of the financial drivers and key elements of a successful business strategy that ... ...

    Abstract Induced pluripotent stem cells (iPS cells) can be exploited for both research and clinical applications. The first part of this review seeks to provide an understanding of the financial drivers and key elements of a successful business strategy that underpin a company focused on developing iPS-related products and services targeted at the research market. The latter part of the review highlights some of the reasons as to why the reprogramming of somatic cells is currently being used to develop cell-based models to screen for small molecules with drug-like properties rather than to develop cell-based regenerative medicines per se. The latter may be used to repair or replace a patient's damaged cells and thereby have the potential to 'cure' a disease and, in doing so, prevent or delay the onset of associated medical conditions. However, the cost of an expensive regenerative medicine and time to accrue any benefit linked to a decrease in co-morbidity expenditure may not outweigh the benefit for a healthcare community that has finite resources. The implications of this are discussed together with evidence that the UK National Institute for Health and Clinical Excellence (NICE) and the National Health Service (NHS) have established a precedent for a cost-sharing strategy with the pharmaceutical industry.
    MeSH term(s) Humans ; Marketing of Health Services/economics ; Marketing of Health Services/methods ; Pluripotent Stem Cells/physiology ; Regenerative Medicine ; Research/economics
    Language English
    Publishing date 2011-06-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2011.0047
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  4. Article ; Online: Regenerative nanomedicines: an emerging investment prospective?

    Prescott, Catherine

    Journal of the Royal Society, Interface

    2010  Volume 7 Suppl 6, Page(s) S783–7

    Abstract: Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, ... ...

    Abstract Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, target the delivery of cells and reduce immune rejection (via encapsulation), thereby supporting the development of regenerative medicines. The overall objective of any therapy is the delivery of the product not just into the clinic but also to patients on a routine basis. Such a goal typically requires a commercial vehicle and substantial levels of investment in scientific, clinical, regulatory and business expertise, resources, time and funding. Therefore, this paper focuses on some of the challenges facing this emerging industry, including investment by the venture capital community.
    MeSH term(s) Cell Culture Techniques ; Financial Support ; Forecasting ; Nanomedicine/economics ; Nanomedicine/trends ; Regenerative Medicine/economics ; Regenerative Medicine/trends ; Stem Cell Research/economics ; Stem Cells/cytology
    Language English
    Publishing date 2010-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2010.0351.focus
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease.

    Guito, Jonathan C / Arnold, Catherine E / Schuh, Amy J / Amman, Brian R / Sealy, Tara K / Spengler, Jessica R / Harmon, Jessica R / Coleman-McCray, Joann D / Sanchez-Lockhart, Mariano / Palacios, Gustavo F / Towner, Jonathan S / Prescott, Joseph B

    Frontiers in immunology

    2024  Volume 14, Page(s) 1306501

    Abstract: Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, ...

    Abstract Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB,
    MeSH term(s) Humans ; Animals ; Filoviridae/genetics ; Chiroptera ; Marburgvirus ; Immune Tolerance ; Immunity
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1306501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Stopping the revolving door: An exploratory analysis of health care super-utilization in gynecologic oncology.

    Zivanov, Catherine N / Apple, Annie / Brown, Alaina J / Robinson, Marc A / Prescott, Lauren S

    Gynecologic oncology reports

    2021  Volume 37, Page(s) 100789

    Abstract: The objective of this study was to determine the prevalence of and risk factors for health care super-utilization among gynecologic oncology patients at a single academic hospital. A retrospective cohort study of gynecologic oncology patients with an ... ...

    Abstract The objective of this study was to determine the prevalence of and risk factors for health care super-utilization among gynecologic oncology patients at a single academic hospital. A retrospective cohort study of gynecologic oncology patients with an index unplanned encounter between January and December 2018 was performed. Super-utilizers were defined as patients with 3 or more unplanned hospital encounters during a 12-month period starting at the time of the index unplanned encounter. We identified 553 patients with gynecologic cancer. Of those, 37(7%) met inclusion criteria for super-utilizers accounting for 193/310(62%) of unplanned visits. The median number of unplanned visits was 4 (range 3-24). The most common cancers were uterine (N = 15 (41%)) and ovarian (N = 11 (30%)). Nineteen (51%) super-utilizers had advanced stage disease. Phases of oncologic care at index unplanned encounter included primary diagnosis (N = 24 (65%)), recurrence (N = 10 (27%)), and surveillance (N = 2 (5%)). Twelve super-utilizers (32%) had new diagnoses of cancer without prior therapy, 19(51%) had prior chemotherapy, 17(46%) had prior surgery, and 10(27%) had prior radiation therapy at the time of initial encounter. Fifteen super-utilizers (41%) were in the last year of life. The most common reasons for unplanned encounters were pain (66%) and gastrointestinal symptoms (61%). Multivariable analysis adjusting for key variables demonstrated that Medicaid insurance, ASA classification, and disease status are risk factors for health care super-utilization. The majority of health care utilization occurred during the first year of diagnosis. This exploratory analysis suggests an opportunity to decrease health care utilization, particularly during upfront treatment.
    Language English
    Publishing date 2021-05-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2021.100789
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  7. Article ; Online: Rationalising neurosurgical head injury referrals: development and validation of the Liverpool Head Injury Tomography Score (Liverpool HITS) for mild TBI.

    Gillespie, Conor S / Mcleavy, Christopher M / Islim, Abdurrahman I / Prescott, Sarah / McMahon, Catherine J

    British journal of neurosurgery

    2020  Volume 34, Issue 2, Page(s) 127–134

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Brain Concussion/diagnosis ; Brain Concussion/etiology ; Brain Concussion/therapy ; Brain Injuries/etiology ; Craniocerebral Trauma/diagnostic imaging ; Craniocerebral Trauma/surgery ; Craniocerebral Trauma/therapy ; England ; Glasgow Coma Scale ; Humans ; Neurosurgery ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Risk Assessment/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2019.1710825
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  8. Article ; Online: A Letter to Your Care Providers: Implementation and Analysis of a Letter-based Advance Care Planning Initiative for Gynecologic Oncology Patients.

    Zivanov, Catherine N / Coogan, Anne / Lane, Robin R / Lin, Sara G / Reed, Sarah C / Robinson, Marc A / Karlekar, Mohana / Prescott, Lauren S / Brown, Alaina J

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2022  Volume 38, Issue 3, Page(s) 963–970

    Abstract: To determine the impact of a letter-based advance care planning (ACP) healthcare improvement (HI) initiative on rates of ACP conversations and documentation among gynecologic oncology (GO) inpatients. An HI initiative was implemented from January to ... ...

    Abstract To determine the impact of a letter-based advance care planning (ACP) healthcare improvement (HI) initiative on rates of ACP conversations and documentation among gynecologic oncology (GO) inpatients. An HI initiative was implemented from January to December 2020 to improve ACP documentation among GO inpatients. Patients admitted to the GO service were given ACP packets with a letter-based ACP worksheet. GO inpatients who were interested in learning more about ACP were visited by medical students trained to lead ACP conversations. ACP documentation rates in the EMR (electronic medical record) pre- and post-intervention were evaluated. Descriptive statistics were calculated. Associations between sociodemographic characteristics and ACP documentation were analyzed using logistic regression. There were 172 patients admitted in 2019 (pre-implementation cohort). Of these, 45/172 patients (26%) had an advance directive (AD) documented in their electronic medical record (EMR). Following the implementation of the ACP HI in 2020, 55/168 patients (33%) had an AD documented in their EMR. This was a 7% absolute increase and 27% relative increase from pre-intervention AD documentation rates. Increasing age was associated with an increased likelihood of having an AD in the chart (p = 0.004). Married women were less likely to have an AD in their chart (p = 0.05). An HI utilizing a letter-based ACP packet given to GO inpatients improved AD documentation in the EMR. This HI offers a unique method for introducing ACP to patients. More work is needed to improve the occurrence and documentation of ACP conversations.
    MeSH term(s) Humans ; Female ; Genital Neoplasms, Female/therapy ; Advance Care Planning ; Advance Directives ; Patients ; Communication ; Documentation/methods
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-022-02214-3
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  9. Article ; Online: Learning from pragmatic local research.

    Prescott, Katherine / Winzor, Gemma / Jumaa, Pauline

    Infection prevention in practice

    2021  Volume 3, Issue 3, Page(s) 100171

    Language English
    Publishing date 2021-08-21
    Publishing country England
    Document type Editorial
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2021.100171
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  10. Article ; Online: Enhancing Pharmacy Faculty Well-Being and Productivity While Reducing Burnout.

    Kennedy, Daniel R / Clapp, Peter / DeLuca, Judith L / Filtz, Theresa M / Kroon, Lisa / Lamberts, Jennifer T / Oliphant, Catherine M / Prescott, William Allan / Ray, Sidhartha D

    American journal of pharmaceutical education

    2021  Volume 86, Issue 5, Page(s) 8764

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Burnout, Professional/prevention & control ; Education, Pharmacy ; Faculty ; Faculty, Pharmacy ; Humans ; Mentoring
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.5688/ajpe8764
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