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  1. Article ; Online: Editorial: Termination of pro-inflammatory signaling and its dysregulation in autoimmune diseases.

    Huber, René / Novick, Daniela / Hu, Guochang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1174996

    MeSH term(s) Humans ; Autoimmune Diseases ; Inflammation ; Signal Transduction
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1174996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design, synthesis, and biological application of A-D-A-type boranil fluorescent dyes.

    Luo, Wei / Li, Yiling / Wang, Liang / Qin, Yanhua / Cheng, Qiao / Hu, Guochang / Yao, Chaoyi / Song, Xiangzhi

    Organic & biomolecular chemistry

    2024  

    Abstract: For the first time, three acceptor-donor-acceptor (A-D-A)-type boranil fluorescent dyes, CSU-BF-R (R = H, ... ...

    Abstract For the first time, three acceptor-donor-acceptor (A-D-A)-type boranil fluorescent dyes, CSU-BF-R (R = H, CH
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00297k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: Alveolar Macrophages in Lung Inflammation and Resolution.

    Hu, Guochang / Christman, John W

    Frontiers in immunology

    2019  Volume 10, Page(s) 2275

    MeSH term(s) Animals ; Cytokines/genetics ; Cytokines/immunology ; Cytokines/metabolism ; Gene Expression/immunology ; Humans ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Macrophage Activation/genetics ; Macrophage Activation/immunology ; Macrophages, Alveolar/classification ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Pneumonia/genetics ; Pneumonia/immunology ; Pneumonia/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2019-09-24
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Assembly of Metal-Organic Frameworks on Transition Metal Phosphides as Self-Supported Electrodes for High-Performance Hybrid Supercapacitors.

    Ma, Xuechun / Xu, Dongdong / Guo, Jie / Tao, Kai / Hu, Yaoping / Li, Guochang / Han, Lei

    Inorganic chemistry

    2022  Volume 61, Issue 48, Page(s) 19240–19247

    Abstract: In this work, the composite electrode composed of metal-organic frameworks and transition metal phosphides is first assembled on the nickel foam substrate. The as-prepared NiCo-MOF-74@ ... ...

    Abstract In this work, the composite electrode composed of metal-organic frameworks and transition metal phosphides is first assembled on the nickel foam substrate. The as-prepared NiCo-MOF-74@Ni
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c02912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In Vivo Calpain Knockdown Using Delivery of siRNA.

    Liu, Xiaoqian / Hu, Guochang

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1915, Page(s) 219–232

    Abstract: Calpain is an intracellular ... ...

    Abstract Calpain is an intracellular Ca
    MeSH term(s) Animals ; Calpain/antagonists & inhibitors ; Calpain/genetics ; Endothelial Cells/chemistry ; Endothelial Cells/metabolism ; Endothelium, Vascular/chemistry ; Endothelium, Vascular/metabolism ; Gene Knockdown Techniques/methods ; Humans ; Liposomes/chemistry ; Lung/chemistry ; Lung/metabolism ; Mice ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics
    Chemical Substances Liposomes ; RNA, Small Interfering ; Calpain (EC 3.4.22.-)
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8988-1_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Task sub-type states decoding via group deep bidirectional recurrent neural network.

    Zhao, Shijie / Fang, Long / Yang, Yang / Tang, Guochang / Luo, Guoxin / Han, Junwei / Liu, Tianming / Hu, Xintao

    Medical image analysis

    2024  Volume 94, Page(s) 103136

    Abstract: Decoding brain states under different cognitive tasks from functional magnetic resonance imaging (fMRI) data has attracted great attention in the neuroimaging filed. However, the well-known temporal dependency in fMRI sequences has not been fully ... ...

    Abstract Decoding brain states under different cognitive tasks from functional magnetic resonance imaging (fMRI) data has attracted great attention in the neuroimaging filed. However, the well-known temporal dependency in fMRI sequences has not been fully exploited in existing studies, due to the limited temporal-modeling capacity of the backbone machine learning algorithms and rigid training sample organization strategies upon which the brain decoding methods are built. To address these limitations, we propose a novel method for fine-grain brain state decoding, namely, group deep bidirectional recurrent neural network (Group-DBRNN) model. We first propose a training sample organization strategy that consists of a group-task sample generation module and a multiple-scale random fragment strategy (MRFS) module to collect training samples that contain rich task-relevant brain activity contrast (i.e., the comparison of neural activity patterns between different tasks) and maintain the temporal dependency. We then develop a novel decoding model by replacing the unidirectional RNNs that are widely used in existing brain state decoding studies with bidirectional stacked RNNs to better capture the temporal dependency, and by introducing a multi-task interaction layer (MTIL) module to effectively model the task-relevant brain activity contrast. Our experimental results on the Human Connectome Project task fMRI dataset (7 tasks consisting of 23 task sub-type states) show that the proposed model achieves an average decoding accuracy of 94.7% over the 23 fine-grain sub-type states. Meanwhile, our extensive interpretations of the intermediate features learned in the proposed model via visualizations and quantitative assessments of their discriminability and inter-subject alignment evidence that the proposed model can effectively capture the temporal dependency and task-relevant contrast.
    MeSH term(s) Humans ; Brain/diagnostic imaging ; Neural Networks, Computer ; Connectome/methods ; Algorithms ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1356436-5
    ISSN 1361-8423 ; 1361-8431 ; 1361-8415
    ISSN (online) 1361-8423 ; 1361-8431
    ISSN 1361-8415
    DOI 10.1016/j.media.2024.103136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Enhancing cation storage performance of layered double hydroxides by increasing the interlayer distance.

    Ge, Chengxuan / Mao, Chenghui / Zhao, Jie / Li, Guochang / Yang, Lijun / Wu, Qiang / Wang, Xizhang / Hu, Zheng

    The Journal of chemical physics

    2023  Volume 158, Issue 9, Page(s) 94703

    Abstract: Layered double hydroxides (LDH) can be transformed from alkaline supercapacitor material into metal-cation storage cathode working in neutral electrolytes through electrochemical activation. However, the rate performance for storing large cations is ... ...

    Abstract Layered double hydroxides (LDH) can be transformed from alkaline supercapacitor material into metal-cation storage cathode working in neutral electrolytes through electrochemical activation. However, the rate performance for storing large cations is restricted by the small interlayer distance of LDH. Herein, the interlayer distance of NiCo-LDH is expanded by replacing the interlayer nitrate ions with 1,4-benzenedicarboxylic anions (BDC), leading to the enhanced rate performance for storing large cations (Na
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0139389
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  8. Article ; Online: Wrought and cast aluminum flows in China in the context of electric vehicle diffusion and automotive lightweighting

    Wang, Binze / Zhang, Zhengyang / Xu, Guochang / Zeng, Xianlai / Hu, Wentao / Matsubae, Kazuyo

    Resources, Conservation & Recycling. 2023 Apr., v. 191 p.106877-

    2023  

    Abstract: Electrification and vehicle weight reduction (lightweighting) trends are driving demand for wrought aluminum alloys. Given that aluminum scrap is currently downgraded as it is recycled into cast aluminum alloys, an imbalance in aluminum cycles is ... ...

    Abstract Electrification and vehicle weight reduction (lightweighting) trends are driving demand for wrought aluminum alloys. Given that aluminum scrap is currently downgraded as it is recycled into cast aluminum alloys, an imbalance in aluminum cycles is predicted to occur. We identified secondary aluminum flows by distinguishing alloy type in China with material flow analysis. Considering the adoption of advanced recovery techniques and the trends towards greater use of electric vehicles and vehicle lightweighting, we also estimated changes in the automotive demand for wrought and cast alloys along with aluminum scrap generation, as well as the reduced amount of primary aluminum used in automobiles. The results revealed the potential to recycle about 87−183 kt of wrought alloys in 2019 and about 1,054−7,152 kt in 2050 within a well-managed vehicle recycling system, thereby reducing the amount of primary aluminum ingot required for automobile production by 10−37% between 2019 to 2050.
    Keywords alloys ; aluminum ; automobiles ; electric vehicles ; material flow analysis ; weight loss ; China ; Secondary aluminum ; Lightweighting ; Recycling
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2023.106877
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Recombinant human annexin A5: a novel drug candidate for treatment of sepsis?

    Hu, Guochang

    Critical care medicine

    2013  Volume 42, Issue 1, Page(s) 219–220

    MeSH term(s) Animals ; Annexin A5/pharmacology ; Endotoxemia/drug therapy ; Heart/drug effects ; Humans ; Inflammation/prevention & control ; Male
    Chemical Substances Annexin A5
    Language English
    Publishing date 2013-12-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/01.ccm.0000435680.21801.0f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: p120-Catenin suppresses NLRP3 inflammasome activation in macrophages.

    Kanmani, Paulraj / Elkafas, Hoda El-Hossiny / Ghazal, Muhammed / Minshall, Richard D / Hu, Guochang

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 324, Issue 5, Page(s) L596–L608

    Abstract: Inflammasome activation is of central importance for the process of generation of overwhelming inflammatory response and the pathogenesis of sepsis. The intrinsic molecular mechanism for controlling inflammasome activation is still poorly understood. ... ...

    Abstract Inflammasome activation is of central importance for the process of generation of overwhelming inflammatory response and the pathogenesis of sepsis. The intrinsic molecular mechanism for controlling inflammasome activation is still poorly understood. Here we investigated the role of p120-catenin expression in macrophages in regulating nucleotide-binding oligomerization domain (NOD) and leucine-rich repeat (LRR)- and pyrin domain-containing proteins 3 (NLRP3) inflammasome activation. Depletion of p120-catenin in murine bone marrow-derived macrophages enhanced caspase-1 activation and secretion of active interleukin (IL)-1β in response to ATP stimulation following LPS priming. Coimmunoprecipitation analysis showed that p120-catenin deletion promoted NLRP3 inflammasome activation by accelerating the assembly of the inflammasome complex comprised of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1. Depletion of p120-catenin also increased the production of mitochondrial reactive oxygen species. Pharmacological inhibition of mitochondrial reactive oxygen species nearly completely abolished NLRP3 inflammasome activation, caspase-1 activation, and the production of IL-1β in p120-catenin-depleted macrophages. Furthermore, p120-catenin ablation significantly disrupted mitochondrial function, evidenced by decreased mitochondrial membrane potential and lower production of intracellular ATP. In alveolar macrophage-depleted mice challenged with cecal ligation and puncture, pulmonary transplantation of p120-catenin-deficient macrophages dramatically enhanced the accumulation of IL-1β and IL-18 in bronchoalveolar lavage fluid. These results demonstrate that p120-catenin prevents NLRP3 inflammasome activation in macrophages by maintaining mitochondrial homeostasis and reducing the production of mitochondrial reactive oxygen species in response to endotoxin insult. Thus, inhibition of NLRP3 inflammasome activation by stabilization of p120-catenin expression in macrophages may be a novel strategy to prevent an uncontrolled inflammatory response in sepsis.
    MeSH term(s) Animals ; Mice ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Delta Catenin ; Reactive Oxygen Species/metabolism ; Macrophages/metabolism ; Caspase 1/metabolism ; Sepsis/metabolism ; Adenosine Triphosphate/metabolism ; Interleukin-1beta/metabolism
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Delta Catenin ; Reactive Oxygen Species ; Caspase 1 (EC 3.4.22.36) ; Adenosine Triphosphate (8L70Q75FXE) ; Interleukin-1beta ; Nlrp3 protein, mouse
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00328.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.A 2749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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