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  1. Article ; Online: To eat or not to eat: type 2 immunity controls food avoidance behavior.

    Kodra, Albana L / Mucida, Daniel

    Trends in immunology

    2023  Volume 44, Issue 9, Page(s) 665–667

    Abstract: Growing evidence suggests that food allergies are regulated by neuroimmune interactions. However, the underlying molecular mechanisms remain unclear. Plum et al. and Florsheim et al. identify IgE-mediated mast cell activation, leukotrienes, and growth ... ...

    Abstract Growing evidence suggests that food allergies are regulated by neuroimmune interactions. However, the underlying molecular mechanisms remain unclear. Plum et al. and Florsheim et al. identify IgE-mediated mast cell activation, leukotrienes, and growth differentiating factor 15 (GDF15) as key regulators of the avoidance response to food allergens in mice.
    MeSH term(s) Animals ; Mice ; Avoidance Learning ; Antigen Presentation ; Neuroimmunomodulation
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.07.007
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  2. Article ; Online: Intraepithelial Lymphocytes of the Intestine.

    Lockhart, Ainsley / Mucida, Daniel / Bilate, Angelina M

    Annual review of immunology

    2024  

    Abstract: The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, ... ...

    Abstract The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, and tissue protection to maintain epithelial homeostasis and barrier integrity. This review discusses the ontogeny, environmental imprinting, T cell receptor (TCR) repertoire, and function of intestinal IELs. Despite distinct developmental pathways, IEL subsets share core traits including an epithelium-adapted profile, innate-like properties, cytotoxic potential, and limited TCR diversity. IELs also receive important developmental and functional cues through interactions with epithelial cells, microbiota, and dietary components. The restricted TCR diversity of IELs suggests that a limited set of intestinal antigens drives IEL responses, with potential functional consequences. Finally, IELs play a key role in promoting homeostatic immunity and epithelial barrier integrity but can become pathogenic upon dysregulation. Therefore, IELs represent intriguing but underexamined therapeutic targets for inflammatory diseases and cancer. Expected final online publication date for the
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-090222-100246
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  3. Article ; Online: Climate change: it's on us too.

    Niec, Rachel / Carvalho, Thiago L / Mucida, Daniel

    Nature immunology

    2023  Volume 24, Issue 9, Page(s) 1395

    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01546-6
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  4. Article ; Online: A triplex for intestinal protection: Neurons, microbes, and goblet cells.

    Kim, Dong-Yoon / Mucida, Daniel

    Immunity

    2022  Volume 55, Issue 12, Page(s) 2228–2230

    Abstract: Diverse intestinal components (e.g., gut-associated neurons, immune cells, gut microbes, and epithelium) are intimately intertwined with each other to maintain homeostasis in the gut. In a recent issue of Cell, Zhang et al. (2022) and Yang et al. (2022) ... ...

    Abstract Diverse intestinal components (e.g., gut-associated neurons, immune cells, gut microbes, and epithelium) are intimately intertwined with each other to maintain homeostasis in the gut. In a recent issue of Cell, Zhang et al. (2022) and Yang et al. (2022) present complementary studies uncovering interactions between nociceptor neurons, gut epithelium, and the microbiome to protect intestinal tissue from inflammation.
    MeSH term(s) Goblet Cells ; Intestinal Mucosa ; Gastrointestinal Microbiome ; Homeostasis ; Neurons
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.11.006
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  5. Article ; Online: Isolation of myenteric and submucosal plexus from mouse gastrointestinal tract and subsequent flow cytometry and immunofluorescence.

    Ahrends, Tomasz / Weiner, Molly / Mucida, Daniel

    STAR protocols

    2022  Volume 3, Issue 1, Page(s) 101157

    Abstract: The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric nervous system (ENS) and control intestinal functions, ... ...

    Abstract The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric nervous system (ENS) and control intestinal functions, such as motility and nutrient sensing. This protocol describes the method for physical separation (peeling) of muscularis and submucosal layers of the mouse intestine. Subsequently, the intestinal layers are then processed for flow cytometry and/or immunofluorescence analysis. For complete details on the use and execution of this profile, please refer to Ahrends et al. (2021).
    MeSH term(s) Animals ; Flow Cytometry/methods ; Fluorescent Antibody Technique ; Gastrointestinal Tract/physiology ; Mice ; Mice, Inbred C57BL ; Myenteric Plexus/cytology ; Submucous Plexus/cytology
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101157
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  6. Article ; Online: Immunity to enteric viruses.

    Lockhart, Ainsley / Mucida, Daniel / Parsa, Roham

    Immunity

    2022  Volume 55, Issue 5, Page(s) 800–818

    Abstract: Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among children in developing countries. The host response to enteric viruses occurs primarily within the mucosa, where the intestinal immune system must balance ... ...

    Abstract Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among children in developing countries. The host response to enteric viruses occurs primarily within the mucosa, where the intestinal immune system must balance protection against pathogens with tissue protection and tolerance to harmless commensal bacteria and food. Here, we summarize current knowledge in natural immunity to enteric viruses, highlighting specialized features of the intestinal immune system. We further discuss how knowledge of intestinal anti-viral mechanisms can be translated into vaccine development with particular focus on immunization in the oral route. Research reveals that the intestine is a complex interface between enteric viruses and the host where environmental factors influence susceptibility and immunity to infection, while viral infections can have lasting implications for host health. A deeper mechanistic understanding of enteric anti-viral immunity with this broader context can ultimately lead to better vaccines for existing and emerging viruses.
    MeSH term(s) Antigens, Viral ; Child ; Enterovirus Infections ; Humans ; Immunity, Innate ; Intestinal Mucosa ; Intestines ; Vaccines ; Viruses
    Chemical Substances Antigens, Viral ; Vaccines
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.04.007
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  7. Article ; Online: Local cellular cues that influence the immunology of colorectal cancer treatment.

    Donaldson, Gregory P / Mucida, Daniel

    Nature medicine

    2020  Volume 26, Issue 6, Page(s) 824–826

    MeSH term(s) Antineoplastic Agents ; Apoptosis ; Colonic Neoplasms ; Colorectal Neoplasms ; Cues ; Humans ; Microbiota ; Monitoring, Immunologic
    Chemical Substances Antineoplastic Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-0902-8
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  8. Article ; Online: Gut immune cells have a role in food metabolism.

    Esterházy, Daria / Mucida, Daniel

    Nature

    2019  Volume 566, Issue 7742, Page(s) 49–50

    MeSH term(s) Cardiovascular Diseases ; Food ; Gastrointestinal Microbiome ; Humans ; Intraepithelial Lymphocytes
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-00235-5
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  9. Article ; Online: Isolation of myenteric and submucosal plexus from mouse gastrointestinal tract and subsequent flow cytometry and immunofluorescence

    Tomasz Ahrends / Molly Weiner / Daniel Mucida

    STAR Protocols, Vol 3, Iss 1, Pp 101157- (2022)

    2022  

    Abstract: Summary: The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric nervous system (ENS) and control intestinal ... ...

    Abstract Summary: The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric nervous system (ENS) and control intestinal functions, such as motility and nutrient sensing. This protocol describes the method for physical separation (peeling) of muscularis and submucosal layers of the mouse intestine. Subsequently, the intestinal layers are then processed for flow cytometry and/or immunofluorescence analysis.For complete details on the use and execution of this profile, please refer to Ahrends et al. (2021).
    Keywords Flow Cytometry/Mass Cytometry ; Immunology ; Microscopy ; Neuroscience ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: SnapShot: Gut Immune Niches.

    Mucida, Daniel / Esterhazy, Daria

    Cell

    2018  Volume 174, Issue 6, Page(s) 1600–1600.e1

    Abstract: The intestinal milieu changes along the proximal to distal axis and across its tissue wall, according to the luminal content and tissue function. Correspondingly, highly specialized immune compartments can be found in each intestinal niche. To view this ... ...

    Abstract The intestinal milieu changes along the proximal to distal axis and across its tissue wall, according to the luminal content and tissue function. Correspondingly, highly specialized immune compartments can be found in each intestinal niche. To view this SnapShot, open or download the PDF.
    MeSH term(s) Humans ; Immune System/metabolism ; Intestines/immunology
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.08.043
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