Article ; Online: Myasthenia gravis associated with a pelvic follicular lymphoma.
BMJ case reports
2022 Volume 15, Issue 1
Abstract: An 81-year-old woman presented with neck weakness, dysarthria, dysphasia and left-sided ptosis. Myasthenia gravis (MG) was strongly suspected. Voltage gated calcium channel (VGCC) antibodies, associated with Lambert-Eaton myasthenic syndrome (LEMS), were ...
Abstract | An 81-year-old woman presented with neck weakness, dysarthria, dysphasia and left-sided ptosis. Myasthenia gravis (MG) was strongly suspected. Voltage gated calcium channel (VGCC) antibodies, associated with Lambert-Eaton myasthenic syndrome (LEMS), were negative. Acetylcholine receptor (AChR) antibody level was 536 nmol/L and diagnosis of MG was confirmed. Imaging revealed a pelvic mass and subsequent biopsy confirmed a pelvic follicular lymphoma. Our searches revealed this to be the first documented case of MG associated with a pelvic follicular lymphoma. She underwent radiotherapy to treat the lymphoma and received both pyridostigmine and immunosuppression to treat the MG. Her AChR antibody level decreased to 38 nmol/L and her MG symptoms resolved aside from head drop which is continuing to improve. Her lymphoma is now in remission. We have presented a case with a successful outcome, which highlights the importance of screening for lymphoma and thymoma in new presentations of MG. |
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MeSH term(s) | Aged, 80 and over ; Autoantibodies ; Female ; Humans ; Lambert-Eaton Myasthenic Syndrome ; Lymphoma, Follicular/complications ; Lymphoma, Follicular/diagnosis ; Myasthenia Gravis/complications ; Myasthenia Gravis/diagnosis ; Thymus Neoplasms |
Chemical Substances | Autoantibodies |
Language | English |
Publishing date | 2022-01-13 |
Publishing country | England |
Document type | Case Reports ; Journal Article |
ISSN | 1757-790X |
ISSN (online) | 1757-790X |
DOI | 10.1136/bcr-2021-248011 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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