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Article ; Online: Native myocardial T

Kida, Katsuhiro / Kurosaki, Takamasa / Fukui, Ryohei / Matsuura, Ryutaro / Goto, Sachiko

2024

Abstract: This study proposes the use of the inversion recovery T ...

Abstract	This study proposes the use of the inversion recovery T
Language	English
Publishing date	2024-03-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2433581-2
ISSN	1865-0341 ; 1865-0333
ISSN (online)	1865-0341
ISSN	1865-0333
DOI	10.1007/s12194-024-00795-w
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Article: [Management of adverse effects in CAR T-cell therapy].

Goto, Hideki

Rinsho ketsueki] The Japanese journal of clinical hematology

2023 Volume 64, Issue 9, Page(s) 1203–1212

Abstract: ... antigen receptor (CAR) T-cell therapy are emerging as new treatments for relapsed and/or refractory ... hematological malignancies. CAR T-cell therapy has attracted attention as a potentially curative treatment for patients ... specific to CAR T-cell therapy, such as cytokine release syndrome (CRS), neurotoxicity (ICANS ...

Abstract	Immunotherapies such as immune checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor (CAR) T-cell therapy are emerging as new treatments for relapsed and/or refractory hematological malignancies. CAR T-cell therapy has attracted attention as a potentially curative treatment for patients incurable by chemotherapy. However, appropriate management is required to avoid serious complications specific to CAR T-cell therapy, such as cytokine release syndrome (CRS), neurotoxicity (ICANS), hypogammaglobulinemia and prolonged cytopenia, as well as post-treatment infections caused by suppressed immune function.
MeSH term(s)	Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy ; Agammaglobulinemia ; Antibodies, Bispecific ; Hematologic Neoplasms/therapy ; Receptors, Antigen, T-Cell
Chemical Substances	Antibodies, Bispecific ; Receptors, Antigen, T-Cell
Language	Japanese
Publishing date	2023-10-29
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.64.1203
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Article: [Successful polatuzumab vedotin and rituximab therapy for post-CAR-T relapse of diffuse large B-cell lymphoma].

Kushida, Tetsu / Hirosawa, Makoto / Goto, Midori / Seike, Yoshiko / Kitamura, Noriaki / Nakanishi, Tsukasa / Tanaka, Aya / Higashi, Takehiro / Morimoto, Hiroaki / Tsukada, Junichi

Rinsho ketsueki] The Japanese journal of clinical hematology

2024 Volume 65, Issue 3, Page(s) 180–182

Abstract: Relapse or progressive disease after chimeric antigen receptor T-cell (CAR-T) treatment remains ... CAR-T use of polatuzumab vedotin. Here we describe the case of a patient with diffuse large B-cell ... lymphoma (DLBCL) who experienced relapse three months after CD19-directed CAR-T therapy ...

Abstract	Relapse or progressive disease after chimeric antigen receptor T-cell (CAR-T) treatment remains a major issue for poor-risk aggressive large B-cell lymphoma. However, limited data are available on post-CAR-T use of polatuzumab vedotin. Here we describe the case of a patient with diffuse large B-cell lymphoma (DLBCL) who experienced relapse three months after CD19-directed CAR-T therapy with tisagenlecleucel. However, the relapsed lesions rapidly disappeared following treatment with polatuzumab vedotin and rituximab. Notably, long-term remission was achieved without severe cytopenia, infections or peripheral neuropathy, showing the therapeutic benefit of polatuzumab vedotin for CAR-T failure.
MeSH term(s)	Humans ; Rituximab/therapeutic use ; Receptors, Chimeric Antigen ; Antibodies, Monoclonal ; Immunoconjugates ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Chronic Disease ; Antineoplastic Combined Chemotherapy Protocols
Chemical Substances	polatuzumab vedotin (KG6VO684Z6) ; Rituximab (4F4X42SYQ6) ; Receptors, Chimeric Antigen ; Antibodies, Monoclonal ; Immunoconjugates
Language	Japanese
Publishing date	2024-04-02
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.65.180
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Article ; Online: The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer.

Haruna, Miya / Ueyama, Azumi / Yamamoto, Yoko / Hirata, Michinari / Goto, Kumiko / Yoshida, Hiroshi / Higuchi, Naoko / Yoshida, Tetsuya / Kidani, Yujiro / Nakamura, Yamami / Nagira, Morio / Kawashima, Atsunari / Iwahori, Kota / Shintani, Yasushi / Ohkura, Naganari / Wada, Hisashi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 5377

Abstract: Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs ... their immune suppressive function, especially the influence on cytotoxic T lymphocyte cell function. The Cancer Genome ... Atlas analysis revealed that CD8 T cell activities were suppressed in high CCR8-expressing tumors ...

Abstract	Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the features of CCR8+ Tregs in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients. We also investigated their immune suppressive function, especially the influence on cytotoxic T lymphocyte cell function. The Cancer Genome Atlas analysis revealed that CD8 T cell activities were suppressed in high CCR8-expressing tumors. Additionally, depletion of CCR8+ cells enhanced CD8 T cell function in an ex vivo culture of lung tumor-infiltrating cells. Moreover, CCR8+ Tregs, but not CCR8- Tregs, induced from human PBMCs markedly suppressed CD8 T cell cytotoxicity. Finally, we demonstrated the therapeutic effect of targeting CCR8 in a murine model of lung cancer. These findings reveal the significance of CCR8+ Tregs for immunosuppression in lung cancer, especially via cytotoxic T lymphocyte cell suppression, and suggest the potential value of CCR8-targeted therapy for cancer treatment.
MeSH term(s)	Animals ; Humans ; Immune Tolerance ; Immunotherapy ; Lung Neoplasms/pathology ; Mice ; Receptors, CCR8/metabolism ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory
Chemical Substances	CCR8 protein, human ; Ccr8 protein, mouse ; Receptors, CCR8
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09458-5
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Article ; Online: Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis.

Hashimoto, Masahiro / Kojima, Yasuhiro / Sakamoto, Takeharu / Ozato, Yuki / Nakano, Yusuke / Abe, Tadashi / Hosoda, Kiyotaka / Saito, Hideyuki / Higuchi, Satoshi / Hisamatsu, Yuichi / Toshima, Takeo / Yonemura, Yusuke / Masuda, Takaaki / Hata, Tsuyoshi / Nagayama, Satoshi / Kagawa, Koichi / Goto, Yasuhiro / Utou, Mitsuaki / Gamachi, Ayako /

EBioMedicine

2024 , Page(s) 105102

Abstract: ... cells colocalised with regulatory T cells (Tregs) at the adenoma-carcinoma interface. At early-stage ...

Abstract	Background: Cell-cell interaction factors that facilitate the progression of adenoma to sporadic colorectal cancer (CRC) remain unclear, thereby hindering patient survival. Methods: We performed spatial transcriptomics on five early CRC cases, which included adenoma and carcinoma, and one advanced CRC. To elucidate cell-cell interactions within the tumour microenvironment (TME), we investigated the colocalisation network at single-cell resolution using a deep generative model for colocalisation analysis, combined with a single-cell transcriptome, and assessed the clinical significance in CRC patients. Findings: CRC cells colocalised with regulatory T cells (Tregs) at the adenoma-carcinoma interface. At early-stage carcinogenesis, cell-cell interaction inference between colocalised adenoma and cancer epithelial cells and Tregs based on the spatial distribution of single cells highlighted midkine (MDK) as a prominent signalling molecule sent from tumour epithelial cells to Tregs. Interaction between MDK-high CRC cells and SPP1+ macrophages and stromal cells proved to be the mechanism underlying immunosuppression in the TME. Additionally, we identified syndecan4 (SDC4) as a receptor for MDK associated with Treg colocalisation. Finally, clinical analysis using CRC datasets indicated that increased MDK/SDC4 levels correlated with poor overall survival in CRC patients. Interpretation: MDK is involved in the immune tolerance shown by Tregs to tumour growth. MDK-mediated formation of the TME could be a potential target for early diagnosis and treatment of CRC. Funding: Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Science Research; OITA Cancer Research Foundation; AMED under Grant Number; Japan Science and Technology Agency (JST); Takeda Science Foundation; The Princess Takamatsu Cancer Research Fund.
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.105102
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Article ; Online: Measurement of J-T

Goto, Ai / Hagiwara-Nagasawa, Mihoko / Kambayashi, Ryuichi / Chiba, Koki / Izumi-Nakaseko, Hiroko / Naito, Atsuhiko T / Kanda, Yasunari / Sugiyama, Atsushi

Cardiovascular toxicology

2019 Volume 19, Issue 4, Page(s) 357–364

Abstract: dl-Sotalol which can block both ... ...

Abstract	dl-Sotalol which can block both K
MeSH term(s)	Action Potentials/drug effects ; Adrenergic beta-Antagonists/toxicity ; Animals ; Cardiotoxicity ; Dogs ; Dose-Response Relationship, Drug ; Female ; Heart Conduction System/drug effects ; Heart Conduction System/physiopathology ; Heart Rate/drug effects ; Male ; Potassium Channel Blockers/toxicity ; Risk Assessment ; Sotalol/toxicity ; Species Specificity ; Swine ; Swine, Miniature ; Torsades de Pointes/chemically induced ; Torsades de Pointes/physiopathology ; Toxicity Tests
Chemical Substances	Adrenergic beta-Antagonists ; Potassium Channel Blockers ; Sotalol (A6D97U294I)
Language	English
Publishing date	2019-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036765-X
ISSN	1559-0259 ; 1530-7905
ISSN (online)	1559-0259
ISSN	1530-7905
DOI	10.1007/s12012-019-09506-z
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Article: [CAR-T therapy for adult B-cell acute lymphoblastic leukemia].

Goto, Hideki

Rinsho ketsueki] The Japanese journal of clinical hematology

2023 Volume 64, Issue 11, Page(s) 1432–1439

Abstract: ... Recently, chimeric antigen receptor T-cell (CAR-T) therapy, targeting CD19, has demonstrated great ... evidence on CAR-T therapy for relapsed or refractory adult B-ALL, which has a poor prognosis when assessed ...

Abstract	Although adult B-cell acute lymphoblastic leukemia (B-ALL) responds to initial treatment, relapse and refractory cases are common. Even when these cases are treated with novel agents (blinatumomab, inotuzumab ozogamicin, etc.) and/or allogeneic stem cell transplantation, the prognosis remains poor. Recently, chimeric antigen receptor T-cell (CAR-T) therapy, targeting CD19, has demonstrated great potential in treating relapsed or refractory B-ALL. We have already used tisagenlecleucel in clinical practice, but it is limited to patients up to 25 years of age. This review summarizes the most recent evidence on CAR-T therapy for relapsed or refractory adult B-ALL, which has a poor prognosis when assessed in younger patients.
MeSH term(s)	Adult ; Humans ; Antigens, CD19 ; Hematopoietic Stem Cell Transplantation ; Immunotherapy, Adoptive ; Inotuzumab Ozogamicin/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Receptors, Chimeric Antigen/therapeutic use
Chemical Substances	Antigens, CD19 ; Inotuzumab Ozogamicin (P93RUU11P7) ; Receptors, Chimeric Antigen
Language	Japanese
Publishing date	2023-12-11
Publishing country	Japan
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.64.1432
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Article ; Online: TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non-Fc Receptor-Binding CD3 Antibodies.

Ota, Takuji / Goto, Ryoichi / Harada, Takuya / Forgioni, Agustina / Kanazawa, Ryo / Ganchiku, Yoshikazu / Kawamura, Norio / Watanabe, Masaaki / Fukai, Moto / Shimamura, Tsuyoshi / Taketomi, Akinobu

ImmunoHorizons

2024 Volume 8, Issue 4, Page(s) 295–306

Abstract: ... graft rejection in sensitized mice (MST, 5 d). A significantly increased percentage of granzyme B+ CD8+ T ... significantly increased the percentage of Foxp3+CD25+CD4+ T cells and phenotypically changed CD8+ T ... cells in the graft (i.e., caused a significant increase in the proportion of Ly108+TCF1highPD-1+CD8+ T ...

Abstract	The non-Fc-binding anti-CD3 Ab [anti-CD3F(ab')2] can induce graft acceptance depending on the therapeutic window in a rodent heart transplant model. The delayed protocol allows for early graft infiltration of lymphocytes, which may behave in an inhibitory manner. We investigated the most effective protocol for anti-CD3F(ab')2 in sensitized conditions to confirm the evidence for clinical application. C57BL/6 mice were sensitized with BALB/c tail skin grafts and transplanted with BALB/c heart grafts at 8-12 wk after sensitization. Fifty micrograms of anti-CD3F(ab')2 was administered daily for 5 consecutive days on days 1-5 (day 1 protocol) or days 3-7 (delayed protocol). In nonsensitized mice, the delayed protocol significantly prolonged graft survival after transplantation from BALB/c to naive B6 (median survival time [MST], >100 d). In contrast, the delayed protocol was unable to prevent graft rejection in sensitized mice (MST, 5 d). A significantly increased percentage of granzyme B+ CD8+ T cells was observed in the graft on day 3 posttransplantation in sensitized conditions. Further, the day 1 protocol significantly prolonged graft survival (MST, 18 d), even in sensitized conditions. Day 1 treatment significantly increased the percentage of Foxp3+CD25+CD4+ T cells and phenotypically changed CD8+ T cells in the graft (i.e., caused a significant increase in the proportion of Ly108+TCF1highPD-1+CD8+ T cells). In conclusion, different timings of delayed anti-CD3F(ab')2 treatment promoted allograft preservation in association with phenotypic changes in CD4+ and CD8+ T cells in the graft under sensitized conditions.
MeSH term(s)	Mice ; Animals ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; CD8-Positive T-Lymphocytes ; Transplantation, Homologous ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2300117
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Article ; Online: Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells.

Kurihara, Shunjiro / Suzuki, Kotaro / Yokota, Masaya / Ito, Takashi / Hayashi, Yuki / Kikuchi, Ryo / Kageyama, Takahiro / Meguro, Kazuyuki / Tanaka, Shigeru / Iwata, Arifumi / Goto, Yoshiyuki / Suto, Akira / Nakajima, Hiroshi

Biomolecules

2024 Volume 14, Issue 1

Abstract: ... Previous studies have shown that dendritic cells (DCs) and regulatory T cells (Tregs) are involved ...

Abstract	Oral tolerance has been defined as the specific suppression of immune responses to an antigen by prior oral administration of the antigen. It has been thought to serve to suppress food allergy. Previous studies have shown that dendritic cells (DCs) and regulatory T cells (Tregs) are involved in the induction of oral tolerance. However, the detailed mechanisms of Treg induction in oral tolerance remain largely unknown. Eosinophils have been recognized as effector cells in allergic diseases, but in recent years, the diverse functions of tissue-resident eosinophils have been reported. Eosinophils in the intestine have been reported to induce Tregs by releasing TGF-β, but the role of eosinophils in oral tolerance is still controversial. In this study, we analyzed the roles of eosinophils in oral tolerance using eosinophil-deficient ΔdblGATA mice (mice lacking a high-affinity GATA-binding site in the GATA1 promoter). ΔdblGATA mice showed impaired antigen-induced oral tolerance compared to wild-type mice. The induction of RORγt
MeSH term(s)	Animals ; Mice ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Eosinophils ; T-Lymphocytes, Regulatory ; Immunity, Innate ; Lymphocytes ; Antigen-Presenting Cells
Chemical Substances	Nuclear Receptor Subfamily 1, Group F, Member 3
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14010089
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Article ; Online: Saturation Recovery Myocardial T

Morita, Kosuke / Oda, Seitaro / Utsunomiya, Daisuke / Nakaura, Takeshi / Matsubara, Takatoshi / Goto, Makoto / Okuaki, Tomoyuki / Yuki, Hideaki / Nagayama, Yasunori / Kidoh, Masafumi / Hirata, Kenichiro / Iyama, Yuij / Taguchi, Narumi / Hatemura, Masahiro / Hashida, Masahiro / Yamashita, Yasuyuki

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

2018 Volume 17, Issue 1, Page(s) 35–41

Abstract: ... SR) myocardial T: Materials and methods: Phantom and in vivo studies were performed ... with a clinical 3T MR scanner. Accuracy and reproducibility of the SR T: Results: The phantom study revealed ... significant differences in the mean T: Conclusion: SR T ...

Abstract	Purpose: To evaluate the effect of a composite radiofrequency (RF) pulse on saturation recovery (SR) myocardial T Materials and methods: Phantom and in vivo studies were performed with a clinical 3T MR scanner. Accuracy and reproducibility of the SR T Results: The phantom study revealed significant differences in the mean T Conclusion: SR T
MeSH term(s)	Adult ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myocardium/pathology ; Phantoms, Imaging ; Radio Waves ; Reproducibility of Results
Language	English
Publishing date	2018-01-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2217833-8
ISSN	1880-2206 ; 1347-3182
ISSN (online)	1880-2206
ISSN	1347-3182
DOI	10.2463/mrms.mp.2016-0092
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