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Article: Screening for Vaginal and Endocervical Infections in the First Trimester of Pregnancy? A Study That Ignites an Old Debate.

Toboso Silgo, Leonie / Cruz-Melguizo, Sara / de la Cruz Conty, María Luisa / Encinas Pardilla, María Begoña / Muñoz Algarra, María / Nieto Jiménez, Yolanda / Arranz Friediger, Alexandra / Martínez-Pérez, Óscar

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 12

Abstract: Objectives: Vaginal and endocervical infections are considered a global health problem, especially after recent evidence of their association with preterm delivery and other adverse obstetric outcomes. Still, there is no consensus on the efficacy of a ... ...

Abstract	Objectives: Vaginal and endocervical infections are considered a global health problem, especially after recent evidence of their association with preterm delivery and other adverse obstetric outcomes. Still, there is no consensus on the efficacy of a screening strategy for these infections in the first trimester of pregnancy. This study evaluated their prevalence and whether screening and treatment resulted as effective in reducing pregnancy and perinatal complications. Methods: A single-center prospective observational study was designed; a sample size of 400 first-trimester pregnant women was established and they were recruited between March 2016-October 2019 at the Puerta de Hierro University Hospital (Spain). They were screened for vaginal and endocervical infections and treated in case of abnormal flora. Pregnancy and delivery outcomes were compared between abnormal and normal flora groups by univariate analysis. Results: 109 patients had an abnormal flora result (27.2%). The most frequently detected infection was Conclusions: Considering the morbimortality related to prematurity and that the results of our study suggest that the early treatment of abnormal flora could improve perinatal outcomes, the implementation of a screening program during the first trimester should be considered.
Language	English
Publishing date	2021-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10121610
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Screening for Vaginal and Endocervical Infections in the First Trimester of Pregnancy? A Study That Ignites an Old Debate

Leonie Toboso Silgo / Sara Cruz-Melguizo / María Luisa de la Cruz Conty / María Begoña Encinas Pardilla / María Muñoz Algarra / Yolanda Nieto Jiménez / Alexandra Arranz Friediger / Óscar Martínez-Pérez

Pathogens, Vol 10, Iss 1610, p

2021 Volume 1610

Abstract	Objectives: Vaginal and endocervical infections are considered a global health problem, especially after recent evidence of their association with preterm delivery and other adverse obstetric outcomes. Still, there is no consensus on the efficacy of a screening strategy for these infections in the first trimester of pregnancy. This study evaluated their prevalence and whether screening and treatment resulted as effective in reducing pregnancy and perinatal complications. Methods: A single-center prospective observational study was designed; a sample size of 400 first-trimester pregnant women was established and they were recruited between March 2016–October 2019 at the Puerta de Hierro University Hospital (Spain). They were screened for vaginal and endocervical infections and treated in case of abnormal flora. Pregnancy and delivery outcomes were compared between abnormal and normal flora groups by univariate analysis. Results: 109 patients had an abnormal flora result (27.2%). The most frequently detected infection was Ureaplasma urealyticum (12.3%), followed by Candida spp. (11.8%), bacterial vaginosis (5%), Mycoplasma hominis (1.2%) and Trichomonas vaginalis (0.8%). Patients with abnormal flora had a 5-fold increased risk of preterm premature rupture of membranes (5.3% vs. 1.1% of patients with normal flora, Odds Ratio 5.11, 95% Confidence Interval 1.20–21.71, p = 0.028). No significant differences were observed regarding preterm delivery or neonatal morbidity. Conclusions: Considering the morbimortality related to prematurity and that the results of our study suggest that the early treatment of abnormal flora could improve perinatal outcomes, the implementation of a screening program during the first trimester should be considered.
Keywords	vaginosis ; Ureaplasma ; preterm birth ; vaginal ; infection ; endocervical ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Screening for Vaginal and Endocervical Infections in the First Trimester of Pregnancy? A Study That Ignites an Old Debate

Pathogens. 2021 Dec. 10, v. 10, no. 12

2021

Abstract	Objectives: Vaginal and endocervical infections are considered a global health problem, especially after recent evidence of their association with preterm delivery and other adverse obstetric outcomes. Still, there is no consensus on the efficacy of a screening strategy for these infections in the first trimester of pregnancy. This study evaluated their prevalence and whether screening and treatment resulted as effective in reducing pregnancy and perinatal complications. Methods: A single-center prospective observational study was designed; a sample size of 400 first-trimester pregnant women was established and they were recruited between March 2016–October 2019 at the Puerta de Hierro University Hospital (Spain). They were screened for vaginal and endocervical infections and treated in case of abnormal flora. Pregnancy and delivery outcomes were compared between abnormal and normal flora groups by univariate analysis. Results: 109 patients had an abnormal flora result (27.2%). The most frequently detected infection was Ureaplasma urealyticum (12.3%), followed by Candida spp. (11.8%), bacterial vaginosis (5%), Mycoplasma hominis (1.2%) and Trichomonas vaginalis (0.8%). Patients with abnormal flora had a 5-fold increased risk of preterm premature rupture of membranes (5.3% vs. 1.1% of patients with normal flora, Odds Ratio 5.11, 95% Confidence Interval 1.20–21.71, p = 0.028). No significant differences were observed regarding preterm delivery or neonatal morbidity. Conclusions: Considering the morbimortality related to prematurity and that the results of our study suggest that the early treatment of abnormal flora could improve perinatal outcomes, the implementation of a screening program during the first trimester should be considered.
Keywords	Candida ; Mycoplasma hominis ; Trichomonas vaginalis ; Ureaplasma urealyticum ; confidence interval ; flora ; hospitals ; morbidity ; observational studies ; odds ratio ; pregnancy ; premature birth ; risk ; sample size ; Spain
Language	English
Dates of publication	2021-1210
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10121610
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus Vaccine (RSVPreF3) in Mothers and Their Infants: A Phase 2 Randomized Trial.

Bebia, Zourab / Reyes, Osvaldo / Jeanfreau, Robert / Kantele, Anu / De Leon, Ruth Graciela / Sánchez, Marta García / Banooni, Peyman / Gardener, Glenn J / Rasero, José Luis Bartha / Pardilla, Maria Begoña Encinas / Langley, Joanne M / Di Leo, Claudio Maañón / Botelho-Nevers, Elisabeth / Buttery, Jim / Laurichesse, Helene / Madhi, Shabir A / García, Adrián Martín / Stanley, Thorsten / Barjat, Tiphaine /

Griffith, Rebecca / Castrejón-Alba, Maria Mercedes / de Heusch, Magali / Dieussaert, Ilse / Hercor, Melanie / Lese, Patricia / Qian, Hui / Tullio, Antonella N / Henry, Ouzama

The Journal of infectious diseases

2023 Volume 228, Issue 3, Page(s) 299–310

Abstract: Background: In a phase 1/2 study, a maternal respiratory syncytial virus vaccine candidate (RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV-specific humoral immune responses in non-pregnant women.: Methods: In this ... ...

Abstract	Background: In a phase 1/2 study, a maternal respiratory syncytial virus vaccine candidate (RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV-specific humoral immune responses in non-pregnant women. Methods: In this phase 2 observer-blind, placebo-controlled, randomized clinical trial (NCT04126213), the safety of RSVPreF3 (60 or 120 µg), administered during late second or third trimester, was evaluated in 213 18- to 40-year-old healthy pregnant women through 6 months postdelivery and their offspring through infancy; immunogenicity was evaluated through day 43 postdelivery and day 181 postbirth, respectively. Results: RSVPreF3 was well tolerated. No pregnancy-related or neonatal adverse events of special interest were considered vaccine/placebo related. In the 60 and 120 µg RSVPreF3 groups: (1) neutralizing antibody (nAb) titers in mothers increased 12.7- and 14.9-fold against RSV-A and 10.6- and 13.2-fold against RSV-B, respectively, 1 month postvaccination and remained 8.9-10.0-fold over prevaccination at day 43 postdelivery; (2) nAb titers were consistently higher compared to placebo recipients; (3) placental transfer ratios for anti-RSVPreF3 antibodies at birth were 1.62 and 1.90, respectively, and (4) nAb levels in infants were highest at birth and declined through day 181 postbirth. Conclusions: RSVPreF3 maternal vaccination had an acceptable safety risk profile and induced robust RSV-specific immune responses with successful antibody transfer to their newborns. Clinical trials registration: NCT04126213.
MeSH term(s)	Pregnancy ; Humans ; Female ; Infant ; Infant, Newborn ; Adolescent ; Young Adult ; Adult ; Respiratory Syncytial Virus Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing ; Mothers ; Respiratory Syncytial Virus Infections/prevention & control ; Viral Fusion Proteins ; Placenta ; Immunogenicity, Vaccine ; Respiratory Syncytial Virus, Human
Chemical Substances	Respiratory Syncytial Virus Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing ; Viral Fusion Proteins
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Infection and C-Section: A Prospective Observational Study.

Morán Antolín, Eva / Broullón Molanes, José Román / de la Cruz Conty, María Luisa / Encinas Pardilla, María Begoña / Guadix Martín, María Del Pilar / Sainz Bueno, José Antonio / Forcén Acebal, Laura / Pintado Recarte, Pilar / Álvarez Bartolomé, Ana / Martínez Cendán, Juan Pedro / Martínez-Pérez, Óscar / On Behalf Of The Spanish Obstetric Emergency Group

Viruses

2021 Volume 13, Issue 11

Abstract: Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to ... ...

Abstract	Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson's classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results. This was a prospective observational study that was carried out in 79 hospitals (Spanish Obstetric Emergency Group) with a cohort of 1704 SARS-CoV-2 PCR-positive pregnant women that were registered consecutively between 26 February and 5 November 2020. The data from 1248 pregnant women who delivered vaginally (vaginal + operative vaginal) was compared with those from 456 (26.8%) who underwent a C-section. C-section patients were older with higher rates of comorbidities, in vitro fertilization and multiple pregnancies (
MeSH term(s)	Adult ; COVID-19/complications ; Cesarean Section ; Comorbidity ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious ; Pregnancy Outcome ; Pregnancy Trimesters ; Premature Birth ; Prospective Studies ; Risk Factors ; Young Adult
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection

Maria Luisa de la Cruz Conty / Maria Begoña Encinas Pardilla / Marta Garcia Sanchez / Laura Gonzalez Rodriguez / Marta Luisa Muner-Hernando / Ana Royuela Vicente / Pilar Pintado Recarte / Alicia Martinez Varea / Clara Martinez Diago / Sara Cruz Melguizo / Oscar Martinez-Perez

Vaccines, Vol 9, Iss 1, p

A Prospective Observational Study

2021 Volume 31

Abstract: The COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the ... ...

Abstract	The COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. A total of 1150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.
Keywords	SARS-CoV-2 ; covid 19 ; pregnancy ; passive immunization ; maternal immunization ; influenza vaccines ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study.

de la Cruz Conty, Maria Luisa / Encinas Pardilla, Maria Begoña / Garcia Sanchez, Marta / Gonzalez Rodriguez, Laura / Muner-Hernando, Marta Luisa / Royuela Vicente, Ana / Pintado Recarte, Pilar / Martinez Varea, Alicia / Martinez Diago, Clara / Cruz Melguizo, Sara / Martinez-Perez, Oscar / On Behalf Of The Spanish Obstetric Emergency Group

Vaccines

2021 Volume 9, Issue 1

Abstract	The COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. A total of 1150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.
Language	English
Publishing date	2021-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines9010031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study.

Cruz Melguizo, Sara / de la Cruz Conty, María Luisa / Carmona Payán, Paola / Abascal-Saiz, Alejandra / Pintando Recarte, Pilar / González Rodríguez, Laura / Cuenca Marín, Celia / Martínez Varea, Alicia / Oreja Cuesta, Ana Belén / Rodríguez, Pilar Prats / Fernández Buhigas, Irene / Rodríguez Gallego, María Victoria / Fernández Alonso, Ana María / López Pérez, Rocío / Broullón Molanes, José Román / Encinas Pardilla, María Begoña / Ramírez Gómez, Mercedes / Gimeno Gimeno, María Joaquina / Sánchez Muñoz, Antonio /

Martínez-Pérez, Oscar / On Behalf Of The Spanish Obstetric Emergency Group S O E G

Viruses

2021 Volume 13, Issue 5

Abstract: Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the ... ...

Abstract	Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%,
MeSH term(s)	Adult ; COVID-19/complications ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications/virology ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Outcome/epidemiology ; Prospective Studies ; SARS-CoV-2/pathogenicity ; Spain/epidemiology
Language	English
Publishing date	2021-05-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13050853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 Infection and C-Section: A Prospective Observational Study

Morán Antolín, Eva / Broullón Molanes, José Román / de la Cruz Conty, María Luisa / Encinas Pardilla, María Begoña / Guadix Martín, María del Pilar / Sainz Bueno, José Antonio / Forcén Acebal, Laura / Pintado Recarte, Pilar / Álvarez Bartolomé, Ana / Martínez Cendán, Juan Pedro / Martínez-Pérez, Óscar / on behalf of the Spanish Obstetric Emergency Group

Viruses. 2021 Nov. 22, v. 13, no. 11

2021

Abstract	Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson’s classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results. This was a prospective observational study that was carried out in 79 hospitals (Spanish Obstetric Emergency Group) with a cohort of 1704 SARS-CoV-2 PCR-positive pregnant women that were registered consecutively between 26 February and 5 November 2020. The data from 1248 pregnant women who delivered vaginally (vaginal + operative vaginal) was compared with those from 456 (26.8%) who underwent a C-section. C-section patients were older with higher rates of comorbidities, in vitro fertilization and multiple pregnancies (p < 0.05) compared with women who delivered vaginally. Moreover, C-section risk was associated with the presence of pneumonia (p < 0.001) and 41.1% of C-sections in patients with pneumonia were preterm (Robson’s 10th category). However, delivery care was similar between asymptomatic and mild–moderate symptomatic patients (p = 0.228) and their predisposing factors to C-section were the presence of uterine scarring (due to a previous C-section) and the induction of labor or programmed C-section for unspecified obstetric reasons. On the other hand, higher rates of hemorrhagic events, hypertensive disorders and thrombotic events were observed in the C-section group (p < 0.001 for all three outcomes), as well as for ICU admission. These findings suggest that this type of delivery was associated with the mother’s clinical conditions that required a rapid and early termination of pregnancy.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; cesarean section ; labor ; models ; observational studies ; pandemic ; pneumonia ; pregnancy
Language	English
Dates of publication	2021-1122
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112330
Database	NAL-Catalogue (AGRICOLA)

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Article: Spanish registry of Covid-19 screening in asymptomatic pregnants

Encinas Pardilla, Maria Begona / Cano Aguilar, Africa / Marcos Puig, Beatriz / Sanz Lorenzana, Amelia / Rodriguez de la Torre, Iria / Hernando Lopez de la Manzanara, Paloma / Fernandez Bernardo, Ana / Martinez Perez, Oscar

Revista espanola de salud publica

Abstract: OBJECTIVE: The Spanish registry of Covid-19 in Spanish pregnant women, made up of 100 centers, is created in response to the need to know the morbidity that Covid-19 generates in pregnant women and their newborns, to know the real incidence of the ... ...

Abstract	OBJECTIVE: The Spanish registry of Covid-19 in Spanish pregnant women, made up of 100 centers, is created in response to the need to know the morbidity that Covid-19 generates in pregnant women and their newborns, to know the real incidence of the disease in this population group and to establish and monitor the package of measures to improve their care The aim of this paper was the creation of a registry of pregnant women with Covid-19 infection in order to establish the interventions and measures necessary to improve the care of these patients during hospital admission METHODS: To prepare the registry, the main researcher of each center collected weekly / biweekly the number of total pregnant women screened, as well as the total number of positive and negative, sending these data to the responsible researchers so that it could be available in real time of the percentage of infected asymptomatic pregnant population and the evolution by weeks in the centers of each participating province The data were analyzed using the linear regression test and the Mantel test RESULTS: As of May 31stsup> 2020, 16,308 screening tests were carried out in these hospitals, in which 338 pregnant women were positive, which translates into 2 07% (95% Confidence Interval: 1 86-2 30) of the asymptomatic pregnant women we attended in our centers were carriers of the virus and could develop the disease in subsequent days CONCLUSIONS: The Spanish epidemiological registry allows us to know the incidence of infection in pregnant women attended in the Spanish delivery centers, as well as the weekly and / or fortnightly evolution of the same, observing a significant decrease in the proportion of positive pregnant women over the total of screenings throughout this period, with an average of 6 5% in early April 2020 to an average of 0 93% positive in late May 2020 OBJETIVO: El registro espanol de Covid-19 en embarazadas espanolas, integrado por 100 centros, surge en respuesta a la necesidad de conocer la morbilidad que la Covid-19 genera en las gestantes y sus recien nacidos, de conocer la incidencia real de la enfermedad en este grupo poblacional y de establecer y monitorizar el paquete de medidas para mejorar su atencion El objetivo de este estudio fue la creacion de un registro de gestantes con infeccion por Covid-19 con la finalidad de establecer y monitorizar las intervenciones y medidas necesarias para mejorar la atencion de estas pacientes durante el ingreso hospitalario METODOS: Para la elaboracion del registro, el investigador principal de cada centro recogio con caracter semanal/quincenal el numero de gestantes totales cribadas, asi como el total de positivas y negativas, remitiendo a los investigadores responsables estos datos de manera que se pudiera disponer a tiempo real del porcentaje de poblacion gestante asintomatica infectada y de la evolucion por semanas en los centros de cada provincia participante Los datos fueron analizados mediante el Test de regresion lineal y test de Mantel RESULTADOS: A dia 31 de mayo de 2020, se realizaron en estos hospitales 16 308 test de cribado, en los cuales 338 gestantes resultaron positivas, lo que se traduce en que un 2,07% (Intervalo de Confianza del 95%: 1,86-2,30) de las gestantes asintomaticas que atendimos en nuestros centros eran portadoras del virus y podian desarrollar la enfermedad en dias posteriores CONCLUSIONES: El registro epidemiologico espanol permite conocer la incidencia de infeccion en gestantes atendidas en los paritorios espanoles, asi como la evolucion semanal y/o quincenal de la misma, observandose un descenso significativo de la proporcion de gestantes positivas sobre el total de cribadas a lo largo de este periodo, con una media del 6,5% a principios de abril de 2020 hasta una media del 0,93% de positivas a finales de mayo de 2020
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #777060
Database	COVID19

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