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  1. Article ; Online: Two different right ventricular pacing waveforms.

    Komatsu, Toshinori / Okada, Ayako / Kuwahara, Koichiro

    European heart journal. Case reports

    2024  Volume 8, Issue 3, Page(s) ytae119

    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae119
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  2. Article ; Online: Response.

    Tashiro, Hiroki / Kuwahara, Yuki / Takahashi, Koichiro / Sueoka-Aragane, Naoko

    Chest

    2024  Volume 163, Issue 6, Page(s) e286

    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.02.013
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  3. Article ; Online: The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications.

    Kuwahara, Koichiro

    Pharmacology & therapeutics

    2021  Volume 227, Page(s) 107863

    Abstract: Natriuretic peptides, which are activated in heart failure, play an important cardioprotective role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are ... ...

    Abstract Natriuretic peptides, which are activated in heart failure, play an important cardioprotective role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are abundantly expressed and secreted in the atrium and ventricles, respectively, and C-type natriuretic peptide (CNP), which is expressed mainly in the vasculature, central nervous system, and bone. ANP and BNP exhibit antagonistic effects against angiotensin II via diuretic/natriuretic actions, vasodilatory actions, and inhibition of aldosterone secretion, whereas CNP is involved in the regulation of vascular tone and blood pressure, among other roles. ANP and BNP are of particular interest with respect to heart failure, as their levels, most notably BNP and N-terminal proBNP-a cleavage product produced when proBNP is processed to mature BNP-are increased in patients with heart failure. Furthermore, the identification of natriuretic peptides as sensitive markers of cardiac load has driven significant research into their physiological roles in cardiovascular homeostasis and disease, as well as their potential use as both biomarkers and therapeutics. In this review, I discuss the physiological functions of the natriuretic peptide family, with a particular focus on the basic research that has led to our current understanding of its roles in maintaining cardiovascular homeostasis, and the pathophysiological implications for the onset and progression of heart failure. The clinical significance and potential of natriuretic peptides as diagnostic and/or therapeutic agents are also discussed.
    MeSH term(s) Biomarkers/blood ; Cardiotonic Agents/therapeutic use ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Natriuretic Peptides/blood ; Natriuretic Peptides/therapeutic use
    Chemical Substances Biomarkers ; Cardiotonic Agents ; Natriuretic Peptides
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2021.107863
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  4. Article ; Online: Successful Management of a Pregnant Patient with Danon Cardiomyopathy.

    Inoue, Wataru / Motoki, Hirohiko / Yoshie, Koji / Kuwahara, Koichiro

    Internal medicine (Tokyo, Japan)

    2024  Volume 63, Issue 5, Page(s) 681–686

    Abstract: A 25-year-old woman with left ventricular (LV) dysfunction became pregnant during the diagnostic period. Decompensated heart failure with frequent ventricular arrhythmias necessitated hospitalization in the 21st week of pregnancy. Under careful ... ...

    Abstract A 25-year-old woman with left ventricular (LV) dysfunction became pregnant during the diagnostic period. Decompensated heart failure with frequent ventricular arrhythmias necessitated hospitalization in the 21st week of pregnancy. Under careful monitoring, diuretics and sotalol were added to her ongoing treatment of carvedilol and spironolactone due to the risk of hemodynamic collapse. An emergency cesarean section was performed in the 32nd week after the detection of rapid nonsustained ventricular tachycardia. Subsequent genetic testing revealed that the LV dysfunction was associated with Danon cardiomyopathy. This case highlights the importance of careful pregnancy management with LV dysfunction along with early genetic testing.
    MeSH term(s) Female ; Pregnancy ; Humans ; Adult ; Cesarean Section ; Cardiomyopathies/complications ; Cardiomyopathies/drug therapy ; Heart Failure/drug therapy ; Heart Failure/etiology ; Carvedilol/therapeutic use ; Ventricular Dysfunction, Left
    Chemical Substances Carvedilol (0K47UL67F2)
    Language English
    Publishing date 2024-03-01
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1673-23
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  5. Article: NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond.

    Inazumi, Hideaki / Kuwahara, Koichiro

    Biology

    2022  Volume 11, Issue 8

    Abstract: Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP ... ...

    Abstract Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP have revealed the involvement of numerous transcriptional factors in the regulation of the fetal cardiac gene program. Among these, we identified that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also named repressor element-1-silencing transcription factor (REST), which was initially detected as a transcriptional repressor of neuron-specific genes in non-neuronal cells, plays a pivotal role in the transcriptional regulation of ANP, BNP and other fetal cardiac genes. Here we review the transcriptional regulation of ANP and BNP gene expression and the role of the NRSF repressor complex in the regulation of cardiac gene expression and the maintenance of cardiac homeostasis.
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11081197
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  6. Article ; Online: NRSF/REST-Mediated Epigenomic Regulation in the Heart

    Hideaki Inazumi / Koichiro Kuwahara

    Biology, Vol 11, Iss 8, p

    Transcriptional Control of Natriuretic Peptides and Beyond

    2022  Volume 1197

    Abstract: Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP ... ...

    Abstract Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP have revealed the involvement of numerous transcriptional factors in the regulation of the fetal cardiac gene program. Among these, we identified that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also named repressor element-1-silencing transcription factor (REST), which was initially detected as a transcriptional repressor of neuron-specific genes in non-neuronal cells, plays a pivotal role in the transcriptional regulation of ANP, BNP and other fetal cardiac genes. Here we review the transcriptional regulation of ANP and BNP gene expression and the role of the NRSF repressor complex in the regulation of cardiac gene expression and the maintenance of cardiac homeostasis.
    Keywords heart failure ; natriuretic peptides ; transcription factors ; epigenetics ; epigenome ; Biology (General) ; QH301-705.5
    Subject code 570 ; 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  7. Article ; Online: Periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention.

    Ueki, Yasushi / Kuwahara, Koichiro

    Journal of cardiology

    2022  Volume 81, Issue 4, Page(s) 364–372

    Abstract: Percutaneous coronary intervention (PCI) in addition to guideline-directed medical therapy reduces the risk of spontaneous myocardial infarction (MI), urgent revascularization, and improves angina status; however, PCI is associated with an increased risk ...

    Abstract Percutaneous coronary intervention (PCI) in addition to guideline-directed medical therapy reduces the risk of spontaneous myocardial infarction (MI), urgent revascularization, and improves angina status; however, PCI is associated with an increased risk of periprocedural myocardial injury and MI. Numerous studies have investigated the mechanisms, predictors, and therapeutic strategies for periprocedural MI. Various definitions of periprocedural MI have been proposed by academic groups and professional societies requiring different cardiac biomarker thresholds and ancillary criteria for myocardial ischemia. The frequency and clinical significance of periprocedural MI substantially varies according to the definitions applied. In daily practice, accurate diagnosis of clinically-relevant periprocedural MI is essential because it may have a substantial impact on subsequent patient management. In the clinical trial setting, only clinically relevant periprocedural MI definitions should be applied as a clinical endpoint in order to avoid obscuring meaningful outcomes. In this review, we aim to summarize the mechanisms, predictors, frequency, and prognostic impact of periprocedural MI in patients undergoing PCI and to provide the current perspective on this issue.
    MeSH term(s) Humans ; Percutaneous Coronary Intervention/adverse effects ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Myocardial Infarction/diagnosis ; Coronary Artery Disease/complications ; Myocardial Ischemia/complications ; Angina Pectoris ; Treatment Outcome ; Risk Factors
    Language English
    Publishing date 2022-11-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2022.11.005
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    Zs.A 1794: Show issues Location:
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  8. Article ; Online: Impact of obesity in asthma: Possible future therapies.

    Tashiro, Hiroki / Kurihara, Yuki / Kuwahara, Yuki / Takahashi, Koichiro

    Allergology international : official journal of the Japanese Society of Allergology

    2023  Volume 73, Issue 1, Page(s) 48–57

    Abstract: Obesity is one of the factors associated with the severity of asthma. Obesity is associated with aggravation of the pathophysiology of asthma, including exacerbations, airway inflammation, decreased pulmonary function, and airway hyperresponsiveness. The ...

    Abstract Obesity is one of the factors associated with the severity of asthma. Obesity is associated with aggravation of the pathophysiology of asthma, including exacerbations, airway inflammation, decreased pulmonary function, and airway hyperresponsiveness. The present review addresses the characteristics of asthma with obesity, focusing especially on the heterogeneity caused by the degree of type 2 inflammation, sex differences, the onset of asthma, and race differences. To understand the severity mechanisms in asthma and obesity, such as corticosteroid resistance, fatty acids, gut microbiome, and cytokines, several basic research studies are evaluated. Finally, possible future therapies, including weight reduction, microbiome-targeted therapies, and other molecular targeted therapies are addressed. We believe that the present review will contribute to better understanding of the severity mechanisms and the establishment of novel treatments for severe asthma patients with obesity.
    MeSH term(s) Humans ; Female ; Male ; Asthma/epidemiology ; Asthma/therapy ; Asthma/etiology ; Obesity/complications ; Respiratory Hypersensitivity ; Cytokines ; Inflammation
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2023.08.007
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  9. Article ; Online: Recommendation for Appropriate Use of Sodium Glucose Cotransporter 2 Inhibitors in Treatment of Heart Failure.

    Tanaka, Atsushi / Kinugawa, Koichiro / Kuwahara, Koichiro / Ito, Hiroshi / Murohara, Toyoaki / Hirata, Ken-Ichi / Node, Koichi

    Circulation journal : official journal of the Japanese Circulation Society

    2023  Volume 87, Issue 11, Page(s) 1707–1709

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Heart Failure/drug therapy ; Canagliflozin
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Canagliflozin (0SAC974Z85)
    Language English
    Publishing date 2023-09-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-23-0605
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  10. Article ; Online: Gigantic Pacemaker Pocket Abscess Infected by Staphylococcus epidermidis.

    Okano, Takahiro / Okada, Ayako / Shoda, Morio / Kuwahara, Koichiro

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 4, Page(s) 593–594

    MeSH term(s) Abscess/diagnostic imaging ; Humans ; Pacemaker, Artificial/adverse effects ; Staphylococcal Infections/diagnosis ; Staphylococcus epidermidis
    Language English
    Publishing date 2022-02-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8035-21
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