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  1. Article: Discovery of SARS-CoV-2 M

    Chan, H T Henry / Moesser, Marc A / Walters, Rebecca K / Malla, Tika R / Twidale, Rebecca M / John, Tobias / Deeks, Helen M / Johnston-Wood, Tristan / Mikhailov, Victor / Sessions, Richard B / Dawson, William / Salah, Eidarus / Lukacik, Petra / Strain-Damerell, Claire / Owen, C David / Nakajima, Takahito / Świderek, Katarzyna / Lodola, Alessio / Moliner, Vicent /
    Glowacki, David R / Spencer, James / Walsh, Martin A / Schofield, Christopher J / Genovese, Luigi / Shoemark, Deborah K / Mulholland, Adrian J / Duarte, Fernanda / Morris, Garrett M

    Chemical science

    2021  Volume 12, Issue 41, Page(s) 13686–13703

    Abstract: The main protease (M ...

    Abstract The main protease (M
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc03628a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.

    Green, Simon R / Davis, Susan H / Damerow, Sebastian / Engelhart, Curtis A / Mathieson, Michael / Baragaña, Beatriz / Robinson, David A / Tamjar, Jevgenia / Dawson, Alice / Tamaki, Fabio K / Buchanan, Kirsteen I / Post, John / Dowers, Karen / Shepherd, Sharon M / Jansen, Chimed / Zuccotto, Fabio / Gilbert, Ian H / Epemolu, Ola / Riley, Jennifer /
    Stojanovski, Laste / Osuna-Cabello, Maria / Pérez-Herrán, Esther / Rebollo, María José / Guijarro López, Laura / Casado Castro, Patricia / Camino, Isabel / Kim, Heather C / Bean, James M / Nahiyaan, Navid / Rhee, Kyu Y / Wang, Qinglan / Tan, Vee Y / Boshoff, Helena I M / Converse, Paul J / Li, Si-Yang / Chang, Yong S / Fotouhi, Nader / Upton, Anna M / Nuermberger, Eric L / Schnappinger, Dirk / Read, Kevin D / Encinas, Lourdes / Bates, Robert H / Wyatt, Paul G / Cleghorn, Laura A T

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5992

    Abstract: ... pyrimidine scaffold is described. The series has been developed against M. tuberculosis lysyl-tRNA synthetase ...

    Abstract Tuberculosis is a major global cause of both mortality and financial burden mainly in low and middle-income countries. Given the significant and ongoing rise of drug-resistant strains of Mycobacterium tuberculosis within the clinical setting, there is an urgent need for the development of new, safe and effective treatments. Here the development of a drug-like series based on a fused dihydropyrrolidino-pyrimidine scaffold is described. The series has been developed against M. tuberculosis lysyl-tRNA synthetase (LysRS) and cellular studies support this mechanism of action. DDD02049209, the lead compound, is efficacious in mouse models of acute and chronic tuberculosis and has suitable physicochemical, pharmacokinetic properties and an in vitro safety profile that supports further development. Importantly, preliminary analysis using clinical resistant strains shows no pre-existing clinical resistance towards this scaffold.
    MeSH term(s) Animals ; Lysine-tRNA Ligase/chemistry ; Lysine-tRNA Ligase/genetics ; Lysine-tRNA Ligase/pharmacology ; Mice ; Mycobacterium tuberculosis/genetics ; Tuberculosis/drug therapy
    Chemical Substances Lysine-tRNA Ligase (EC 6.1.1.6)
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33736-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

    Abud, A Abed / Abi, B / Acciarri, R / Acero, M A / Adames, M R / Adamov, G / Adamowski, M / Adams, D / Adinolfi, M / Aduszkiewicz, A / Aguilar, J / Ahmad, Z / Ahmed, J / Aimard, B / Ali-Mohammadzadeh, B / Alion, T / Allison, K / Monsalve, S Alonso / AlRashed, M /
    Alt, C / Alton, A / Alvarez, R / Amedo, P / Anderson, J / Andreopoulos, C / Andreotti, M / Andrews, M / Andrianala, F / Andringa, S / Anfimov, N / Ankowski, A / Antoniassi, M / Antonova, M / Antoshkin, A / Antusch, S / Aranda-Fernandez, A / Arellano, L / Arnold, L O / Arroyave, M A / Asaadi, J / Asquith, L / Aurisano, A / Aushev, V / Autiero, D / Lara, V Ayala / Ayala-Torres, M / Azfar, F / Back, A / Back, H / Back, J J / Backhouse, C / Bagaturia, I / Bagby, L / Balashov, N / Balasubramanian, S / Baldi, P / Baller, B / Bambah, B / Barao, F / Barenboim, G / Alzas, P Barham / Barker, G / Barkhouse, W / Barnes, C / Barr, G / Monarca, J Barranco / Barros, A / Barros, N / Barrow, J L / Basharina-Freshville, A / Bashyal, A / Basque, V / Batchelor, C / Chagas, E Batista das / Battat, J B R / Battisti, F / Bay, F / Bazetto, M C Q / Alba, J L L Bazo / Beacom, J F / Bechetoille, E / Behera, B / Beigbeder, C / Bellantoni, L / Bellettini, G / Bellini, V / Beltramello, O / Benekos, N / Montiel, C Benitez / Neves, F Bento / Berger, J / Berkman, S / Bernardini, P / Berner, R M / Bersani, A / Bertolucci, S / Betancourt, M / Rodríguez, A Betancur / Bevan, A / Bezawada, Y / Bezerra, T J C / Bhardwaj, A / Bhatnagar, V / Bhattacharjee, M / Bhattarai, D / Bhuller, S / Bhuyan, B / Biagi, S / Bian, J / Biassoni, M / Biery, K / Bilki, B / Bishai, M / Bitadze, A / Blake, A / Blaszczyk, F / Blazey, G C / Blucher, E / Boissevain, J / Bolognesi, S / Bolton, T / Bomben, L / Bonesini, M / Bongrand, M / Bonilla-Diaz, C / Bonini, F / Booth, A / Boran, F / Bordoni, S / Borkum, A / Bostan, N / Bour, P / Bourgeois, C / Boyden, D / Bracinik, J / Braga, D / Brailsford, D / Branca, A / Brandt, A / Bremer, J / Breton, D / Brew, C / Brice, S J / Brizzolari, C / Bromberg, C / Brooke, J / Bross, A / Brunetti, G / Brunetti, M / Buchanan, N / Budd, H / Butorov, I / Cagnoli, I / Cai, T / Caiulo, D / Calabrese, R / Calafiura, P / Calcutt, J / Calin, M / Calvez, S / Calvo, E / Caminata, A / Campanelli, M / Caratelli, D / Carber, D / Carceller, J C / Carini, G / Carlus, B / Carneiro, M F / Carniti, P / Terrazas, I Caro / Carranza, H / Carroll, T / Forero, J F Castaño / Castillo, A / Castromonte, C / Catano-Mur, E / Cattadori, C / Cavalier, F / Cavallaro, G / Cavanna, F / Centro, S / Cerati, G / Cervelli, A / Villanueva, A Cervera / Chalifour, M / Chappell, A / Chardonnet, E / Charitonidis, N / Chatterjee, A / Chattopadhyay, S / Neyra, M S S Chavarry / Chen, H / Chen, M / Chen, Y / Chen, Z / Chen-Wishart, Z / Cheon, Y / Cherdack, D / Chi, C / Childress, S / Chirco, R / Chiriacescu, A / Chisnall, G / Cho, K / Choate, S / Chokheli, D / Chong, P S / Christensen, A / Christian, D / Christodoulou, G / Chukanov, A / Chung, M / Church, E / Cicero, V / Clarke, P / Cline, G / Coan, T E / Cocco, A G / Coelho, J A B / Colton, N / Conley, E / Conley, R / Conrad, J / Convery, M / Copello, S / Cova, P / Cremaldi, L / Cremonesi, L / Crespo-Anadón, J I / Crisler, M / Cristaldo, E / Crnkovic, J / Cross, R / Cudd, A / Cuesta, C / Cui, Y / Cussans, D / Dalager, O / da Motta, H / Da Silva Peres, L / David, C / David, Q / Davies, G S / Davini, S / Dawson, J / De, K / De, S / Debbins, P / De Bonis, I / Decowski, M P / De Gouvêa, A / De Holanda, P C / De Icaza Astiz, I L / Deisting, A / De Jong, P / Delbart, A / Delepine, D / Delgado, M / Dell'Acqua, A / Delmonte, N / De Lurgio, P / de Mello Neto, J R T / DeMuth, D M / Dennis, S / Densham, C / Deptuch, G W / De Roeck, A / De Romeri, V / De Souza, G / Devi, R / Dharmapalan, R / Dias, M / Diaz, F / Díaz, J S / Domizio, S Di / Giulio, L Di / Ding, P / Noto, L Di / Dirkx, G / Distefano, C / Diurba, R / Diwan, M / Djurcic, Z / Doering, D / Dolan, S / Dolek, F / Dolinski, M / Domine, L / Donon, Y / Douglas, D / Douillet, D / Dragone, A / Drake, G / Drielsma, F / Duarte, L / Duchesneau, D / Duffy, K / Dunne, P / Dutta, B / Duyang, H / Dvornikov, O / Dwyer, D / Dyshkant, A / Eads, M / Earle, A / Edmunds, D / Eisch, J / Emberger, L / Emery, S / Englezos, P / Ereditato, A / Erjavec, T / Escobar, C / Eurin, G / Evans, J J / Ewart, E / Ezeribe, A C / Fahey, K / Falcone, A / Fani', M / Farnese, C / Farzan, Y / Fedoseev, D / Felix, J / Feng, Y / Fernandez-Martinez, E / Menendez, P Fernandez / Morales, M Fernandez / Ferraro, F / Fields, L / Filip, P / Filthaut, F / Fiorini, M / Fischer, V / Fitzpatrick, R S / Flanagan, W / Fleming, B / Flight, R / Fogarty, S / Foreman, W / Fowler, J / Fox, W / Franc, J / Francis, K / Franco, D / Freeman, J / Freestone, J / Fried, J / Friedland, A / Robayo, F Fuentes / Fuess, S / Furic, I K / Furman, K / Furmanski, A P / Gabrielli, A / Gago, A / Gallagher, H / Gallas, A / Gallego-Ros, A / Gallice, N / Galymov, V / Gamberini, E / Gamble, T / Ganacim, F / Gandhi, R / Gandrajula, R / Gao, F / Gao, S / Garcia-Gamez, D / García-Peris, M Á / Gardiner, S / Gastler, D / Gauvreau, J / Ge, G / Geffroy, N / Gelli, B / Gendotti, A / Gent, S / Ghorbani-Moghaddam, Z / Giammaria, P / Giammaria, T / Giangiacomi, N / Gibin, D / Gil-Botella, I / Gilligan, S / Girerd, C / Giri, A K / Gnani, D / Gogota, O / Gold, M / Gollapinni, S / Gollwitzer, K / Gomes, R A / Bermeo, L V Gomez / Fajardo, L S Gomez / Gonnella, F / Gonzalez-Diaz, D / Gonzalez-Lopez, M / Goodman, M C / Goodwin, O / Goswami, S / Gotti, C / Goudzovski, E / Grace, C / Gran, R / Granados, E / Granger, P / Grant, A / Grant, C / Gratieri, D / Green, P / Greenler, L / Greer, J / Grenard, J / Griffith, W C / Groh, M / Grudzinski, J / Grzelak, K / Gu, W / Guardincerri, E / Guarino, V / Guarise, M / Guenette, R / Guerard, E / Guerzoni, M / Guffanti, D / Guglielmi, A / Guo, B / Gupta, A / Gupta, V / Guthikonda, K K / Gutierrez, R / Guzowski, P / Guzzo, M M / Gwon, S / Ha, C / Haaf, K / Habig, A / Hadavand, H / Haenni, R / Hahn, A / Haiston, J / Hamacher-Baumann, P / Hamernik, T / Hamilton, P / Han, J / Harris, D A / Hartnell, J / Hartnett, T / Harton, J / Hasegawa, T / Hasnip, C / Hatcher, R / Hatfield, K W / Hatzikoutelis, A / Hayes, C / Hayrapetyan, K / Hays, J / Hazen, E / He, M / Heavey, A / Heeger, K M / Heise, J / Henry, S / Morquecho, M A Hernandez / Herner, K / Hewes, J / Hilgenberg, C / Hill, T / Hillier, S J / Himmel, A / Hinkle, E / Hirsch, L R / Ho, J / Hoff, J / Holin, A / Hoppe, E / Horton-Smith, G A / Hostert, M / Hourlier, A / Howard, B / Howell, R / Hoyos, J / Hristova, I / Hronek, M S / Huang, J / Hulcher, Z / Iles, G / Ilic, N / Iliescu, A M / Illingworth, R / Ingratta, G / Ioannisian, A / Irwin, B / Isenhower, L / Itay, R / Jackson, C M / Jain, V / James, E / Jang, W / Jargowsky, B / Jediny, F / Jena, D / Jeong, Y S / Jesús-Valls, C / Ji, X / Jiang, L / Jiménez, S / Jipa, A / Johnson, R / Johnson, W / Johnston, N / Jones, B / Jones, S / Judah, M / Jung, C K / Junk, T / Jwa, Y / Kabirnezhad, M / Kaboth, A / Kadenko, I / Kakorin, I / Kalitkina, A / Kalra, D / Kamiya, F / Kaneshige, N / Kaplan, D M / Karagiorgi, G / Karaman, G / Karcher, A / Karolak, M / Karyotakis, Y / Kasai, S / Kasetti, S P / Kashur, L / Kazaryan, N / Kearns, E / Keener, P / Kelly, K J / Kemp, E / Kemularia, O / Ketchum, W / Kettell, S H / Khabibullin, M / Khotjantsev, A / Khvedelidze, A / Kim, D / King, B / Kirby, B / Kirby, M / Klein, J / Klustova, A / Kobilarcik, T / Koehler, K / Koerner, L W / Koh, D H / Kohn, S / Koller, P P / Kolupaeva, L / Korablev, D / Kordosky, M / Kosc, T / Kose, U / Kostelecký, V A / Kothekar, K / Kralik, R / Kreczko, L / Krennrich, F / Kreslo, I / Kropp, W / Kroupova, T / Kubota, S / Kudenko, Y / Kudryavtsev, V A / Kulagin, S / Kumar, J / Kumar, P / Kunze, P / Kurita, N / Kuruppu, C / Kus, V / Kutter, T / Kvasnicka, J / Kwak, D / Lambert, A / Land, B / Lane, C E / Lang, K / Langford, T / Langstaff, M / Larkin, J / Lasorak, P / Last, D / Laundrie, A / Laurenti, G / Lawrence, A / Lazanu, I / LaZur, R / Lazzaroni, M / Le, T / Leardini, S / Learned, J / LeBrun, P / LeCompte, T / Lee, C / Lee, S Y / Miotto, G Lehmann / Lehnert, R / de Oliveira, M A Leigui / Leitner, M / Lepin, L M / Li, S W / Li, Y / Liao, H / Lin, C S / Lin, Q / Lin, S / Lineros, R A / Ling, J / Lister, A / Littlejohn, B R / Liu, J / Liu, Y / Lockwitz, S / Loew, T / Lokajicek, M / Lomidze, I / Long, K / Lord, T / LoSecco, J M / Louis, W C / Lu, X-G / Luk, K B / Lunday, B / Luo, X / Luppi, E / Lux, T / Luzio, V P / Maalmi, J / MacFarlane, D / Machado, A A / Machado, P / Macias, C T / Macier, J R / Maddalena, A / Madera, A / Madigan, P / Magill, S / Mahn, K / Maio, A / Major, A / Maloney, J A / Mandrioli, G / Mandujano, R C / Maneira, J / Manenti, L / Manly, S / Mann, A / Manolopoulos, K / Plata, M Manrique / Manyam, V N / Manzanillas, L / Marchan, M / Marchionni, A / Marciano, W / Marfatia, D / Mariani, C / Maricic, J / Marie, R / Marinho, F / Marino, A D / Marsden, D / Marshak, M / Marshall, C / Marshall, J / Marteau, J / Martín-Albo, J / Martinez, N / Caicedo, D A Martinez / Miravé, P Martínez / Martynenko, S / Mascagna, V / Mason, K / Mastbaum, A / Matichard, F / Matsuno, S / Matthews, J / Mauger, C / Mauri, N / Mavrokoridis, K / Mawby, I / Mazza, R / Mazzacane, A / Mazzucato, E / McAskill, T / McCluskey, E / McConkey, N / McFarland, K S / McGrew, C / McNab, A / Mefodiev, A / Mehta, P / Melas, P / Mena, O / Mendez, H / Mendez, P / Méndez, D P / Menegolli, A / Meng, G / Messier, M D / Metcalf, W / Mettler, T / Mewes, M / Meyer, H / Miao, T / Michna, G / Miedema, T / Mikola, V / Milincic, R / Miller, G / Miller, W / Mills, J / Mineev, O / Minotti, A / Miranda, O G / Miryala, S / Mishra, C S / Mishra, S R / Mislivec, A / Mitchell, M / Mladenov, D / Mocioiu, I / Moffat, K / Moggi, N / Mohanta, R / Mohayai, T A / Mokhov, N / Molina, J / Bueno, L Molina / Montagna, E / Montanari, A / Montanari, C / Montanari, D / Zetina, L M Montañno / Moon, S H / Mooney, M / Moor, A F / Moreno, D / Moretti, D / Morris, C / Mossey, C / Mote, M / Motuk, E / Moura, C A / Mousseau, J / Mouster, G / Mu, W / Mualem, L / Mueller, J / Muether, M / Mufson, S / Muheim, F / Muir, A / Mulhearn, M / Munford, D / Muramatsu, H / Murphy, S / Musser, J / Nachtman, J / Nagu, S / Nalbandyan, M / Nandakumar, R / Naples, D / Narita, S / Nath, A / Navrer-Agasson, A / Nayak, N / Nebot-Guinot, M / Negishi, K / Nelson, J K / Nesbit, J / Nessi, M / Newbold, D / Newcomer, M / Newton, H / Nichol, R / Nicolas-Arnaldos, F / Nikolica, A / Niner, E / Nishimura, K / Norman, A / Norrick, A / Northrop, R / Novella, P / Nowak, J A / Oberling, M / Ochoa-Ricoux, J / Olivier, A / Olshevskiy, A / Onel, Y / Onishchuk, Y / Ott, J / Pagani, L / Palacio, G / Palamara, O / Palestini, S / Paley, J M / Pallavicini, M / Palomares, C / Vazquez, W Panduro / Pantic, E / Paolone, V / Papadimitriou, V / Papaleo, R / Papanestis, A / Paramesvaran, S / Parke, S / Parozzi, E / Parsa, Z / Parvu, M / Pascoli, S / Pasqualini, L / Pasternak, J / Pater, J / Patrick, C / Patrizii, L / Patterson, R B / Patton, S J / Patzak, T / Paudel, A / Paulos, B / Paulucci, L / Pavlovic, Z / Pawloski, G / Payne, D / Pec, V / Peeters, S J M / Perez, A Pena / Pennacchio, E / Penzo, A / Peres, O L G / Perry, J / Pershey, D / Pessina, G / Petrillo, G / Petta, C / Petti, R / Pia, V / Piastra, F / Pickering, L / Pietropaolo, F / Pimentel, V L / Pinaroli, G / Plows, K / Plunkett, R / Poling, R / Pompa, F / Pons, X / Poonthottathil, N / Poppi, F / Pordes, S / Porter, J / Potekhin, M / Potenza, R / Potukuchi, B V K S / Pozimski, J / Pozzato, M / Prakash, S / Prakash, T / Prest, M / Prince, S / Psihas, F / Pugnere, D / Qian, X / Raaf, J L / Radeka, V / Rademacker, J / Radics, B / Rafique, A / Raguzin, E / Rai, M / Rajaoalisoa, M / Rakhno, I / Rakotonandrasana, A / Rakotondravohitra, L / Rameika, R / Delgado, M A Ramirez / Ramson, B / Rappoldi, A / Raselli, G / Ratoff, P / Raut, S / Razakamiandra, R F / Rea, E M / Real, J S / Rebel, B / Rechenmacher, R / Reggiani-Guzzo, M / Reichenbacher, J / Reitzner, S D / Sfar, H Rejeb / Renshaw, A / Rescia, S / Resnati, F / Ribas, M / Riboldi, S / Riccio, C / Riccobene, G / Rice, L C J / Ricol, J S / Rigamonti, A / Rigaut, Y / Rincón, E V / Ritchie-Yates, H / Rivera, D / Robert, A / Rochester, L / Roda, M / Rodrigues, P / Alonso, M J Rodriguez / Bonilla, E Rodriguez / Rondon, J Rodriguez / Rosauro-Alcaraz, S / Rosenberg, M / Rosier, P / Roskovec, B / Rossella, M / Rossi, M / Rout, J / Roy, P / Rubbia, A / Rubbia, C / Russell, B / Ruterbories, D / Rybnikov, A / Saa-Hernandez, A / Saakyan, R / Sacerdoti, S / Safford, T / Sahu, N / Sakashita, K / Sala, P / Samios, N / Samoylov, O / Sanchez, M C / Sandberg, V / Sanders, D A / Sankey, D / Santana, S / Santos-Maldonado, M / Saoulidou, N / Sapienza, P / Sarasty, C / Sarcevic, I / Savage, G / Savinov, V / Scaramelli, A / Scarff, A / Scarpelli, A / Schefke, T / Schellman, H / Schifano, S / Schlabach, P / Schmitz, D / Schneider, A W / Scholberg, K / Schukraft, A / Segreto, E / Selyunin, A / Senise, C R / Sensenig, J / Sergi, A / Sgalaberna, D / Shaevitz, M H / Shafaq, S / Shaker, F / Shamma, M / Sharankova, R / Sharma, H R / Sharma, R / Sharma, R K / Shaw, T / Shchablo, K / Shepherd-Themistocleous, C / Sheshukov, A / Shin, S / Shoemaker, I / Shooltz, D / Shrock, R / Siegel, H / Simard, L / Sinclair, J / Sinev, G / Singh, J / Singh, L / Singh, P / Singh, V / Sipos, R / Sippach, F W / Sirri, G / Sitraka, A / Siyeon, K / Skarpaas, K / Smith, A / Smith, E / Smith, P / Smolik, J / Smy, M / Snider, E / Snopok, P / Snowden-Ifft, D / Nunes, M Soares / Sobel, H / Soderberg, M / Sokolov, S / Salinas, C J Solano / Söldner-Rembold, S / Soleti, S R / Solomey, N / Solovov, V / Sondheim, W E / Sorel, M / Sotnikov, A / Soto-Oton, J / Ugaldi, F A Soto / Sousa, A / Soustruznik, K / Spagliardi, F / Spanu, M / Spitz, J / Spooner, N J C / Spurgeon, K / Stancari, M / Stanco, L / Stanford, C / Stein, R / Steiner, H M / Lisbôa, A F Steklain / Stewart, J / Stillwell, B / Stock, J / Stocker, F / Stokes, T / Strait, M / Strauss, T / Strigari, L / Stuart, A / Suarez, J G / Sunción, J M Suárez / Sullivan, H / Summers, D / Surdo, A / Susic, V / Suter, L / Sutera, C M / Svoboda, R / Szczerbinska, B / Szelc, A M / Tanaka, H / Tang, S / Tapia, A / Oregui, B Tapia / Tapper, A / Tariq, S / Tarpara, E / Tata, N / Tatar, E / Tayloe, R / Teklu, A M / Tennessen, P / Tenti, M / Terao, K / Ternes, C A / Terranova, F / Testera, G / Thakore, T / Thea, A / Thompson, J L / Thorn, C / Timm, S C / Tishchenko, V / Tomassetti, L / Tonazzo, A / Torbunov, D / Torti, M / Tortola, M / Tortorici, F / Tosi, N / Totani, D / Toups, M / Touramanis, C / Travaglini, R / Trevor, J / Trilov, S / Trzaska, W H / Tsai, Y / Tsai, Y-T / Tsamalaidze, Z / Tsang, K V / Tsverava, N / Tufanli, S / Tull, C / Tyley, E / Tzanov, M / Uboldi, L / Uchida, M A / Urheim, J / Usher, T / Uzunyan, S / Vagins, M R / Vahle, P / Valder, S / Valdiviesso, G D A / Valencia, E / Valentim, R / Vallari, Z / Vallazza, E / Valle, J W F / Vallecorsa, S / Berg, R Van / de Water, R G Van / Forero, D Vanegas / Vannerom, D / Varanini, F / Oliva, D Vargas / Varner, G / Vasel, J / Vasina, S / Vasseur, G / Vaughan, N / Vaziri, K / Ventura, S / Verdugo, A / Vergani, S / Vermeulen, M A / Verzocchi, M / Vicenzi, M / de Souza, H Vieira / Vignoli, C / Vilela, C / Viren, B / Vrba, T / Wachala, T / Waldron, A V / Wallbank, M / Wallis, C / Wang, H / Wang, J / Wang, L / Wang, M H L S / Wang, X / Wang, Y / Warburton, K / Warner, D / Wascko, M O / Waters, D / Watson, A / Wawrowska, K / Weatherly, P / Weber, A / Weber, M / Wei, H / Weinstein, A / Wenman, D / Wetstein, M / White, A / Whitehead, L H / Whittington, D / Wilking, M J / Wilkinson, A / Wilkinson, C / Williams, Z / Wilson, F / Wilson, R J / Wisniewski, W / Wolcott, J / Wongjirad, T / Wood, A / Wood, K / Worcester, E / Worcester, M / Wresilo, K / Wret, C / Wu, W / Xiao, Y / Xie, F / Yaeggy, B / Yandel, E / Yang, G / Yang, K / Yang, T / Yankelevich, A / Yershov, N / Yonehara, K / Yoon, Y S / Young, T / Yu, B / Yu, H / Yu, J / Yu, Y / Yuan, W / Zaki, R / Zalesak, J / Zambelli, L / Zamorano, B / Zani, A / Zazueta, L / Zeller, G P / Zennamo, J / Zeug, K / Zhang, C / Zhang, S / Zhang, Y / Zhao, M / Zhivun, E / Zhu, G / Zimmerman, E D / Zucchelli, S / Zuklin, J / Zutshi, V / Zwaska, R

    The European physical journal. C, Particles and fields

    2022  Volume 82, Issue 7, Page(s) 618

    Abstract: DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a ... ...

    Abstract DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6
    Language English
    Publishing date 2022-07-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-022-10549-w
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  4. Article ; Online: Does the Addition of M-Mode to B-Mode Ultrasound Increase the Accuracy of Identification of Lung Sliding in Traumatic Pneumothoraces?

    Avila, Jacob / Smith, Ben / Mead, Therese / Jurma, Duane / Dawson, Matthew / Mallin, Michael / Dugan, Adam

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2018  Volume 37, Issue 11, Page(s) 2681–2687

    Abstract: Objectives: It is unknown whether the addition of M-mode to B-mode ultrasound (US) has any effect ... randomized via online software to receive a quiz with B-mode clips alone or B-mode with corresponding M-mode ... specificity, and accuracy of the diagnosis of lung sliding with and without M-mode US were compared. Overall ...

    Abstract Objectives: It is unknown whether the addition of M-mode to B-mode ultrasound (US) has any effect on the overall accuracy of interpretation of lung sliding in the evaluation of a pneumothorax by emergency physicians. This study aimed to determine what effect, if any, this addition has on US interpretation by emergency physicians of varying training levels.
    Methods: One hundred forty emergency physicians were randomized via online software to receive a quiz with B-mode clips alone or B-mode with corresponding M-mode images and asked to identify the presence or absence of lung sliding.
    Results: The sensitivity, specificity, and accuracy of the diagnosis of lung sliding with and without M-mode US were compared. Overall, the sensitivities, specificities, and accuracies of B-mode + M-mode US versus B-mode US alone were 93.1% and 93.2% (P = .8), 96.0% and 89.8% (P < .0001), and 91.5% and 94.5% (P = .0091), respectively. A subgroup analysis showed that in those providers with fewer than 250 total US scans done previously, M-mode US increased accuracy from 88.2% (95% confidence interval, 86.2%-90.2%) to 94.4% (92.8%-96.0%; P = .001) and increased the specificity from 87.0% (84.5%-89.5%) to 97.2% (95.4%-99.0%; P < .0001) compared with B-mode US alone. There was no statistically significant difference observed in the sensitivity, specificity, and accuracy of B-mode + M-mode US compared with B-mode US alone in those with more than 250 scans.
    Conclusions: The addition of M-mode images to B-mode clips aids in the accurate diagnosis of lung sliding by emergency physicians. The subgroup analysis showed that the benefit of M-mode US disappears after emergency physicians have performed more than 250 US examinations.
    MeSH term(s) Clinical Competence/statistics & numerical data ; Emergency Medicine/methods ; Humans ; Lung/diagnostic imaging ; Lung Injury/diagnostic imaging ; Pneumothorax/diagnostic imaging ; Reproducibility of Results ; Sensitivity and Specificity ; Thoracic Injuries/diagnostic imaging ; Ultrasonography/methods
    Language English
    Publishing date 2018-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.14629
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  5. Article ; Online: Early differential expression of oncostatin M in obstructive nephropathy.

    Elbjeirami, Wafa M / Truong, Luan D / Tawil, Ahmad / Wang, Wansheng / Dawson, Sara / Lan, Hui Y / Zhang, Ping / Garcia, Gabriela E / Wayne Smith, C

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2010  Volume 30, Issue 7, Page(s) 513–523

    Abstract: Interstitial fibrosis plays a major role in progression of renal diseases. Oncostatin M (OSM) is ...

    Abstract Interstitial fibrosis plays a major role in progression of renal diseases. Oncostatin M (OSM) is a cytokine that regulates cell survival, differentiation, and proliferation. Renal tissue from patients with chronic obstructive nephropathy was examined for OSM expression. The elevated levels in diseased human kidneys suggested possible correlation between OSM level and kidney tissue fibrosis. Indeed, unilateral ureteral obstruction (UUO), a model of renal fibrosis, increased OSM and OSM receptor (OSM-R) expression in a time-dependent manner within hours following UUO. In vitro, OSM overexpression in tubular epithelial cells (TECs) resulted in epithelial-myofibroblast transdifferentiation. cDNA microarray technology identified up-regulated expression of immune modulators in obstructed compared with sham-operated kidneys. In vitro, OSM treatment up-regulated CC chemokine ligand CCL7, and CXC chemokine ligand (CXCL)-14 mRNA in kidney fibroblasts. In vivo, treatment of UUO mice with neutralizing anti-OSM antibody decreased renal chemokines expression. In conclusion, OSM is up-regulated in kidney tissue early after urinary obstruction. Therefore, OSM might play an important role in initiation of renal fibrogenesis, possibly by inducing myofibroblast transdifferentiation of TECs as well as leukocyte infiltration. This process may, in turn, contribute in part to progression of obstructive nephropathy and makes OSM a promising therapeutic target in renal fibrosis.
    MeSH term(s) Animals ; Antibodies, Blocking/administration & dosage ; Cell Transdifferentiation/drug effects ; Cells, Cultured ; Chemokines/biosynthesis ; Chemokines/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Fibrosis ; Gene Expression Profiling ; Humans ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Oligonucleotide Array Sequence Analysis ; Oncostatin M/genetics ; Oncostatin M/immunology ; Oncostatin M/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Oncostatin M/genetics ; Receptors, Oncostatin M/immunology ; Receptors, Oncostatin M/metabolism ; Ureteral Obstruction/genetics ; Ureteral Obstruction/metabolism ; Ureteral Obstruction/pathology ; Ureteral Obstruction/physiopathology
    Chemical Substances Antibodies, Blocking ; Chemokines ; Receptors, Oncostatin M ; Oncostatin M (106956-32-5)
    Language English
    Publishing date 2010-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2009.0105
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  6. Article ; Online: Repeat Application of Ischemic Preconditioning Improves Maximal 1,000-m Kayak Ergometer Performance in a Simulated Competition Format.

    Halley, Samuel L / Peeling, Peter / Brown, Henry / Sim, Marc / Mallabone, Jason / Dawson, Brian / Binnie, Martyn J

    Journal of strength and conditioning research

    2020  

    Abstract: Halley, SL, Peeling, P, Brown, H, Sim, M, Mallabone, J, Dawson, B, and Binnie, MJ. Repeat ... application of ischemic preconditioning improves maximal 1,000-m kayak ergometer performance in a simulated ... of ischemic preconditioning (IPC) on repeat 1,000-m kayak ergometer time-trial (TT) performance, completed in a simulated ...

    Abstract Halley, SL, Peeling, P, Brown, H, Sim, M, Mallabone, J, Dawson, B, and Binnie, MJ. Repeat application of ischemic preconditioning improves maximal 1,000-m kayak ergometer performance in a simulated competition format. J Strength Cond Res XX(X): 000-000, 2020-This study examined the effects of ischemic preconditioning (IPC) on repeat 1,000-m kayak ergometer time-trial (TT) performance, completed in a simulated competition format. Eight well-trained male kayak athletes performed 3 experimental trials, each consisting of two 1,000-m TTs separated by 80 minutes (TT 1 and TT 2). Trials included; (a) IPC (4 × 5 minutes 220 mm Hg alternating bilateral leg occlusion) 40 minutes before TT 1 only (IPC1); (b) IPC 40 minutes before TT 1 and 20 minutes before TT 2 (IPC2); and (c) no IPC (CON). Time, power, stroke rate, and expired gas variables (V[Combining Dot Above]O2 and accumulated oxygen deficit) were measured throughout each TT; blood gas variables (blood lactate, partial pressure of oxygen and blood pH) and rating of perceived exertion were measured before and after each effort. Physiological, perceptual, and physical measures were analyzed via a repeated measures analysis of variance with the level of significance set at p ≤ 0.05. There were large improvements in completion time for TT 1 in IPC1 (d = 1.24 ± 0.68, p < 0.05) and IPC2 (d = 1.53 ± 0.99, p < 0.05) versus CON. There was also a large improvement in TT 2 completion time in IPC2 versus CON (d = 1.26 ± 1.13, p = 0.03) whereas, IPC1 and CON were indifferent (d = 0.3 ± 0.54, p = 0.23). This study showed that a repeat application of IPC in a simulated competition format may offer further benefit in comparison to a single pre-exercise application of IPC.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1156349-7
    ISSN 1533-4287 ; 1064-8011
    ISSN (online) 1533-4287
    ISSN 1064-8011
    DOI 10.1519/JSC.0000000000003748
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  7. Article ; Online: M-class hypertrophic cardiomyopathy cardiac actin mutations increase calcium sensitivity of regulated thin filaments.

    Teng, Grace Zi / Shaikh, Zeeshan / Liu, Haidun / Dawson, John F

    Biochemical and biophysical research communications

    2019  Volume 519, Issue 1, Page(s) 148–152

    Abstract: ... Changes in cardiac actin located exclusively in the myosin binding site are called M-class variants and ... in the presence of regulated thin filaments containing M-class cardiac actin variants. We found that all M-class ... significant decreases in maximal myosin activity. This work represents the first characterization of all M ...

    Abstract Hypertrophic cardiomyopathy is a commonly occurring cardiovascular disease resulting primarily from changes in proteins participating in muscle contraction in the heart, including the cardiac actin protein. Changes in cardiac actin located exclusively in the myosin binding site are called M-class variants and include the H88Y, R95C, and E99K substitutions and F90Δ deletion. The prevailing hypothesis for these mutations is that hypertrophic cardiomyopathy is the result of increased calcium sensitivity of contraction in the myocardium. To test this hypothesis, we studied the activity of myosin at varying calcium concentrations in the presence of regulated thin filaments containing M-class cardiac actin variants. We found that all M-class cardiac actin variants exhibit increased calcium sensitivity, with the R95C variant also displaying significant decreases in maximal myosin activity. This work represents the first characterization of all M-class variant proteins and suggests that drugs targeting contraction specifically to treat hypertrophic cardiomyopathy must consider the impact on both calcium sensitivity and maximal myosin activity on overall heart health.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actins/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Calcium/metabolism ; Cardiomyopathy, Hypertrophic/genetics ; Cattle ; Mutation/genetics ; Myosins/metabolism ; Rabbits
    Chemical Substances Actins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Myosins (EC 3.6.4.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2019.08.151
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  8. Article ; Online: 7 Introduction of M&x0101;ori and Pacific nurse navigators to improve equity in surgical pathway in Auckand, New Zealand

    Andrew Jones / Dawson Ward / Pauline Fakalata

    BMJ Open Quality, Vol 9, Iss Suppl

    2020  Volume 1

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Transmission of Mycobacterium orygis (M. tuberculosis complex species) from a tuberculosis patient to a dairy cow in New Zealand.

    Dawson, Kara L / Bell, Anita / Kawakami, R Pamela / Coley, Kathryn / Yates, Gary / Collins, Desmond M

    Journal of clinical microbiology

    2012  Volume 50, Issue 9, Page(s) 3136–3138

    Abstract: Mycobacterium orygis, previously called the oryx bacillus, is a member of the Mycobacterium tuberculosis complex and has been reported only recently as a cause of human tuberculosis in patients of South Asian origin. We present the first case documenting ...

    Abstract Mycobacterium orygis, previously called the oryx bacillus, is a member of the Mycobacterium tuberculosis complex and has been reported only recently as a cause of human tuberculosis in patients of South Asian origin. We present the first case documenting the transmission of this organism from a human to a cow.
    MeSH term(s) Adult ; Animals ; Cattle ; DNA Gyrase/genetics ; Female ; Genotype ; Humans ; Molecular Epidemiology ; Molecular Typing ; Mycobacterium/classification ; Mycobacterium/isolation & purification ; New Zealand ; Phylogeny ; Polymerase Chain Reaction ; Tuberculosis/microbiology ; Tuberculosis/transmission ; Tuberculosis, Bovine/diagnosis ; Tuberculosis, Bovine/microbiology
    Chemical Substances DNA Gyrase (EC 5.99.1.3)
    Language English
    Publishing date 2012-07-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01652-12
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  10. Article ; Online: Response to the letter regarding "Is it really safe to withhold folinic acid when less than 1000 mg/m

    Chan, Betty S / Dawson, Andrew H / Buckley, Nicholas A

    Clinical toxicology (Philadelphia, Pa.)

    2017  Volume 55, Issue 9, Page(s) 1020

    MeSH term(s) Drug-Related Side Effects and Adverse Reactions ; Humans ; Leucovorin ; Methotrexate
    Chemical Substances Leucovorin (Q573I9DVLP) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2017-04-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2017.1315822
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