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  1. Article: The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS.

    Zhao, Jindong / Liu, Lili / Xin, Ling / Lu, Yunxia / Yang, Xiaojun / Hou, Yong / Shi, Mei / Han, Sha / Zhou, Hao / Liu, Yonghua / Fang, Zhaohui / Li, Yan / Zhang, Guoliang

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 6611563

    Abstract: Objective: The aim of this study was to evaluate the effects of a modified Xiaohua Funing ...

    Abstract Objective: The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether the protective mechanisms are related to alterations in the gut microbiota.
    Methods: An animal model of ALF was induced by intraperitoneal injection of D-galactosamine (D-Gal, 0.5 g/kg) and lipopolysaccharide (LPS, 100 
    Results: D-Gal/LPS treatment caused severe ALF, illustrating that the ALF model was successfully established. The administration of Sil and Xfd greatly reduced the serum ALT and AST levels and improved the pathological signs of liver injury. However, no significant difference was found between the two groups. In contrast to the Mod group, the Sil and Xfd groups showed a shift toward the Con group in terms of the gut microbiota structure. The abundances of Firmicutes and Bacteroidetes and the Bacteroidetes/Firmicutes ratio in the Mod group significantly differed from those in the Con group. The Sil and Xfd groups showed restoration of the disordered microbiota. Significantly increased relative abundances of Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas and a markedly decreased Muribaculaceae abundance were found in the Sil and Xfd mice compared with those in the Mod mice (
    Conclusion: In summary, our results indicate that Xfd may protect the liver and modify the gut microbiota in ALF mice.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/6611563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS

    Jindong Zhao / Lili Liu / Ling Xin / Yunxia Lu / Xiaojun Yang / Yong Hou / Mei Shi / Sha Han / Hao Zhou / Yonghua Liu / Zhaohui Fang / Yan Li / Guoliang Zhang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Objective. The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction ...

    Abstract Objective. The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether the protective mechanisms are related to alterations in the gut microbiota. Methods. An animal model of ALF was induced by intraperitoneal injection of D-galactosamine (D-Gal, 0.5 g/kg) and lipopolysaccharide (LPS, 100 μg/kg). Male BALB/c mice were randomly divided into the following 4 groups: the control group (saline, Con), model group (D-Gal/LPS, Mod), silymarin pretreatment group (200 mg/kg, Sil), and modified Xfd pretreatment group (650 mg/kg, Xfd). The Sil and Xfd groups received the respective intervention orally for 14 days and 2 h before D-Gal/LPS treatment. The liver injury markers included alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver histology. 16S rRNA gene sequencing was performed to assess the effects on the caecum content. Results. D-Gal/LPS treatment caused severe ALF, illustrating that the ALF model was successfully established. The administration of Sil and Xfd greatly reduced the serum ALT and AST levels and improved the pathological signs of liver injury. However, no significant difference was found between the two groups. In contrast to the Mod group, the Sil and Xfd groups showed a shift toward the Con group in terms of the gut microbiota structure. The abundances of Firmicutes and Bacteroidetes and the Bacteroidetes/Firmicutes ratio in the Mod group significantly differed from those in the Con group. The Sil and Xfd groups showed restoration of the disordered microbiota. Significantly increased relative abundances of Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas and a markedly decreased Muribaculaceae abundance were found in the Sil and Xfd mice compared with those in the Mod mice (P<0.01, P<0.05). Interestingly, a negative correlation was observed between the abundances of the gut microbiota constituents, specifically Clostridia_UCG-014, and ALT and AST levels. Conclusion. In ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Editorial: Regulation of Ubiquitination and Sumoylation Signaling in Disease.

    Lin, Zhenghong / Yan, Xiaohua

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 970683

    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.970683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The shift to plant-based dietary patterns in China would have significant effects on cultivated land resources.

    Zhu, Xiaohua / Zhang, Yan / Zhu, Yuanyuan / Li, Yurui

    Science bulletin

    2023  Volume 69, Issue 6, Page(s) 737–740

    MeSH term(s) Dietary Patterns ; China ; Agriculture
    Language English
    Publishing date 2023-12-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.12.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Asymmetric Synthesis of Hydroindoles via Desymmetrizing [3+2] Annulation of

    Chen, Qianping / Zhang, Yan / Song, Yanji / Zhang, Yang / Su, Zhishan / Feng, Xiaoming / Liu, Xiaohua

    Organic letters

    2024  Volume 26, Issue 16, Page(s) 3366–3370

    Abstract: The asymmetric desymmetrizing [3+2] annulation reaction ... ...

    Abstract The asymmetric desymmetrizing [3+2] annulation reaction of
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Control of metal oxides' electronic conductivity through visual intercalation chemical reactions.

    Zhang, Yuanyuan / Zhang, Xiaohua / Pang, Quanquan / Yan, Jianhua

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6130

    Abstract: Cation intercalation is an effective method to optimize the electronic structures of metal oxides, but tuning intercalation structure and conductivity by manipulating ion movement is difficult. Here, we report a visual topochemical synthesis strategy to ... ...

    Abstract Cation intercalation is an effective method to optimize the electronic structures of metal oxides, but tuning intercalation structure and conductivity by manipulating ion movement is difficult. Here, we report a visual topochemical synthesis strategy to control intercalation pathways and structures and realize the rapid synthesis of flexible conductive metal oxide films in one minute at room temperature. Using flexible TiO
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41935-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Real-Time Experience of Abrocitinib for the Treatment of Mucous Membrane Pemphigoid: A Case Report.

    Teng, Yan / Ren, Mingyang / Yang, Xianhong / Lu, Wei / Tao, Xiaohua

    Patient preference and adherence

    2024  Volume 18, Page(s) 503–506

    Abstract: Background: Mucous membrane pemphigoid (MMP), a rare autoimmune vesiculous and erosive disorder, may affect multiple mucous membranes, with the oral cavity being the most commonly affected site. Its treatment depends on the site(s) of mucosal ... ...

    Abstract Background: Mucous membrane pemphigoid (MMP), a rare autoimmune vesiculous and erosive disorder, may affect multiple mucous membranes, with the oral cavity being the most commonly affected site. Its treatment depends on the site(s) of mucosal involvement and disease severity.
    Patients and methods: A 62-year-old female patient with MMP that predominantly involved the oral cavity strongly rejected systemic corticosteroid or immunosuppressive agents and was successfully treated with abrocitinib, a highly selective JAK-1 inhibitor with a good safety profile.
    Results: The case demonstrated good efficacy and safety profile of abrocitinib for the treatment of MMP with predominant oral involvement.
    Conclusion: Abrocitinib is a promising agent for the treatment of MMP with oral involvement.
    Language English
    Publishing date 2024-02-23
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S451007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ferrostatin 1 ameliorates UVB-induced damage of HaCaT cells by regulating ferroptosis.

    Teng, Yan / Tang, Hui / Tao, Xiaohua / Huang, Youming / Fan, Yibin

    Experimental dermatology

    2024  Volume 33, Issue 2, Page(s) e15018

    Abstract: Ferroptosis, a type of programmed cell death, occurs when there is oxidative stress and lipid peroxides. This condition is marked by lipid peroxidation that relies on iron and the reduction of cellular defences against oxidation. To investigate the ... ...

    Abstract Ferroptosis, a type of programmed cell death, occurs when there is oxidative stress and lipid peroxides. This condition is marked by lipid peroxidation that relies on iron and the reduction of cellular defences against oxidation. To investigate the effect of UVB irradiation on ferroptosis of human keratinocytes HaCaT cells, the cells were pretreated with Ferrostatin 1 (Fer-1, 10 μM), an ferroptosis inhibitor and then irradiated with UVB (20 mJ/cm
    MeSH term(s) Humans ; HaCaT Cells ; Reactive Oxygen Species/metabolism ; Ferroptosis ; Proteomics ; Apoptosis ; Keratinocytes/metabolism ; Iron ; Ultraviolet Rays/adverse effects
    Chemical Substances Reactive Oxygen Species ; Iron (E1UOL152H7)
    Language English
    Publishing date 2024-02-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15018
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    Zs.A 3508: Show issues Location:
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  9. Article: Study of Aerogel-Modified Recycled Polyurethane Nanocomposites.

    Gu, Xiaohua / Zhu, Shangwen / Liu, Siwen / Liu, Yan

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 18

    Abstract: In this study, a liquid regenerated polyether polyol was obtained after the degradation of waste PU foam by the two-component decrosslinker agents ethylene glycol and ethanolamine. The regenerated polyol-based polyurethane foam was modified by adding ... ...

    Abstract In this study, a liquid regenerated polyether polyol was obtained after the degradation of waste PU foam by the two-component decrosslinker agents ethylene glycol and ethanolamine. The regenerated polyol-based polyurethane foam was modified by adding different ratios of SiO
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13182583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: TGF-

    Yan, Xiaohua / Zhang, Long / Miyazawa, Keiji / Ten Dijke, Peter

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 1012326

    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1012326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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