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  1. Article ; Online: Dead or alive: DEAD-box ATPases as regulators of ribonucleoprotein complex condensation.

    Weis, Karsten

    Biological chemistry

    2021  Volume 402, Issue 5, Page(s) 653–661

    Abstract: DEAD-box ATPase proteins are found in all clades of life and have been associated with a diverse array of RNA-processing reactions in eukaryotes, bacteria and archaea. Their highly conserved core enables them to bind RNA, often in an ATP-dependent manner. ...

    Abstract DEAD-box ATPase proteins are found in all clades of life and have been associated with a diverse array of RNA-processing reactions in eukaryotes, bacteria and archaea. Their highly conserved core enables them to bind RNA, often in an ATP-dependent manner. In the course of the ATP hydrolysis cycle, they undergo conformational rearrangements, which enable them to unwind short RNA duplexes or remodel RNA-protein complexes. Thus, they can function as RNA helicases or chaperones. However, when their conformation is locked, they can also clamp RNA and create ATP-dependent platforms for the formation of higher-order ribonucleoprotein complexes. Recently, it was shown that DEAD-box ATPases globally regulate the phase-separation behavior of RNA-protein complexes
    MeSH term(s) Adenosine Triphosphatases/metabolism ; DEAD-box RNA Helicases/metabolism ; Hydrolysis ; Models, Molecular ; Protein Conformation ; Ribonucleoproteins/metabolism
    Chemical Substances Ribonucleoproteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2021-04-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2020-0381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Nuclear transport

    Weis, Karsten

    (Results and problems in cell differentiation ; 35)

    2002  

    Author's details Karsten Weis (ed.)
    Series title Results and problems in cell differentiation ; 35
    Collection
    Keywords Eukaryontische Zelle ; Zellkern ; Proteintransport ; RNS ; Stofftransport
    Subject Transport ; Biologischer Transport ; Ribonucleinsäure ; Ribonukleinsäure ; RNA ; Ribonucleinsäuren ; Ribonukleinsäuren ; Karyon ; Kern ; Nucleus ; Nukleus ; Eukaryotische Zelle ; Proteine ; Proteintranslokation
    Language English
    Size XIII, 197 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013208264
    ISBN 3-540-42368-0 ; 978-3-540-42368-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 A 5366 order for loan Magazin

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  3. Article ; Online: The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates.

    Weis, Karsten / Hondele, Maria

    Annual review of biochemistry

    2022  Volume 91, Page(s) 197–219

    Abstract: DEAD-box ATPases constitute a very large protein family present in all cells, often in great abundance. From bacteria to humans, they play critical roles in many aspects of RNA metabolism, and due to their widespread importance in RNA biology, they have ... ...

    Abstract DEAD-box ATPases constitute a very large protein family present in all cells, often in great abundance. From bacteria to humans, they play critical roles in many aspects of RNA metabolism, and due to their widespread importance in RNA biology, they have been characterized in great detail at both the structural and biochemical levels. DEAD-box proteins function as RNA-dependent ATPases that can unwind short duplexes of RNA, remodel ribonucleoprotein (RNP) complexes, or act as clamps to promote RNP assembly. Yet, it often remains enigmatic how individual DEAD-box proteins mechanistically contribute to specific RNA-processing steps. Here, we review the role of DEAD-box ATPases in the regulation of gene expression and propose that one common function of these enzymes is in the regulation of liquid-liquid phase separation of RNP condensates.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; DEAD-box RNA Helicases/chemistry ; Gene Expression ; Humans ; RNA/metabolism
    Chemical Substances RNA (63231-63-0) ; Adenosine Triphosphatases (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-032620-105429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Liquid but not contactless.

    Kornmann, Benoît / Weis, Karsten

    Science (New York, N.Y.)

    2020  Volume 367, Issue 6477, Page(s) 507–508

    MeSH term(s) Endoplasmic Reticulum ; Mitochondrial Membranes
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aba3771
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  5. Article ; Online: [No title information]

    Damkjær, Mathias Weis / Hess, Søren / Gerke, Oke / Jørgensen, Karsten Juhl / Schroll, Jepppe B

    Ugeskrift for laeger

    2024  Volume 186, Issue 2

    Abstract: The issue of this review is diagnostic accuracy studies by means of which it can be determined how precisely a test can identify patients with or without a given target condition. Diagnostic accuracy studies vary substantially in design but usually ... ...

    Title translation Critical reading of scientific arcticles on diagnostic studies.
    Abstract The issue of this review is diagnostic accuracy studies by means of which it can be determined how precisely a test can identify patients with or without a given target condition. Diagnostic accuracy studies vary substantially in design but usually report outcome measures such as sensitivity and specificity. Diagnostic accuracy studies can be critically appraised by using QUADAS-2. Some study characteristics to consider is the avoidance of a case-control study design, patient selection, and the reference standard. Also, the statistical imprecision and the applicability of a study to a general population are essential factors to consider.
    MeSH term(s) Humans ; Case-Control Studies ; Sensitivity and Specificity
    Language Danish
    Publishing date 2024-01-08
    Publishing country Denmark
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    DOI 10.61409/V06230404
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  6. Article ; Online: Tailoring Vacancy Defects in Isolated Atomically Precise Silver Clusters through Mercury-Doped Intermediates.

    Chakraborty, Papri / Malola, Sami / Weis, Patrick / Neumaier, Marco / Schneider, Erik Karsten / Häkkinen, Hannu / Kappes, Manfred M

    The journal of physical chemistry letters

    2023  Volume 14, Issue 51, Page(s) 11659–11664

    Abstract: Vacancy defects are known to have significant effects on the physical and chemical properties of nanomaterials. However, the formation and structural dynamics of vacancy defects in atomically precise coinage metal clusters have hardly been explored due ... ...

    Abstract Vacancy defects are known to have significant effects on the physical and chemical properties of nanomaterials. However, the formation and structural dynamics of vacancy defects in atomically precise coinage metal clusters have hardly been explored due to the challenges associated with isolation of such defected clusters. Herein, we isolate [Ag
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02866
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  7. Article ; Online: Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity.

    Linsenmeier, Miriam / Hondele, Maria / Grigolato, Fulvio / Secchi, Eleonora / Weis, Karsten / Arosio, Paolo

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3030

    Abstract: Biomolecular condensates require suitable control of material properties for their function. Here we apply Differential Dynamic Microscopy (DDM) to probe the material properties of an in vitro model of processing bodies consisting of out-of-equilibrium ... ...

    Abstract Biomolecular condensates require suitable control of material properties for their function. Here we apply Differential Dynamic Microscopy (DDM) to probe the material properties of an in vitro model of processing bodies consisting of out-of-equilibrium condensates formed by the DEAD-box ATPase Dhh1 in the presence of ATP and RNA. By applying this single-droplet technique we show that condensates within the same population exhibit a distribution of material properties, which are regulated on several levels. Removal of the low-complexity domains (LCDs) of the protein decreases the fluidity of the condensates. Structured RNA leads to a larger fraction of dynamically arrested condensates with respect to unstructured polyuridylic acid (polyU). Promotion of the enzymatic ATPase activity of Dhh1 reduces aging of the condensates and the formation of arrested structures, indicating that biochemical activity and material turnover can maintain fluid-like properties over time.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Biomolecular Condensates ; DEAD-box RNA Helicases/metabolism ; RNA/genetics
    Chemical Substances RNA (63231-63-0) ; Adenosine Triphosphatases (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30521-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity

    Miriam Linsenmeier / Maria Hondele / Fulvio Grigolato / Eleonora Secchi / Karsten Weis / Paolo Arosio

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Here the authors analyze material properties and aging of active phase-separated condensates by Differential Dynamic Microscopy. Arrested states are promoted by structured RNA. Low-complexity domains and biochemical reaction keep the droplets fluid-like. ...

    Abstract Here the authors analyze material properties and aging of active phase-separated condensates by Differential Dynamic Microscopy. Arrested states are promoted by structured RNA. Low-complexity domains and biochemical reaction keep the droplets fluid-like.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Membraneless organelles: phasing out of equilibrium.

    Hondele, Maria / Heinrich, Stephanie / De Los Rios, Paolo / Weis, Karsten

    Emerging topics in life sciences

    2020  Volume 4, Issue 3, Page(s) 331–342

    Abstract: Over the past years, liquid-liquid phase separation (LLPS) has emerged as a ubiquitous principle of cellular organization implicated in many biological processes ranging from gene expression to cell division. The formation of biological condensates, like ...

    Abstract Over the past years, liquid-liquid phase separation (LLPS) has emerged as a ubiquitous principle of cellular organization implicated in many biological processes ranging from gene expression to cell division. The formation of biological condensates, like the nucleolus or stress granules, by LLPS is at its core a thermodynamic equilibrium process. However, life does not operate at equilibrium, and cells have evolved multiple strategies to keep condensates in a non-equilibrium state. In this review, we discuss how these non-equilibrium drivers counteract solidification and potentially detrimental aggregation, and at the same time enable biological condensates to perform work and control the flux of substrates and information in a spatial and temporal manner.
    MeSH term(s) Cell Nucleolus ; Gene Expression ; Organelles ; Thermodynamics
    Language English
    Publishing date 2020-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20190190
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  10. Article ; Online: Disconnected Cardiac Autonomic Nerves in Genetic Ganglionic Acetylcholine Receptor Alpha-3 Subunit Deficiency.

    Heusser, Karsten / Erger, Florian / Ebner, Ulrich / Namer, Barbara / Eisenhofer, Graeme / Haensch, Carl-Albrecht / Weis, Henning / Schmidt, Matthias / Drzezga, Alexander / Tank, Jens / Netzer, Christian / Jordan, Jens

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 8, Page(s) e137–e139

    MeSH term(s) Humans ; Receptors, Cholinergic ; Heart ; Autonomic Nervous System Diseases ; Autonomic Pathways ; Autoantibodies
    Chemical Substances Receptors, Cholinergic ; Autoantibodies
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21172
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