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  1. Article ; Online: High-Dose Vitamin D

    Ganmaa, Davaasambuu / Munkhzul, Baatar / Fawzi, Wafaie / Spiegelman, Donna / Willett, Walter C / Bayasgalan, Purev / Baasansuren, Erkhembayar / Buyankhishig, Burneebaatar / Oyun-Erdene, Sereeter / Jolliffe, David A / Xenakis, Theodoros / Bromage, Sabri / Bloom, Barry R / Martineau, Adrian R

    American journal of respiratory and critical care medicine

    2017  Volume 196, Issue 5, Page(s) 628–637

    Abstract: Rationale: Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB ... are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D ... status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D ...

    Abstract Rationale: Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking.
    Objectives: To determine the effect of high-dose vitamin D
    Methods: We conducted a clinical trial in 390 adults with PTB in Ulaanbaatar, Mongolia, who were randomized to receive four biweekly doses of 3.5 mg (140,000 IU) vitamin D
    Measurements and main results: The intervention elevated 8-week serum 25-hydroxyvitamin D concentrations (154.5 nmol/L vs. 15.2 nmol/L in active vs. placebo arms, respectively; 95% confidence interval for difference, 125.9-154.7 nmol/L; P < 0.001) but did not influence time to sputum culture conversion overall (adjusted hazard ratio, 1.09; 95% confidence interval, 0.86-1.36; P = 0.48). Adjunctive vitamin D
    Conclusions: Vitamin D
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Cholecalciferol/metabolism ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Mongolia ; Polymorphism, Single Nucleotide/drug effects ; Sputum/drug effects ; Sputum/metabolism ; Treatment Outcome ; Tuberculosis, Pulmonary/drug therapy ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism ; Vitamins/metabolism ; Vitamins/therapeutic use ; Young Adult
    Chemical Substances Antitubercular Agents ; Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2017-07-05
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201705-0936OC
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  2. Article ; Online: Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.

    Ganmaa, Davaasambuu / Uyanga, Buyanjargal / Zhou, Xin / Gantsetseg, Garmaa / Delgerekh, Baigali / Enkhmaa, Davaasambuu / Khulan, Dorjnamjil / Ariunzaya, Saranjav / Sumiya, Erdenebaatar / Bolortuya, Batbileg / Yanjmaa, Jutmaan / Enkhtsetseg, Tserenkhuu / Munkhzaya, Ankhbat / Tunsag, Murneren / Khudyakov, Polyna / Seddon, James A / Marais, Ben J / Batbayar, Ochirbat / Erdenetuya, Ganbaatar /
    Amarsaikhan, Bazarsaikhan / Spiegelman, Donna / Tsolmon, Jadambaa / Martineau, Adrian R

    The New England journal of medicine

    2020  Volume 383, Issue 4, Page(s) 359–368

    Abstract: Background: Vitamin D metabolites support innate immune responses to : Methods: We randomly ... randomization: 4418 were assigned to the vitamin D group, and 4433 to the placebo group; 95.6% of children had ... a baseline serum 25(OH)D level of less than 20 ng per milliliter. Among children with a valid QFT result ...

    Abstract Background: Vitamin D metabolites support innate immune responses to
    Methods: We randomly assigned children who had negative results for
    Results: A total of 8851 children underwent randomization: 4418 were assigned to the vitamin D group, and 4433 to the placebo group; 95.6% of children had a baseline serum 25(OH)D level of less than 20 ng per milliliter. Among children with a valid QFT result at the end of the trial, the percentage with a positive result was 3.6% (147 of 4074 children) in the vitamin D group and 3.3% (134 of 4043) in the placebo group (adjusted risk ratio, 1.10; 95% confidence interval [CI], 0.87 to 1.38; P = 0.42). The mean 25(OH)D level at the end of the trial was 31.0 ng per milliliter in the vitamin D group and 10.7 ng per milliliter in the placebo group (mean between-group difference, 20.3 ng per milliliter; 95% CI, 19.9 to 20.6). Tuberculosis disease was diagnosed in 21 children in the vitamin D group and in 25 children in the placebo group (adjusted risk ratio, 0.87; 95% CI, 0.49 to 1.55). A total of 29 children in the vitamin D group and 34 in the placebo group were hospitalized for treatment of acute respiratory infection (adjusted risk ratio, 0.86; 95% CI, 0.52 to 1.40). The incidence of adverse events did not differ significantly between the two groups.
    Conclusions: Vitamin D supplementation did not result in a lower risk of tuberculosis infection, tuberculosis disease, or acute respiratory infection than placebo among vitamin D-deficient schoolchildren in Mongolia. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT02276755.).
    MeSH term(s) Child ; Cholecalciferol/adverse effects ; Cholecalciferol/therapeutic use ; Dietary Supplements/adverse effects ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Incidence ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/prevention & control ; Male ; Mycobacterium tuberculosis/isolation & purification ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Treatment Failure ; Tuberculin Test ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamins/adverse effects ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1915176
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  3. Article ; Online: Plasma free 25-hydroxyvitamin D, vitamin D binding protein, and risk of breast cancer in the Nurses' Health Study II.

    Wang, Jun / Eliassen, A Heather / Spiegelman, Donna / Willett, Walter C / Hankinson, Susan E

    Cancer causes & control : CCC

    2014  Volume 25, Issue 7, Page(s) 819–827

    Abstract: ... hydroxyvitamin D [25(OH)D] and breast cancer risk with inconsistent results. However, recent studies suggest ... that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D ... binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D ...

    Abstract Purpose: Prior prospective studies, including our own, have evaluated total plasma 25-hydroxyvitamin D [25(OH)D] and breast cancer risk with inconsistent results. However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D.
    Methods: We conducted a case-control study nested within the Nurses' Health Study II to evaluate the association of plasma free 25(OH)D and DBP with breast cancer risk in predominantly premenopausal women. Plasma samples were assayed for 25(OH)D and DBP in 584 case-control pairs. Free 25(OH)D levels were calculated based on plasma levels of total 25(OH)D, DBP, and a constant value representing average albumin levels. Conditional logistic regression was used to estimate relative risks (RRs) and 95% confidence intervals (CIs).
    Results: We found no association between plasma calculated free 25(OH)D and risk of breast cancer overall (highest vs. lowest quartile RR 1.21, 95% CI 0.83-1.77, trend test p value = 0.50). No association was observed for plasma DBP as well (highest vs. lowest quartile RR 0.95, 95% CI 0.67-1.36, trend test p value = 0.96). Results were similar by tumor hormone receptor status. Neither the total nor the calculated free 25(OH)D and breast cancer association substantially varied by plasma DBP levels.
    Conclusions: Our study does not support an important role of either calculated circulating free 25(OH)D or circulating DBP levels in breast cancer risk among predominantly premenopausal women.
    MeSH term(s) Adult ; Breast Neoplasms/blood ; Breast Neoplasms/epidemiology ; Calcitriol/blood ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Premenopause ; Risk Factors ; Vitamin D-Binding Protein/blood
    Chemical Substances Vitamin D-Binding Protein ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2014-04-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-014-0383-5
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    Zs.A 3375: Show issues Location:
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  4. Article ; Online: Dietary intake of vitamin D during adolescence and risk of multiple sclerosis.

    Munger, Kassandra L / Chitnis, Tanuja / Frazier, A Lindsay / Giovannucci, Edward / Spiegelman, Donna / Ascherio, Alberto

    Journal of neurology

    2010  Volume 258, Issue 3, Page(s) 479–485

    Abstract: ... and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined ... whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 ... questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was ...

    Abstract Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥ 400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies.
    MeSH term(s) Adolescent ; Adult ; Calcium, Dietary/administration & dosage ; Cohort Studies ; Dairy Products ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/etiology ; Multiple Sclerosis/prevention & control ; Risk Factors ; Surveys and Questionnaires ; Vitamin D/administration & dosage ; Vitamin D/adverse effects ; Vitamin D/therapeutic use
    Chemical Substances Calcium, Dietary ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2010-10-14
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-010-5783-1
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  5. Article ; Online: Vitamin D and prostate cancer risk--a less sunny outlook?

    Mucci, Lorelei A / Spiegelman, Donna

    Journal of the National Cancer Institute

    2008  Volume 100, Issue 11, Page(s) 759–761

    MeSH term(s) Humans ; Incidence ; Male ; Mass Screening/methods ; Prevalence ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/prevention & control ; Risk Assessment ; Risk Factors ; United States/epidemiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2008-06-04
    Publishing country United States
    Document type Editorial ; Review ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djn164
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  6. Article: Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk.

    Mikhak, Bahar / Hunter, David J / Spiegelman, Donna / Platz, Elizabeth A / Hollis, Bruce W / Giovannucci, Edward

    The Prostate

    2007  Volume 67, Issue 9, Page(s) 911–923

    Abstract: Background: The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25 ... dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes ... their interaction with plasma vitamin D metabolites in relation to prostate cancer (PC) risk.: Results: No ...

    Abstract Background: The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes.
    Methods: We conducted a nested case-control study in the Health Professionals Follow-up Study to investigate the role of the VDR Cdx2, Fok1, and Bsm1 gene polymorphisms and associated haplotypes and their interaction with plasma vitamin D metabolites in relation to prostate cancer (PC) risk.
    Results: No association was found between these SNPs or their associated haplotypes and all PC subtypes except that haplotype 2 (A-f-b) with Cdx2 A, Fok1 f, and Bsm1 b alleles and haplotype 3 (A-F-B) with Cdx2 A, Fok1 F and Bsm1 B alleles compared to the most common haplotype (A-F-b), were associated with reduced risk of aggressive PC (high stage or Gleason sum > or =7; P = 0.02), both with two alleles suspected of being low risk. Carriers of the variant Cdx2 A allele who were deficient in plasma 25-hydroxyvitamin D (< or =15 ng/ml) compared to non-carriers with normal 25-hydroxyvitamin D, had a lower risk of total and poorly differentiated PCs (Gleason sum > or =7) (P for interaction = 0.02 and 0.04, respectively). Plasma 1,25-dihydroxyvitamin D deficiency (< or =26 pg/ml) was associated with a threefold risk of poorly differentiated PC (P for interaction = 0.01) when comparing carriers of the Cdx2 A allele to non-carriers with normal 1,25-dihydroxyvitamin D.
    Conclusion: In this population of men, none of the VDR polymorphisms studied was associated with susceptibility to PC.
    MeSH term(s) CDX2 Transcription Factor ; Calcifediol/blood ; Calcifediol/metabolism ; Calcitriol/blood ; Calcitriol/metabolism ; Case-Control Studies ; Follow-Up Studies ; Genetic Predisposition to Disease ; Homeodomain Proteins/genetics ; Humans ; Male ; Polymorphism, Genetic ; Prostatic Neoplasms/epidemiology ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Risk Assessment ; Vitamin D Deficiency/genetics
    Chemical Substances CDX2 Transcription Factor ; CDX2 protein, human ; Homeodomain Proteins ; Receptors, Calcitriol ; Calcitriol (FXC9231JVH) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2007-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.20570
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    Zs.A 1608: Show issues Location:
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  7. Article ; Online: Maternal vitamin D status and child morbidity, anemia, and growth in human immunodeficiency virus-exposed children in Tanzania.

    Finkelstein, Julia L / Mehta, Saurabh / Duggan, Christopher / Manji, Karim P / Mugusi, Ferdinand M / Aboud, Said / Spiegelman, Donna / Msamanga, Gernard I / Fawzi, Wafaie W

    The Pediatric infectious disease journal

    2012  Volume 31, Issue 2, Page(s) 171–175

    Abstract: Background: Vitamin D may help prevent adverse pediatric outcomes, including infectious diseases ... of maternal vitamin D status and pediatric health outcomes in children born to human immunodeficiency virus ... HIV)-infected women.: Methods: Vitamin D status was determined in 884 HIV-infected pregnant women ...

    Abstract Background: Vitamin D may help prevent adverse pediatric outcomes, including infectious diseases and growth failure, based on its role in immune and metabolic functions. We examined the association of maternal vitamin D status and pediatric health outcomes in children born to human immunodeficiency virus (HIV)-infected women.
    Methods: Vitamin D status was determined in 884 HIV-infected pregnant women at 12 to 27 weeks of gestation in a trial of vitamin supplementation (not excluding vitamin D) in Tanzania. Information on child morbidities, anemia and hypochromic microcytosis, and anthropometry was recorded through monthly clinic visits. Generalized estimating equations and Cox proportional hazards models were used to assess the relationships of outcomes with maternal vitamin D status.
    Results: A total of 39% of women had low vitamin D levels (<32 ng/mL). Children born to women with low vitamin D status were 1.11 times more likely to report cough during follow-up (relative risk [RR], 1.11; 95% confidence interval [CI], 1.02-1.21). No significant associations were noted for other respiratory symptoms, diarrhea, or anemia outcomes. Low maternal vitamin D status was associated with significantly increased risk of stunting (height-for-age z score, <-2; RR, 1.29; 95% CI, 1.05-1.59) and being underweight (weight-for-age z score, <-2; RR, 1.33; 95% CI, 1.03-1.71).
    Conclusions: Maternal vitamin D status may be important for preventing respiratory infections and ensuring optimal growth in HIV-exposed children.
    MeSH term(s) Adult ; Anemia, Hypochromic/epidemiology ; Anthropometry ; Child Development ; Female ; Growth ; HIV Infections/complications ; Humans ; Infant ; Infant, Newborn ; Male ; Pregnancy ; Pregnancy Complications, Infectious ; Respiratory Tract Infections/epidemiology ; Statistics as Topic ; Tanzania ; Vitamin D/blood ; Young Adult
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2012-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0b013e318245636b
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  8. Article ; Online: Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II.

    Eliassen, A Heather / Spiegelman, Donna / Hollis, Bruce W / Horst, Ronald L / Willett, Walter C / Hankinson, Susan E

    Breast cancer research : BCR

    2011  Volume 13, Issue 3, Page(s) R50

    Abstract: Introduction: Experimental evidence indicates vitamin D may play an important role in breast ... cancer etiology but epidemiologic evidence to date is inconsistent. Vitamin D comes from dietary intake ... and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure ...

    Abstract Introduction: Experimental evidence indicates vitamin D may play an important role in breast cancer etiology but epidemiologic evidence to date is inconsistent. Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status.
    Methods: We conducted a prospective nested case-control study within the Nurses' Health Study II (NHSII). Plasma samples collected in 1996 to 1999 were assayed for 25(OH)D in 613 cases, diagnosed after blood collection and before 1 June 2007, and in 1,218 matched controls. Multivariate relative risks (RR) and 95% confidence intervals (CI) were calculated by conditional logistic regression, adjusting for several breast cancer risk factors.
    Results: No significant association was observed between plasma 25(OH)D levels and breast cancer risk (top vs. bottom quartile multivariate RR = 1.20, 95% CI (0.88 to 1.63), P-value, test for trend = 0.32). Results were similar when season-specific quartile cut points were used. Results did not change when restricted to women who were premenopausal at blood collection or premenopausal at diagnosis. Results were similar between estrogen receptor (ER)+/progesterone receptor (PR)+ and ER-/PR- tumors (P-value, test for heterogeneity = 0.51). The association did not vary by age at blood collection or season of blood collection, but did vary when stratified by body mass index (P-value, test for heterogeneity = 0.01).
    Conclusions: Circulating 25(OH)D levels were not significantly associated with breast cancer risk in this predominantly premenopausal population.
    MeSH term(s) Adult ; Body Mass Index ; Breast Neoplasms/blood ; Breast Neoplasms/epidemiology ; Female ; Humans ; Middle Aged ; Nurses ; Premenopause ; Prospective Studies ; Receptors, Estrogen/biosynthesis ; Receptors, Progesterone/biosynthesis ; Risk ; Risk Factors ; Surveys and Questionnaires ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Receptors, Estrogen ; Receptors, Progesterone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2011-05-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/bcr2880
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  9. Article ; Online: Sunlight exposure, vitamin D, and risk of non-Hodgkin lymphoma in the Nurses' Health Study.

    Bertrand, Kimberly A / Chang, Ellen T / Abel, Gregory A / Zhang, Shumin M / Spiegelman, Donna / Qureshi, Abrar A / Laden, Francine

    Cancer causes & control : CCC

    2011  Volume 22, Issue 12, Page(s) 1731–1741

    Abstract: ... on residence at various times during life, vitamin D intake, and predicted plasma 25-hydroxyvitamin D levels ... vitamin D measures and risk of NHL overall or by subtype.: Conclusions: Our findings do not support ... vitamin D and NHL risk. ...

    Abstract Purpose: Case-control studies suggest increased sun exposure reduces non-Hodgkin lymphoma (NHL) risk. Evidence from prospective cohort studies, however, is limited and inconsistent. We evaluated the association between ambient ultraviolet radiation (UV) exposure and NHL in a nationwide cohort of women, the Nurses' Health Study (NHS).
    Methods: Between 1976 and 2006, we identified 1064 incident NHL cases among 115,482 women in the prospective NHS. Exposures assessed included average annual UV-B flux based on residence at various times during life, vitamin D intake, and predicted plasma 25-hydroxyvitamin D levels. We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) for risk of all NHL and histologic subtypes using Cox proportional hazards models.
    Results: NHL risk was increased for women residing in areas of high ambient UV radiation (UV-B flux >113 R-B count × 10(-4)) compared to those with lower exposure (<113), with positive linear trends at all time points. The multivariable-adjusted RR for high UV area at age 15 was 1.21 (95% CI: 1.00, 1.47; p-trend < 0.01). There was no evidence of statistical heterogeneity by subtype, although power was limited for subtype analyses. We observed no association between vitamin D measures and risk of NHL overall or by subtype.
    Conclusions: Our findings do not support the hypothesis of a protective effect of UV radiation exposure on NHL risk. We found no association between vitamin D and NHL risk.
    MeSH term(s) Adult ; Cohort Studies ; Diet ; Dietary Supplements ; Humans ; Lymphoma, Non-Hodgkin/epidemiology ; Middle Aged ; Nurses ; Proportional Hazards Models ; Risk Factors ; Sunlight/adverse effects ; Surveys and Questionnaires ; Ultraviolet Rays/adverse effects ; Vitamin D/pharmacology ; Vitamins/pharmacology
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2011-10-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-011-9849-x
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  10. Article ; Online: Vitamin D status and its association with morbidity including wasting and opportunistic illnesses in HIV-infected women in Tanzania.

    Mehta, Saurabh / Mugusi, Ferdinand M / Spiegelman, Donna / Villamor, Eduardo / Finkelstein, Julia L / Hertzmark, Ellen / Giovannucci, Edward L / Msamanga, Gernard I / Fawzi, Wafaie W

    AIDS patient care and STDs

    2011  Volume 25, Issue 10, Page(s) 579–585

    Abstract: Vitamin D has a potential role in preventing HIV-related complications, based on its extensive ... Vitamin D levels were assessed in 884 HIV-infected pregnant women at enrollment in a trial of multivitamin ... supplementation (excluding vitamin D) in Tanzania. Information on HIV related complications was recorded during ...

    Abstract Vitamin D has a potential role in preventing HIV-related complications, based on its extensive involvement in immune and metabolic function, including preventing osteoporosis and premature cardiovascular disease. However, this association has not been examined in large studies or in resource-limited settings. Vitamin D levels were assessed in 884 HIV-infected pregnant women at enrollment in a trial of multivitamin supplementation (excluding vitamin D) in Tanzania. Information on HIV related complications was recorded during follow-up (median, 70 months). Proportional hazards models and generalized estimating equations were used to assess the relationship of vitamin D status with these outcomes. Women with low vitamin D status (serum 25-hydroxyvitamin D<32 ng/mL) had 43% higher risk of reaching a body mass index (BMI) less than 18 kg/m(2) during the first 2 years of follow-up, compared to women with adequate vitamin D levels (hazard ratio [HR]: 1.43; 95% confidence intervals: [1.03-1.99]). The relationship between continuous vitamin D levels and risk of BMI less than 18 kg/m(2) during follow-up was inverse and linear (p=0.03). Women with low vitamin D levels had significantly higher incidence of acute upper respiratory infections (HR: 1.27 [1.04-1.54]) and thrush (HR: 2.74 [1.29-5.83]) diagnosed during the first 2 years of follow-up. Low vitamin D status was a significant risk factor for wasting and HIV-related complications such as thrush during follow-up in this prospective cohort in Tanzania. If these protective associations are confirmed in randomized trials, vitamin D supplementation could represent a simple and inexpensive method to improve health and quality of life of HIV-infected patients, particularly in resource-limited settings.
    MeSH term(s) AIDS-Related Opportunistic Infections/blood ; AIDS-Related Opportunistic Infections/epidemiology ; AIDS-Related Opportunistic Infections/etiology ; Adult ; Candidiasis, Oral/blood ; Candidiasis, Oral/epidemiology ; Candidiasis, Oral/etiology ; Dietary Supplements ; Disease Progression ; Double-Blind Method ; Female ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/physiopathology ; HIV Wasting Syndrome/blood ; HIV Wasting Syndrome/epidemiology ; Humans ; Pregnancy ; Pregnancy Complications, Infectious/blood ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/etiology ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Proportional Hazards Models ; Respiratory Tract Infections/blood ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology ; Tanzania/epidemiology ; Treatment Outcome ; Vitamin D/administration & dosage ; Vitamin D/blood ; Vitamins/administration & dosage ; Young Adult
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2011-09-14
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2011.0182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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