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Article ; Online: Device's design and clinical perspectives for resistant hypertension therapy.

Jami, Oussama / Oussama, El Allam / Mohammed, Zaki / Soulaymane, Imai / Ilhaam, Ben Sahi / Tijani, Youssef / Aziz, Ettahir

International journal of cardiology. Cardiovascular risk and prevention

2024 Volume 20, Page(s) 200240

Abstract: Introduction: Hypertension is the leading cause of death in the cardiovascular system. Indeed, untreated hypertension can affect one's general health, but medicine can help hypertensive people reduce their chance of developing high blood pressure. ... ...

Abstract	Introduction: Hypertension is the leading cause of death in the cardiovascular system. Indeed, untreated hypertension can affect one's general health, but medicine can help hypertensive people reduce their chance of developing high blood pressure. However, secondary hypertension remains an unresolved illness. Areas covered: This review will go through the typical and unusual device-based therapies for resistant hypertension that have arisen in recent years. Further to that, the innovations developed in device-based RH treatment will be covered, as well as the research and studies assessing these novel technologies. Expert opinion: The innovative device-based techniques that target resistant hypertension provide a potential therapy that has been backed by a number of studies and clinical trials, whereas pharmacological non-adherence and increased sympathetic activity are recognized to be the primary causes of resistant hypertension. Nevertheless, some limitations will be critical for the future of these RH systems, with the device's design and larger RCTs playing a significant role in determining whether a position in routine treatment could be warranted.
Language	English
Publishing date	2024-01-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2772-4875
ISSN (online)	2772-4875
DOI	10.1016/j.ijcrp.2024.200240
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Article ; Online: Improving the physicomechanical performance of geopolymer mortars using human hair as fibers: new horizons for sustainable applications.

Aziz, Ayoub / Driouich, Anas / Ali, Mohammed Ben / Felaous, Khadija / Bellil, Abdelilah / Jindal, Bharat Bhushan

Environmental science and pollution research international

2023 Volume 30, Issue 26, Page(s) 68129–68142

Abstract: Blast furnace slag-based geopolymer mortars strengthened with human hair fibers were synthesized in the present study. The mixture of NaOH and ... ...

Abstract	Blast furnace slag-based geopolymer mortars strengthened with human hair fibers were synthesized in the present study. The mixture of NaOH and Na
MeSH term(s)	Humans ; Calcium Carbonate ; Commerce ; Compressive Strength ; Hair ; Microscopy, Electron, Scanning
Chemical Substances	Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2023-04-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-27257-x
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Article: Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery.

Khalife, Maher / Ben Aziz, Mohammed / Balestra, Costantino / Valsamis, Joseph / Sosnowski, Maurice

Frontiers in physiology

2021 Volume 12, Page(s) 744074

Abstract: The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to ... ...

Abstract	The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. Consequently, we here study the effect of one model of relative hypoxia on EPO, reticulocytes and hemoglobin stimulation in patients after surgery. Patients were prospectively randomized in two groups. The O
Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.744074
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Article ; Online: Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study.

Habous, Mohamad / Giona, Simone / Tealab, Alaa / Aziz, Mohammed / Williamson, Ben / Nassar, Mohammed / Abdelrahman, Zeyad / Remeah, Abdallah / Abdelkader, Mohamed / Binsaleh, Saleh / Muir, Gordon

BJU international

2018 Volume 122, Issue 5, Page(s) 889–897

Abstract: Objectives: To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies.: Patients and methods: ... ...

Abstract	Objectives: To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies. Patients and methods: A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n = 95); 5000 IU hCG injections twice weekly (n = 94); or a combination of both therapies (CC + hCG; n = 94). All participants had complete medical history and had undergone thorough physical examination, including body mass index (BMI) assessment. Laboratory tests included serum total testosterone and glycated haemoglobin (HbA1c) measurements. Quantitative Androgen Deficiency in the Aging Male (qADAM) questionnaire scores were also recorded. Morning samples of total serum testosterone levels were assessed at three time points: baseline, 1 and 3 months. Results: Testosterone levels increased at 1 and 3 months in all three groups. The mean baseline testosterone level was 2.31 ± 0.66 nmol/L, BMI was 30.8 ± 6.2 kg/m Conclusions: All three treatments were equally effective in restoring testosterone levels. Single-agent CC is simple, cheap and may be used as treatment for hypogonadism when maintenance of fertility is desired. This approach seems to be as effective as either hCG alone or a combination of hCG and CC.
MeSH term(s)	Administration, Oral ; Adult ; Chorionic Gonadotropin/administration & dosage ; Chorionic Gonadotropin/therapeutic use ; Clomiphene/administration & dosage ; Clomiphene/therapeutic use ; Estrogen Antagonists/administration & dosage ; Estrogen Antagonists/therapeutic use ; Humans ; Hypogonadism/blood ; Hypogonadism/drug therapy ; Infertility, Male/prevention & control ; Injections, Subcutaneous ; Male ; Middle Aged ; Testosterone/blood ; Testosterone/deficiency
Chemical Substances	Chorionic Gonadotropin ; Estrogen Antagonists ; Clomiphene (1HRS458QU2) ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2018-06-14
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.14401
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Article ; Online: Genome-Wide B Cell, CD4

Prakash, Swayam / Srivastava, Ruchi / Coulon, Pierre-Gregoire / Dhanushkodi, Nisha R / Chentoufi, Aziz A / Tifrea, Delia F / Edwards, Robert A / Figueroa, Cesar J / Schubl, Sebastian D / Hsieh, Lanny / Buchmeier, Michael J / Bouziane, Mohammed / Nesburn, Anthony B / Kuppermann, Baruch D / BenMohamed, Lbachir

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 206, Issue 11, Page(s) 2566–2582

Abstract: Over the last two decades, there have been three deadly human outbreaks of coronaviruses (CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats and ... ...

Abstract	Over the last two decades, there have been three deadly human outbreaks of coronaviruses (CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats and transmitted to humans via various intermediate animal reservoirs. It remains highly possible that other global COVID pandemics will emerge in the coming years caused by yet another spillover of a bat-derived SARS-like coronavirus (SL-CoV) into humans. Determining the Ag and the human B cells, CD4
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Female ; Genome, Viral/immunology ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/immunology ; SARS Virus/genetics ; SARS Virus/immunology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Chemical Substances	Epitopes, T-Lymphocyte ; Viral Vaccines
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2001438
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Article: Genome-Wide Asymptomatic B-Cell, CD4

bioRxiv : the preprint server for biology

2020

Abstract: Over the last two decades, there have been three deadly human outbreaks of Coronaviruses (CoVs) caused by emerging zoonotic CoVs: SARS-CoV, MERS-CoV, and the latest highly transmissible and deadly SARS-CoV-2, which has caused the current COVID-19 global ... ...

Abstract	Over the last two decades, there have been three deadly human outbreaks of Coronaviruses (CoVs) caused by emerging zoonotic CoVs: SARS-CoV, MERS-CoV, and the latest highly transmissible and deadly SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats, the natural hosts, and transmitted to humans
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.09.27.316018
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Article ; Online: Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive.

Hakkou, Zineb / Maciuk, Alexandre / Leblais, Veronique / Bouanani, Nour Elhouda / Mekhfi, Hassane / Bnouham, Mohammed / Aziz, Mohammed / Ziyyat, Abderrahime / Rauf, Abdur / Hadda, Taibi Ben / Shaheen, Usama / Patel, Seema / Fischmeister, Rodolphe / Legssyer, Abdelkhaleq

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Volume 93, Page(s) 62–69

Abstract: Background: Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive ...

Abstract	Background: Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP) was measured using a non-invasive indirect tail-cuff plethysmographic method. Four groups of rats were used: a control group; a hypertensive group treated with L-NAME (32mg/kg/day); a positive control group treated with L-NAME plus enalapril (15mg/kg/day) as a reference antihypertensive agent; and a group treated with L-NAME plus MeOH-extract (40mg/kg/day). Methods: Treatment with L-NAME alone caused a progressive increase in SBP. After 4 weeks, the value of SBP reached 160±2mmHg which shows the installation of hypertension. Enalapril prevented the increase in SBP, which remained normal at 123±1mmHg after 4 weeks of treatment. The administration of MeOH-extract along with L-NAME prevented the increase in SBP as well, which remained constant at 115±1mmHg after 4 weeks of treatment. In ex-vivo models, MeOH-extract produced a relaxation of pre-contracted ring aorta (54 ± 2% of relaxation at 3g/L). But, when the rings were denuded, MeOH-extract failed to relax pre-contracted rings of aorta. Phytochemical study of I. viscosa MeOH-extract revealed the presence of phenolic compounds, such as cynarin and chlorogenic acid. Results: The present results suggest that I. viscosa MeOH-extract has an antihypertensive, predominantly mediated by an endothelium-dependent vasodilatory effect. Cynarin and chlorogenic acid, which have a strong vasorelaxant effect may be involved in the antihypertensive effect of the plant extract. The bioinformatic POM analysis confirms the therapeutic potential of cynarin and chlorogenic acids as inhibitors of various biotargets. Based on the results, the coordination of these phytochemicals with calcium and transition metals should be studied, for better scope at antihypertensive drug development.
Language	English
Publishing date	2017-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2017.06.015
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Article ; Online: Influence of Lumbar Plexus Block for Proximal Modular Megaprostheses in Metastatic Bone Disease of the Femur

Mohammed Ben Aziz / Maher Khalife / Sonia Hontoir / Maurice Sosnowski / Michael Gebhart / Fouad Aoun

Open Access Journal of Science and Technology, Vol 3, Pp 1-

2015 Volume 6

Abstract: Background Modular megaprosthesis for proximal femur reconstruction after wide resection of metastatic lesion is a long-lasting painful procedure associated with prolonged hospital stay and significant blood loss. We evaluated the influence of lumbar ... ...

Abstract	Background Modular megaprosthesis for proximal femur reconstruction after wide resection of metastatic lesion is a long-lasting painful procedure associated with prolonged hospital stay and significant blood loss. We evaluated the influence of lumbar plexus block on intraoperative and postoperative complications as well as length of hospital stay. Materials and Methods A retrospective study comparing two groups of patients for intraoperative and postoperative complications undergoing modular megaprosthesis for metastatic bone disease of the femur according to the type of anesthesia received. Group 1 included 20 patients undergoing the procedure under general anesthesia and group 2 had 19 patients undergoing the same procedure by the same surgeon under general anesthesia combined to lumbar plexus block. Results The two groups were comparable in terms of demographic characteristics and the primary location of the tumor except for smoking and lung cancer which were more frequent in group 1. Intraoperative variables were not statistically different between the two groups except for intraoperative blood loss (P = 0.046) and transfusion (P = 0.007). Respiratory complications were more frequent in the group 1 compared to group 2 (32% vs. 0%, P = 0.006) while there were no statistically significant difference for local complications, postoperative Hb and LOS. On multivariate analysis, NSAIDs consumption and general anesthesia were found to be and independent predictive factors for intraoperative blood loss. Age and ASA score were independent predictive factors for prolonged LOS. Smoking and lung cancer were predictive factors for respiratory complications. General anesthesia alone was not found to be a predictive risk factor for respiratory complications (P = 0.245) and prolonged LOS (P = 0.052). Conclusion Lumbar plexus block is an effective complement to general anaesthesia and intraoperative analgesic management of modular megaprosthesis for proximal femoral malignant lesions, reducing blood loss and transfusion during the surgical procedure. Prospective randomized trials are needed to confirm these findings.
Keywords	lumbar plexus block ; anesthesia ; prostheses ; metastatic ; femur ; Technology ; T ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	AgiAl Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines

Prakash, Swayam / Ruchi, Srivastava / Coulon, Pierre-Gregoire / Dhanushkodi, Nisha R / Chentoufi, Aziz A / Tifrea, Delia F / Edwards, Robert A / Figueroa, Cesar J / Schubl, Sebastian D / Hsieh, Lanny, / Buchmeier, Michael J / Bouziane, Mohammed / Nesburn, Anthony B / Kuppermann, Baruch D / BenMohamed, Lbachir

bioRxiv

Abstract	Over the last two decades, there have been three deadly human outbreaks of Coronaviruses (CoVs) caused by emerging zoonotic CoVs: SARS-CoV, MERS-CoV, and the latest highly transmissible and deadly SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats, the natural hosts, and transmitted to humans via various intermediate animal reservoirs. Because there is currently no universal pan-Coronavirus vaccine available, two worst-case scenarios remain highly possible: (1) SARS-CoV-2 mutates and transforms into a seasonal flu-like global pandemic; and/or (2) Other global COVID-like pandemics will emerge in the coming years, caused by yet another spillover of an unknown zoonotic bat-derived SARS-like Coronavirus (SL-CoV) into an unvaccinated human population. Determining the antigen and epitope landscapes that are conserved among human and animal Coronaviruses as well as the repertoire, phenotype and function of B cells and CD4+ and CD8+ T cells that correlate with resistance seen in asymptomatic COVID-19 patients should inform in the development of pan-Coronavirus vaccines. In the present study, using several immuno-informatics and sequence alignment approaches, we identified several human B-cell, CD4+ and CD8+ T cell epitopes that are highly conserved in: (i) greater than 81,000 SARS-CoV-2 human strains identified to date in 190 countries on six continents; (ii) six circulating CoVs that caused previous human outbreaks of the Common Cold; (iii) five SL-CoVs isolated from bats; (iv) five SL-CoV isolated from pangolins; (v) three SL-CoVs isolated from Civet Cats; and (vi) four MERS strains isolated from camels. Furthermore, we identified cross-reactive asymptomatic epitopes that: (i) recalled B cell, CD4+ and CD8+ T cell responses from both asymptomatic COVID-19 patients and healthy individuals who were never exposed to SARS-CoV-2; and (ii) induced strong B cell and T cell responses in humanized Human Leukocyte Antigen (HLA)-DR/HLA-A*02:01 double transgenic mice. The findings herein pave the way to develop a pre-emptive multi-epitope pan-Coronavirus vaccine to protect against past, current, and potential future outbreaks.
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2020.09.27.316018
Database	COVID19

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Article ; Online: The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Tegally, Houriiyah / San, James E / Cotten, Matthew / Moir, Monika / Tegomoh, Bryan / Mboowa, Gerald / Martin, Darren P / Baxter, Cheryl / Lambisia, Arnold W / Diallo, Amadou / Amoako, Daniel G / Diagne, Moussa M / Sisay, Abay / Zekri, Abdel-Rahman N / Gueye, Abdou Salam / Sangare, Abdoul K / Ouedraogo, Abdoul-Salam / Sow, Abdourahmane / Musa, Abdualmoniem O /

Sesay, Abdul K / Abias, Abe G / Elzagheid, Adam I / Lagare, Adamou / Kemi, Adedotun-Sulaiman / Abar, Aden Elmi / Johnson, Adeniji A / Fowotade, Adeola / Oluwapelumi, Adeyemi O / Amuri, Adrienne A / Juru, Agnes / Kandeil, Ahmed / Mostafa, Ahmed / Rebai, Ahmed / Sayed, Ahmed / Kazeem, Akano / Balde, Aladje / Christoffels, Alan / Trotter, Alexander J / Campbell, Allan / Keita, Alpha K / Kone, Amadou / Bouzid, Amal / Souissi, Amal / Agweyu, Ambrose / Naguib, Amel / Gutierrez, Ana V / Nkeshimana, Anatole / Page, Andrew J / Yadouleton, Anges / Vinze, Anika / Happi, Anise N / Chouikha, Anissa / Iranzadeh, Arash / Maharaj, Arisha / Batchi-Bouyou, Armel L / Ismail, Arshad / Sylverken, Augustina A / Goba, Augustine / Femi, Ayoade / Sijuwola, Ayotunde E / Marycelin, Baba / Salako, Babatunde L / Oderinde, Bamidele S / Bolajoko, Bankole / Diarra, Bassirou / Herring, Belinda L / Tsofa, Benjamin / Lekana-Douki, Bernard / Mvula, Bernard / Njanpop-Lafourcade, Berthe-Marie / Marondera, Blessing T / Khaireh, Bouh Abdi / Kouriba, Bourema / Adu, Bright / Pool, Brigitte / McInnis, Bronwyn / Brook, Cara / Williamson, Carolyn / Nduwimana, Cassien / Anscombe, Catherine / Pratt, Catherine B / Scheepers, Cathrine / Akoua-Koffi, Chantal G / Agoti, Charles N / Mapanguy, Chastel M / Loucoubar, Cheikh / Onwuamah, Chika K / Ihekweazu, Chikwe / Malaka, Christian N / Peyrefitte, Christophe / Grace, Chukwa / Omoruyi, Chukwuma E / Rafaï, Clotaire D / Morang'a, Collins M / Erameh, Cyril / Lule, Daniel B / Bridges, Daniel J / Mukadi-Bamuleka, Daniel / Park, Danny / Rasmussen, David A / Baker, David / Nokes, David J / Ssemwanga, Deogratius / Tshiabuila, Derek / Amuzu, Dominic S Y / Goedhals, Dominique / Grant, Donald S / Omuoyo, Donwilliams O / Maruapula, Dorcas / Wanjohi, Dorcas W / Foster-Nyarko, Ebenezer / Lusamaki, Eddy K / Simulundu, Edgar / Ong'era, Edidah M / Ngabana, Edith N / Abworo, Edward O / Otieno, Edward / Shumba, Edwin / Barasa, Edwine / Ahmed, El Bara / Ahmed, Elhadi A / Lokilo, Emmanuel / Mukantwari, Enatha / Philomena, Eromon / Belarbi, Essia / Simon-Loriere, Etienne / Anoh, Etilé A / Manuel, Eusebio / Leendertz, Fabian / Taweh, Fahn M / Wasfi, Fares / Abdelmoula, Fatma / Takawira, Faustinos T / Derrar, Fawzi / Ajogbasile, Fehintola V / Treurnicht, Florette / Onikepe, Folarin / Ntoumi, Francine / Muyembe, Francisca M / Ragomzingba, Frank E Z / Dratibi, Fred A / Iyanu, Fred-Akintunwa / Mbunsu, Gabriel K / Thilliez, Gaetan / Kay, Gemma L / Akpede, George O / van Zyl, Gert U / Awandare, Gordon A / Kpeli, Grace S / Schubert, Grit / Maphalala, Gugu P / Ranaivoson, Hafaliana C / Omunakwe, Hannah E / Onywera, Harris / Abe, Haruka / Karray, Hela / Nansumba, Hellen / Triki, Henda / Kadjo, Herve Albéric Adje / Elgahzaly, Hesham / Gumbo, Hlanai / Mathieu, Hota / Kavunga-Membo, Hugo / Smeti, Ibtihel / Olawoye, Idowu B / Adetifa, Ifedayo M O / Odia, Ikponmwosa / Ben Boubaker, Ilhem Boutiba / Muhammad, Iluoreh Ahmed / Ssewanyana, Isaac / Wurie, Isatta / Konstantinus, Iyaloo S / Halatoko, Jacqueline Wemboo Afiwa / Ayei, James / Sonoo, Janaki / Makangara, Jean-Claude C / Tamfum, Jean-Jacques M / Heraud, Jean-Michel / Shaffer, Jeffrey G / Giandhari, Jennifer / Musyoki, Jennifer / Nkurunziza, Jerome / Uwanibe, Jessica N / Bhiman, Jinal N / Yasuda, Jiro / Morais, Joana / Kiconco, Jocelyn / Sandi, John D / Huddleston, John / Odoom, John K / Morobe, John M / Gyapong, John O / Kayiwa, John T / Okolie, Johnson C / Xavier, Joicymara S / Gyamfi, Jones / Wamala, Joseph F / Bonney, Joseph H K / Nyandwi, Joseph / Everatt, Josie / Nakaseegu, Joweria / Ngoi, Joyce M / Namulondo, Joyce / Oguzie, Judith U / Andeko, Julia C / Lutwama, Julius J / Mogga, Juma J H / O'Grady, Justin / Siddle, Katherine J / Victoir, Kathleen / Adeyemi, Kayode T / Tumedi, Kefentse A / Carvalho, Kevin S / Mohammed, Khadija Said / Dellagi, Koussay / Musonda, Kunda G / Duedu, Kwabena O / Fki-Berrajah, Lamia / Singh, Lavanya / Kepler, Lenora M / Biscornet, Leon / de Oliveira Martins, Leonardo / Chabuka, Lucious / Olubayo, Luicer / Ojok, Lul Deng / Deng, Lul Lojok / Ochola-Oyier, Lynette I / Tyers, Lynn / Mine, Madisa / Ramuth, Magalutcheemee / Mastouri, Maha / ElHefnawi, Mahmoud / Mbanne, Maimouna / Matsheka, Maitshwarelo I / Kebabonye, Malebogo / Diop, Mamadou / Momoh, Mambu / Lima Mendonça, Maria da Luz / Venter, Marietjie / Paye, Marietou F / Faye, Martin / Nyaga, Martin M / Mareka, Mathabo / Damaris, Matoke-Muhia / Mburu, Maureen W / Mpina, Maximillian G / Owusu, Michael / Wiley, Michael R / Tatfeng, Mirabeau Y / Ayekaba, Mitoha Ondo'o / Abouelhoda, Mohamed / Beloufa, Mohamed Amine / Seadawy, Mohamed G / Khalifa, Mohamed K / Matobo, Mooko Marethabile / Kane, Mouhamed / Salou, Mounerou / Mbulawa, Mphaphi B / Mwenda, Mulenga / Allam, Mushal / Phan, My V T / Abid, Nabil / Rujeni, Nadine / Abuzaid, Nadir / Ismael, Nalia / Elguindy, Nancy / Top, Ndeye Marieme / Dia, Ndongo / Mabunda, Nédio / Hsiao, Nei-Yuan / Silochi, Nelson Boricó / Francisco, Ngiambudulu M / Saasa, Ngonda / Bbosa, Nicholas / Murunga, Nickson / Gumede, Nicksy / Wolter, Nicole / Sitharam, Nikita / Ndodo, Nnaemeka / Ajayi, Nnennaya A / Tordo, Noël / Mbhele, Nokuzola / Razanajatovo, Norosoa H / Iguosadolo, Nosamiefan / Mba, Nwando / Kingsley, Ojide C / Sylvanus, Okogbenin / Femi, Oladiji / Adewumi, Olubusuyi M / Testimony, Olumade / Ogunsanya, Olusola A / Fakayode, Oluwatosin / Ogah, Onwe E / Oludayo, Ope-Ewe / Faye, Ousmane / Smith-Lawrence, Pamela / Ondoa, Pascale / Combe, Patrice / Nabisubi, Patricia / Semanda, Patrick / Oluniyi, Paul E / Arnaldo, Paulo / Quashie, Peter Kojo / Okokhere, Peter O / Bejon, Philip / Dussart, Philippe / Bester, Phillip A / Mbala, Placide K / Kaleebu, Pontiano / Abechi, Priscilla / El-Shesheny, Rabeh / Joseph, Rageema / Aziz, Ramy Karam / Essomba, René G / Ayivor-Djanie, Reuben / Njouom, Richard / Phillips, Richard O / Gorman, Richmond / Kingsley, Robert A / Neto Rodrigues, Rosa Maria D E S A / Audu, Rosemary A / Carr, Rosina A A / Gargouri, Saba / Masmoudi, Saber / Bootsma, Sacha / Sankhe, Safietou / Mohamed, Sahra Isse / Femi, Saibu / Mhalla, Salma / Hosch, Salome / Kassim, Samar Kamal / Metha, Samar / Trabelsi, Sameh / Agwa, Sara Hassan / Mwangi, Sarah Wambui / Doumbia, Seydou / Makiala-Mandanda, Sheila / Aryeetey, Sherihane / Ahmed, Shymaa S / Ahmed, Side Mohamed / Elhamoumi, Siham / Moyo, Sikhulile / Lutucuta, Silvia / Gaseitsiwe, Simani / Jalloh, Simbirie / Andriamandimby, Soa Fy / Oguntope, Sobajo / Grayo, Solène / Lekana-Douki, Sonia / Prosolek, Sophie / Ouangraoua, Soumeya / van Wyk, Stephanie / Schaffner, Stephen F / Kanyerezi, Stephen / Ahuka-Mundeke, Steve / Rudder, Steven / Pillay, Sureshnee / Nabadda, Susan / Behillil, Sylvie / Budiaki, Sylvie L / van der Werf, Sylvie / Mashe, Tapfumanei / Mohale, Thabo / Le-Viet, Thanh / Velavan, Thirumalaisamy P / Schindler, Tobias / Maponga, Tongai G / Bedford, Trevor / Anyaneji, Ugochukwu J / Chinedu, Ugwu / Ramphal, Upasana / George, Uwem E / Enouf, Vincent / Nene, Vishvanath / Gorova, Vivianne / Roshdy, Wael H / Karim, Wasim Abdul / Ampofo, William K / Preiser, Wolfgang / Choga, Wonderful T / Ahmed, Yahaya Ali / Ramphal, Yajna / Bediako, Yaw / Naidoo, Yeshnee / Butera, Yvan / de Laurent, Zaydah R / Ouma, Ahmed E O / von Gottberg, Anne / Githinji, George / Moeti, Matshidiso / Tomori, Oyewale / Sabeti, Pardis C / Sall, Amadou A / Oyola, Samuel O / Tebeje, Yenew K / Tessema, Sofonias K / de Oliveira, Tulio / Happi, Christian / Lessells, Richard / Nkengasong, John / Wilkinson, Eduan

Science (New York, N.Y.)

2022 Volume 378, Issue 6615, Page(s) eabq5358

Abstract: Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number ... ...

Abstract	Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century.
MeSH term(s)	Africa/epidemiology ; COVID-19/epidemiology ; COVID-19/virology ; Epidemiological Monitoring ; Genomics ; Humans ; Pandemics ; SARS-CoV-2/genetics
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abq5358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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