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  1. Article ; Online: Is a Genetic Diathesis for Poor Nutrition Becoming More Crucial Due to the Uniformity of COVID Social Stress?

    DeSoto, M Catherine

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: The important role of nutrition in proper neural functioning and mental health has seen wider acceptance, but is still sadly under recognized given the existent body of research. This Special Issue was designed to unite authoritative information on this ... ...

    Abstract The important role of nutrition in proper neural functioning and mental health has seen wider acceptance, but is still sadly under recognized given the existent body of research. This Special Issue was designed to unite authoritative information on this topic in one volume. This editorial provides an overview of the issue, and suggests that the combination of social isolation, lack of exercise, and remaining indoors that overtook industrialized societies during 2020 are specific factors expected to change the Gene × Environment interactions for anxiety and depression. Importantly, the recent environmental changes may make biological diatheses for nutritional deficiencies even more problematic. The concept of G × E interaction is dissected to clarify a non-intuitive scenario: heritability may increase, even when a sharp increase in prevalence is entirely the result of an environmental change (e.g., COVID anxiety and isolation). Key research is highlighted, specific genetic examples are noted, and theoretical implications regarding natural selection are discussed.
    MeSH term(s) Humans ; Anxiety/epidemiology ; Anxiety Disorders ; COVID-19 ; Depression/epidemiology ; Genetic Predisposition to Disease ; Malnutrition
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15040960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regional differences in use of immune-modulating catechins should be investigated regarding COVID-19.

    Catherine DeSoto, M

    Brain, behavior, and immunity

    2020  Volume 89, Page(s) 526–527

    MeSH term(s) Antioxidants ; Betacoronavirus ; COVID-19 ; Catechin ; Coronavirus Infections ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Antioxidants ; Catechin (8R1V1STN48)
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.07.012
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  4. Article ; Online: Regional differences in use of immune-modulating catechins should be investigated regarding COVID-19

    Catherine DeSoto, M.

    Brain, Behavior, and Immunity

    2020  Volume 89, Page(s) 526–527

    Keywords Immunology ; Behavioral Neuroscience ; Endocrine and Autonomic Systems ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639219-2
    ISSN 0889-1591
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.07.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Suppression of women's cortisol variance: Depression doesn't mediate the sex difference.

    DeSoto, M Catherine

    Psychoneuroendocrinology

    2016  Volume 63, Page(s) 383–384

    MeSH term(s) Anxiety Disorders/metabolism ; Anxiety Disorders/psychology ; Female ; Humans ; Hydrocortisone/analysis ; Male ; Sex Characteristics
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2015.08.030
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  6. Article ; Online: Ignoring the forest and the trees: vaccine antigen study is overmatched.

    DeSoto, M Catherine

    The Journal of pediatrics

    2013  Volume 163, Issue 4, Page(s) 1231

    MeSH term(s) Antibodies/immunology ; Child Development Disorders, Pervasive/etiology ; Female ; Humans ; Male ; Polysaccharides/immunology ; Proteins/immunology ; Vaccines/immunology
    Chemical Substances Antibodies ; Polysaccharides ; Proteins ; Vaccines
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2013.05.046
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  7. Article: Is High Folic Acid Intake a Risk Factor for Autism?-A Review.

    Wiens, Darrell / DeSoto, M Catherine

    Brain sciences

    2017  Volume 7, Issue 11

    Abstract: Folate is required for metabolic processes and neural development. Insuring its adequate levels for pregnant women through supplementation of grain-based foods with synthetic folic acid (FA) in order to prevent neural tube defects has been an ongoing ... ...

    Abstract Folate is required for metabolic processes and neural development. Insuring its adequate levels for pregnant women through supplementation of grain-based foods with synthetic folic acid (FA) in order to prevent neural tube defects has been an ongoing public health initiative. However, because women are advised to take multivitamins containing FA before and throughout pregnancy, the supplementation together with natural dietary folates has led to a demographic with high and rising serum levels of unmetabolized FA. This raises concerns about the detrimental effects of high serum synthetic FA, including a rise in risk for autism spectrum disorder (ASD). Some recent studies have reported a protective effect of FA fortification against ASD, but others have concluded there is an increased risk for ASD and other negative neurocognitive development outcomes. These issues are accompanied by further health questions concerning high, unmetabolized FA levels in serum. In this review, we outline the reasons excess FA supplementation is a concern and review the history and effects of supplementation. We then examine the effects of FA on neuronal development from tissue culture experiments, review recent advances in understanding of metabolic functional blocks in causing ASD and treatment for these with alternative forms such as folinic acid, and finally summarize the conflicting epidemiological findings regarding ASD. Based on the evidence evaluated, we conclude that caution regarding over supplementing is warranted.
    Language English
    Publishing date 2017-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci7110149
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  8. Article ; Online: Ockham's Razor and autism: the case for developmental neurotoxins contributing to a disease of neurodevelopment.

    DeSoto, M Catherine

    Neurotoxicology

    2009  Volume 30, Issue 3, Page(s) 331–337

    Abstract: Much professional awareness regarding environmental triggers for ASD has been narrowly focused on a single possible exposure pathway (vaccines). Meanwhile, empirical support for environmental toxins as a broad class has been quietly accumulating. Recent ... ...

    Abstract Much professional awareness regarding environmental triggers for ASD has been narrowly focused on a single possible exposure pathway (vaccines). Meanwhile, empirical support for environmental toxins as a broad class has been quietly accumulating. Recent research has shown that persons with ASD have comparatively higher levels of various toxins and are more likely to have reduced detoxifying ability, and, that rates of ASD may be higher in areas with greater pollution. This report documents that within the state with the highest rate of ASD, the rate is higher for schools near EPA Superfund sites, t (332)=3.84, p=.0001. The reasons for the rise in diagnoses likely involve genetically predisposed individuals being exposed to various environmental triggers at higher rates than in past generations.
    MeSH term(s) Adolescent ; Autistic Disorder/chemically induced ; Autistic Disorder/epidemiology ; Child ; Environmental Pollutants/toxicity ; Hazardous Waste/statistics & numerical data ; Humans ; Minnesota/epidemiology ; Neurotoxins/genetics ; Neurotoxins/pharmacokinetics ; Prevalence ; Schools/statistics & numerical data
    Chemical Substances Environmental Pollutants ; Hazardous Waste ; Neurotoxins
    Language English
    Publishing date 2009-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2009.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1547: Show issues Location:
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  9. Article ; Online: A reply to Soden et al.: your data shows autistic children have higher levels of heavy metals.

    DeSoto, M Catherine

    Clinical toxicology (Philadelphia, Pa.)

    2008  Volume 46, Issue 10, Page(s) 1098; author reply 1098

    MeSH term(s) Autistic Disorder/drug therapy ; Autistic Disorder/urine ; Chelating Agents/therapeutic use ; Child ; Humans ; Metals, Heavy/urine ; Succimer/therapeutic use ; Urinalysis/methods ; Urinalysis/standards
    Chemical Substances Chelating Agents ; Metals, Heavy ; Succimer (DX1U2629QE)
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650802314368
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  10. Article ; Online: Neuroticism and cortisol: The importance of checking for sex differences.

    DeSoto, M Catherine / Salinas, Manuel

    Psychoneuroendocrinology

    2015  Volume 62, Page(s) 174–179

    Abstract: Existent research documents an unclear and contradictory pattern between cortisol and personality variables, especially neuroticism. Specifically, no effect, positive correlations and negative correlations have all been reported to exist between cortisol ...

    Abstract Existent research documents an unclear and contradictory pattern between cortisol and personality variables, especially neuroticism. Specifically, no effect, positive correlations and negative correlations have all been reported to exist between cortisol and neuroticism. The current study tested whether males and females have a fundamentally different relationship between HPA activation and neuroticism and if this might partially account for some of the discrepancy in findings. Saliva samples (n=183) for cortisol were collected three times across a 90min period. Neuroticism was measured via the NEO-FFI. For men, neuroticism was positively correlated with cortisol level (r=.29). For women it was negatively correlated. The negative correlation between neuroticism and cortisol level remained when oral contraceptive use was statistically controlled, and the statistical significance actually increased (partial r=-.20). This suggests a slight suppressor effect, explainable by prior research on correlates of oral contraceptive use. Overall, these findings may offer some explanation for the discrepant results that have been reported in the existing literature regarding neuroticism and cortisol measures.
    MeSH term(s) Adolescent ; Adult ; Anxiety Disorders/metabolism ; Anxiety Disorders/physiopathology ; Anxiety Disorders/psychology ; Female ; Humans ; Hydrocortisone/analysis ; Hypothalamo-Hypophyseal System/physiopathology ; Male ; Neuroticism ; Personality Inventory ; Pituitary-Adrenal System/physiopathology ; Saliva/chemistry ; Sex Characteristics ; Young Adult
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2015-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2015.07.608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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