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  1. Article ; Online: C

    Stein, Rebekah A / Sheldon, Nathan D / Smith, Selena Y

    The New phytologist

    2020  Volume 229, Issue 5, Page(s) 2576–2585

    Abstract: Plant carbon isotope discrimination is complex, and could be driven by climate, evolution and/or edaphic factors. We tested the climate drivers of carbon isotope discrimination in modern and historical plant chemistry, and focus in particular on the ... ...

    Abstract Plant carbon isotope discrimination is complex, and could be driven by climate, evolution and/or edaphic factors. We tested the climate drivers of carbon isotope discrimination in modern and historical plant chemistry, and focus in particular on the relationship between rising [CO
    MeSH term(s) Atmosphere ; Carbon Dioxide ; Carbon Isotopes/analysis ; Phylogeny ; Plants
    Chemical Substances Carbon Isotopes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.17030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  2. Article ; Online: Photochemical C(

    Görlich, Tim / Frost, Daniel S / Boback, Nico / Coles, Nathan T / Dittrich, Birger / Müller, Peter / Jones, William D / Müller, Christian

    Journal of the American Chemical Society

    2021  Volume 143, Issue 46, Page(s) 19365–19373

    Abstract: The photochemical activation of the C( ...

    Abstract The photochemical activation of the C(
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c07370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  3. Article ; Online: CDC's New Hepatitis C Virus Testing Recommendations for Perinatally Exposed Infants and Children: A Step Towards Hepatitis C Elimination.

    Panagiotakopoulos, Lakshmi / Miele, Kathryn / Cartwright, Emily J / Kamili, Saleem / Furukawa, Nathan / Woodworth, Kate / Tong, Van T / Kim, Shin Y / Wester, Carolyn / Sandul, Amy L

    Journal of women's health (2002)

    2024  

    Abstract: New U.S. Centers for Disease Control and Prevention (CDC) guidelines for hepatitis C virus (HCV ...

    Abstract New U.S. Centers for Disease Control and Prevention (CDC) guidelines for hepatitis C virus (HCV) testing of perinatally exposed infants and children released in 2023 recommend a nucleic acid test (NAT) for detection of HCV ribonucleic acid (
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2023.1114
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3584: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Systematic approaches to C-lignin engineering in Medicago truncatula.

    Ha, Chan Man / Escamilla-Trevino, Luis / Zhuo, Chunliu / Pu, Yunqiao / Bryant, Nathan / Ragauskas, Arthur J / Xiao, Xirong / Li, Ying / Chen, Fang / Dixon, Richard A

    Biotechnology for biofuels and bioproducts

    2023  Volume 16, Issue 1, Page(s) 100

    Abstract: Background: C-lignin is a homopolymer of caffeyl alcohol present in the seed coats of a variety ... Because of its unique chemical and physical properties, there is considerable interest in engineering C-lignin ... from a transcriptomic analysis of developing C. hassleriana seed coats to suggest strategies for engineering C-lignin ...

    Abstract Background: C-lignin is a homopolymer of caffeyl alcohol present in the seed coats of a variety of plant species including vanilla orchid, various cacti, and the ornamental plant Cleome hassleriana. Because of its unique chemical and physical properties, there is considerable interest in engineering C-lignin into the cell walls of bioenergy crops as a high-value co-product of bioprocessing. We have used information from a transcriptomic analysis of developing C. hassleriana seed coats to suggest strategies for engineering C-lignin in a heterologous system, using hairy roots of the model legume Medicago truncatula.
    Results: We systematically tested strategies for C-lignin engineering using a combination of gene overexpression and RNAi-mediated knockdown in the caffeic acid/5-hydroxy coniferaldehyde 3/5-O-methyltransferase (comt) mutant background, monitoring the outcomes by analysis of lignin composition and profiling of monolignol pathway metabolites. In all cases, C-lignin accumulation required strong down-regulation of caffeoyl CoA 3-O-methyltransferase (CCoAOMT) paired with loss of function of COMT. Overexpression of the Selaginella moellendorffii ferulate 5-hydroxylase (SmF5H) gene in comt mutant hairy roots resulted in lines that unexpectedly accumulated high levels of S-lignin.
    Conclusion: C-Lignin accumulation of up to 15% of total lignin in lines with the greatest reduction in CCoAOMT expression required the strong down-regulation of both COMT and CCoAOMT, but did not require expression of a heterologous laccase, cinnamyl alcohol dehydrogenase (CAD) or cinnamoyl CoA reductase (CCR) with preference for 3,4-dihydroxy-substituted substrates in M. truncatula hairy roots. Cell wall fractionation studies suggested that the engineered C-units are not present in a heteropolymer with the bulk of the G-lignin.
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article
    ISSN 2731-3654
    ISSN (online) 2731-3654
    DOI 10.1186/s13068-023-02339-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Responding to Bill C-7.

    Corbett, Nathan P / Gratzer, David G

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 30, Page(s) E1068

    Language English
    Publishing date 2022-08-08
    Publishing country Canada
    Document type Letter
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.146597-l
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.136: Show issues Location:
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  6. Article ; Online: Accurate Crystal Structures of C

    Hill, Nathan D D / Lilienthal, Elaura / Bender, Christopher O / Boeré, René T

    The Journal of organic chemistry

    2022  

    Abstract: ... within Olex2 v1.5. This results in the determination of C-H bond lengths with near to neutron diffraction ... accuracies at far lower experimental cost, and with an average improvement in C-C bond precision of 42 ... with anisotropic displacement parameters. Nonclassical H-bonding (C-H···N≡C) in this series is analyzed, and ...

    Abstract Fourteen crystal structures, mostly from good-quality datasets but including some marginal and twinned exemplars, from a series of novel polycyclic benzo- and naphtho-fused organic nitriles are presented and accurately described, including some related structures of a bromo-substituted and partially hydrogenated analogues. These structures represent a considerable increase in the number of published structures within their archetypes. This work highlights the significant advancement in structural refinement software proffered by NoSpherA2, which enables Hirshfeld Atom Refinement (HAR) of the structures within Olex2 v1.5. This results in the determination of C-H bond lengths with near to neutron diffraction accuracies at far lower experimental cost, and with an average improvement in C-C bond precision of 42% compared to Independent Atom Model refinements. H-atoms (apart from disordered components) refined well with anisotropic displacement parameters. Nonclassical H-bonding (C-H···N≡C) in this series is analyzed, and dipolar nitrile-nitrile interactions (C≡N···C≡N) in three major motifs described by (Wood, P. A.
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01706
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Synthesis of 2-Cyanobenzothiazoles via Pd-Catalyzed/Cu-Assisted C-H Functionalization/Intramolecular C-S Bond Formation from

    Broudic, Nathan / Pacheco-Benichou, Alexandra / Fruit, Corinne / Besson, Thierry

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: We report herein on a catalytic system involving palladium and copper to achieve the cyclization ... ...

    Abstract We report herein on a catalytic system involving palladium and copper to achieve the cyclization of
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238426
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Effect of Family Navigation on Participation in Part C Early Intervention.

    Feinberg, Emily / Stransky, Michelle L / Augustyn, Marilyn / Broder-Fingert, Sarabeth / Bennett, Amanda / Weitzman, Carol / Kuhn, Jocelyn / Chu, Andrea / Cabral, Howard J / Fenick, Ada M / Blum, Nathan J

    Academic pediatrics

    2023  Volume 23, Issue 5, Page(s) 904–912

    Abstract: Objective: Part C Early Intervention (EI) services have been shown to reduce autism symptoms and ... until age 3, when Part C EI eligibility ends; 65 (89%, 21 censored) children in the FN arm and 50 (79%, 13 ...

    Abstract Objective: Part C Early Intervention (EI) services have been shown to reduce autism symptoms and promote healthy development among young children. However, EI participation remains low, particularly among children from structurally marginalized communities. We investigated whether family navigation (FN) improved EI initiation following positive primary care screening for autism compared to conventional care management (CCM).
    Methods: We conducted a randomized clinical trial among 339 families of children (ages 15-27 months) who screened as having an increased likelihood for autism at 11 urban primary care sites in 3 cities. Families were randomized to FN or CCM. Families in the FN arm received community-based outreach from a navigator trained to support families to overcome structural barriers to autism evaluation and services. EI service records were obtained from state or local agencies. The primary outcome of this study, EI service participation, was measured as the number of days from randomization to the first EI appointment.
    Results: EI service records were available for 271 children; 156 (57.6%) children were not engaged with EI at study enrollment. Children were followed for 100 days after diagnostic ascertainment or until age 3, when Part C EI eligibility ends; 65 (89%, 21 censored) children in the FN arm and 50 (79%, 13 censored) children in the CCM arm were newly engaged in EI. In Cox proportional hazards regression, families receiving FN were approximately 54% more likely to engage EI than those receiving CCM (1.54 (95% confidence interval: 1.09-2.19), P = .02).
    Conclusions: FN improved the likelihood of EI participation among urban families from marginalized communities.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Early Intervention, Educational ; Cities ; Eligibility Determination
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2023.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5914: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.

    Théroux, Léa / Van Den Hauwe, Robin / Trân, Kien / Fournier, Justin / Desgagné, Michael / Meneboo, Nathan / Lavallée, Alexis / Fröhlich, Ulrike / Côté, Jérôme / Hollanders, Charlie / Longpré, Jean-Michel / Murza, Alexandre / Marsault, Eric / Sarret, Philippe / Boudreault, Pierre-Luc / Ballet, Steven

    ACS pharmacology & translational science

    2023  Volume 6, Issue 2, Page(s) 290–305

    Abstract: Apelin is an endogenous peptide that is involved in many diseases such as cardiovascular diseases, obesity, and cancer, which has made it an attractive target for drug discovery. Herein, we explore the penultimate and final sequence positions of [ ... ...

    Abstract Apelin is an endogenous peptide that is involved in many diseases such as cardiovascular diseases, obesity, and cancer, which has made it an attractive target for drug discovery. Herein, we explore the penultimate and final sequence positions of [Pyr
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.2c00219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hepatitis C virus infects and perturbs liver stem cells.

    Meyers, Nathan L / Ashuach, Tal / Lyons, Danielle E / Khalid, Mir M / Simoneau, Camille R / Erickson, Ann L / Bouhaddou, Mehdi / Nguyen, Thong T / Kumar, G Renuka / Taha, Taha Y / Natarajan, Vaishaali / Baron, Jody L / Neff, Norma / Zanini, Fabio / Mahmoudi, Tokameh / Quake, Stephen R / Krogan, Nevan J / Cooper, Stewart / McDevitt, Todd C /
    Yosef, Nir / Ott, Melanie

    mBio

    2023  , Page(s) e0131823

    Abstract: Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes ...

    Abstract Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk remains unclear. Here, we identify bipotent liver stem cells as novel targets for HCV infection, and their erroneous differentiation as the potential cause of impaired liver regeneration and cancer development. We show 3D organoids generated from liver stem cells from actively HCV-infected individuals carry replicating virus and maintain low-grade infection over months. Organoids can be infected with a primary HCV isolate. Virus-inclusive single-cell RNA sequencing uncovered transcriptional reprogramming in HCV
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01318-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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