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  1. Article ; Online: The Yun/Prohibitin complex regulates adult

    Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ren, Xuejing / Ma, Rui / Jia, Lemei / Ma, Meifang / Lu, Shan / Xu, Ran / Binari, Richard / Wang, Jian-Hua / Dong, Meng-Qiu / Perrimon, Norbert / Li, Zhouhua

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 6

    Abstract: Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, ... ...

    Abstract Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult
    MeSH term(s) Adult Stem Cells/metabolism ; Animals ; Animals, Genetically Modified ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; E2F1 Transcription Factor/metabolism ; Homeostasis/physiology ; Intestines/metabolism ; Prohibitins/metabolism ; RNA Interference/physiology ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; E2F1 Transcription Factor ; Prohibitins
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2111711119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis.

    Ren, Xuejing / Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ma, Rui / Jia, Lemei / Lu, Shan / Wang, Jian-Hua / Dong, Meng-Qiu / Wang, Yingchun / Li, Zhouhua

    Cell proliferation

    2022  Volume 55, Issue 5, Page(s) e13230

    Abstract: ... understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation ... of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun ... among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important ...

    Abstract Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post-translational modification of Yun in stem cell proliferation.
    MeSH term(s) Adult ; Cell Proliferation ; Cell Transformation, Neoplastic ; Drosophila Proteins/metabolism ; Humans ; Intestines ; Phosphorylation
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064202-x
    ISSN 1365-2184 ; 0008-8730 ; 0960-7722
    ISSN (online) 1365-2184
    ISSN 0008-8730 ; 0960-7722
    DOI 10.1111/cpr.13230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 532: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Efficacy of Yun-type pelvic floor optimal training therapy and PFMT on middle aged women with mild to moderate overactive bladder: a randomized controlled trial.

    Wang, Yangyun / Shi, Chaoliang / Wang, Jiawei / Shi, Guowei

    Annals of translational medicine

    2022  Volume 10, Issue 14, Page(s) 796

    Abstract: ... reconstruction training method [Yun-type pelvic floor optimal training (Yun-type training)] for OAB patients ... to moderate OAB. Patients were randomly assigned to receive Yun-type training (n=83) or PFMT (n=67 ... The intervention group was first given Yun-type training for 6 weeks, then switched to PFMT for 6 weeks after 2 ...

    Abstract Background: The symptoms of overactive bladder (OAB) are highly bothersome to patients. In behavioral therapy, traditional pelvic floor muscle training (PFMT) can be boring and monotonous, which can cause poor compliance. It's important to establish a new safe and effective crotch-pelvic floor functional reconstruction training method [Yun-type pelvic floor optimal training (Yun-type training)] for OAB patients.
    Methods: This randomized, double-blind, crossover trial recruited a total of 150 women with mild to moderate OAB. Patients were randomly assigned to receive Yun-type training (n=83) or PFMT (n=67). The intervention group was first given Yun-type training for 6 weeks, then switched to PFMT for 6 weeks after 2 weeks of elution. Patients in the control group were first treated with PFMT for 6 weeks, and changed to the use of Yun-type training for 6 weeks after 2 weeks of elution. The primary endpoint was overactive bladder symptom scores (OABSS) after 6 and 14 weeks of Yun-type training and PFMT.
    Results: Yun-type training could significantly improve OABSS compared with PFMT after 6 and 14 weeks (P<0.001). Yun-type training was associated with an improvement in urine, urgency, urge urinary incontinence (UUI), urogenital distress inventory-6 (UDI-6), patient's perception of bladder condition (PPBC), voiding volume (VV), incontinence impact questionnaire-7 (IIQ-7), female sexual function index (FSFI), sexual desire, arousal, pain, satisfaction, pelvic floor muscle tone, type I muscle strength, type II muscle strength, and sex partner satisfaction as compared with PFMT after 6 and 14 weeks. Moreover, nocturia, maximum flow rate (Q
    Conclusions: Yun-type training could yield additional benefits on OAB symptoms, sexual function, and sex partner satisfaction as compared with PFMT. The superior sexual function resulting from Yun-type training can be explained by the fact that it can contract deep and superficial muscle layers, resulting in increased vaginal wall pressure and blood flow, which further improves FSFI and sex partner satisfaction. It could lead to a new non-invasive treatment for OAB patients.
    Trial registration: Chinese Clinical Trial Registry ChiCTR-INR-17012192.
    Language English
    Publishing date 2022-07-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-3357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter by Lei Wang and Yun-Tao Zhao Regarding Article, "Young Male With Incessantly Wide Complex Tachycardia: What Is the Substrate of the Arrhythmia?"

    Wang, Lei / Zhao, Yun-Tao

    Circulation

    2018  Volume 138, Issue 2, Page(s) 211

    MeSH term(s) Arrhythmias, Cardiac ; Humans ; Male ; Tachycardia
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.034580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Erratum: PING PENG, DAYOU ZHAI, ROBIN J. SMITH, QIANWEI WANG, YUN GUO amp; LIPING ZHU (2021) On some modern Ostracoda (Crustacea) from the Tibetan Plateau in SW China, with descriptions of three new species. Zootaxa/, 4942: 501-542.

    Peng, Ping / Zhai, Dayou / Smith, Robin J / Wang, Qianwei / Guo, Yun / Zhu, Liping

    Zootaxa

    2021  Volume 4964, Issue 3, Page(s) zootaxa.4964.3.11

    Language English
    Publishing date 2021-04-23
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4964.3.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Efficacy of Yun-Type Optimized Pelvic Floor Training Therapy for Middle-Aged Women With Severe Overactive Bladder: A Randomized Clinical Trial.

    Shi, Chaoliang / Zhou, Dan / Yu, Wandong / Jiao, Wei / Shi, Guowei / Wang, Yangyun

    Frontiers in surgery

    2021  Volume 8, Page(s) 670123

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2021.670123
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  7. Article ; Online: Application of the Deep Neural Network in Retrieving the Atmospheric Temperature and Humidity Profiles from the Microwave Humidity and Temperature Sounder Onboard the Feng-Yun-3 Satellite.

    He, Qiurui / Wang, Zhenzhan / Li, Jiaoyang

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 14

    Abstract: The shallow neural network (SNN) is a popular algorithm in atmospheric parameters retrieval from microwave remote sensing. However, the deep neural network (DNN) has a stronger nonlinear mapping capability compared to SNN and has great potential for ... ...

    Abstract The shallow neural network (SNN) is a popular algorithm in atmospheric parameters retrieval from microwave remote sensing. However, the deep neural network (DNN) has a stronger nonlinear mapping capability compared to SNN and has great potential for applications in microwave remote sensing. The Microwave Humidity and Temperature Sounder (Beijing, China, MWHTS) onboard the Fengyun-3 (FY-3) satellite has the ability to independently retrieve atmospheric temperature and humidity profiles. A study on the application of DNN in retrieving atmospheric temperature and humidity profiles from MWHTS was carried out. Three retrieval schemes of atmospheric parameters in microwave remote sensing based on DNN were performed in the study of bias correction of MWHTS observation and the retrieval of the atmospheric temperature and humidity profiles using MWHTS observations. The experimental results show that, compared with SNN, DNN can obtain better bias-correction results when applied to MWHTS observation, and can obtain higher retrieval accuracy of temperature and humidity profiles in all three retrieval schemes. Meanwhile, DNN shows higher stability than SNN when applied to the retrieval of temperature and humidity profiles. The comparative study of DNN and SNN applied in different atmospheric parameter retrieval schemes shows that DNN has a more superior performance.
    MeSH term(s) China ; Humidity ; Microwaves ; Neural Networks, Computer ; Temperature
    Language English
    Publishing date 2021-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21144673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

    Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

    Zootaxa

    2022  Volume 5115, Issue 4, Page(s) 600

    Language English
    Publishing date 2022-03-16
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5115.4.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retrieval of the vertical evolution of the cloud effective radius from the Chinese FY-4 (Feng Yun 4) next-generation geostationary satellites

    Y. Chen / G. Chen / C. Cui / A. Zhang / R. Wan / S. Zhou / D. Wang / Y. Fu

    Atmospheric Chemistry and Physics, Vol 20, Pp 1131-

    2020  Volume 1145

    Abstract: ... meteorological satellites (FY-4A, Feng Yun 4), we established a new method for objectively obtaining the vertical ...

    Abstract The vertical evolution of the cloud effective radius ( R e ) reflects the precipitation-forming process. Based on observations from the first Chinese next-generation geostationary meteorological satellites (FY-4A, Feng Yun 4), we established a new method for objectively obtaining the vertical temperature vs. R e profile. First of all, R e was calculated using a bispectral lookup table. Then, cloud clusters were objectively identified using the maximum temperature gradient method. Finally, the R e profile in a certain cloud was then obtained by combining these two sets of data. Compared with the conventional method used to obtain the R e profile from the subjective division of a region, objective cloud-cluster identification establishes a unified standard, increases the credibility of the R e profile, and facilitates the comparison of different R e profiles. To investigate its performance, we selected a heavy precipitation event from the Integrative Monsoon Frontal Rainfall Experiment in summer 2018. The results showed that the method successfully identified and tracked the cloud cluster. The R e profile showed completely different morphologies in different life stages of the cloud cluster, which is important in the characterization of the formation of precipitation and the temporal evolution of microphysical processes.
    Keywords Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 290
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Comparison and Interpretation of Taxonomical Structure of Bacterial Communities in Two Types of Lakes on Yun-Gui plateau of China.

    Han, Maozhen / Gong, Yanhai / Zhou, Chunyu / Zhang, Junqian / Wang, Zhi / Ning, Kang

    Scientific reports

    2016  Volume 6, Page(s) 30616

    Abstract: ... on Yun-Gui plateau of China, Lake Dianchi and Lake Haixihai, and analyzed the bacterial community ...

    Abstract Bacterial communities from freshwater lakes are shaped by various factors such as nutrients, pH value, temperature, etc. Their compositions and relative abundances would undergo changes to adapt the changing environments, and in turn could affect the environments of freshwater lakes. Analyses of the freshwater lake's bacterial communities under different environments would be of pivotal importance to monitor the condition of waterbody. In this study, we have collected freshwater samples from two lakes on Yun-Gui plateau of China, Lake Dianchi and Lake Haixihai, and analyzed the bacterial community structures from these samples based on 16S rRNA sequencing. Results have shown that: Firstly, the bacterial community of these samples have very different taxonomical structures, not only between two lakes but also among the intra-groups for samples collected from Dianchi. Secondly, the differences between samples from two lakes are highly associated with the chemical-geographical properties of the two lakes. Thirdly, for samples of Dianchi and Haixihai, analytical results of physicochemical, taxonomical structure and relative abundance of community revealed that extreme physicochemical factors caused by human activities have strongly affected the bacterial ecosystem in Dianchi. These results have clearly indicated the importance of combining biological profiling and chemical-geographical properties for monitoring Chinese plateau freshwater bacterial ecosystem, which could provide clues for Chinese freshwater ecosystem remediation on plateau.
    Language English
    Publishing date 2016-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep30616
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