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Article ; Online: Trends in Phenylephrine and Pseudoephedrine Sales in the US.

Anderson, Timothy S / Suda, Katie J / Gellad, Walid F / Tadrous, Mina

2024 Volume 331, Issue 9, Page(s) 796–798

MeSH term(s)	Commerce/trends ; Phenylephrine/economics ; Phenylephrine/therapeutic use ; Pseudoephedrine/economics ; Pseudoephedrine/therapeutic use ; United States/epidemiology
Chemical Substances	Phenylephrine (1WS297W6MV) ; Pseudoephedrine (7CUC9DDI9F)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2023.27932
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Article ; Online: Elevated temperatures reduce population-specific transcriptional plasticity in developing lake sturgeon (Acipenser fulvescens).

Bugg, William S / Thorstensen, Matt J / Marshall, Katie E / Anderson, W Gary / Jeffries, Ken M

Molecular ecology

2023 Volume 32, Issue 14, Page(s) 4044–4062

Abstract: Rising mean and variance in temperatures elevates threats to endangered freshwater species such as lake sturgeon, Acipenser fulvescens. Previous research demonstrated that higher temperatures during development result in physiological consequences for ... ...

Abstract	Rising mean and variance in temperatures elevates threats to endangered freshwater species such as lake sturgeon, Acipenser fulvescens. Previous research demonstrated that higher temperatures during development result in physiological consequences for lake sturgeon populations throughout Manitoba, Canada, with alteration of metabolic rate, thermal tolerance, transcriptional responses, growth and mortality. We acclimated lake sturgeon (30-60 days post fertilization, a period of high mortality) from northern and southern populations (56°02'46.5″N, 96°54'18.6″W and 50°17'52″N, 95°32'51″W, respectively, separated by approximately 650 km) within Manitoba to current (summer highs of 20-23°C) and future projected (+2-3°C) environmental temperatures of 16, 20 and 24°C for 30 days, and we measured gill transcriptional responses using RNAseq. Transcripts revealed SNPs consistent with genetically distinct populations and transcriptional responses altered by acclimation temperature. There were a higher number of differentially expressed transcripts observed in the southern, compared to the northern, population as temperatures increased, indicating enhanced transcriptional plasticity. Both lake sturgeon populations responded to elevated acclimation temperatures by downregulating the transcription of genes involved in protein synthesis and energy production. Furthermore, there were population-specific thresholds for the downregulation of processes promoting transcriptional plasticity as well as mitochondrial function as the northern population showed decreases at 20°C, while this capacity was not diminished until 24°C in the southern population. These transcriptional responses highlight the molecular impacts of increasing temperatures for divergent lake sturgeon populations during vulnerable developmental periods and the critical influence of transcriptome plasticity on acclimation capacity.
MeSH term(s)	Animals ; Temperature ; Fishes/physiology ; Canada ; Fresh Water ; Manitoba ; Endangered Species
Language	English
Publishing date	2023-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16967
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Article ; Online: The ascent of man(made oxidoreductases).

Grayson, Katie J / Anderson, Jl Ross

Current opinion in structural biology

2018 Volume 51, Page(s) 149–155

Abstract: Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to ... ...

Abstract	Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules as plug-and-play components in the metabolic pathways of living cells. To this end, there are now de novo metalloenzymes that are assembled in vivo, including the recently reported C45 maquette, which can catalyse a variety of substrate oxidations with efficiencies rivalling those of closely related natural enzymes. Here we explore the successful design of this de novo enzyme, which was designed to minimise the undesirable complexity of natural proteins using a minimalistic bottom-up approach.
MeSH term(s)	Binding Sites ; Catalysis ; Models, Molecular ; Oxidation-Reduction ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Protein Binding ; Protein Engineering ; Protein Interaction Domains and Motifs ; Recombinant Proteins ; Structure-Activity Relationship ; Substrate Specificity
Chemical Substances	Recombinant Proteins ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2018-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1068353-7
ISSN	1879-033X ; 0959-440X
ISSN (online)	1879-033X
ISSN	0959-440X
DOI	10.1016/j.sbi.2018.04.008
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Zs.A 3206: Show issues

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Article ; Online: Importance of valid, reliable, and responsive outcome measures for lumbar spinal stenosis.

Anderson, David B / Mobbs, Ralph J / Smith, Zachary A / De Luca, Katie / Sabet, Tamer / Van Gelder, James M

The spine journal : official journal of the North American Spine Society

2022 Volume 23, Issue 3, Page(s) 345–349

MeSH term(s)	Humans ; Spinal Stenosis/surgery ; Treatment Outcome ; Outcome Assessment, Health Care ; Reproducibility of Results ; Lumbar Vertebrae/surgery
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2037072-6
ISSN	1878-1632 ; 1529-9430
ISSN (online)	1878-1632
ISSN	1529-9430
DOI	10.1016/j.spinee.2022.11.014
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Zs.A 5898: Show issues

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Article ; Online: Elevated temperatures reduce population‐specific transcriptional plasticity in developing lake sturgeon (Acipenser fulvescens)

Bugg, William S. / Thorstensen, Matt J. / Marshall, Katie E. / Anderson, W. Gary / Jeffries, Ken M.

Molecular Ecology. 2023 July, v. 32, no. 14 p.4044-4062

2023

Abstract	Rising mean and variance in temperatures elevates threats to endangered freshwater species such as lake sturgeon, Acipenser fulvescens. Previous research demonstrated that higher temperatures during development result in physiological consequences for lake sturgeon populations throughout Manitoba, Canada, with alteration of metabolic rate, thermal tolerance, transcriptional responses, growth and mortality. We acclimated lake sturgeon (30–60 days post fertilization, a period of high mortality) from northern and southern populations (56°02′46.5″N, 96°54′18.6″W and 50°17′52″N, 95°32′51″W, respectively, separated by approximately 650 km) within Manitoba to current (summer highs of 20–23°C) and future projected (+2–3°C) environmental temperatures of 16, 20 and 24°C for 30 days, and we measured gill transcriptional responses using RNAseq. Transcripts revealed SNPs consistent with genetically distinct populations and transcriptional responses altered by acclimation temperature. There were a higher number of differentially expressed transcripts observed in the southern, compared to the northern, population as temperatures increased, indicating enhanced transcriptional plasticity. Both lake sturgeon populations responded to elevated acclimation temperatures by downregulating the transcription of genes involved in protein synthesis and energy production. Furthermore, there were population‐specific thresholds for the downregulation of processes promoting transcriptional plasticity as well as mitochondrial function as the northern population showed decreases at 20°C, while this capacity was not diminished until 24°C in the southern population. These transcriptional responses highlight the molecular impacts of increasing temperatures for divergent lake sturgeon populations during vulnerable developmental periods and the critical influence of transcriptome plasticity on acclimation capacity.
Keywords	Acipenser fulvescens ; acclimation ; energy ; freshwater ; gene expression regulation ; heat tolerance ; mitochondria ; mortality ; protein synthesis ; summer ; temperature ; transcription (genetics) ; transcriptome ; variance ; Manitoba
Language	English
Dates of publication	2023-07
Size	p. 4044-4062.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16967
Database	NAL-Catalogue (AGRICOLA)

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Article: Symbiotic Modulation as a Driver of Niche Expansion of Coastal Plants in the San Juan Archipelago of Washington State.

Redman, Regina S / Anderson, Joe A / Biaggi, Taylor M / Malmberg, Katie E L / Rienstra, Melissa N / Weaver, Jamie L / Rodriguez, Rusty J

Frontiers in microbiology

2022 Volume 13, Page(s) 868081

Abstract: Modern evolutionary theory and population genetics posit that adaptation and habitat expansion of plants result from processes exclusive to their genomes. Here, we present studies showing that plants can grow across complex habitat gradients by ... ...

Abstract	Modern evolutionary theory and population genetics posit that adaptation and habitat expansion of plants result from processes exclusive to their genomes. Here, we present studies showing that plants can grow across complex habitat gradients by modulating symbiotic associations with Class 2 fungal endophytes. Endophyte analysis of three native (
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.868081
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Article ; Online: Risk of recurrent stroke and dementia following acute stroke by changes in kidney function: results from the Perindopril Protection Against Recurrent Stroke Study.

Maeda, Toshiki / Woodward, Mark / Jun, Min / Sakamoto, Yuki / Chen, Xiaoying / Matsushita, Kunihiro / Mancia, Guiseppe / Arima, Hisatomi / Anderson, Craig S / Chalmers, John / Harris, Katie

Journal of hypertension

2024

Abstract: ... had a major cardiovascular event, 221 (4.8%) developed dementia, and 271 (5.9%) died. Reverse J-like ...

Abstract	Background: Limited data exist on the relationship between declining kidney function and cardiovascular events, dementia, and mortality in patients with a history of stroke.Thus the aims of the study were to investigate functional relationships between dynamic kidney function change and cardiovascular outcomes, and clarify whether adding kidney parameters to conventional cardiovascular risk factors improves model discrimination. Methods: Post hoc analysis of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) clinical trial of blood pressure lowering for the secondary prevention of stroke. We examined the association between dynamic kidney function defined as percentage change (declines of >30%, and >0 to ≤30%, and increases of ≥0 to <30%, and ≥30%) in estimated glomerular filtration rate (eGFR) over 2 years and recurrent stroke, major cardiovascular events, dementia and all-cause death over the next 2 years using Cox proportional hazard models controlling for eGFR at registration and potential confounders. Restricted cubic splines were used to assess the functional relationships. C-statistics and Net Reclassification Improvement (NRI) at 2 years were used to assess model discrimination. Results: In 4591 patients followed for a mean of approximately 2 years, 254 (5.5%) developed recurrent stroke, 391 (8.5%) had a major cardiovascular event, 221 (4.8%) developed dementia, and 271 (5.9%) died. Reverse J-like or U-like relationships were observed for percent declines in eGFR and outcomes. Using declines in eGFR of >0 to ≤30% as a reference, increased risks were evident for a greater decline (>30%) in relation to recurrent stroke [adjusted hazard ratio 1.85, 95% confidence interval (CI) 1.20-2.85], major cardiovascular event (2.24, 1.62-3.10) and all-cause death (2.09, 1.39-3.15). A larger increase (≥30%) in eGFR was also associated with a greater risk of all-cause death (1.96, 1.14-3.37). Improvements in the C-statistic were found by adding baseline eGFR and percent change compared with a model with conventional cardiovascular risk factors alone, for major cardiovascular events, dementia, and all-cause mortality. Conclusion: Declining kidney function following an incident cerebrovascular event is associated with additional risk of a major cardiovascular events, dementia, and 2-year mortality. However, a large increase in kidney function was also found to be associated with a higher risk of mortality.
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003711
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Substrate promiscuity of a de novo designed peroxidase.

Jenkins, Jonathan M X / Noble, Claire E M / Grayson, Katie J / Mulholland, Adrian J / Anderson, J L Ross

Journal of inorganic biochemistry

2021 Volume 217, Page(s) 111370

Abstract: The design and construction of de novo enzymes offer potentially facile routes to exploiting powerful chemistries in robust, expressible and customisable protein frameworks, while providing insight into natural enzyme function. To this end, we have ... ...

Abstract	The design and construction of de novo enzymes offer potentially facile routes to exploiting powerful chemistries in robust, expressible and customisable protein frameworks, while providing insight into natural enzyme function. To this end, we have recently demonstrated extensive catalytic promiscuity in a heme-containing de novo protein, C45. The diverse transformations that C45 catalyses include substrate oxidation, dehalogenation and carbon‑carbon bond formation. Here we explore the substrate promiscuity of C45's peroxidase activity, screening the de novo enzyme against a panel of peroxidase and dehaloperoxidase substrates. Consistent with the function of natural peroxidases, C45 exhibits a broad spectrum of substrate activities with selectivity dictated primarily by the redox potential of the substrate, and by extension, the active oxidising species in peroxidase chemistry, compounds I and II. Though the comparison of these redox potentials provides a threshold for determining activity for a given substrate, substrate:protein interactions are also likely to play a significant role in determining electron transfer rates from substrate to heme, affecting the kinetic parameters of the enzyme. We also used biomolecular simulation to screen substrates against a computational model of C45 to identify potential interactions and binding sites. Several sites of interest in close proximity to the heme cofactor were discovered, providing insight into the catalytic workings of C45.
MeSH term(s)	Binding Sites ; Heme/chemistry ; Kinetics ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peroxidases/chemistry ; Peroxidases/metabolism ; Protein Binding ; Substrate Specificity
Chemical Substances	Heme (42VZT0U6YR) ; Peroxidases (EC 1.11.1.-)
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111370
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Zs.B 1730: Show issues

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Article ; Online: Designed for life: biocompatible de novo designed proteins and components.

Grayson, Katie J / Anderson, J L Ross

Journal of the Royal Society, Interface

2018 Volume 15, Issue 145

Abstract: A principal goal of synthetic biology is the de novo design or redesign of biomolecular components. In addition to revealing fundamentally important information regarding natural biomolecular engineering and biochemistry, functional building blocks will ... ...

Abstract	A principal goal of synthetic biology is the de novo design or redesign of biomolecular components. In addition to revealing fundamentally important information regarding natural biomolecular engineering and biochemistry, functional building blocks will ultimately be provided for applications including the manufacture of valuable products and therapeutics. To fully realize this ambitious goal, the designed components must be biocompatible, working in concert with natural biochemical processes and pathways, while not adversely affecting cellular function. For example, de novo protein design has provided us with a wide repertoire of structures and functions, including those that can be assembled and function
MeSH term(s)	Humans ; Protein Engineering/methods
Language	English
Publishing date	2018-08-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2018.0472
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Article ; Online: Transitioning to Environmentally Sustainable, Climate-Smart Radiation Oncology Care.

Lichter, Katie E / Anderson, Justin / Sim, Austin J / Baniel, Claire C / Thiel, Cassandra L / Chuter, Robert / Collins, Amy / Carollo, Erin / Berg, Christine D / Coleman, C Norman / Abdel-Wahab, May / Grover, Surbhi / Singer, Lisa / Mohamad, Osama

International journal of radiation oncology, biology, physics

2022 Volume 113, Issue 5, Page(s) 915–924

MeSH term(s)	Humans ; Medical Oncology ; Radiation Oncology ; Sustainable Development
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Editorial
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2022.04.039
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Zs.A 1218: Show issues

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