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Article ; Online: Interfacial covalent bonding of the MXene-stabilized Sb

Lv, Chengkui / Tai, Linlin / Li, Xiao / Miao, Xiaowei / Wei, Huaixin / Yang, Jun / Geng, Hongbo

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 34, Page(s) 5094–5097

Abstract: An interfacial covalent bonding strategy is proposed for the synthesis of the MXene-stabilized ... ...

Abstract	An interfacial covalent bonding strategy is proposed for the synthesis of the MXene-stabilized Sb
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc00614j
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Article ; Online: In situ

Geng, Jitao / Dong, Huilong / Liu, Jing / Lv, Chengkui / Wei, Huaixin / Cheng, Yafei / Yang, Jun / Geng, Hongbo

Nanoscale

2023 Volume 15, Issue 35, Page(s) 14641–14650

Abstract: The progress of sodium-ion batteries is currently confronted with a noteworthy obstacle, specifically the paucity of electrode materials that can store large quantities of ... ...

Abstract	The progress of sodium-ion batteries is currently confronted with a noteworthy obstacle, specifically the paucity of electrode materials that can store large quantities of Na
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr03182a
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Article: Ginseng-Sanqi-Chuanxiong (GSC) extracts attenuate d-galactose-induced vascular aging in mice via inhibition of endothelial progenitor cells senescence.

Liu, Yinan / Liu, Yiqing / Wang, Xue / Xiu, Chengkui / Hu, Yanhong / Wang, Jiali / Lei, Yan / Yang, Jing

Heliyon

2024 Volume 10, Issue 4, Page(s) e25253

Abstract: Vascular aging is an independent risk factor for age-related diseases and a specific type of organic aging. Endothelial progenitor cells (EPCs), a type of bone marrow stem cell, has been linked to vascular aging. The purpose of this study is to ... ...

Abstract	Vascular aging is an independent risk factor for age-related diseases and a specific type of organic aging. Endothelial progenitor cells (EPCs), a type of bone marrow stem cell, has been linked to vascular aging. The purpose of this study is to investigate if Ginseng-Sanqi-Chuanxiong (GSC) extract, a traditional Chinese medicine, can delay aortic aging in mice by enhancing the performance and aging of EPCs in vivo and to analyze the potential mechanisms through a d-Galactose (D-gal)-induced vascular aging model in mice. Our study revealed that GSC extracts not only enhanced the aortic structure, endothelial function, oxidative stress levels, and aging in mice, but also enhanced the proliferation, migration, adhesion, and secretion of EPCs in vivo, while reducing the expression of p53, p21, and p16. To conclude, GSC can delay vascular senescence by enhancing the function and aging of EPCs, which could be linked to a decrease in p16 and p53/p21 signaling. Consequently, utilizing GSC extracts to enhance the function and senescence of autologous EPCs may present a novel avenue for enhancing autologous stem cells in alleviating senescence.
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25253
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Article ; Online: A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma.

Yu, Bin / Geng, Chengkui / Wu, Zhongxiong / Zhang, Zhongzi / Zhang, Aili / Yang, Ze / Huang, Jiazheng / Xiong, Ying / Yang, Huiqin / Chen, Zhuoyuan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1308

Abstract: Osteosarcoma is generally considered a cold tumor and is characterized by epigenetic alterations. Although tumor cells are surrounded by many immune cells such as macrophages, T cells may be suppressed, be inactivated, or not be presented due to various ... ...

Abstract	Osteosarcoma is generally considered a cold tumor and is characterized by epigenetic alterations. Although tumor cells are surrounded by many immune cells such as macrophages, T cells may be suppressed, be inactivated, or not be presented due to various mechanisms, which usually results in poor prognosis and insensitivity to immunotherapy. Immunotherapy is considered a promising anti-cancer therapy in osteosarcoma but requires more research, but osteosarcoma does not currently respond well to this therapy. The cancer immunity cycle (CIC) is essential for anti-tumor immunity, and is epigenetically regulated. Therefore, it is possible to modulate the immune microenvironment of osteosarcoma by targeting epigenetic factors. In this study, we explored the correlation between epigenetic modulation and CIC in osteosarcoma through bioinformatic methods. Based on the RNA data from TARGET and GSE21257 cohorts, we identified epigenetic related subtypes by NMF clustering and constructed a clinical prognostic model by the LASSO algorithm. ESTIMATE, Cibersort, and xCell algorithms were applied to analyze the tumor microenvironment. Based on eight epigenetic biomarkers (SFMBT2, SP140, CBX5, HMGN2, SMARCA4, PSIP1, ACTR6, and CHD2), two subtypes were identified, and they are mainly distinguished by immune response and cell cycle regulation. After excluding ACTR6 by LASSO regression, the prognostic model was established and it exhibited good predictive efficacy. The risk score showed a strong correlation with the tumor microenvironment, drug sensitivity and many immune checkpoints. In summary, our study sheds a new light on the CIC-related epigenetic modulation mechanism of osteosarcoma and helps search for potential drugs for osteosarcoma treatment.
MeSH term(s)	Humans ; Tumor Microenvironment/genetics ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics ; Immunotherapy ; Epigenesis, Genetic ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Prognosis ; DNA Helicases ; Nuclear Proteins ; Transcription Factors ; Actins ; Chromosomal Proteins, Non-Histone
Chemical Substances	SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; Nuclear Proteins ; Transcription Factors ; ACTR6 protein, human ; Actins ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49770-2
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Article ; Online: Alpha-synuclein Affects Certain Iron Transporters of BV2 Microglia Cell through its ferric reductase activity.

Li, Yinghui / Shi, Chengkui / Liu, Rong / Yang, Jiahua / Xie, Junxia / Wang, Jun

publication RETRACTED

Journal of neurophysiology

2023

Abstract: Alpha-synuclein (α-syn) is a major component of lewy bodies, which is biomarker of Parkinson's disease (PD). It accumulates in substantia nigra pars compacts (SNpc) to form insoluble aggregates and cause neurotoxicity, which is often accompanied by iron ... ...

Abstract	Alpha-synuclein (α-syn) is a major component of lewy bodies, which is biomarker of Parkinson's disease (PD). It accumulates in substantia nigra pars compacts (SNpc) to form insoluble aggregates and cause neurotoxicity, which is often accompanied by iron deposition. In this study, we compared the iron reductase activity between monomeric α-syn (M-α-syn) and oligomeric α-syn (O-α-syn), investigated the effect of α-syn on iron metabolism of BV2 microglia cells as well. We found that α-syn had ferric reductase activity, and O-α-syn had stronger enzyme activity than M-α-syn. M-α-syn upregulated iron uptake protein, divalent metal transporter1 (DMT1) expression and iron influx, but did not regulate iron release protein, ferroportin1 (FPN1) expression and iron efflux. O-α-syn elevated the expression of both DMT1 and FPN1, thus increased the iron influx and efflux in BV2 microglial cells, but the expressions of iron regulatory protein1 and hypoxia inducible factor2α have no significant change. Moreover, both M-α-syn and O-α-syn could increase the mRNA expressions of TNF-α and IL-1β in BV2 microglia cells. Taken together, our data suggest that both types of α-syn can activate microglia, which leads to increased expressions of pro-inflammatory factors. α-syn can affect DMT1 and FPN1 expressions in BV2 microglia cells, which might be through its ferric reductase activity.
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00163.2023
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Article ; Online: Whole-transcriptome sequencing analysis reveal mechanisms of Yiqi Huoxue Yangyin (YHY) decoction in ameliorating D-gal-induced cardiac aging.

Wang, Xue / Zhang, Jiaqi / Xiu, Chengkui / Yang, Jing / Liu, Yiqing / Lei, Yan

Aging

2023 Volume 15, Issue 8, Page(s) 2906–2919

Abstract: Background: Aging is a major factor for cardiovascular disease, and cardiac aging is closely related to the incidence of cardiovascular disease. Clarifying the mechanism of cardiac aging and finding reliable intervention is critical for preventing ... ...

Abstract	Background: Aging is a major factor for cardiovascular disease, and cardiac aging is closely related to the incidence of cardiovascular disease. Clarifying the mechanism of cardiac aging and finding reliable intervention is critical for preventing cardiovascular diseases and achieving healthy longevity. Traditional Chinese medicine Yiqi Huoxue Yangyin (YHY) decoction has unique advantage in the treatment of cardiovascular disease and aging. However, the associated molecular mechanisms remain unknown. Purpose: The present study aimed to verify the efficacy of YHY decoction against cardiac aging in D-gal-induced mouse model, and explore the potential mechanism of YHY decoction treatment through whole-transcriptome sequencing technique, providing novel insights into the molecular basis of YHY decoction in treating cardiac aging. Methods: The component of YHY decoction was identified by High Performance Liquid Chromatography (HPLC). D-gal-induced aging mouse model was established for this study. HE and Masson staining were applied to determine pathological changes of heart; telomere length, telomerase activity, AGEs and p53 were used to evaluate the degree of heart aging. Transcriptome sequencing, GO, KEGG, GSEA and ceRNA network were applied to analyze the potential mechanism of YHY decoction treatment of cardiac aging. Results: In this study, we found that YHY decoction not only improved the pathological structure of aging heart, but also regulated the expression of aging-related markers, telomere length, telomerase activity, AGEs and p53, the myocardial tissue, suggesting that it has a specific effect in delaying cardiac aging. Whole-transcriptome sequencing showed that the total of 433 mRNAs, 284 lncRNAs, 62 miRNAs, and 39 circRNAs were significantly differentially expressed after YHY decoction treatment. According to the analysis results of KEGG and GSEA, the differentially expressed mRNAs were found significantly involved in immune system, cytokine-cytokine receptor interaction and cell adhesion molecules. The ceRNA network showed that miR-770, miR-324, and miR-365 are localized in center, mainly affecting the immune system, PI3K-Akt signaling pathway, and MAPK signaling pathway. Conclusion: In conclusion, our results evaluated the ceRNA network of YHY decoction in treating cardiac aging for the first time, which could provide better understanding of the potential mechanism of YHY decoction treatment of cardiac aging.
MeSH term(s)	Animals ; Mice ; Cardiovascular Diseases ; Phosphatidylinositol 3-Kinases ; Telomerase ; Transcriptome ; Tumor Suppressor Protein p53 ; Aging/genetics ; Disease Models, Animal ; Glycation End Products, Advanced
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Telomerase (EC 2.7.7.49) ; Tumor Suppressor Protein p53 ; Glycation End Products, Advanced
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204532
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Article ; Online: Removal characteristics of heavy metal ions in rainwater runoff by bioretention cell modified with biochar

Xiong, Jiaqing / Li, Guohao / Zhu, Junguo / Li, Jianqiang / Yang, Yuan / An, Shengxia / Liu, Chengkui

Environmental Technology. 2022 Dec. 19, v. 43, no. 28 p.4515-4527

2022

Abstract: As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical, and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of ... ...

Abstract	As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical, and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal of multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates of various heavy metals: copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd), were enhanced using a biochar modified bioretention cell, as compared to the traditional sandy soil bioretention process. Following treatment with the biochar modified bioretention cell, the average concentrations of Cu, Zn, Pb, and Cd were 55%, 61%, 19.66%, and 36.43% lower than the traditional sandy soil bioretention effluent, respectively. These results show that biochar significantly improves the removal of heavy metals by the bioretention process, especially Cu and Zn. This study also evaluated the effect of biochar on the inhibition of heavy metal migration in the filler material, by sampling and analysing the filler and retained water at different filler depths, then repeating the filler leaching experiment after simulated rainfall. The content of heavy metals at a filler depth of 45 cm in the traditional sandy soil bioretention system, was significantly higher than in the biochar modified bioretention system, showing that biochar plays an important role in the inhibition of heavy metal migration.
Keywords	biochar ; bioretention areas ; cadmium ; copper ; environmental technology ; heavy metals ; lead ; nonpoint source pollution ; rain ; rainfall simulation ; sandy soils ; stormwater ; zinc ; Bioretention cell ; heavy metal removal ; rainwater runoff ; LID
Language	English
Dates of publication	2022-1219
Size	p. 4515-4527.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1479-487X
DOI	10.1080/09593330.2021.1954697
Database	NAL-Catalogue (AGRICOLA)

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Article: Comparison of curative effect between OBS assisted by 3D printing and PFNA in the treatment of AO/OTA type 31-A3 femoral intertrochanteric fractures in elderly patients.

Huang, Jiazheng / Xiong, Ying / Mithu, Md Miftahul / Li, Jinping / Geng, Chengkui / Lu, Jipeng / Ren, Yunfeng / Yang, Ze / Gan, Xuewen / Zhang, Aili / Yang, Huiqin / Chen, Zhuoyuan

Frontiers in medicine

2023 Volume 10, Page(s) 1234764

Abstract: Objective: To compare and analyze the Ortho-Bridge System (OBS) clinical efficacy assisted by 3D printing and proximal femoral nail anti-rotation (PFNA) of AO/OTA type 31-A3 femoral intertrochanteric fractures in elderly patients.: Methods: A ... ...

Abstract	Objective: To compare and analyze the Ortho-Bridge System (OBS) clinical efficacy assisted by 3D printing and proximal femoral nail anti-rotation (PFNA) of AO/OTA type 31-A3 femoral intertrochanteric fractures in elderly patients. Methods: A retrospective analysis of 25 elderly patients diagnosed with AO/OTA type 31-A3 femoral intertrochanteric fracture was conducted from January 2020 to August 2022 at Yan'an Hospital, affiliated to Kunming Medical University. The patients were divided into 10 patients in the OBS group and 15 in the PFNA group according to different surgical methods. The OBS group reconstructed the bone models and designed the guide plate by computer before the operation, imported the data of the guide plate and bone models into a stereolithography apparatus (SLA) 3D printer, and printed them using photosensitive resin, thus obtaining the physical object, then simulating the operation and finally applying the guide plate to assist OBS to complete the operation; the PFNA group was treated by proximal femoral nail anti-rotation. The operation time, the intraoperative blood loss, Harris hip score (HHS), Oxford Hip Score (OHS), and complications were compared between the two groups. Results: The operation time and the intraoperative blood loss in the PFNA group were less than that in the OBS group, and there was a significant difference between the two groups ( Conclusion: The OBS assisted by 3D printing and PFNA are effective measures for treating intertrochanteric fractures. Prior to making any decisions regarding internal fixation, it is crucial to evaluate the distinct circumstances of each patient thoroughly.
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1234764
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Article ; Online: Removal characteristics of heavy metal ions in rainwater runoff by bioretention cell modified with biochar.

Xiong, Jiaqing / Li, Guohao / Zhu, Junguo / Li, Jianqiang / Yang, Yuan / An, Shengxia / Liu, Chengkui

Environmental technology

2021 , Page(s) 1–13

Abstract	As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical, and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal of multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates of various heavy metals: copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd), were enhanced using a biochar modified bioretention cell, as compared to the traditional sandy soil bioretention process. Following treatment with the biochar modified bioretention cell, the average concentrations of Cu, Zn, Pb, and Cd were 55%, 61%, 19.66%, and 36.43% lower than the traditional sandy soil bioretention effluent, respectively. These results show that biochar significantly improves the removal of heavy metals by the bioretention process, especially Cu and Zn. This study also evaluated the effect of biochar on the inhibition of heavy metal migration in the filler material, by sampling and analysing the filler and retained water at different filler depths, then repeating the filler leaching experiment after simulated rainfall. The content of heavy metals at a filler depth of 45 cm in the traditional sandy soil bioretention system, was significantly higher than in the biochar modified bioretention system, showing that biochar plays an important role in the inhibition of heavy metal migration.
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ISSN	1479-487X
ISSN (online)	1479-487X
DOI	10.1080/09593330.2021.1954697
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Article ; Online: Purification effect of bioretention with improved filler on runoff pollution under low temperature conditions.

Xiong, Jiaqing / Zhu, Junguo / Li, Guohao / Yang, Yuan / An, Shengxia / Liu, Chengkui / Jiaxuan Wang

Journal of environmental management

2021 Volume 295, Page(s) 113065

Abstract: In recent years, there have been a number of studies on bioretention during hot summer, with only few studies reported during low-temperature winters. The application of bioretention in cold areas still lacks effective guidance. In this study, runoff ... ...

Abstract	In recent years, there have been a number of studies on bioretention during hot summer, with only few studies reported during low-temperature winters. The application of bioretention in cold areas still lacks effective guidance. In this study, runoff simulation experiments were conducted to explore the influence of wood chips filler and water treatment residue on the removal of runoff pollutants under different packing gradations and low temperature conditions. Under low temperature, nitrate nitrogen removal rate of wood chips filler decreased from 70% to 90% in autumn to -23%- 35% in winter, the total nitrogen removal rate decreased from 75 to 90% in autumn to 20%-50% in winter, the removal rate of ammonia nitrogen and total phosphorus exceeded 70% during the entire experiment. Water treatment residue filler maintained a high ammonia nitrogen and total phosphorus removal rate during the experiment, with the total phosphorus removal rate above 90% and ammonia nitrogen removal rate above 80%. The bioretention effluent concentration of nitrate and total nitrogen was higher than 7.3 mg/L and 8.5 mg/L, respectively, most of the time. However, at low temperature, the COD removal rate of the two fillers was 25%-50%, which was very poor. Therefore, wood chips filler was observed to be better suited for the removal of nitrate and total nitrogen from the runoff, while water treatment residue had a better effect on the removal of ammonia nitrogen and total phosphorus in winter. Thus, for the application of bioretention in northern China, appropriate fillers should be selected considering the water quality characteristics of the area.
MeSH term(s)	China ; Nitrogen/analysis ; Phosphorus/analysis ; Rain ; Temperature ; Water Pollutants, Chemical ; Water Purification
Chemical Substances	Water Pollutants, Chemical ; Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75)
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.113065
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