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Article ; Online: Wnt/β-catenin signaling pathway in liver biology and tumorigenesis.

Matsumoto, Shinji / Kikuchi, Akira

In vitro cellular & developmental biology. Animal

2024

Abstract: The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway that controls fundamental physiological and pathological processes by regulating cell proliferation and differentiation. The Wnt/β-catenin pathway enables liver homeostasis by ... ...

Abstract	The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway that controls fundamental physiological and pathological processes by regulating cell proliferation and differentiation. The Wnt/β-catenin pathway enables liver homeostasis by inducing differentiation and contributes to liver-specific features such as metabolic zonation and regeneration. In contrast, abnormalities in the Wnt/β-catenin pathway promote the development and progression of hepatocellular carcinoma (HCC). Similarly, hepatoblastoma, the most common childhood liver cancer, is frequently associated with β-catenin mutations, which activate Wnt/β-catenin signaling. HCCs with activation of the Wnt/β-catenin pathway have unique gene expression patterns and pathological and clinical features. Accordingly, they are highly differentiated with retaining hepatocyte-like characteristics and tumorigenic. Activation of the Wnt/β-catenin pathway in HCC also alters the state of immune cells, causing "immune evasion" with inducing resistance to immune checkpoint inhibitors, which have recently become widely used to treat HCC. Activated Wnt/β-catenin signaling exhibits these phenomena in liver tumorigenesis through the expression of downstream target genes, and the molecular basis is still poorly understood. In this review, we describe the physiological roles of Wnt/b-catenin signaling and then discuss their characteristic changes by the abnormal activation of Wnt/b-catenin signaling. Clarification of the mechanism would contribute to the development of therapeutic agents in the future.
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-024-00858-7
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Article ; Online: Radiological complete response with regorafenib for multiple lung metastases of ascending colon cancer: a case report.

Kikuchi, Koji / Ogawa, Masaaki / Sasaki, Akira

Journal of medical case reports

2024 Volume 18, Issue 1, Page(s) 45

Abstract: Background: Regorafenib is an oral diphenylurea multikinase inhibitor and currently approved for use following third-line therapy for metastatic colorectal cancer (CRC) patients. Only one case has previously been reported of metastatic CRC showing a ... ...

Abstract	Background: Regorafenib is an oral diphenylurea multikinase inhibitor and currently approved for use following third-line therapy for metastatic colorectal cancer (CRC) patients. Only one case has previously been reported of metastatic CRC showing a complete response (CR) to regorafenib. Case presentation: A 68-year-old Japanese man underwent laparoscopy-assisted ileocecal resection and D3 lymphadenectomy due to his ascending colon cancer. Eighteen months after surgery, a laparoscopic hepatic left lateral segmentectomy was performed due to a liver tumor, and a pathological diagnosis of colorectal liver metastasis was made. Three months after the second surgery, contrast-enhanced computed tomography (CT) revealed multiple lung metastases. The patient had undergone 18 courses of the FOLFOX + bevacizumab chemotherapy regimen as their first-line therapy and 11 courses of the FOLFIRI + ramucirumab chemotherapy regimen as their second-line therapy. As their third-line therapy, the patient was administered the regorafenib chemotherapy regimen. We evaluated the chemotherapy treatment's effect on the lung tumors by CT after 3, 7, 11, and 17 courses of the regorafenib chemotherapy regimen, finding that the lung tumors had shrunk with time; thus, each tumor was considered a partial response (PR) based on the RECIST guidelines. After 21 courses of the regorafenib chemotherapy regimen, the chemotherapy was discontinued in response to the patient's wishes. Even at 1 and 3 months after the discontinuation of the chemotherapy, CT revealed that the lung tumors had shrunk, with each considered a PR. Furthermore, 9 months after the discontinuation of the chemotherapy, CT revealed scarring of the lung tumors. This was considered a CR, rather than a PR. The patient remains disease-free 18 months after the discontinuation of chemotherapy. Conclusions: In this paper, we present the second case of radiological CR with regorafenib for multiple lung metastases of ascending colon cancer. Currently, there is no consensus on a treatment strategy for patients with radiological CR.
MeSH term(s)	Male ; Humans ; Aged ; Colon, Ascending/pathology ; Colonic Neoplasms/pathology ; Bevacizumab/therapeutic use ; Rectal Neoplasms ; Lung Neoplasms/secondary ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Phenylurea Compounds ; Pyridines
Chemical Substances	regorafenib (24T2A1DOYB) ; Bevacizumab (2S9ZZM9Q9V) ; Phenylurea Compounds ; Pyridines
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04337-7
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Article ; Online: Trends in endometrial carcinoma: experience of a single institute for four decades.

Yamaguchi, Masayuki / Kushiya, Naohisa / Tamura, Ryo / Nishikawa, Nobumichi / Kikuchi, Akira

Japanese journal of clinical oncology

2024

Abstract: Objective: To determine the current prognosis of endometrial carcinoma in Japan by analyzing long-term trends in endometrial carcinoma at our hospital.: Methods: We divided 1463 patients with endometrial carcinoma who visited our hospital between ... ...

Abstract	Objective: To determine the current prognosis of endometrial carcinoma in Japan by analyzing long-term trends in endometrial carcinoma at our hospital. Methods: We divided 1463 patients with endometrial carcinoma who visited our hospital between 1984 and 2022 into group 1984-1991, group 1992-1999, group 2000-2006, group 2007-2014 and group 2015-2022. Trends were determined using the Jonckheere-Terpstra and Cochran-Armitage tests. Data were analyzed using Cox regression analysis. Results: When group 2015-2022 was used as a reference in the univariate analysis, the hazard ratios for the other groups were <1. In particular, the hazard ratio for group 2007-2014 was 0.65 (95% confidence interval, 0.47-0.90, P = 0.009), suggesting that the prognosis of group 2015-2022 was worse than that of group 2007-2014 and seemed to be the worst among all prognoses. In multivariate analysis, the hazard ratios for each group were 1.38, 1.42, 1.88, 1.16 and 1, respectively; the group with the worst prognosis changed from group 2015-2022 to group 2000-2006 (hazard ratio, 1.88; 95% confidence interval, 1.27-2.78, P = 0.001). Age and the rate of non-endometrioid carcinoma exhibited significantly increasing trends (P < 0.001 and P < 0.001, respectively), as did the rates of serous and mixed carcinomas (P = 0.001 and 0.024, respectively). The rates of non-endometrioid carcinoma, serous carcinoma and mixed carcinoma were 19.0%, 5.5% and 3.1% in group 2007-2014 and 28.2%, 10.8% and 4.6% in group 2015-2022, respectively. Conclusions: The increasing rates of non-endometrioid carcinoma-especially serous and mixed carcinoma-may be associated with the worsening prognosis of endometrial carcinoma at our institution. Careful monitoring is needed to confirm whether this phenomenon is observed throughout Japan.
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyae012
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Article: Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins.

Kikuchi, Akira Kio V / Tayo, Lemmuel L

Biology

2022 Volume 12, Issue 1

Abstract: Predatory cone snails ( ...

Abstract	Predatory cone snails (
Language	English
Publishing date	2022-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12010020
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Article ; Online: A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972-2022).

Kikuchi, Akira / Chang, Zengyi / Gleeson, Paul A

IUBMB life

2022 Volume 74, Issue 12, Page(s) 1124–1125

MeSH term(s)	Anniversaries and Special Events
Language	English
Publishing date	2022-11-22
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1492141-8
ISSN	1521-6551 ; 1521-6543
ISSN (online)	1521-6551
ISSN	1521-6543
DOI	10.1002/iub.2691
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Article ; Online: Hemostatic Efficacy of Oxidized Regenerated Cellulose Powder in Le Fort 1 Osteotomy.

Seguchi, Noriko / Sakamoto, Yoshiaki / Kikuchi, Akira / Kishi, Kazuo

The Journal of craniofacial surgery

2023 Volume 35, Issue 1, Page(s) 189–191

Abstract: A challenging aspect of Le Fort I osteotomy is bleeding control. Osteotomy techniques, devices, drugs, and anesthetic management have been reported to reduce bleeding; however, there are no reports on the use of hemostatic agents. We aimed to evaluate ... ...

Abstract	A challenging aspect of Le Fort I osteotomy is bleeding control. Osteotomy techniques, devices, drugs, and anesthetic management have been reported to reduce bleeding; however, there are no reports on the use of hemostatic agents. We aimed to evaluate the hemostatic efficacy of a new topical absorbent hemostatic agent, Surgicel Powder, consisting of oxidized regenerated cellulose (ORC). We reviewed the records of 40 patients who underwent Le Fort I surgery for jaw deformities, with or without cleft lip and palate. Twenty of the 40 patients did not have cleft lips or cleft palates (CLCP); the remaining 20 had CLCP. In each group, an absorbent hemostatic agent was used in 10 patients but not in the other 10. Total blood loss and operative time for each group were evaluated. In the jaw deformity without CLCP group, the amount of bleeding with or without ORC was 112.0±33.8 and 158.6±75.3 mL, respectively, with a significant difference between groups ( P <0.05). Operative time with or without ORC was 206.4±31.3 and 238.3±42.5 minutes, respectively, with a significant difference observed between groups ( P <0.05). In the jaw deformity with CLCP group, the amount of bleeding with or without ORC was 199.7±64.6 and 476.8±104.8 mL, respectively, with a significant difference between groups ( P <0.05). Operative time with or without ORC was 213.7±27.6 and 220.8±41.5 minutes, respectively, with no significant difference between groups ( P =0.329). In conclusion, oxidized regenerated cellulose powder may be a beneficial hemostatic agent for reducing blood loss during Le Fort I osteotomy.
MeSH term(s)	Humans ; Cleft Lip/surgery ; Cleft Palate/surgery ; Hemostatics/pharmacology ; Hemostatics/therapeutic use ; Powders ; Maxilla/surgery ; Cellulose, Oxidized/therapeutic use ; Osteotomy, Le Fort/methods ; Cellulose
Chemical Substances	rayon, purified (BX81F82EWG) ; Hemostatics ; Powders ; Cellulose, Oxidized ; Cellulose (9004-34-6)
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009772
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Real-world evaluation of asthma reliever therapy among continuous users of asthma maintenance medication in Japan: A retrospective cohort study using a claims database.

Hozawa, Soichiro / Kikuchi, Akira / Maeda, Shotaro

Respiratory investigation

2023 Volume 61, Issue 2, Page(s) 164–171

Abstract: Background: The decrease in mortality rate owing to asthma has slowed in recent years. A large proportion of patients with asthma remain uncontrolled in Japan. This study aimed to determine the prevalence of short-acting beta 2 agonists (SABA) overuse ... ...

Abstract	Background: The decrease in mortality rate owing to asthma has slowed in recent years. A large proportion of patients with asthma remain uncontrolled in Japan. This study aimed to determine the prevalence of short-acting beta 2 agonists (SABA) overuse and its associated factors. Methods: This large-scale retrospective cohort study analyzed continuously treated patients with asthma aged 15-74 years between January 2017 and December 2017 using a Japanese insurance claims database. Characteristics, disease information, and prescribed drugs were extracted from the database, and treatment steps were defined according to drug combinations based on the criteria of the Japanese asthma guidelines. SABA overuse was defined as ≥3 canisters per year. Factors associated with SABA overuse were estimated using multivariable logistic regression. Results: Among 7,483 patients with mild-to-moderate asthma, 7,001 (93.6%) and 482 (6.4%) had low and high SABA use, respectively. Inhaled corticosteroids (ICS)/long-acting β-agonists (LABA) were the main asthma control treatments. The proportions of patients who overused SABA were 347 (9.9%) and 1,201 (5.6%) in the ICS and ICS/LABA groups, respectively. The factors associated with SABA overuse were male sex, ICS monotherapy, higher treatment steps, no history of allergic rhinitis, no history of chronic sinusitis, and no asthma management. Conclusions: There is a relatively low prevalence of SABA overuse among asthmatic patients in Japan. ICS/LABA therapy, treatment steps, allergic rhinitis, chronic sinusitis, and asthma management are associated with a decreased risk of SABA overuse. Further studies are needed to investigate the association between SABA overuse and asthma exacerbation and mortality.
MeSH term(s)	Humans ; Male ; Female ; Anti-Asthmatic Agents/adverse effects ; Retrospective Studies ; Japan ; Rhinitis ; Administration, Inhalation ; Asthma/drug therapy ; Adrenal Cortex Hormones
Chemical Substances	Anti-Asthmatic Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2022.12.007
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Article ; Online: Rectal Polyp on Extrinsic Compression Due to Prostatic Stromal Tumor.

Ochiai, Yorinari / Matsui, Akira / Kikuchi, Daisuke / Hoteya, Shu

The American journal of gastroenterology

2022 Volume 118, Issue 1, Page(s) 14

MeSH term(s)	Humans ; Male ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology ; Rectal Neoplasms/complications ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Polyps
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001975
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Ui V Zs.36: Show issues

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Article ; Online: Le Fort I osteotomy by the precious technique contributes to the reduction of bleeding.

Kikuchi, Akira / Sakamoto, Yoshiaki / Kishi, Kazuo

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2022 Volume 75, Issue 8, Page(s) 2831–2870

MeSH term(s)	Facial Bones ; Humans ; Maxilla/surgery ; Osteotomy, Le Fort/methods
Language	English
Publishing date	2022-06-23
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2022.06.015
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Article ; Online: Growth Characteristics of Seven Willow Species Distributed in Eastern Japan in Response to Compost Application

Masazumi Kayama / Satoshi Kikuchi / Akira Uemura / Masayoshi Takahashi

Forests, Vol 14, Iss 606, p

2023 Volume 606

Abstract: To establish a short rotation coppice (SRC) system in the temperate region of East Asia, planting was conducted for cuttings from seven species, including Salix eriocarpa , S. gilgiana , S. gracilistyla , S. integra , S. sachalinensis , S. serissaefolia , ...

Abstract	To establish a short rotation coppice (SRC) system in the temperate region of East Asia, planting was conducted for cuttings from seven species, including Salix eriocarpa , S. gilgiana , S. gracilistyla , S. integra , S. sachalinensis , S. serissaefolia , and S. subfragilis , with wide distribution in eastern Japan. During cultivation, cheap compost derived from swine manure and containing high concentrations of various nutrients was added. Three treatment groups, including control, low manure (5 Mg ha −1 ), and high manure (10 Mg ha −1 ) treatments, were established, and seven willows were grown for two complete growing seasons to obtain the clone density of 10,000 cuttings ha −1 . The manure treatments accelerated the growth of all the willow species after two growing seasons. The averages of annual biomass production of seven willows grown under the control, low manure, and high manure treatments were 0.2 Mg ha −1 yr −1 , 5.3 Mg ha −1 yr −1 , and 8.5 Mg ha −1 yr −1 , respectively. By comparing with the biomasses of seven willows, the largest annual biomass production rates of 14.1 and 13.7 Mg ha −1 yr −1 were observed in the high manure treatments of S. sachalinensis and S. subfragilis , respectively. For two species under the high manure treatment, S. sachalinensis had the thickest shoots, and S. subfragilis had the tallest shoots. These growth characteristics of S. sachalinensis and S. subfragilis originate from their high biomass production. Overall, these results suggest that S. sachalinensis and S. subfragilis are potentially feasible candidates for the SRC system in temperate regions of East Asia.
Keywords	willow ; swine manure ; vector analysis ; nutrients ; photosynthesis ; Plant ecology ; QK900-989
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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