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  1. Article ; Online: Combining pure shift and J-edited spectroscopies: A strategy for extracting chemical shifts and scalar couplings from highly crowded proton spectra of oligomeric saccharides.

    Pitoux, D / Hu, Z / Plainchont, B / Merlet, D / Farjon, J / Bonnaffé, D / Giraud, N

    Magnetic resonance in chemistry : MRC

    2018  Volume 56, Issue 10, Page(s) 954–962

    Abstract: We report the application of pure shift and J-edited nuclear magnetic resonance spectroscopies ...

    Abstract We report the application of pure shift and J-edited nuclear magnetic resonance spectroscopies to the structural analysis of a protected maltotrioside synthetic intermediate whose crowded
    MeSH term(s) Molecular Conformation ; Proton Magnetic Resonance Spectroscopy/methods ; Trisaccharides/chemistry
    Chemical Substances Trisaccharides
    Language English
    Publishing date 2018-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.4715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mixing neural networks, continuation and symbolic computation to solve parametric systems of non linear equations.

    Merlet, J-P

    Neural networks : the official journal of the International Neural Network Society

    2024  Volume 176, Page(s) 106316

    Abstract: We consider a square non linear parametric equations system F(P,X) = 0 which is constituted of n non differential equations in the n unknowns { ... ...

    Abstract We consider a square non linear parametric equations system F(P,X) = 0 which is constituted of n non differential equations in the n unknowns {x
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2024.106316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nuclear magnetic resonance using a spatial frequency encoding: application to J-edited spectroscopy along the sample.

    Giraud, Nicolas / Béguin, Laetitia / Courtieu, Jacques / Merlet, Denis

    Angewandte Chemie (International ed. in English)

    2010  Volume 49, Issue 20, Page(s) 3481–3484

    Language English
    Publishing date 2010-05-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.200907103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Combining J-edited and correlation spectroscopies within a multi-dimensional spatial frequency encoding: toward fully resolved 1H NMR spectra.

    Giraud, Nicolas / Pitoux, Daisy / Ouvrard, Jean-Michel / Merlet, Denis

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2013  Volume 19, Issue 37, Page(s) 12221–12224

    Abstract: J-resolved at a glance: Passive coupling refocusing-COSY experiments based on a frequency encoding ...

    Abstract J-resolved at a glance: Passive coupling refocusing-COSY experiments based on a frequency encoding of the sample along two directions of space are presented. It allows various spin evolutions to be triggered in different parts of the sample in a selective and fully controlled manner. This yields 2D spectra in which the whole proton network appears as a series of fully resolved and straightforwardly assignable doublets, triplets or quartets (see figure).
    Language English
    Publishing date 2013-10-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201302005
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  5. Article: Nuclear Magnetic Resonance Using a Spatial Frequency Encoding: Application to J-Edited Spectroscopy along the Sample

    Giraud, Nicolas / Béguin, Laetitia / Courtieu, Jacques / Merlet, Denis

    Angewandte Chemie. 2010 May 03, v. 49, no. 20

    2010  

    Language English
    Dates of publication 2010-0503
    Size p. 3481-3484.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.200907103
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: An antibody free approach to probe the presence of poly-ubiquitin chains on

    Cailloce, Justine / Husson, Fanny / Galy, Vincent / Merlet, Jorge

    microPublication biology

    2023  Volume 2023

    Abstract: ... ...

    Abstract Upon
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Fast and easy method to culture and obtain large populations of male nematodes.

    Cailloce, Justine / Husson, Fanny / Zablocki, Aniela / Galy, Vincent / Merlet, Jorge

    MethodsX

    2023  Volume 11, Page(s) 102293

    Abstract: Caenorhabditis ... ...

    Abstract Caenorhabditis elegans
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2023.102293
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  8. Article ; Online: Elucidating Curvature-Capacitance Relationships in Carbon-Based Supercapacitors.

    Seebeck, Jannes / Merlet, Céline / Meißner, Robert H

    Physical review letters

    2022  Volume 128, Issue 8, Page(s) 86001

    Abstract: Nanoscale surface curvatures, either convex or concave, strongly influence the charging behavior of supercapacitors. Rationalizing individual influences of electrode atoms to the capacitance is possible by interpreting distinct elements of the charge- ... ...

    Abstract Nanoscale surface curvatures, either convex or concave, strongly influence the charging behavior of supercapacitors. Rationalizing individual influences of electrode atoms to the capacitance is possible by interpreting distinct elements of the charge-charge covariance matrix derived from individual charge variations of the electrode atoms. An ionic liquid solvated in acetonitrile and confined between two electrodes, each consisting of three undulated graphene layers, serves as a demonstrator to illustrate pronounced and nontrivial features of the capacitance with respect to the electrode curvature. In addition, the applied voltage determines whether a convex or concave surface contributes to increased capacitance. While at lower voltages capacitance variations are in general correlated with ion number density variations in the double layer formed in the concave region of the electrode, for certain electrode designs a surprisingly strong contribution of the convex part to the differential capacitance is found both at higher and lower voltages.
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.086001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Structural disorder determines capacitance in nanoporous carbons.

    Liu, Xinyu / Lyu, Dongxun / Merlet, Céline / Leesmith, Matthew J A / Hua, Xiao / Xu, Zhen / Grey, Clare P / Forse, Alexander C

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6693, Page(s) 321–325

    Abstract: The difficulty in characterizing the complex structures of nanoporous carbon electrodes has led to a lack of clear design principles with which to improve supercapacitors. Pore size has long been considered the main lever to improve capacitance. However, ...

    Abstract The difficulty in characterizing the complex structures of nanoporous carbon electrodes has led to a lack of clear design principles with which to improve supercapacitors. Pore size has long been considered the main lever to improve capacitance. However, our evaluation of a large series of commercial nanoporous carbons finds a lack of correlation between pore size and capacitance. Instead, nuclear magnetic resonance spectroscopy measurements and simulations reveal a strong correlation between structural disorder in the electrodes and capacitance. More disordered carbons with smaller graphene-like domains show higher capacitances owing to the more efficient storage of ions in their nanopores. Our findings suggest ways to understand and exploit disorder to achieve highly energy-dense supercapacitors.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adn6242
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  10. Article ; Online: The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.

    Maghe, Clément / Trillet, Kilian / André-Grégoire, Gwennan / Kerhervé, Mathilde / Merlet, Laura / Jacobs, Kathryn A / Schauer, Kristine / Bidère, Nicolas / Gavard, Julie

    Cell reports

    2024  Volume 43, Issue 1, Page(s) 113631

    Abstract: Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and -propagating population remarkably vulnerable to variation in the stability and integrity of the lysosomal compartment. Previous work has shown that the expression and activity of the ... ...

    Abstract Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and -propagating population remarkably vulnerable to variation in the stability and integrity of the lysosomal compartment. Previous work has shown that the expression and activity of the paracaspase MALT1 control GSC viability via lysosome abundance. However, the underlying mechanisms remain elusive. By combining RNA sequencing (RNA-seq) with proteome-wide label-free quantification, we now report that MALT1 repression in patient-derived GSCs alters the homeostasis of cholesterol, which accumulates in late endosomes (LEs)-lysosomes. This failure in cholesterol supply culminates in cell death and autophagy defects, which can be partially reverted by providing exogenous membrane-permeable cholesterol to GSCs. From a molecular standpoint, a targeted lysosome proteome analysis unraveled that Niemann-Pick type C (NPC) lysosomal cholesterol transporters are diluted when MALT1 is impaired. Accordingly, we found that NPC1/2 inhibition and silencing partially mirror MALT1 loss-of-function phenotypes. This supports the notion that GSC fitness relies on lysosomal cholesterol homeostasis.
    MeSH term(s) Humans ; Proteome/metabolism ; Carrier Proteins/metabolism ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Homeostasis ; Lysosomes/metabolism ; Cholesterol/metabolism ; Niemann-Pick Disease, Type C/metabolism
    Chemical Substances Proteome ; Carrier Proteins ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein (EC 3.4.22.-) ; Intracellular Signaling Peptides and Proteins ; Cholesterol (97C5T2UQ7J) ; MALT1 protein, human (EC 3.4.22.-)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113631
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