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Article ; Online: Potential functions of hsa-miR-155-5p and core genes in chronic myeloid leukemia and emerging role in human cancer: A joint bioinformatics analysis.

Soltani, Ismael / Bahia, Wael / Farrah, Ahlem / Mahdhi, Abdelkarim / Ferchichi, Salima / Almawi, Wassim Y

2021 Volume 113, Issue 4, Page(s) 1647–1658

Abstract: Considering the critical roles of hsa-miR-155-5p participated in hematopoietic system, this study aims to clarify the possible pathogenesis of chronic myeloid leukemia (CML) induced by hsa-miR-155-5p.Three different strategies were employed, namely a ... ...

Abstract	Considering the critical roles of hsa-miR-155-5p participated in hematopoietic system, this study aims to clarify the possible pathogenesis of chronic myeloid leukemia (CML) induced by hsa-miR-155-5p.Three different strategies were employed, namely a network-based pipeline, a survival analysis and genetic screening method, and a simulation modeling approach, to assess the oncogenic role of hsa-miR-155-5p in CML. We identified new potential roles of hsa-miR-155-5p in CML, involving the BCR/ABL-mediated leukemogenesis through MAPK signaling. Several promising targets including E2F2, KRAS and FLI1 were screened as candidate diagnostic marker genes. The survival analysis revealed that mRNA expression of E2F2, KRAS and FLI1 was negatively correlated with hsa-miR-155-5p and these targets were significantly associated with poor overall survival. Furthermore, an overlap between CML-related genes and hsa-miR-155-5p target genes was revealed using competing endogenous RNA (ceRNA) networks analysis. Taken together, our results reveal the dynamic regulatory aspect of hsa-miR-155-5p as potential player in CML pathogenesis.
MeSH term(s)	Carcinogenesis ; Computational Biology ; Gene Regulatory Networks ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	MIRN155 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2021.04.014
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Article ; Online: Human forkhead box protein 3 gene variants associated with altered susceptibility to idiopathic recurrent pregnancy loss: A retrospective case-control study.

Bahia, Wael / Zitouni, Hedia / Kanabekova, Perizat / Bauyrzhanova, Zhansaya / Shaimardanova, Moldir / Finan, Ramzi R / Aimagambetova, Gulzhanat / Almawi, Wassim Y

American journal of reproductive immunology (New York, N.Y. : 1989)

2022 Volume 88, Issue 2, Page(s) e13551

Abstract: Background: The pathogenesis of recurrent pregnancy loss (RPL) is multifactorial and not completely elucidated. Dysregulated immunity was implicated with RPL, in which regulatory T cells (Tregs) are key. As Tregs development and function are regulated ... ...

Abstract	Background: The pathogenesis of recurrent pregnancy loss (RPL) is multifactorial and not completely elucidated. Dysregulated immunity was implicated with RPL, in which regulatory T cells (Tregs) are key. As Tregs development and function are regulated by forkhead box P3 (FOXP3) transcription factor, and as FOXP3 expression is genetically determined, a role for FOXP3 polymorphisms in RPL pathogenesis was suggested. Aim: To investigate the association of rs2294021, rs2232365, rs3761548, and rs141704699 FOXP3 variants with idiopathic RPL in Lebanese women. Methods: This retrospective case-control study included 386 RPL cases and 398 age-matched control women. Logistic odds ratios (OR) were estimated with 95% confidence interval after adjustment; a significance value of P<.05 was set. Results: Significantly lower rs22944021 and rs2232365 minor allele frequency (MAF) was found in patients with idiopathic RPL in comparison with the control group. Furthermore, statistically significantly lower frequency of heterozygous and homozygous rs2294021 and rs2232365 genotypes was seen in controls, while significantly lower rs3761548 heterozygous genotype frequencies were found in the patient group. Obesity, antihypertension treatment, smoking, positive RPL family history, abortion state, and infertility treatment correlated negatively with rs2294021, while rs2232365 negatively correlated with obesity, and rs3761548 negatively correlated with infertility treatment. Marked linkage disequilibrium (LD) was noted among FOXP3 SNPs, with TGCC and CGAC haplotypes being positive, while CAAC, CACC, and TGAC haplotypes being negatively associated with RPL risk. Except for CGAC, the association of these haplotypes with RPL persisted after adjustment. Conclusion: FOXP3 gene variants and haplotypes are associated with altered incidence of RPL, proposing the role of Treg in RPL pathogenesis.
MeSH term(s)	Abortion, Habitual/genetics ; Case-Control Studies ; Female ; Forkhead Transcription Factors/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Infertility, Female/genetics ; Obesity ; Polymorphism, Single Nucleotide ; Pregnancy ; Retrospective Studies
Chemical Substances	FOXP3 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2022-05-16
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.13551
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Article ; Online: Comprehensive in-silico analysis of damage associated SNPs in hOCT1 affecting Imatinib response in chronic myeloid leukemia.

Soltani, Ismael / Bahia, Wael / Radhouani, Assala / Mahdhi, Abdelkarim / Ferchichi, Salima / Almawi, Wassim Y

Genomics

2020 Volume 113, Issue 1 Pt 2, Page(s) 755–766

Abstract: Non-synonymous single nucleotide polymorphisms (nsSNPs) in hOCT1 (encoded by SLC22A1 gene) are expected to affect Imatinib uptake in chronic myeloid leukemia (CML). In this study, sequence homology-based genetic analysis of a set of 270 coding SNPs ... ...

Abstract	Non-synonymous single nucleotide polymorphisms (nsSNPs) in hOCT1 (encoded by SLC22A1 gene) are expected to affect Imatinib uptake in chronic myeloid leukemia (CML). In this study, sequence homology-based genetic analysis of a set of 270 coding SNPs identified 18 nsSNPs to be putatively damaging/deleterious using eight different algorithms. Subsequently, based on conservation of amino acid residues, stability analysis, posttranscriptional modifications, and solvent accessibility analysis, the possible structural-functional relationship was established for high-confidence nsSNPs. Furthermore, based on the modeling results, some dissimilarities of mutant type amino acids from wild-type amino acids such as size, charge, interaction and hydrophobicity were revealed. Three highly deleterious mutations consisting of P283L, G401S and R402G in SLC22A1 gene that may alter the protein structure, function and stability were identified. These results provide a filtered data to explore the effect of uncharacterized nsSNP and find their association with Imatinib resistance in CML.
MeSH term(s)	Amino Acid Substitution ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Humans ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Molecular Dynamics Simulation ; Octamer Transcription Factor-1/chemistry ; Octamer Transcription Factor-1/genetics ; Octamer Transcription Factor-1/metabolism ; Polymorphism, Single Nucleotide
Chemical Substances	Antineoplastic Agents ; Octamer Transcription Factor-1 ; POU2F1 protein, human ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2020.10.007
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Zs.A 2367: Show issues

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Article ; Online: Authors' reply re: Genetic variation in the progesterone receptor gene and susceptibility to recurrent pregnancy loss: a case-control study.

Almawi, Wassim Y / Bahia, Wael / Mahjoub, Touhami

BJOG : an international journal of obstetrics and gynaecology

2017 Volume 125, Issue 6, Page(s) 761–762

MeSH term(s)	Abortion, Habitual ; Case-Control Studies ; Epidemiologic Studies ; Female ; Genetic Variation ; Humans ; Pregnancy ; Receptors, Progesterone
Chemical Substances	Receptors, Progesterone
Language	English
Publishing date	2017-12-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.14995
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Article: Links between SNPs in

Bahia, W / Soltani, I / Haddad, A / Radhouani, A / Mahdhi, Abdelkarim / Ferchichi, S / Almawi, W Y

British journal of biomedical science

2019 Volume 77, Issue 2, Page(s) 64–68

Abstract: ... ...

Abstract	Background
MeSH term(s)	Abortion, Habitual/genetics ; Adult ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Pregnancy ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics
Chemical Substances	TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
Language	English
Publishing date	2019-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1152119-3
ISSN	0967-4845
ISSN	0967-4845
DOI	10.1080/09674845.2019.1687151
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Zs.A 225: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Protein Z, an anticoagulant protein with expanding role in reproductive biology.

Almawi, Wassim Y / Al-Shaikh, Fatima S / Melemedjian, Ohannes K / Almawi, Ahmad W

Reproduction (Cambridge, England)

2013 Volume 146, Issue 2, Page(s) R73–80

Abstract: Protein Z (PZ) is a vitamin K-dependent factor characterized by its homology to other vitamin K-dependent factors (factors VII, IX, and X, protein C and protein S), but lacks any enzymatic activity. Instead, PZ acts as a cofactor for the inhibition of ... ...

Abstract	Protein Z (PZ) is a vitamin K-dependent factor characterized by its homology to other vitamin K-dependent factors (factors VII, IX, and X, protein C and protein S), but lacks any enzymatic activity. Instead, PZ acts as a cofactor for the inhibition of factor Xa through the serpin PZ-dependent protease inhibitor (ZPI). PZ deficiency is associated with a procoagulant state, highlighted by excessive FXa secretion and thrombin production, and is linked with several thrombotic disorders, including arterial vascular and venous thromboembolic diseases. A role for the PZ-ZPI complex in the regulation of physiological pregnancy has been demonstrated, highlighted by the progressive elevation in PZ levels in the first trimester of gestation, which then steadily decline toward delivery. An association between altered plasma PZ concentrations and adverse pregnancy outcomes (recurrent miscarriage, stillbirth, preeclampsia, intrauterine growth restriction, and placental abruption) has been reported. The mechanism by which PZ deficiency leads to adverse pregnancy outcomes is not clear, but it is multifactorial. It may be attributed to the anti-PZ IgG and IgM autoantibodies, which apparently act independently of classical antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, and anti-β2-glycoprotein I antibodies). PZ deficiency has also been reported to be constitutional, and a number of variants in the PROZ (PZ) gene and SERPINA10 (ZPI) gene are linked with specific adverse pregnancy complications. This review summarizes the relationship between adverse pregnancy outcomes and acquired and constitutional PZ-ZPI deficiency, in order to understand whether or not PZ deficiency could be considered as a risk factor for poor pregnancy outcomes.
MeSH term(s)	Autoantibodies/analysis ; Blood Coagulation ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/genetics ; Blood Coagulation Disorders/immunology ; Blood Coagulation Disorders/metabolism ; Blood Proteins/chemistry ; Blood Proteins/deficiency ; Blood Proteins/genetics ; Blood Proteins/metabolism ; Female ; Genetic Variation ; Humans ; Molecular Conformation ; Pregnancy ; Pregnancy Complications, Hematologic/blood ; Pregnancy Complications, Hematologic/genetics ; Pregnancy Complications, Hematologic/immunology ; Pregnancy Complications, Hematologic/metabolism ; Pregnancy Maintenance ; Serpins/blood ; Serpins/deficiency ; Serpins/genetics ; Serpins/metabolism
Chemical Substances	Autoantibodies ; Blood Proteins ; SERPINA10 protein, human ; Serpins ; plasma protein Z
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-13-0072
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Uc I Zs.362: Show issues

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Article ; Online: Identification of genes and miRNA associated with idiopathic recurrent pregnancy loss: an exploratory data mining study.

Bahia, Wael / Soltani, Ismael / Abidi, Anouar / Haddad, Anis / Ferchichi, Salima / Menif, Samia / Almawi, Wassim Y

BMC medical genomics

2020 Volume 13, Issue 1, Page(s) 75

Abstract: Background: Recurrent pregnancy loss (RPL) is a significant adverse pregnancy complication, with an incompletely understood pathology. While many entities were proposed to elucidate the pathogenic basis of RPL, only few were significant enough to ... ...

Abstract	Background: Recurrent pregnancy loss (RPL) is a significant adverse pregnancy complication, with an incompletely understood pathology. While many entities were proposed to elucidate the pathogenic basis of RPL, only few were significant enough to warrant investigation in all affected couples.. The aim of this study was to provide novel insights into the biological characteristics and related pathways of differentially expressed miRNA (DEMs) and genes (DEGs), in RPL, and construct a molecular miRNAs-mRNAs network. Methods: miRNAs and gene expression data were collected, and a number of DEMs and (DEGs) were obtained, and regulatory co-expression network were constructed. Function and enrichment analyses of DEMs were conducted using DIANA-miRPath. DEGs were screened, and were used in generation of protein-protein interaction (PPI) network, using STRING online database. Modularity analysis, and pathway identification operations were used in identifying graph clusters and associated pathways. DEGs were also used for further gene ontology (GO) analysis, followed by analysis of KEGG pathway. Results: A total of 34 DEMs were identified, and were found to be highly enriched in TGF-β signaling pathway, Fatty acid metabolism and TNF signaling pathway. Hub miRNAs were selected and were found to be involved in several functional pathways including progesterone-mediated oocyte maturation and Thyroid hormone signaling pathway. Five dysregulated feedback loops involving miRNA and TFs were identified and characterized. Most notably, PPI network analysis identified hub-bottleneck protein panel. These appear to offer potential candidate biomarker pattern for RPL diagnosis and treatment. Conclusions: The present study provides novel insights into the molecular mechanisms underlying RPL.
MeSH term(s)	Abortion, Habitual/genetics ; Abortion, Habitual/metabolism ; Abortion, Habitual/pathology ; Biomarkers/analysis ; Computational Biology ; Data Mining ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Genes ; Humans ; MicroRNAs/genetics ; Pregnancy ; Protein Interaction Maps ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Recurrence ; Transcriptome
Chemical Substances	Biomarkers ; MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2020-06-01
Publishing country	England
Document type	Journal Article
ISSN	1755-8794
ISSN (online)	1755-8794
DOI	10.1186/s12920-020-00730-z
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Article ; Online: Contribution of ADIPOQ Variants to the Genetic Susceptibility of Recurrent Pregnancy Loss.

Bahia, Wael / Soltani, Ismael / Haddad, Anis / Radhouani, Assala / Mahdhi, Abdelkarim / Ferchichi, Salima / Almawi, Wassim Y

Reproductive sciences (Thousand Oaks, Calif.)

2020 Volume 28, Issue 1, Page(s) 263–270

Abstract: Adiponectin is a hormone implicated in regulating energy, lipid, and glucose metabolism and is encoded by the ADIPOQ gene. ADIPOQ variants can regulate the circulating levels of adiponectin. Irregular adiponectin concentrations have been associated with ... ...

Abstract	Adiponectin is a hormone implicated in regulating energy, lipid, and glucose metabolism and is encoded by the ADIPOQ gene. ADIPOQ variants can regulate the circulating levels of adiponectin. Irregular adiponectin concentrations have been associated with numerous reproductive diseases including recurrent pregnancy loss (RPL). The main objective of this study was to determine whether the 14 selected polymorphisms of the ADIPOQ gene are linked with RPL. The retrospective case-control study comprised a total of 332 women with RPL, adjusted as more than three consecutive abortions of unknown etiology, and 286 healthy controls. They were genotyped for the ADIPOQ variants using allele exclusion method on real-time PCR. Significantly higher rs1501299 minor allele frequencies (MAF) and lower rs2241767 and rs2241766 MAF were seen among RPL women, thereby assigning disease susceptibility and protective aspect to the mentioned variants, respectively. Different associations of ADIPOQ genotypes with RPL were noticed according to the genetic model exploited: rs1501299 and rs2241767 were significantly linked with RPL under the three models, while rs17366568 and rs2241766 were associated with RPL under codominant and dominant models, and rs7649121 was related to RPL under the dominant and recessive models. rs4632532 was linked according to the recessive model only. Based on LD pattern, 2-haplotype blocks were specified. Reduced frequency of AGG and GAGG and increased frequency of TAAG were noted in cases, compared with controls, hence indicating these haplotypes as RPL-protective and RPL-susceptible, respectively. These results support a significant role of ADIPOQ as an RPL candidate locus.
MeSH term(s)	Abortion, Habitual/diagnosis ; Abortion, Habitual/genetics ; Adiponectin/genetics ; Adult ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Phenotype ; Polymorphism, Single Nucleotide ; Pregnancy ; Protective Factors ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tunisia
Chemical Substances	ADIPOQ protein, human ; Adiponectin
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-020-00274-8
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Zs.A 4113: Show issues

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Article ; Online: Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case-control study.

Dendana, Maryam / Bahia, Wael / Finan, Ramzi R / Al-Mutawa, Mariam / Almawi, Wassim Y

Journal of translational medicine

2018 Volume 16, Issue 1, Page(s) 76

Abstract: Background: This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.: Methods: Retrospective case-control study performed in outpatient obstetrics/ ... ...

Abstract	Background: This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity. Methods: Retrospective case-control study performed in outpatient obstetrics/gynecology clinics. Study subjects comprised 308 women with RPL, defined as ≥ 3 consecutive miscarriages of unknown etiology, and 310 control women. ADIPOQ genotyping was done by allele exclusion method on real-time PCR. Results: Of the 14 ADIPOQ variants tested, the minor allele frequency (MAF) of rs4632532, rs17300539, rs266729, rs182052, rs16861209, and rs7649121 were significantly higher, while rs2241767, and rs1063539 MAF were lower in RPL cases, hence assigning RPL-susceptibility and protection to these variants, respectively. Higher frequencies of heterozygous rs17300539 and rs16861209, and homozygous rs4632532, rs266729, and rs182052 genotypes, and reduced frequencies of heterozygous rs1063539 and rs2241767, homozygous rs2241766 genotypes were seen in RPL cases. ADIPOQ rs4632532, and rs2241766 were associated with RPL in obese, while rs1063539 and rs16861209 were associated with RPL in non-obese women; rs182052 and rs7649121 associated with RPL independently of BMI changes. Based on LD pattern, two haplotype blocks were identified. Within Block 1 containing rs4632532, rs16861194, rs17300539, rs266729, rs182052, rs16861209, rs822396, and rs7649121, increased frequency of CAGGACAT and TAACGAAA, and reduced frequency of TAGCGCAA haplotypes were seen in RPL cases when compared to controls, thereby assigning RPL susceptibility and protection, respectively. Conclusion: This is the first study to document contribution of ADIPOQ variants and haplotypes with RPL, and also to underscore the contribution of obesity to genetic association studies.
MeSH term(s)	Abortion, Habitual/genetics ; Adiponectin/genetics ; Case-Control Studies ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes/genetics ; Humans ; Obesity/complications ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Adiponectin
Language	English
Publishing date	2018-03-20
Publishing country	England
Document type	Journal Article
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-018-1453-3
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Article: TLR3 and TLR4 SNP variants in the liver disease resulting from hepatitis B virus and hepatitis C virus infection.

Sghaier, I / Zidi, S / Mouelhi, L / Ghazoueni, E / Brochot, E / Almawi, W Y / Loueslati, B Y

British journal of biomedical science

2018 Volume 76, Issue 1, Page(s) 35–41

Abstract: Background: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in ... ...

Abstract	Background: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised a link TLR3 and TLR4 polymorphisms and HCC, as surrogates for the significance of TLR signalling in the promotion and initiation of HCC. Materials and methods: We recruited 174 HCV-infected patients, 100 HBV-infected patients and 360 healthy control subjects. TLR3 (rs3775290) and TLR4 (rs4986790) genotyping was done by PCR-restriction fragment length polymorphisms (PCR-RFLP), LFTs and AFP by standard routine techniques. Liver fibrosis was assessed clinically by the Fibrotest and Actitest. Result: The TLR3 rs3775290 minor T genotype was linked with increased risk of chronic HBV (P = 0.05) and HCV (P = 0.031) infection. The TLR4 rs4986790 minor G genotype was linked with significantly increased risk for HBV/HCV chronic infection (P < 0.001). Subgroups analyses indicated decreased risk of HBV-related HCC in relation to TLR3 rs3775290 CC/CT genotype (P = 0.022), with increased risk ascribed to the minor (T) allele (P = 0.04). Likewise, TLR4 rs4985790 minor (GG) genotype was positively associated with HBV-linked HCC (P < 0.001). Furthermore, a link between TLR3 TT (P < 0.001) andTLR4 GG (P = 0.04) minor genotypes was noted in relation to increased risk of HCV-related disease. Conclusion: TLR3 and TLR4 polymorphisms are promising biomarkers of liver cirrhosis and cancer associated with HBV and HCV infection.
MeSH term(s)	Adult ; Aged ; Alleles ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/virology ; Case-Control Studies ; Female ; Gene Expression ; Gene Frequency ; Genetic Predisposition to Disease ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/genetics ; Hepatitis B, Chronic/virology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/virology ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/virology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/genetics ; Liver Neoplasms/virology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 3/immunology ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology
Chemical Substances	TLR3 protein, human ; TLR4 protein, human ; Toll-Like Receptor 3 ; Toll-Like Receptor 4
Language	English
Publishing date	2018-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1152119-3
ISSN	0967-4845
ISSN	0967-4845
DOI	10.1080/09674845.2018.1547179
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