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  1. Article ; Online: Urinary C4d in crescentic IgA nephropathy: expectancy and hope for a non-invasive lectin pathway biomarker.

    Maillard, Nicolas / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 37, Issue 11, Page(s) 2042–2043

    MeSH term(s) Humans ; Glomerulonephritis, IGA/complications ; Cohort Studies ; Lectins ; Disease Progression ; Biomarkers
    Chemical Substances Lectins ; Biomarkers
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac168
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    Zs.A 2198: Show issues Location:
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  2. Article ; Online: Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy.

    Ștefan, Gabriel / Alamartine, Eric / Mariat, Christophe / Maillard, Nicolas

    Kidney international reports

    2023  Volume 9, Issue 2, Page(s) 356–369

    Abstract: Introduction: IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review.! ...

    Abstract Introduction: IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review.
    Methods: We adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and conducted a systematic review, utilizing databases like MEDLINE (PubMed), Embase, Scopus, and Cochrane from January 2016 (year of updated MEST-C classification) to January 2023. We specifically selected studies that employed established methods to evaluate complement activation and the MEST-C classification.
    Results: A total of 34 studies with 10,082 patients were included. Among these, 7 studies focused on the pediatric population (500 patients), and 22 studies involved 8128 patients from Asian populations. C4d, C3, C5b9, MBL, C4, and factor H-related protein 5 (FHR5) were the most frequently studied complement proteins in relation to the MEST-C classification. Complement activation assessment was primarily conducted using immunofluorescence and immunohistochemistry on kidney biopsy specimens. All complement proteins investigated showed associations with the C1-2 class. Notably, FB, FH, MASP1/3, MASP2, C5a, and C5b9 from the alternative, lectin, and terminal pathways were uniquely present in the C1-2 class. Whereas C3, FHR5, C4, and C4d were associated with all the MEST-C classes.
    Conclusion: We found evidence supporting the involvement of alternative and lectin complement pathways across all MEST-C classes. All examined complement factors were associated with the C1-2 class, emphasizing the critical role of complement activation, possibly at the endothelial surface. These findings may guide the development of personalized treatment strategies targeting complement pathways in relation to the MEST-C lesions.
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.11.005
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  3. Article ; Online: Importance of measuring glomerular filtration rate for candidates to living kidney donation.

    Gaillard, François / Mariat, Christophe

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2021  Volume 22, Issue 5, Page(s) 1494–1495

    MeSH term(s) Glomerular Filtration Rate ; Humans ; Kidney ; Living Donors ; Nephrectomy
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16924
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  4. Article ; Online: Comparing Multiple-Biomarker Panels for Estimating GFR With Estimating Equations Without a Coefficient Distinguishing Black Individuals From Persons of Other Groups.

    Delanaye, Pierre / Mariat, Christophe

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 77, Issue 5, Page(s) 823–824

    MeSH term(s) African Americans ; Biomarkers ; Humans ; Intramolecular Oxidoreductases ; Lipocalins
    Chemical Substances Biomarkers ; Lipocalins ; Intramolecular Oxidoreductases (EC 5.3.-) ; prostaglandin R2 D-isomerase (EC 5.3.99.2)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.12.016
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    Zs.MO 468: Show issues

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  5. Article ; Online: Adherence to Therapy: Burden, Complexity, and Perception.

    Delanaye, Pierre / Mariat, Christophe

    Kidney international reports

    2020  Volume 6, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.11.005
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  6. Article ; Online: Systemic corticosteroids and mucosal-associated lymphoid tissue-targeted therapy in immunoglobulin A nephropathy: insight from the NEFIGAN study.

    Coppo, Rosanna / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 35, Issue 8, Page(s) 1291–1294

    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Editorial
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz249
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  7. Article ; Online: Transplantation rénale en France, avantages liés au donneur vivant.

    Maillard, Nicolas / Mariat, Christophe

    La Revue du praticien

    2020  Volume 71, Issue 6, Page(s) 617–620

    Abstract: Renal transplantation and living donation in France. While renal transplantation remains the best option for patients with end-stage renal disease, it does not cover the needs of the population. Transplantation from living donors is becoming the strategy ...

    Title translation Renal transplantation and living donation in France.
    Abstract Renal transplantation and living donation in France. While renal transplantation remains the best option for patients with end-stage renal disease, it does not cover the needs of the population. Transplantation from living donors is becoming the strategy of first choice to address the numerous challenges faced by both the patients and the transplant community. However, living kidney donor transplantation remains marginal in France and concerns only 15% of the transplanted patients. Herein, after reviewing the main epidemiological trends of renal transplantation in France, we discuss the reasons and opportunities of further developing living kidney donation.
    MeSH term(s) France/epidemiology ; Humans ; Kidney ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Living Donors
    Language French
    Publishing date 2020-12-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  8. Article ; Online: The Oxford Classification for immunoglobulin A nephropathy: a common language blurred by dissonant voices.

    Maillard, Nicolas / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2019  Volume 34, Issue 10, Page(s) 1617–1618

    MeSH term(s) Biopsy ; Glomerulonephritis, IGA ; Humans ; Immunoglobulin A ; Language ; Reproducibility of Results
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz009
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  9. Article ; Online: Diagnostic standard: assessing glomerular filtration rate.

    Delanaye, Pierre / Pottel, Hans / Cavalier, Etienne / Flamant, Martin / Stehlé, Thomas / Mariat, Christophe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  

    Abstract: Creatinine-based estimated GFR (eGFR) is imprecise at individual level, due to non-GFR-related serum creatinine determinants, including atypical muscle mass. Cystatin C has the advantage of being independent on muscle mass, a feature that led to the ... ...

    Abstract Creatinine-based estimated GFR (eGFR) is imprecise at individual level, due to non-GFR-related serum creatinine determinants, including atypical muscle mass. Cystatin C has the advantage of being independent on muscle mass, a feature that led to the development of race- and sex-free equations. Yet, cystatin C-based equations do not perform better than creatinine-based equations to estimate GFR, unless both variables are included together. The new race-free Chronic Kidney Disease Epidemiology (CKD-EPI) equation, had slight opposite biases between Black and Non-Black subjects in USA, but performs poorer than that the previous version in European populations. The European Kidney Function Consortium (EKFC) equation developed in 2021 can be used both in children and adults, is more accurate in young and old adults, and is applicable to non-white European populations, by rescaling the Q factor, i.e. population median creatinine, in a potentially universal way. A sex- and race-free cystatin C-based EKFC, with the same mathematical design, has also be defined. New developments in the field of GFR estimation would be standardization of cystatin C assays, development of creatinine-based eGFR equations that would incorporate muscle mass data, implementation of new endogenous biomarkers, and the use of artificial intelligence. Standardization of different GFR measurement methods would also be a future challenge, as well as new technologies for measuring GFR. Future research is also needed on discrepancies between cystatin C and creatinine, which is associated with high risk of adverse events: standardize the definition of discrepancy, and understand its determinants.
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Circulating alternative pathway complement cleavage factor Bb is associated with vascular lesions and outcomes in IgA nephropathy.

    Ștefan, Gabriel / Jullien, Perrine / Masson, Ingrid / Alamartine, Eric / Mariat, Christophe / Maillard, Nicolas

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue Supplement_2, Page(s) ii11–ii18

    Abstract: Background: Complement alternative pathway (AP) activation is linked to immunoglobulin A nephropathy (IgAN) prognosis severity, but Bb fragment's role is unclear. We examined the relationship between serum Bb fragment concentration at IgAN diagnosis and ...

    Abstract Background: Complement alternative pathway (AP) activation is linked to immunoglobulin A nephropathy (IgAN) prognosis severity, but Bb fragment's role is unclear. We examined the relationship between serum Bb fragment concentration at IgAN diagnosis and disease activity and outcomes.
    Methods: This retrospective study included 125 biopsy-proven IgAN patients [age 39.9 years, 75% male, estimated glomerular filtration rate (eGFR) 82 ml/min, proteinuria 0.5 g/day] enrolled from 1984 to 2010 and followed for a minimum of 18 months. Monitoring continued until the last follow-up, end-stage kidney disease (ESKD) or death. Serum Bb fragment was measured using an enzyme-linked immunosorbent assay at diagnosis. Oxford classification and global optical score (GOS) were utilized for pathology assessment.
    Results: Patients were followed for a median of 16 years; 42% developed chronic kidney disease stage ≥3, 19% reached ESKD and 9% died. Serum Bb fragment concentration negatively correlated with eGFR values at the last follow-up and positively with vascular and tubular histopathological indices. In univariate Cox regression analyses, higher Bb fragment concentration was associated with ESKD alongside older age, increased body mass index, arterial hypertension, lower eGFR, higher proteinuria, E1, S1, T1-2, GOS and corticotherapy. Patients with Bb levels ≥14.3 μg/ml had shorter mean kidney survival time (19.5 versus 22.7 years, P = .07); after adjusting for progression risk factors, the association persisted [hazard ratio 4.76 (95% confidence interval 1.56-14.43)].
    Conclusions: Serum Bb fragment concentration at diagnosis may predict long-term IgAN outcomes, potentially due to AP activation at the endothelial surface. Further research is needed to confirm these results and evaluate Bb fragment's role in IgAN management.
    MeSH term(s) Humans ; Male ; Adult ; Female ; Glomerulonephritis, IGA/pathology ; Retrospective Studies ; Complement Factor B ; Disease Progression ; Prognosis ; Kidney Failure, Chronic/complications ; Proteinuria/complications ; Glomerular Filtration Rate
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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