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  1. Book ; Thesis: ShRNA-based viability screening to identify potential oncogenes on human chromosome 21 in Down syndrome acute megakaryoblastic leukemia

    Thangapandi, Veera Raghavan / Hampe, Jochen / Hauer, Julia Christina

    A functional genomic approach

    2022  

    Institution Medizinische Klinik und Poliklinik I
    Author's details von Veera Raghavan Thangapandi geboren 1986 in Virudhunagar/Indien ; Medizinische Klinik und Poliklinik I [Dresden]
    Language English
    Size XIV, 90 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021700106
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 E 149 order for loan Magazin

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  2. Book ; Thesis: Die Expression von "Junction Adhesion Molecules" zur Abschätzung der Prognose von Patienten mit Akuter Myeloischer Leukämie

    Moll, Katharina / Bonin, Malte von / Hauer, Julia Christina

    2021  

    Institution Medizinische Klinik und Poliklinik I
    Author's details von Katharina Moll aus Tübingen ; Medizinische Klinik und Poliklinik I [Dresden]
    Language German
    Size 100 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021729505
    Database Catalogue ZB MED Medicine, Health

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    2023 E 329 order for loan Magazin

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  3. Book ; Thesis: Die Rho-assoziierte coiled-coil Kinase als potenzielles therapeutisches Ziel zur Behandlung der akuten myeloischen Leukämie

    Frimmel, Julia / Bornhäuser, Martin / Hauer, Julia Christina

    2020  

    Institution Medizinische Klinik und Poliklinik I
    Author's details von Julia Frimmel aus Ibbenbüren ; Medizinische Klinik und Poliklinik I [Dresden]
    Language German
    Size VIII, 80 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT030708697
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2024 E 561 Magazin

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  4. Book ; Online: Übersicht über vorhandene Tiermodelle, die für die Leukämieforschung angewandt werden könnten

    Borkhardt, Arndt / Sanchez-Garcia, I. / Cobaleda, C. / Hauer, Julia Christina

    Vorhaben 3612S70029

    (Ressortforschungsberichte zur kerntechnischen Sicherheit und zum Strahlenschutz ; 102/15)

    2015  

    Author's details A. Borkhardt, I. Sanchez-Garcia, C. Cobaleda, J. Hauer
    Series title Ressortforschungsberichte zur kerntechnischen Sicherheit und zum Strahlenschutz ; 102/15
    Collection
    Language German
    Size 1 Online-Ressource (83 Seiten)
    Publisher Bundesamt für Strahlenschutz
    Publishing place Salzgitter
    Publishing country Germany
    Document type Book ; Online
    Note Enthält eine Zusammenfassung in englischer Sprache
    HBZ-ID HT019029228
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online ; Thesis: Inhibition des IL-6 Trans Signaling durch Nanobody-Fusionsproteine

    Dambietz, Christine Anna [Verfasser] / Scheller, Jürgen [Gutachter] / Hauer, Julia [Gutachter]

    2023  

    Author's details Christine Anna Dambietz ; Gutachter: Jürgen Scheller, Julia Hauer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Conference proceedings: Kinderschutz in der Geburtshilfe, Neonatologie und Pädiatrie – ein Präventionskonzept

    Brickmann, Christian / Chmiel, Ruth / Meyer, Christine / Rehbinder, Julia / Hauer, Julia / Scholz, Christoph / Krüger, Marcus

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769410
    Database Thieme publisher's database

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    Um I Zs.80: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: YB-1-based oncolytic virotherapy in combination with CD47 blockade enhances phagocytosis of pediatric sarcoma cells.

    von Ofen, Anna Josefine / Thiel, Uwe / Eck, Jennifer / Gassmann, Hendrik / Thiede, Melanie / Hauer, Julia / Holm, Per Sonne / Schober, Sebastian J

    Frontiers in oncology

    2024  Volume 14, Page(s) 1304374

    Abstract: Oncolytic viruses (OVs) selectively replicate in tumor cells resulting in lysis, spreading of new infectious units and induction of antitumor immune responses through abrogating an immunosuppressive tumor microenvironment (TME). Due to their mode of ... ...

    Abstract Oncolytic viruses (OVs) selectively replicate in tumor cells resulting in lysis, spreading of new infectious units and induction of antitumor immune responses through abrogating an immunosuppressive tumor microenvironment (TME). Due to their mode of action, OVs are ideal combination partners with targeted immunotherapies. One highly attractive combination is the inhibition of the 'don't-eat-me'-signal CD47, which is known to increase the phagocytic potential of tumor-associated macrophages. In this work, we analyzed the combination approach consisting of the YB-1-based oncolytic adenovirus XVir-N-31 (XVir) and the CD47 inhibitor (CD47i) B6.H12.2 concerning its phagocytic potential. We investigate phagocytosis of XVir-, adenovirus wildtype (AdWT)-, and non-infected established pediatric sarcoma cell lines by different monocytic cells. Phagocytes (immature dendritic cells and macrophages) were derived from THP-1 cells and healthy human donors. Phagocytosis of tumor cells was assessed via FACS analysis in the presence and absence of CD47i. Additional characterization of T cell-stimulatory surface receptors as well as chemo-/cytokine analyses were performed. Furthermore, tumor cells were infected and studied for the surface expression of the 'eat-me'-signal calreticulin (CALR) and the 'don't-eat-me'-signal CD47. We herein demonstrate that (1) XVir-infected tumor cells upregulate both CALR and CD47. XVir induces higher upregulation of CD47 than AdWT. (2) XVir-infection enhances phagocytosis in general and (3) the combination of XVir and CD47i compared to controls showed by far superior enhancement of phagocytosis, tumor cell killing and innate immune activation. In conclusion, the combination of CD47i and XVir causes a significant increase in phagocytosis exceeding the monotherapies considerably accompanied by upregulation of T cell-stimulatory receptor expression and inflammatory chemo/-cytokine secretion.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1304374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Toward prevention of childhood ALL by early-life immune training.

    Hauer, Julia / Fischer, Ute / Borkhardt, Arndt

    Blood

    2021  Volume 138, Issue 16, Page(s) 1412–1428

    Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in ∼20% of cases. Thus, prevention of leukemia would be preferable to treatment. ... ...

    Abstract B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in ∼20% of cases. Thus, prevention of leukemia would be preferable to treatment. Childhood leukemia frequently starts before birth, during fetal hematopoiesis. A first genetic hit (eg, the ETV6-RUNX1 gene fusion) leads to the expansion of preleukemic B-cell clones, which are detectable in healthy newborn cord blood (up to 5%). These preleukemic clones give rise to clinically overt leukemia in only ∼0.2% of carriers. Experimental evidence suggests that a major driver of conversion from the preleukemic to the leukemic state is exposure to immune challenges. Novel insights have shed light on immune host responses and how they shape the complex interplay between (1) inherited or acquired genetic predispositions, (2) exposure to infection, and (3) abnormal cytokine release from immunologically untrained cells. Here, we integrate the recently emerging concept of "trained immunity" into existing models of childhood BCP-ALL and suggest future avenues toward leukemia prevention.
    MeSH term(s) Animals ; Child ; Child, Preschool ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Models, Animal ; Genetic Predisposition to Disease ; Humans ; Immunity, Innate ; Infant ; Infections/complications ; Infections/genetics ; Infections/immunology ; Mice ; Oncogene Proteins, Fusion/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/prevention & control
    Chemical Substances Core Binding Factor Alpha 2 Subunit ; Oncogene Proteins, Fusion ; TEL-AML1 fusion protein
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020009895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  9. Article ; Online: Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia.

    Hauer, Julia / Fischer, Ute / Auer, Franziska / Borkhardt, Arndt

    Leukemia

    2020  Volume 34, Issue 8, Page(s) 2217–2219

    MeSH term(s) BCG Vaccine/administration & dosage ; Betacoronavirus/drug effects ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Germany/epidemiology ; Humans ; Incidence ; Leukemia/drug therapy ; Leukemia/epidemiology ; Leukemia/virology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index ; Vaccination/methods
    Chemical Substances BCG Vaccine
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-020-0871-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2295: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Book ; Online ; Thesis: Evaluation eines familienintegrierenden Behandlungspfades für Frühgeborene mit sehr niedrigem Geburtsgewicht in Bezug auf Ernährung, Wachstum und assoziierte Qualitätsindikatoren (2008 – 2017)

    Pricoco, Rafael Paolo Verfasser] / [Keller, Matthias [Akademischer Betreuer] / Hauer, Julia Gutachter] / [Keller, Matthias [Gutachter]

    2023  

    Author's details Rafael Paolo Pricoco ; Gutachter: Julia Hauer, Matthias Keller ; Betreuer: Matthias Keller
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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