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  1. Article: [Direct True Lumen Cannulation in the Ascending Aorta During Stanford Type A Acute Aortic Dissection Repair:Report of a Case].

    Yamamoto, Nobuyuki / Nie, Masaki / Sakaki, Kenjiro / Toyoda, Makoto

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 9, Page(s) 711–713

    Abstract: A 51 years-old male with sudden onset of chest and back pain was referred to our hospital from another hospital. Contrast-enhanced computed tomography( CT) revealed the presence of Stanford type A acute aortic dissection with critically narrow true lumen ...

    Abstract A 51 years-old male with sudden onset of chest and back pain was referred to our hospital from another hospital. Contrast-enhanced computed tomography( CT) revealed the presence of Stanford type A acute aortic dissection with critically narrow true lumen in the ascending aorta. Then, emergency surgery was performed. One umbilical tape tourniquet was placed around the ascending aorta. A vent tube was inserted into the main pulmonary artery. A venous drainage cannula was inserted into the right atrium. In the head-down position, pulmonary artery venting and venous drainage were initiated. As the blood puressure fell down around 40 mmHg, the ascending aorta was incised. A cannula (DLP 24 Fr) was placed in the true lumen and the aorta was snared. Cardiopulmonary bypass was established followed by selective antegrade cardioplegia, and systemic cooling. An entry was found in the ascending aorta, so ascending aorta graft replacement was performed under selective antegrade cerebral perfusion. There were no perioperative complications, and he was discharged home on 24th postoperative day. There is still remain controversies as to the optimal arterial cannulation site for cardiopulmonary bypass in patients with Stanford type A aortic dissection. We think the ascending aorta is most simply, rapidly and reliably available. In this case, direct true lumen cannulation in the ascending aorta was useful.
    MeSH term(s) Humans ; Male ; Middle Aged ; Aorta, Thoracic ; Aorta/diagnostic imaging ; Aorta/surgery ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/surgery ; Cannula ; Catheterization
    Language Japanese
    Publishing date 2023-09-21
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Giant Right Coronary Artery Aneurysm Complicated by Acute Myocardial Infarction:Report of a Case].

    Sakaki, Kenjiro / Hanayama, Naoji

    Kyobu geka. The Japanese journal of thoracic surgery

    2021  Volume 74, Issue 7, Page(s) 550–553

    Abstract: The patient was a 45-year-old man who was transported by ambulance to a nearby clinic owing to sudden chest pain. He was diagnosed with myocardial infarction and giant coronary artery aneurysm by coronary arteriogram and underwent an emergency ... ...

    Abstract The patient was a 45-year-old man who was transported by ambulance to a nearby clinic owing to sudden chest pain. He was diagnosed with myocardial infarction and giant coronary artery aneurysm by coronary arteriogram and underwent an emergency intervention for the myocardial infarction. The patient was referred to our hospital. Intraoperative findings showed the mass-like right coronary artery aneurysm at the anterior to the right atrium. The origin of the right coronary artery was ligated in addition to the fenestration and the proximal and distal regions of the coronary artery aneurysm. It has been reported that coronary artery aneurysms are usually asymptomatic and are often discovered by chance during screenings, such as echocardiography, computed tomography, and coronary arteriogram. Here, we report a surgical case of giant right coronary artery aneurysm complicated by acute myocardial infarction.
    MeSH term(s) Coronary Aneurysm/complications ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/surgery ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Echocardiography ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications
    Language Japanese
    Publishing date 2021-07-01
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Detachment of a prosthetic valve due to infective endocarditis caused by

    Nakamura, Saori / Hanayama, Naoji / Matushita, Hiroshi / Sakaki, Kenjiro

    Clinical case reports

    2020  Volume 8, Issue 8, Page(s) 1357–1360

    Abstract: The incidence of infective endocarditis (IE) due ... ...

    Abstract The incidence of infective endocarditis (IE) due to
    Language English
    Publishing date 2020-07-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Stanford Type A Acute Aortic Dissection Complicated with Intestinal Ischemia Preceded by Superior Mesenteric Artery Bypass:Report of a Case].

    Sakaki, Kenjiro / Onishi, Yoshihiko / Toyoda, Makoto / Yamamoto, Nobuyuki / Shibata, Ko / Nie, Masaki / Ohara, Kuniyoshi

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 5, Page(s) 375–378

    Abstract: A 78-year-old male with sudden onset of chest and back pain was transported to our institution by ambulance. Upon arrival at our hospital, he also complained of abdominal pain. Contrast-enhanced computed tomography (CT) revealed the presence of Stanford ... ...

    Abstract A 78-year-old male with sudden onset of chest and back pain was transported to our institution by ambulance. Upon arrival at our hospital, he also complained of abdominal pain. Contrast-enhanced computed tomography (CT) revealed the presence of Stanford type A acute aortic dissection complicated with intestinal ischemia;because of the effects of aortic dissection, the superior mesenteric artery 378 Vol.76 No.5(2023-5) (SMA) was obstructed, leading to the complication of intestinal ischemia. An arterial blood gas test showed elevated lactate and metabolic acidosis. We immediately performed resection of the necrotic portion of the intestine and bypass of the common iliac artery to the SMA. Subsequently, after confirmation of the improvement of acidosis, ascending aortic replacement was performed on the same day. Although the patient's condition was complicated by acute kidney injury and pneumonia, he was discharged home on the 55th postoperative day. Acute aortic dissection complicated by intestinal ischemia has a poor prognosis;however, here we reported a life-saving surgical procedure in a patient with this presentation.
    MeSH term(s) Male ; Humans ; Aged ; Mesenteric Artery, Superior ; Aortic Dissection/complications ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/surgery ; Mesenteric Ischemia/diagnostic imaging ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/surgery ; Aorta, Abdominal ; Ischemia/etiology ; Ischemia/surgery
    Language Japanese
    Publishing date 2023-05-08
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Metastatic Right Atrial Tumor of Renal Cell Carcinoma:Report of a Case].

    Onishi, Yoshihiko / Sakaki, Kenjiro / Toyoda, Makoto / Yamamoto, Nobuyuki / Shibata, Ko / Nie, Masaki / Ohara, Kuniyoshi

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 8, Page(s) 652–655

    Abstract: Metastatic cardiac tumors are known to be more common than primary cardiac tumors, and most patients are asymptomatic. In patients with renal cell carcinoma (RCC) with cardiac metastases, total tumor resection is known to improve the prognosis. We report ...

    Abstract Metastatic cardiac tumors are known to be more common than primary cardiac tumors, and most patients are asymptomatic. In patients with renal cell carcinoma (RCC) with cardiac metastases, total tumor resection is known to improve the prognosis. We report a case of a successfully resected RCC with right atrial metastasis under cardiopulmonary bypass. A 71-year-old female with abdominal distention was diagnosed with right RCC and extension to the right atrium. After neoadjuvant chemotherapy, she underwent right nephrectomy and neiection of intraocular tumor extention with partial right atrium under cardiopulmonary bypass, because the tumor tightly adhered to the right atrium. She had a good postoperative course and was discharged home on the 22nd postoperative day. Nine months after surgery, she shows no sign of recurrence.
    MeSH term(s) Female ; Humans ; Aged ; Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/pathology ; Atrial Fibrillation/surgery ; Vena Cava, Inferior/pathology ; Vena Cava, Inferior/surgery ; Heart Atria/surgery ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Heart Neoplasms/pathology ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Nephrectomy
    Language Japanese
    Publishing date 2023-07-27
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Stanford Type A Acute Aortic Dissection in a Patient with a Single Coronary Artery:Report of a Case].

    Sakaki, Kenjiro / Nie, Masaki / Ohara, Kuniyoshi

    Kyobu geka. The Japanese journal of thoracic surgery

    2021  Volume 74, Issue 8, Page(s) 620–622

    Abstract: A single coronary artery is a very rare anomaly and is usually asymptomatic. Here we report a case of a single coronary artery complicated with Stanford type A acute aortic dissection. A 58-year-old male with chest pain was transported to our institution ...

    Abstract A single coronary artery is a very rare anomaly and is usually asymptomatic. Here we report a case of a single coronary artery complicated with Stanford type A acute aortic dissection. A 58-year-old male with chest pain was transported to our institution by ambulance. He was diagnosed with a single coronary artery accompanied by acute coronary syndrome. The single coronary artery originated from the left sinus of Valsalva and the right coronary branch coursed between the aorta and the pulmonary artery. It was, therefore considered difficult to perform catheter intervention, and urgent coronary artery bypass surgery was planned. Enhanced computed tomography, however, revealed Stanford type A acute aortic dissection, and aortic root replacement combined with coronary artery bypass grafting was performed by emergency. The postoperative course was uneventful.
    MeSH term(s) Aneurysm, Dissecting/complications ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Aorta ; Coronary Artery Bypass ; Coronary Artery Disease ; Humans ; Male ; Middle Aged
    Language Japanese
    Publishing date 2021-08-01
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detachment of a prosthetic valve due to infective endocarditis caused by Streptococcus pneumoniae

    Saori Nakamura / Naoji Hanayama / Hiroshi Matushita / Kenjiro Sakaki

    Clinical Case Reports, Vol 8, Iss 8, Pp 1357-

    2020  Volume 1360

    Abstract: Abstract The incidence of infective endocarditis (IE) due to S pneumoniae has decreased, thanks to antibiotics. However, when it does occur, it can be lethal. The present case provides a reminder of the potential lethality of this postoperative infection. ...

    Abstract Abstract The incidence of infective endocarditis (IE) due to S pneumoniae has decreased, thanks to antibiotics. However, when it does occur, it can be lethal. The present case provides a reminder of the potential lethality of this postoperative infection.
    Keywords aortic valve replacement ; cardiac surgery ; prosthetic valve endocarditis ; Streptococcus pneumoniae infection ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Interaction between quality control systems for ER protein folding and RNA biogenesis.

    Sakaki, Kenjiro / Kaufman, Randal J

    Worm

    2013  Volume 2, Issue 2, Page(s) e23005

    Abstract: The endoplasmic reticulum (ER) is the intracellular organelle responsible for the synthesis, folding and assembly of proteins destined for secretion and the endomembrane system of the cell. ER quality control (ERQC) is an intensively studied surveillance ...

    Abstract The endoplasmic reticulum (ER) is the intracellular organelle responsible for the synthesis, folding and assembly of proteins destined for secretion and the endomembrane system of the cell. ER quality control (ERQC) is an intensively studied surveillance mechanism that selectively degrades misfolded proteins to ensure that only properly folded proteins exit the ER en route to the Golgi compartment. Proper protein folding is indispensable for the differentiation and function of cells that secrete high levels of protein and defects in protein folding are implicated in many pathologies, including metabolic, genetic, neurodegenerative and inflammatory diseases. Accumulation of misfolded proteins in the ER activates an adaptive set of signaling pathways, collectively known as the unfolded protein response (UPR), to resolve protein misfolding and restore ER homeostasis. Nonsense-mediated RNA decay (NMD) is an RNA surveillance system that selectively degrades nascent mRNAs containing premature termination codons (PTCs). Recently, we used a genetic screen to identify genes that interact with UPR signaling in C. elegans. These studies identified NMD-associated genes that are required for ER protein folding homeostasis. These findings link the quality control systems required for ER protein folding and RNA biogenesis, provide new insights into mechanisms of ERQC and have implications on diseases of ER dysfunction and therapeutic approaches based on NMD inhibition. Here, we discuss the biological significance of these findings and future directions for study.
    Language English
    Publishing date 2013-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682460-7
    ISSN 2162-4054 ; 2162-4046
    ISSN (online) 2162-4054
    ISSN 2162-4046
    DOI 10.4161/worm.23005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery.

    Sakaki, Kenjiro / Kitamura, Tadashi / Kohira, Satoshi / Torii, Shinzo / Mishima, Toshiaki / Hanayama, Naoji / Kobayashi, Kensuke / Ohkubo, Hirotoki / Miyaji, Kagami

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

    2020  Volume 23, Issue 4, Page(s) 315–320

    Abstract: Cardiopulmonary bypass-associated acute kidney injury may appear postoperatively, but predictive factors are unclear. We investigated the potential of regional tissue oxygen saturation as a predictor of cardiopulmonary bypass-associated acute kidney ... ...

    Abstract Cardiopulmonary bypass-associated acute kidney injury may appear postoperatively, but predictive factors are unclear. We investigated the potential of regional tissue oxygen saturation as a predictor of cardiopulmonary bypass-associated acute kidney injury. We analyzed the clinical data of 150 adult patients not on dialysis who underwent elective cardiac surgical procedures during January 2015-March 2017. Near-infrared spectroscopy was used to measure regional oxygen saturation. Sensors were placed on the patients' forehead, abdomen, and thigh. The incidence of acute kidney injury was 2% at the end of surgery, 13% at 24 h, and 9% at 48 h, with the highest at 24 h after surgery. The multiple regression analysis revealed that the thigh regional oximetry during cardiopulmonary bypass, oxygen delivery index, and neutrophil count at the end of cardiopulmonary bypass and surgery were independent risk factors for acute kidney injury. The receiver-operating characteristic curve analysis suggested that a cutoff of regional oxygen saturation at the thigh of ≤ 67% was predictive of acute kidney injury within 24 h after surgery. In conclusion, the regional oxygen saturation at the thigh during cardiopulmonary bypass is a crucial marker to predict postoperative acute kidney injury in adults undergoing cardiac surgery.
    MeSH term(s) Acute Kidney Injury/etiology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cardiopulmonary Bypass/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Oximetry ; Oxygen/analysis ; Prognosis ; Prospective Studies ; Risk Factors ; Spectroscopy, Near-Infrared/methods ; Thigh/blood supply
    Chemical Substances Biomarkers ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-05-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1463555-0
    ISSN 1619-0904 ; 1434-7229
    ISSN (online) 1619-0904
    ISSN 1434-7229
    DOI 10.1007/s10047-020-01175-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Emergency Surgery for Acute Pulmonary Embolism].

    Sakaki, Kenjiro / Nie, Masaki / Sasahara, Akihiro / Nakashima, Koki / Ohara, Kuniyoshi / Miyaji, Kagami

    Kyobu geka. The Japanese journal of thoracic surgery

    2016  Volume 69, Issue 3, Page(s) 197–200

    Abstract: According to the current guidelines for acute pulmonary embolism in Japan, it is standard to perform surgical thrombectomy only after introducing percutaneous cardiopulmonary support (PCPS) for circulatory collapse. We experienced 2 cases of surgical ... ...

    Abstract According to the current guidelines for acute pulmonary embolism in Japan, it is standard to perform surgical thrombectomy only after introducing percutaneous cardiopulmonary support (PCPS) for circulatory collapse. We experienced 2 cases of surgical thrombectomy without using PCPS. The 1st patient was a 49-year-old man. Computed tomography (CT) on admission revealed a thrombus in the main trunk of the pulmonary artery. He developed severe dyspnea and drop of consciousness after admission, and underwent emergency surgical thrombectomy. The 2nd patient was a 52-year-old man whose levels of consciousness and arterial oxygenation rapidly declined after admission. His CT revealed thrombi in the main trunk of the pulmonary artery, and he underwent emergency thrombectomy. Both patients had a history of diabetes and obesity. At our institute, we actively choose surgical thrombectomy for cases in which a thrombus is revealed in the main trunk of the pulmonary artery on CT and for cases in which abnormal symptoms and/or signs such as impaired consciousness and oxygenation develop.
    MeSH term(s) Acute Disease ; Diabetes Complications ; Humans ; Male ; Middle Aged ; Obesity/complications ; Pulmonary Embolism/surgery ; Thrombectomy/methods
    Language Japanese
    Publishing date 2016-03
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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