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Article ; Online: Stakeholder Requirements for an Ethical Framework to Sustain Multiple Research Projects in an Emerging Living Lab Involving Older Adults.

Callari, Tiziana C / Moody, Louise / Saunders, Janet / Ward, Gill / Woodley, Julie

Journal of empirical research on human research ethics : JERHRE

2019 Volume 15, Issue 3, Page(s) 111–127

Abstract: Living Lab (LL) research should follow clear ethical guidelines and principles. While these exist in specific disciplinary contexts, there is a lack of tailored and specific ethical guidelines for the design, development, and implementation of LL ... ...

Abstract	Living Lab (LL) research should follow clear ethical guidelines and principles. While these exist in specific disciplinary contexts, there is a lack of tailored and specific ethical guidelines for the design, development, and implementation of LL projects. As well as the complexity of these dynamic and multi-faceted contexts, the engagement of older adults, and adults with reducing cognitive and physical capacity in LL research, poses additional ethical challenges. Semi-structured interviews were undertaken with 26 participants to understand multistakeholder experiences related to user engagement and related ethical issues in emerging LL research. The participants' experiences and concerns are reported and translated into an ethical framework to guide future LL research initiatives.
MeSH term(s)	Aged ; Ethics, Research ; Humans ; Qualitative Research
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2263068-5
ISSN	1556-2654 ; 1556-2646
ISSN (online)	1556-2654
ISSN	1556-2646
DOI	10.1177/1556264619873790
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A survey of physiotherapy practice (2018) in the United Kingdom for patients with greater trochanteric pain syndrome.

Stephens, Gareth / O'Neill, Seth / French, Helen P / Fearon, Angela / Grimaldi, Alison / O'Connor, Louise / Woodley, Stephanie / Littlewood, Chris

Musculoskeletal science & practice

2019 Volume 40, Page(s) 10–20

Abstract: Purpose: Greater Trochanteric Pain syndrome (GTPS) is a debilitating condition causing lateral hip pain. It affects up to 23.5% of women and 8% of men between 50 and 75 years old. Sufferers report comparable quality of life and functional performance to ...

Abstract	Purpose: Greater Trochanteric Pain syndrome (GTPS) is a debilitating condition causing lateral hip pain. It affects up to 23.5% of women and 8% of men between 50 and 75 years old. Sufferers report comparable quality of life and functional performance to patients with end stage osteoarthritis of the hip. Understanding of optimal management strategies for GTPS remains limited. Hence, the purpose of this cross-sectional survey was to describe current UK physiotherapy practice so as to understand current practice and inform the systematic development of a physiotherapy intervention. Methods: An online survey was developed and distributed via Twitter, the interactive Chartered Society of Physiotherapy website, Musculoskeletal Association of Chartered Physiotherapists and the professional networks of the authors via email. Responses were collected over a four-week period, this was finalised in April 2018. Results: A total of 409 surveys were submitted; 382 were eligible for use. Nearly all physiotherapists were either somewhat, or very confident diagnosing (372/382; 97.4%) and treating (372/382; 97.4%) patients with GTPS. The management strategies most commonly used were: education on load management (377/381; 98.7%) and self-management strategies (375/381; 98.4%). Strengthening exercises (376/382; 98.4%) were commonly used and targeted to the hip abductors (355/379; 93.7%). Most frequently these exercises were delivered using a combination of home exercise programme (380/380; 100%) and one-to-one exercise sessions (344/377; 91.2%). Conclusion: The data from this large survey highlights that physiotherapists in the UK most commonly use education on load management and self-management strategies, alongside strengthening exercises targeting the hip abductors for patients with GTPS.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Exercise Therapy/methods ; Female ; Femur/physiopathology ; Humans ; Male ; Middle Aged ; Pain Management/methods ; Physical Therapists/statistics & numerical data ; Physical Therapy Modalities ; Surveys and Questionnaires ; Tendinopathy/therapy ; United Kingdom
Language	English
Publishing date	2019-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2019.01.004
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Article ; Online: An international consensus on effective, inclusive, and career-spanning short-format training in the life sciences and beyond.

Williams, Jason J / Tractenberg, Rochelle E / Batut, Bérénice / Becker, Erin A / Brown, Anne M / Burke, Melissa L / Busby, Ben / Cooch, Nisha K / Dillman, Allissa A / Donovan, Samuel S / Doyle, Maria A / van Gelder, Celia W G / Hall, Christina R / Hertweck, Kate L / Jordan, Kari L / Jungck, John R / Latour, Ainsley R / Lindvall, Jessica M / Lloret-Llinares, Marta /

McDowell, Gary S / Morris, Rana / Mourad, Teresa / Nisselle, Amy / Ordóñez, Patricia / Paladin, Lisanna / Palagi, Patricia M / Sukhai, Mahadeo A / Teal, Tracy K / Woodley, Louise

PloS one

2023 Volume 18, Issue 11, Page(s) e0293879

Abstract: Science, technology, engineering, mathematics, and medicine (STEMM) fields change rapidly and are increasingly interdisciplinary. Commonly, STEMM practitioners use short-format training (SFT) such as workshops and short courses for upskilling and ... ...

Abstract	Science, technology, engineering, mathematics, and medicine (STEMM) fields change rapidly and are increasingly interdisciplinary. Commonly, STEMM practitioners use short-format training (SFT) such as workshops and short courses for upskilling and reskilling, but unaddressed challenges limit SFT's effectiveness and inclusiveness. Education researchers, students in SFT courses, and organizations have called for research and strategies that can strengthen SFT in terms of effectiveness, inclusiveness, and accessibility across multiple dimensions. This paper describes the project that resulted in a consensus set of 14 actionable recommendations to systematically strengthen SFT. A diverse international group of 30 experts in education, accessibility, and life sciences came together from 10 countries to develop recommendations that can help strengthen SFT globally. Participants, including representation from some of the largest life science training programs globally, assembled findings in the educational sciences and encompassed the experiences of several of the largest life science SFT programs. The 14 recommendations were derived through a Delphi method, where consensus was achieved in real time as the group completed a series of meetings and tasks designed to elicit specific recommendations. Recommendations cover the breadth of SFT contexts and stakeholder groups and include actions for instructors (e.g., make equity and inclusion an ethical obligation), programs (e.g., centralize infrastructure for assessment and evaluation), as well as organizations and funders (e.g., professionalize training SFT instructors; deploy SFT to counter inequity). Recommendations are aligned with a purpose-built framework-"The Bicycle Principles"-that prioritizes evidenced-based teaching, inclusiveness, and equity, as well as the ability to scale, share, and sustain SFT. We also describe how the Bicycle Principles and recommendations are consistent with educational change theories and can overcome systemic barriers to delivering consistently effective, inclusive, and career-spanning SFT.
MeSH term(s)	Humans ; Consensus ; Students ; Technology ; Engineering
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0293879
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Regulation of alternative pre-mRNA splicing.

Woodley, Louise / Valcárcel, Juan

Briefings in functional genomics & proteomics

2004 Volume 1, Issue 3, Page(s) 266–277

Abstract: The first wave of bioinformatic studies that followed genome and complementary DNA sequencing projects revealed that alternative splicing of messenger RNA precursors (pre-mRNAs) contributes substantially to transcriptome complexity in higher eukaryotes. ... ...

Abstract	The first wave of bioinformatic studies that followed genome and complementary DNA sequencing projects revealed that alternative splicing of messenger RNA precursors (pre-mRNAs) contributes substantially to transcriptome complexity in higher eukaryotes. Together with the realisation of the impact of the process on cell differentiation, development and disease, these studies portray alternative splicing as a fundamental component of gene regulation. Both detailed mechanistic studies and genome-wide analyses will be necessary to unravel the molecular basis for cell type-specific splice site selection. This paper will highlight some recent progress and future challenges for functional genomics and bioinformatics in this rapidly developing area.
MeSH term(s)	Alternative Splicing ; RNA Precursors/genetics ; RNA, Messenger/chemistry ; RNA, Messenger/genetics
Chemical Substances	RNA Precursors ; RNA, Messenger
Language	English
Publishing date	2004-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2138368-6
ISSN	1477-4062 ; 1473-9550
ISSN (online)	1477-4062
ISSN	1473-9550
DOI	10.1093/bfgp/1.3.266
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Article ; Online: Retraction Notice to: Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge.

Dun, Xin-Peng / Carr, Lauren / Woodley, Patricia K / Barry, Riordan W / Drake, Louisa K / Mindos, Thomas / Roberts, Sheridan L / Lloyd, Alison C / Parkinson, David B

Cell reports

2023 Volume 42, Issue 5, Page(s) 112517

Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112517
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Article ; Online: An international consensus on effective, inclusive, and career-spanning short-format training in the life sciences and beyond.

Jason J Williams / Rochelle E Tractenberg / Bérénice Batut / Erin A Becker / Anne M Brown / Melissa L Burke / Ben Busby / Nisha K Cooch / Allissa A Dillman / Samuel S Donovan / Maria A Doyle / Celia W G van Gelder / Christina R Hall / Kate L Hertweck / Kari L Jordan / John R Jungck / Ainsley R Latour / Jessica M Lindvall / Marta Lloret-Llinares /

Gary S McDowell / Rana Morris / Teresa Mourad / Amy Nisselle / Patricia Ordóñez / Lisanna Paladin / Patricia M Palagi / Mahadeo A Sukhai / Tracy K Teal / Louise Woodley

PLoS ONE, Vol 18, Iss 11, p e

2023 Volume 0293879

Abstract	Science, technology, engineering, mathematics, and medicine (STEMM) fields change rapidly and are increasingly interdisciplinary. Commonly, STEMM practitioners use short-format training (SFT) such as workshops and short courses for upskilling and reskilling, but unaddressed challenges limit SFT's effectiveness and inclusiveness. Education researchers, students in SFT courses, and organizations have called for research and strategies that can strengthen SFT in terms of effectiveness, inclusiveness, and accessibility across multiple dimensions. This paper describes the project that resulted in a consensus set of 14 actionable recommendations to systematically strengthen SFT. A diverse international group of 30 experts in education, accessibility, and life sciences came together from 10 countries to develop recommendations that can help strengthen SFT globally. Participants, including representation from some of the largest life science training programs globally, assembled findings in the educational sciences and encompassed the experiences of several of the largest life science SFT programs. The 14 recommendations were derived through a Delphi method, where consensus was achieved in real time as the group completed a series of meetings and tasks designed to elicit specific recommendations. Recommendations cover the breadth of SFT contexts and stakeholder groups and include actions for instructors (e.g., make equity and inclusion an ethical obligation), programs (e.g., centralize infrastructure for assessment and evaluation), as well as organizations and funders (e.g., professionalize training SFT instructors; deploy SFT to counter inequity). Recommendations are aligned with a purpose-built framework-"The Bicycle Principles"-that prioritizes evidenced-based teaching, inclusiveness, and equity, as well as the ability to scale, share, and sustain SFT. We also describe how the Bicycle Principles and recommendations are consistent with educational change theories and can overcome systemic barriers to delivering ...
Keywords	Medicine ; R ; Science ; Q
Subject code	028
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A global analysis of management capacity and ecological outcomes in terrestrial protected areas

Geldmann, Jonas / Andrew Balmford / Ian D. Craigie / Kathryn Knights / Lauren Coad / Louise McRae / Marc Hockings / Megan D. Barnes / Michael B. Mascia / Neil D. Burgess / Stephen Woodley / Thomas M. Brooks

Conservation letters. 2018 May, v. 11, no. 3

2018

Abstract: Protecting important sites is a key strategy for halting the loss of biodiversity. However, our understanding of the relationship between management inputs and biodiversity outcomes in protected areas (PAs) remains weak. Here, we examine biodiversity ... ...

Abstract	Protecting important sites is a key strategy for halting the loss of biodiversity. However, our understanding of the relationship between management inputs and biodiversity outcomes in protected areas (PAs) remains weak. Here, we examine biodiversity outcomes using species population trends in PAs derived from the Living Planet Database in relation to management data derived from the Management Effectiveness Tracking Tool (METT) database for 217 population time‐series from 73 PAs. We found a positive relationship between our METT‐based scores for Capacity and Resources and changes in vertebrate abundance, consistent with the hypothesis that PAs require adequate resourcing to halt biodiversity loss. Additionally, PA age was negatively correlated with trends for the mammal subsets and PA size negatively correlated with population trends in the global subset. Our study highlights the paucity of appropriate data for rigorous testing of the role of management in maintaining species populations across multiple sites, and describes ways to improve our understanding of PA performance.
Keywords	biodiversity ; conservation areas ; correlation ; databases ; mammals ; time series analysis
Language	English
Dates of publication	2018-05
Size	p. e12434.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	LETTER
ISSN	1755-263X
DOI	10.1111/conl.12434
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia.

Williamson, Neil R / Fineran, Peter C / Ogawa, Wakano / Woodley, Louise R / Salmond, George P C

Environmental microbiology

2008 Volume 10, Issue 5, Page(s) 1202–1217

Abstract: Serratia sp. ATCC 39006 (Serratia 39006) is a Gram-negative bacterium which produces the secondary metabolite antibiotics, prodigiosin and 1-carbapen-2-em-3-carboxylic acid and secretes plant cell wall degrading enzymes. In this study we have identified ... ...

Abstract	Serratia sp. ATCC 39006 (Serratia 39006) is a Gram-negative bacterium which produces the secondary metabolite antibiotics, prodigiosin and 1-carbapen-2-em-3-carboxylic acid and secretes plant cell wall degrading enzymes. In this study we have identified mutations in the genes, pigX, rap and rsmA, which caused increased production of a previously unidentified surfactant and flagella-dependent swarming phenotype in Serratia 39006. Analysis of both the biosynthesis and regulation of surfactant production and swarming, revealed FlhC, quorum sensing, a GGDEF/EAL domain protein (PigX), a GacAS two-component system, an Rsm system and Rap as key regulators. In addition, surfactant biosynthesis required a protein similar to RhlA, involved in rhamnolipid synthesis in Pseudomonas aeruginosa. Homologues of RhlA have not previously been identified in members of the Enterobacteriaceae. Furthermore, we provide evidence that the surfactant may be responsible for dispersal of the antimicrobial pigment, prodigiosin. This study demonstrates the complex regulatory inputs into the coordinated multicellular swarming phenotype in Serratia.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Flagella/metabolism ; Gene Expression Regulation, Bacterial ; Movement ; Mutation ; Prodigiosin/metabolism ; Quorum Sensing ; Serratia/genetics ; Serratia/growth & development ; Serratia/metabolism ; Serratia/physiology ; Signal Transduction ; Surface-Active Agents/metabolism ; Transcription, Genetic
Chemical Substances	Bacterial Proteins ; Surface-Active Agents ; Prodigiosin (OL369FU7CJ)
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/j.1462-2920.2007.01536.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Capacity shortfalls hinder the performance of marine protected areas globally.

Nature

2017 Volume 543, Issue 7647, Page(s) 665–669

Abstract: Marine protected areas (MPAs) are increasingly being used globally to conserve marine resources. However, whether many MPAs are being effectively and equitably managed, and how MPA management influences substantive outcomes remain unknown. We developed a ...

Abstract	Marine protected areas (MPAs) are increasingly being used globally to conserve marine resources. However, whether many MPAs are being effectively and equitably managed, and how MPA management influences substantive outcomes remain unknown. We developed a global database of management and fish population data (433 and 218 MPAs, respectively) to assess: MPA management processes; the effects of MPAs on fish populations; and relationships between management processes and ecological effects. Here we report that many MPAs failed to meet thresholds for effective and equitable management processes, with widespread shortfalls in staff and financial resources. Although 71% of MPAs positively influenced fish populations, these conservation impacts were highly variable. Staff and budget capacity were the strongest predictors of conservation impact: MPAs with adequate staff capacity had ecological effects 2.9 times greater than MPAs with inadequate capacity. Thus, continued global expansion of MPAs without adequate investment in human and financial capacity is likely to lead to sub-optimal conservation outcomes.
MeSH term(s)	Animals ; Aquatic Organisms ; Biomass ; Conservation of Natural Resources/economics ; Conservation of Natural Resources/methods ; Conservation of Natural Resources/statistics & numerical data ; Conservation of Natural Resources/trends ; Ecology/economics ; Ecology/manpower ; Ecology/organization & administration ; Fishes ; Goals ; Internationality ; Population Dynamics
Language	English
Publishing date	2017--30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature21708
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Article ; Online: Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge.

Dun, Xin-Peng / Carr, Lauren / Woodley, Patricia K / Barry, Riordan W / Drake, Louisa K / Mindos, Thomas / Roberts, Sheridan L / Lloyd, Alison C / Parkinson, David B

publication RETRACTED

Cell reports

2019 Volume 26, Issue 6, Page(s) 1458–1472.e4

Abstract: Slit-Robo signaling has been characterized as a repulsive signal for precise axon pathfinding and cell migration during embryonic development. Here, we describe a role for Sox2 in the regulation of Robo1 in Schwann cells and for Slit3-Robo1 signaling in ... ...

Abstract	Slit-Robo signaling has been characterized as a repulsive signal for precise axon pathfinding and cell migration during embryonic development. Here, we describe a role for Sox2 in the regulation of Robo1 in Schwann cells and for Slit3-Robo1 signaling in controlling axon guidance within the newly formed nerve bridge following peripheral nerve transection injury. In particular, we show that macrophages form the outermost layer of the nerve bridge and secrete high levels of Slit3, while migratory Schwann cells and fibroblasts inside the nerve bridge express the Robo1 receptor. In line with this pattern of Slit3 and Robo1 expression, we observed multiple axon regeneration and cell migration defects in the nerve bridge of Sox2-, Slit3-, and Robo1-mutant mice. Our findings have revealed important functions for macrophages in the peripheral nervous system, utilizing Slit3-Robo1 signaling to control correct peripheral nerve bridge formation and precise axon targeting to the distal nerve stump following injury.
MeSH term(s)	Animals ; Axon Guidance ; Cell Movement ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Macrophages/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mutation ; Nerve Regeneration ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Peripheral Nerves/metabolism ; Peripheral Nerves/physiology ; Rats ; Rats, Wistar ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; Schwann Cells/metabolism ; Signal Transduction ; Roundabout Proteins
Chemical Substances	Membrane Proteins ; Nerve Tissue Proteins ; Receptors, Immunologic ; SOXB1 Transcription Factors ; Slit3 protein, mouse ; Sox2 protein, mouse
Language	English
Publishing date	2019-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2018.12.081
Database	MEDical Literature Analysis and Retrieval System OnLINE

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