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Article ; Online: Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis.

Brogan, Anna P / Habib, Cameron / Hobbs, Samuel J / Kranzusch, Philip J / Rudner, David Z

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 40, Page(s) e2310862120

Abstract: Gram-positive bacteria use SigI/RsgI-family sigma factor/anti-sigma factor pairs to sense and respond to cell wall defects and plant polysaccharides. ... ...

Abstract	Gram-positive bacteria use SigI/RsgI-family sigma factor/anti-sigma factor pairs to sense and respond to cell wall defects and plant polysaccharides. In
MeSH term(s)	Mechanotransduction, Cellular ; Proteolysis ; Bacillus subtilis ; Cell Wall ; Eukaryota
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2310862120
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis.

Brogan, Anna P / Habib, Cameron / Hobbs, Samuel J / Kranzusch, Philip J / Rudner, David Z

bioRxiv : the preprint server for biology

2023

Abstract: Gram-positive bacteria use SigI/RsgI-family sigma factor/anti-sigma factor pairs to sense and respond to cell wall defects and plant polysaccharides. In : Significance: SEA domains are broadly conserved among eukaryotes but absent in bacteria. They ... ...

Abstract	Gram-positive bacteria use SigI/RsgI-family sigma factor/anti-sigma factor pairs to sense and respond to cell wall defects and plant polysaccharides. In Significance: SEA domains are broadly conserved among eukaryotes but absent in bacteria. They are present on diverse membrane-anchored proteins some of which have been implicated in mechanotransducive signaling pathways. Many of these domains have been found to undergo autoproteolysis and remain noncovalently associated following cleavage. Their dissociation requires mechanical force. Here, we identify a family of bacterial SEA-like (SEAL) domains that arose independently from their eukaryotic counterparts but have structural and functional similarities. We show these SEAL domains autocleave and the cleavage products remain stably associated. Importantly, these domains are present on membrane-anchored anti-sigma factors that have been implicated in mechanotransduction pathways analogous to those in eukaryotes. Our findings suggest that bacterial and eukaryotic signaling systems have evolved a similar mechanism to transduce mechanical stimuli across the lipid bilayer.
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.27.546760
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Article ; Online: T cell receptor signaling strength establishes the chemotactic properties of effector CD8

Abdelbary, Mahmoud / Hobbs, Samuel J / Gibbs, James S / Yewdell, Jonathan W / Nolz, Jeffrey C

Nature communications

2023 Volume 14, Issue 1, Page(s) 3928

Abstract: Tissue-resident memory ( ... ...

Abstract	Tissue-resident memory (T
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; Receptors, Antigen, T-Cell/metabolism ; Immunologic Memory ; Skin/immunology ; Skin/virology ; Virus Diseases/immunology ; Cell Movement ; Female ; Animals ; Mice ; Mice, Inbred C57BL ; Interferon-gamma/metabolism ; Positive Regulatory Domain I-Binding Factor 1/metabolism ; Receptors, CXCR6/metabolism
Chemical Substances	Receptors, Antigen, T-Cell ; sphingosine 1-phosphate (26993-30-6) ; Interferon-gamma (82115-62-6) ; Prdm1 protein, mouse ; Cxcr6 protein, mouse ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-) ; Receptors, CXCR6
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39592-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeted Expansion of Tissue-Resident CD8

Hobbs, Samuel J / Nolz, Jeffrey C

Cell reports

2019 Volume 29, Issue 10, Page(s) 2990–2997.e2

Abstract: Tissue-resident memory ( ... ...

Abstract	Tissue-resident memory (T
MeSH term(s)	Animals ; Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/immunology ; CD8-Positive T-Lymphocytes/immunology ; Immunity, Cellular/immunology ; Immunologic Memory/immunology ; Lectins, C-Type/immunology ; Mice ; Mice, Inbred C57BL ; Skin/immunology
Chemical Substances	Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; Lectins, C-Type
Language	English
Publishing date	2019-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.10.126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency

Mahmoud Abdelbary / Samuel J. Hobbs / James S. Gibbs / Jonathan W. Yewdell / Jeffrey C. Nolz

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated effector T cells, but the mechanisms that control the extent of TRM differentiation within tissue microenvironments remain unresolved. Here, using an IFNγ-YFP ... ...

Abstract	Abstract Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated effector T cells, but the mechanisms that control the extent of TRM differentiation within tissue microenvironments remain unresolved. Here, using an IFNγ-YFP reporter system to identify CD8+ T cells executing antigen-dependent effector functions, we define the transcriptional consequences and functional mechanisms controlled by TCR-signaling strength that occur within the skin during viral infection to promote TRM differentiation. TCR-signaling both enhances CXCR6-mediated migration and suppresses migration toward sphingosine-1-phosphate, indicating the programming of a ‘chemotactic switch’ following secondary antigen encounter within non-lymphoid tissues. Blimp1 was identified as the critical target of TCR re-stimulation that is necessary to establish this chemotactic switch and for TRM differentiation to efficiently occur. Collectively, our findings show that access to antigen presentation and strength of TCR-signaling required for Blimp1 expression establishes the chemotactic properties of effector CD8+ T cells to promote residency within non-lymphoid tissues.
Keywords	Science ; Q
Subject code	570
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity.

Richmond-Buccola, Desmond / Hobbs, Samuel J / Garcia, Jasmine M / Toyoda, Hunter / Gao, Jingjing / Shao, Sichen / Lee, Amy S Y / Kranzusch, Philip J

bioRxiv : the preprint server for biology

2023

Abstract: CBASS is an anti-phage defense system that protects bacteria from phage infection and is evolutionarily related to human cGAS-STING immunity. cGAS-STING signaling is initiated by viral DNA but the stage of phage replication which activates bacterial ... ...

Abstract	CBASS is an anti-phage defense system that protects bacteria from phage infection and is evolutionarily related to human cGAS-STING immunity. cGAS-STING signaling is initiated by viral DNA but the stage of phage replication which activates bacterial CBASS remains unclear. Here we define the specificity of Type I CBASS immunity using a comprehensive analysis of 975 operon-phage pairings and show that Type I CBASS operons composed of distinct CD-NTases, and Cap effectors exhibit striking patterns of defense against dsDNA phages across five diverse viral families. We demonstrate that escaper phages evade CBASS immunity by acquiring mutations in structural genes encoding the prohead protease, capsid, and tail fiber proteins. Acquired CBASS resistance is highly operon-specific and typically does not affect overall fitness. However, we observe that some resistance mutations drastically alter phage infection kinetics. Our results define late-stage virus assembly as a critical determinant of CBASS immune activation and evasion by phages.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.21.541620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The water incident database (WAID) 2012 to 2019: a systematic evaluation of the documenting of UK drownings.

Hills, Samuel P / Hobbs, Matthew / Tipton, Michael J / Barwood, Martin J

BMC public health

2021 Volume 21, Issue 1, Page(s) 1760

Abstract: Background: Death by drowning is a leading cause of accidental death in the United Kingdom (UK) and worldwide. The World Health Organization (WHO) states that effective documentation of drowning is required to describe drowning frequency and to underpin ...

Abstract	Background: Death by drowning is a leading cause of accidental death in the United Kingdom (UK) and worldwide. The World Health Organization (WHO) states that effective documentation of drowning is required to describe drowning frequency and to underpin effective drowning prevention intervention, thus improving the quality of data describing drowning frequency represents a key initiative. The water incident database (WAID) has been used to document UK fatal and non-fatal water-based incidents since 2009. WAID has not undergone a systematic evaluation of its data or data collection procedures to establish if the database meets the WHO requirements. The present study investigated the characteristics of UK fatal drowning incidents and audited current WAID data capture procedures. Methods: Data for the fatal drowning cases recorded between 2012 and 2019 were reviewed. Descriptive data were generated 1) to describe fatal drownings in the UK's WAID in this period; 2) a sub-set of drownings were audited i) for completeness of data entry and, based on source documents, ii) for quality of data entry; 3) these processes were used to make recommendations for onward revisions to WAID. Results: A total of 5051 fatalities were recorded between 2012 and 2019. Drowning was most frequent amongst males aged 35 to 60 years (n = 1346), whilst suspected accidents and suicides accounted for 44 and 35% of fatalities. Suicide by drowning was at a peak in the most recent year of data analysed (i.e., 2019; 279 cases) highlighting an urgent need for targeted intervention. Audit part 2i) indicated that 16% of all fields were incomplete, thus indicating potential redundancy, duplication, or the need for onward review. Audit part 2ii) indicated high levels of agreement (80 ± 12%) between audited cases and the 'true' WAID entries. Conclusions: This study confirms WAID as a rigorous, transparent and effective means of documenting UK drownings thereby meeting WHO requirements for data quality; yet future improvements are recommended. Such findings allow researchers and policy makers to use WAID to further investigate UK drowning with a view to improving public safety measures and drowning prevention interventions. Observations alongside several expert recommendations have informed a revised version of WAID.
MeSH term(s)	Accidents ; Drowning/epidemiology ; Drowning/prevention & control ; Humans ; Male ; Suicide ; United Kingdom/epidemiology ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2021-09-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-021-11827-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans.

Hobbs, Samuel J / Nolz, Jeffrey C

Frontiers in immunology

2017 Volume 8, Page(s) 600

Abstract: Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph ... ...

Abstract	Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate extravasation into non-lymphoid tissues. The capacity for T cells to interact with all of these selectins is dependent on the enzymatic synthesis of complex O-glycans, and thus, this protein modification plays an indispensable role in regulating the distribution and homing of both naive and previously activated T cells
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00600
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Article ; Online: Impact of a quality improvement initiative and monthly multidisciplinary meetings on outcomes after posterior spinal fusion for adolescent idiopathic scoliosis.

Hengartner, Astrid C / Elsamadicy, Aladine A / Jonnalagadda, Anshu / Craft, Samuel / Sherman, Josiah J Z / Reeves, Benjamin C / Fernandez, Tiana / Hobbs, Joshua / Koo, Andrew B / DiLuna, Michael / Tuason, Dominick A

Spine deformity

2024

Abstract: Introduction: Several studies have demonstrated the benefits of enhanced recovery after surgery (ERAS) protocols for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal instrumented fusion (PSIF). However, there are ... ...

Abstract	Introduction: Several studies have demonstrated the benefits of enhanced recovery after surgery (ERAS) protocols for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal instrumented fusion (PSIF). However, there are relatively few studies investigating the effect of regular multidisciplinary team meetings on level selection, surgical performance parameters, and patient outcomes after PSIF for AIS. The aim of this study was to assess changes in intra- and postoperative outcomes following multidisciplinary team meeting implementation for patients undergoing PSIF for AIS. Methods: The medical records of 96 adolescents (10 to 18 years old) diagnosed with AIS and undergoing PSIF at a major academic institution from 2017 to 2022 were retrospectively reviewed. A quality improvement (QI) initiative was implemented in February 2020, including institution of monthly multidisciplinary conferences focusing on preoperative indications, level selection, postoperative review of surgical performance parameters for previous cases, and discussion and optimization of postoperative ambulation and pain control protocols. Patients were placed into "Pre-QI" (treated pre-February 2020) and "Post-QI" (treated post-February 2020) cohorts. Patient demographics, comorbidities, deformity characteristics, intraoperative variables, ambulation status, postoperative complications, length of stay (LOS), and unplanned readmission rates were assessed. Results: Of the 96 study patients, 44 (45.8%) were in the Pre-QI cohort, and 52 (54.2%) were in the Post-QI cohort. Mean major curve was not significantly different between the two cohorts (Pre-QI: 58.0 ± 7.3° vs Post-QI: 57.9 ± 14.5°, p = 0.169). The Pre-QI cohort had a greater mean minor curve degree (Pre-QI: 42.7 ± 11.8° vs Post-QI: 36.8 ± 12.4, p = 0.008). The Pre-QI cohort had significantly greater mean spinal levels fused (Pre-QI: 11.7 ± 1.7 vs Post-QI: 10.4 ± 2.6, p = 0.009), significantly greater mean estimated blood loss (Pre-QI: 1063.6 ± 631.5 ml vs. Post-QI: 415.8 ± 189.9 ml, p < 0.001), significantly greater mean operative time normalized to levels fused (Pre-QI: 0.6 ± 0.1 h/level fused vs Post-QI: 0.4 ± 0.1 h/level fused, p < 0.001), and a significantly greater proportion of patients with intraoperative drain placement (Pre-QI: 93.2% vs Post-QI: 5.8%, p < 0.001). The Post-QI cohort had significantly shorter time to postoperative ambulation (Pre-QI: 2.1 ± 0.9 days vs Post-QI: 1.3 ± 0.5 days, p < 0.001). A significantly greater proportion of patients in the Pre-QI cohort developed any postoperative complication (Pre-QI: 72.7% vs Post-QI: 34.6%, p < 0.001), and mean LOS was significantly greater among Pre-QI patients (Pre-QI: 4.5 ± 1.1 days vs Post-QI: 3.2 ± 0.8 days, p < 0.001). Discharge disposition (p = 0.758) and 30-day unplanned readmissions (p = 0.207) were similar between the cohorts. Conclusions: Our findings suggest that monthly multidisciplinary pediatric spine team meetings may improve patient care. Further studies exploring the incorporation of QI implementation with frequent multidisciplinary team meetings into existing ERAS protocols are merited.
Language	English
Publishing date	2024-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-024-00859-2
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Article ; Online: Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.

Hobbs, Samuel J / Wein, Tanita / Lu, Allen / Morehouse, Benjamin R / Schnabel, Julia / Leavitt, Azita / Yirmiya, Erez / Sorek, Rotem / Kranzusch, Philip J

Nature

2022 Volume 605, Issue 7910, Page(s) 522–526

Abstract: The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals to induce cell death and prevent ...

Abstract	The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals to induce cell death and prevent viral propagation
MeSH term(s)	Bacteria/metabolism ; Bacterial Proteins/metabolism ; Bacteriophage T4/metabolism ; Bacteriophages/physiology ; CRISPR-Cas Systems/genetics ; Endonucleases/metabolism ; Escherichia coli/metabolism ; Nucleotides, Cyclic/metabolism ; Oligonucleotides ; Pyrimidines/metabolism
Chemical Substances	Bacterial Proteins ; Nucleotides, Cyclic ; Oligonucleotides ; Pyrimidines ; Endonucleases (EC 3.1.-)
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04716-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Zs.MO 244: Show issues

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