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Article ; Online: Breast cancer screening participation in women using mental health services in NSW, Australia: a population study.

Lambeth, Chris / Burgess, Philip / Curtis, Jackie / Currow, David / Sara, Grant

Social psychiatry and psychiatric epidemiology

2023

Abstract: Purpose: Population screening programs have contributed to reduced breast cancer mortality, but disadvantaged or vulnerable groups may not have shared these improvements. In North American and European studies, women living with mental health conditions ...

Abstract	Purpose: Population screening programs have contributed to reduced breast cancer mortality, but disadvantaged or vulnerable groups may not have shared these improvements. In North American and European studies, women living with mental health conditions have reduced breast screening rates. There are no current Australasian data to support health system planning and improvement strategies. Methods: The New South Wales (NSW) BreastScreen program offers free screening to NSW women aged 50-74. We compared 2-year breast screening rates for mental health service users (n = 33,951) and other NSW women (n = 1,051,495) in this target age range, after standardisation for age, socioeconomic status and region of residence. Mental health service contacts were identified through linkage to hospital and community mental health data. Results: Only 30.3% of mental health service users participated in breast screening, compared with 52.7% of other NSW women (crude incidence rate ratio 0.57, 95% CI 0.56-0.59). Standardisation for age, socioeconomic disadvantage or rural residence did not alter this screening gap. Around 7000 fewer women received screening than would be expected from comparable population rates. Screening gaps were largest in women over 60 and in socioeconomically advantaged areas. Women with severe or persistent mental illness had slightly higher screening rates than other mental health service users. Conclusions: Low breast cancer screening participation rates for NSW mental health service users suggest significant risk of later detection, possibly leading to more extensive treatment and premature mortality. Focussed strategies are needed to support greater breast screening participation for NSW women who use mental health services.
Language	English
Publishing date	2023-06-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-023-02509-w
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Zs.A 327: Show issues

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Article ; Online: Breast screening participation and degree of spread of invasive breast cancer at diagnosis in mental health service users: A population linkage study.

Sara, Grant / Lambeth, Chris / Burgess, Philip / Curtis, Jackie / Walton, Richard / Currow, David

Cancer

2023 Volume 130, Issue 1, Page(s) 77–85

Abstract: Background: Women living with mental health conditions may not have shared in improvements in breast cancer screening and care. No studies have directly examined the link between reduced screening participation and breast cancer spread in women using ... ...

Abstract	Background: Women living with mental health conditions may not have shared in improvements in breast cancer screening and care. No studies have directly examined the link between reduced screening participation and breast cancer spread in women using mental health (MH) services. Methods: Population-wide linkage of a population cancer register, BreastScreen register, and mental health service data set in women aged 50 to 74 years in New South Wales, Australia, from 2008 to 2017. Incident invasive breast cancers were identified. Predictors of degree of spread (local, regional, metastatic) at diagnosis were examined using partial proportional odds regression, adjusting for age, socioeconomic status, rurality, and patterns of screening participation. Results: A total of 29 966 incident cancers were identified and included 686 (2.4%) in women with MH service before cancer diagnoses. More than half of MH service users had regional or metastatic spread at diagnosis (adjusted odds ratio, 1.63; 95% CI, 1.41-1.89). MH service users had lower screening participation; however, advanced cancer was more common even when adjusting for screening status (adjusted odds ratio, 1.53; 95% CI, 1.32-1.77). Advanced cancer was more common in women with severe or persistent MH conditions. Conclusions: Low screening participation rates explain only small part of the risk of more advanced breast cancer in women who use MH services. More study is needed to understand possible mechanisms contributing to more advanced breast cancer in women living with MH conditions. Health systems need strategies to ensure that women living with MH conditions enjoy population gains in breast cancer outcomes.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Mammography ; Early Detection of Cancer ; Australia/epidemiology ; Social Class ; Mass Screening
Language	English
Publishing date	2023-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.35002
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Article ; Online: A phase 4, open-label study to evaluate the safety and immunogenicity of DTaP5-HBV-IPV-Hib in children previously vaccinated with DTaP2-HBV-IPV-Hib or DTaP5-HBV-IPV-Hib (V419-016).

Guerra, Andrea / Costantino, Claudio / Martinon-Torres, Federico / Westerholt, Soeren / Lambeth, Courtney / Chen, Ziqiang / Lumley, Jessie / Marcek, Tomas / Johnson, David / Wilck, Marissa

Human vaccines & immunotherapeutics

2024 Volume 20, Issue 1, Page(s) 2310900

Abstract: DTaP5-HBV-IPV-Hib (Vaxelis®) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive disease due ... ...

Abstract	DTaP5-HBV-IPV-Hib (Vaxelis®) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive disease due to
MeSH term(s)	Humans ; Infant ; Haemophilus influenzae type b ; Hepatitis B virus ; Diphtheria-Tetanus-Pertussis Vaccine ; Vaccines, Combined ; Tetanus/prevention & control ; Diphtheria/prevention & control ; Whooping Cough/prevention & control ; Poliovirus Vaccine, Inactivated ; Hepatitis B Vaccines ; Haemophilus Vaccines ; Immunization Schedule ; Antibodies, Bacterial
Chemical Substances	Diphtheria-Tetanus-Pertussis Vaccine ; Vaccines, Combined ; Poliovirus Vaccine, Inactivated ; Hepatitis B Vaccines ; Haemophilus Vaccines ; Antibodies, Bacterial
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Clinical Trial, Phase IV ; Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2024.2310900
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Zs.A 6967: Show issues

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Article ; Online: Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited.

Lambeth, J David / Neish, Andrew S

Annual review of pathology

2013 Volume 9, Page(s) 119–145

Abstract: Reactive oxygen species (ROS) are a chemical class of molecules that have generally been conceptualized as deleterious entities, albeit ones whose destructive properties could be harnessed as antimicrobial effector functions to benefit the whole organism. ...

Abstract	Reactive oxygen species (ROS) are a chemical class of molecules that have generally been conceptualized as deleterious entities, albeit ones whose destructive properties could be harnessed as antimicrobial effector functions to benefit the whole organism. This appealingly simplistic notion has been turned on its head in recent years with the discovery of the NADPH oxidases, or Noxes, a family of enzymes dedicated to the production of ROS in a variety of cells and tissues. The Nox-dependent, physiological generation of ROS is highly conserved across virtually all multicellular life, often as a generalized response to microbes and/or other exogenous stressors. This review discusses the current knowledge of the role of physiologically generated ROS and the enzymes that form them in both normal biology and disease.
MeSH term(s)	Animals ; Humans ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2013-09-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2227429-7
ISSN	1553-4014 ; 1553-4006
ISSN (online)	1553-4014
ISSN	1553-4006
DOI	10.1146/annurev-pathol-012513-104651
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Article: Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.

Lambeth, J David

Free radical biology & medicine

2007 Volume 43, Issue 3, Page(s) 332–347

Abstract: Reactive oxygen species (ROS) are considered to be chemically reactive with and damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to ROS induces oxidative stress and causes genetic mutations. However, the recently ... ...

Abstract	Reactive oxygen species (ROS) are considered to be chemically reactive with and damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to ROS induces oxidative stress and causes genetic mutations. However, the recently described family of Nox and Duox enzymes generates ROS in a variety of tissues as part of normal physiological functions, which include innate immunity, signal transduction, and biochemical reactions, e.g., to produce thyroid hormone. Nature's "choice" of ROS to carry out these biological functions seems odd indeed, given its predisposition to cause molecular damage. This review describes normal biological roles of Nox enzymes as well as pathological conditions that are associated with ROS production by Nox enzymes. By far the most common conditions associated with Nox-derived ROS are chronic diseases that tend to appear late in life, including atherosclerosis, hypertension, diabetic nephropathy, lung fibrosis, cancer, Alzheimer's disease, and others. In almost all cases, with the exception of a few rare inherited conditions (e.g., related to innate immunity, gravity perception, and hypothyroidism), diseases are associated with overproduction of ROS by Nox enzymes; this results in oxidative stress that damages tissues over time. I propose that these pathological roles of Nox enzymes can be understood in terms of antagonistic pleiotropy: genes that confer a reproductive advantage early in life can have harmful effects late in life. Such genes are retained during evolution despite their harmful effects, because the force of natural selection declines with advanced age. This review discusses some of the proposed physiologic roles of Nox enzymes, and emphasizes the role of Nox enzymes in disease and the likely beneficial effects of drugs that target Nox enzymes, particularly in chronic diseases associated with an aging population.
MeSH term(s)	Alzheimer Disease/physiopathology ; Animals ; Bone Resorption/enzymology ; Brain/enzymology ; Cardiovascular Physiological Phenomena ; Chronic Disease ; Diabetic Angiopathies/physiopathology ; Ear, Inner/physiology ; Endocrine System/physiopathology ; Humans ; Hypertension/physiopathology ; Immunity, Innate/physiology ; Kidney Diseases/physiopathology ; Lung/immunology ; Lung/physiopathology ; NADPH Oxidases/metabolism ; Neoplasms/physiopathology ; Nervous System/physiopathology ; Osteoarthritis/physiopathology ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2007-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2007.03.027
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Zs.A 2109: Show issues

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Article: NOX enzymes and the biology of reactive oxygen.

Lambeth, J David

Nature reviews. Immunology

2004 Volume 4, Issue 3, Page(s) 181–189

MeSH term(s)	Animals ; Apoptosis/physiology ; Cell Division/physiology ; Humans ; NADPH Oxidases/metabolism ; Phagocytes/enzymology ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2004-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/nri1312
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals.

Aguirre, Jesús / Lambeth, J David

Free radical biology & medicine

2010 Volume 49, Issue 9, Page(s) 1342–1353

Abstract: The production of reactive oxygen species (ROS) in a highly regulated fashion is a hallmark of members of the NADPH oxidase (Nox) family of enzymes. Nox enzymes are present in most eukaryotic groups such as the amebozoid, fungi, algae and plants, and ... ...

Abstract	The production of reactive oxygen species (ROS) in a highly regulated fashion is a hallmark of members of the NADPH oxidase (Nox) family of enzymes. Nox enzymes are present in most eukaryotic groups such as the amebozoid, fungi, algae and plants, and animals, in which they are involved in seemingly diverse biological processes. However, a comprehensive survey of Nox functions throughout biology reveals common functional themes. Noxes are often activated in response to stressful conditions such as nutrient starvation, physical damage, or pathogen attack. Although the end result varies depending on the organism and tissue, Nox-produced ROS mediate the response to the adverse stimuli, such as innate immunity responses in plants and animals or cell differentiation in Dictyostelium, fungi, and plants. These responses involve ROS-mediated signaling mechanisms occurring at intracellular or cell-to-cell levels and sometimes involve cell wall or extracellular matrix cross-linking. Indeed, Noxes are involved in local and systemic signaling from plants to fish and in cross-linking of the plant hair-cell wall, synthesis of the nematode cuticle, and formation of the sea urchin fertilization envelope. The extensive use of Nox enzymes in biology to regulate cell-to-cell signaling and morphogenesis suggests that additional functions in mammalian signaling and development remain to be discovered.
MeSH term(s)	Animals ; Cell Differentiation ; Diptera ; Fishes ; Fungi ; Humans ; Immunity, Innate ; Morphogenesis ; NADPH Oxidases/physiology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Stress, Physiological
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2010-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2010.07.027
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Zs.A 2109: Show issues

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Article ; Online: Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival.

De La Cruz, Juan A / Ganesh, Thota / Diebold, Becky A / Cao, Weiping / Hofstetter, Amelia / Singh, Neetu / Kumar, Amrita / McCoy, James / Ranjan, Priya / Smith, Susan M E / Sambhara, Suryaprakash / Lambeth, J David / Gangappa, Shivaprakash

PloS one

2021 Volume 16, Issue 7, Page(s) e0254632

Abstract: Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on ... ...

Abstract	Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung monocytic cells and freshly isolated peripheral blood mononuclear cells (PBMC). TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-γ, MCP-1, TNF-α, MIP-1β) and in human PBMC (IL-6, IL-8, TNF-α, MCP-1). Interestingly, TG6-44-treated THP-1 cells showed a decrease in percent cells expressing viral nucleoprotein, as well as a delay in translocation of viral nucleoprotein into the nucleus. Furthermore, in influenza A virus-infected cells, TG6-44 treatment led to suppression of virus-induced cell death as evidenced by decreased caspase-3 activation, decreased proportion of Annexin V+PI+ cells, and increased Bcl-2 phosphorylation. Taken together, our results demonstrate the anti-inflammatory and anti-infective effects of TG6-44.
MeSH term(s)	Cell Survival/drug effects ; Chemokine CCL2/genetics ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/drug therapy ; Inflammation/pathology ; Inflammation/virology ; Inflammation Mediators/pharmacology ; Influenza A virus/drug effects ; Influenza A virus/pathogenicity ; Interleukin-6/genetics ; Interleukin-8/genetics ; Leukocytes, Mononuclear/drug effects ; Lung/drug effects ; Lung/pathology ; Peroxidase/antagonists & inhibitors ; Peroxidase/genetics ; Quinazolines/pharmacology ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Superoxides/metabolism ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	CCL2 protein, human ; Chemokine CCL2 ; Inflammation Mediators ; Interleukin-6 ; Interleukin-8 ; Quinazolines ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Superoxides (11062-77-4) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0254632
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Article ; Online: On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation.

Zielonka, Jacek / Lambeth, J David / Kalyanaraman, Balaraman

Free radical biology & medicine

2013 Volume 65, Page(s) 1310–1314

Abstract: L-012, a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2(*-)) and identify Nox inhibitors. Yet understanding of the free radical chemistry of the L-012 probe is still ... ...

Abstract	L-012, a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2(-)) and identify Nox inhibitors. Yet understanding of the free radical chemistry of the L-012 probe is still lacking. We report that peroxidase and H2O2 induce superoxide dismutase (SOD)-sensitive, L-012-derived CL in the presence of oxygen. O2(-) alone does not react with L-012 to emit luminescence. Self-generated O2(-) during oxidation of L-012 and luminol analogs artifactually induce CL inhibitable by SOD. These aspects make assays based on luminol analogs less than ideal for specific detection and identification of O2(-) and NOX inhibitors.
MeSH term(s)	Catalase/chemistry ; Free Radicals ; Hydrogen Peroxide/chemistry ; Luminescence ; Luminescent Measurements/methods ; Luminol/analogs & derivatives ; Luminol/chemistry ; NADPH Oxidases/analysis ; NADPH Oxidases/antagonists & inhibitors ; NADPH Oxidases/metabolism ; Oxidation-Reduction ; Oxygen/chemistry ; Peroxidase/chemistry ; Superoxide Dismutase/chemistry ; Superoxides/analysis ; Superoxides/chemistry
Chemical Substances	Free Radicals ; Superoxides (11062-77-4) ; L 012 (143323-55-1) ; Luminol (5EXP385Q4F) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Peroxidase (EC 1.11.1.7) ; Superoxide Dismutase (EC 1.15.1.1) ; NADPH Oxidases (EC 1.6.3.-) ; Oxygen (S88TT14065)
Language	English
Publishing date	2013-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2013.09.017
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Article: Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.

Lambeth, J David

Current opinion in hematology

2001 Volume 9, Issue 1, Page(s) 11–17

Abstract: Reactive oxygen species are classically described as occurring as an accidental byproduct of respiration, and are generally thought to be deleterious to biologic systems. The phagocyte nicotinamide adenine dinucleotide phosphate oxidase provides an ... ...

Abstract	Reactive oxygen species are classically described as occurring as an accidental byproduct of respiration, and are generally thought to be deleterious to biologic systems. The phagocyte nicotinamide adenine dinucleotide phosphate oxidase provides an example of deliberate reactive oxygen species generation, but the function of this enzyme is to oxidatively modify bacteria as part of bactericidal mechanisms. The discovery of a family of nicotinamide adenine dinucleotide (phosphate) oxidases related to the phagocyte oxidase, the Nox/Duox family, provides additional examples of deliberate generation of reactive oxygen species. This article describes this new family of enzymes and considers hypotheses for their function. Potential roles of Nox/Duox in generation of reactive oxygen species that function in cell signaling (related to growth and angiogenesis), immune function, hypoxic response, and oxidative modification of extracellular matrix proteins are discussed.
MeSH term(s)	Animals ; Dual Oxidases ; Extracellular Matrix Proteins/metabolism ; Flavoproteins ; Hypoxia/enzymology ; NADPH Oxidases/chemistry ; NADPH Oxidases/genetics ; NADPH Oxidases/physiology ; Phagocytes/enzymology ; Phylogeny ; Protein Structure, Tertiary ; Reactive Oxygen Species/metabolism ; Signal Transduction
Chemical Substances	Extracellular Matrix Proteins ; Flavoproteins ; Reactive Oxygen Species ; Dual Oxidases (EC 1.11.1.-) ; NADPH Oxidases (EC 1.6.3.-) ; DUOX1 protein, human (EC 1.6.3.1)
Language	English
Publishing date	2001-12-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/00062752-200201000-00003
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