Article ; Online: Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as a Bifunctional Antibiofilm Agent and Antibacterial Synergist against
Journal of medicinal chemistry
2023 Volume 66, Issue 17, Page(s) 11927–11939
Abstract: Antibiotic resistance caused by biofilm formation is a clinical challenge. Nitric oxide (NO) can effectively disperse a mature biofilm and can also synergistically influence the level of cyclic diguanylate (c-di-GMP), a universal secondary messenger that ...
Abstract | Antibiotic resistance caused by biofilm formation is a clinical challenge. Nitric oxide (NO) can effectively disperse a mature biofilm and can also synergistically influence the level of cyclic diguanylate (c-di-GMP), a universal secondary messenger that plays an important role in biofilm formation in bacteria. Based on our previous finding that c-di-GMP G-quadruplex inducers are effective biofilm formation inhibitors, we designed and synthesized a c-di-GMP G-quadruplex inducer-NO donor conjugate ( |
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MeSH term(s) | Animals ; Nitric Oxide Donors/pharmacology ; Pseudomonas aeruginosa ; Anti-Bacterial Agents/pharmacology ; Tobramycin/pharmacology ; Nitric Oxide ; Biofilms ; Caenorhabditis elegans ; Phenotype |
Chemical Substances | Nitric Oxide Donors ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK) ; Nitric Oxide (31C4KY9ESH) |
Language | English |
Publishing date | 2023-08-22 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 218133-2 |
ISSN | 1520-4804 ; 0022-2623 |
ISSN (online) | 1520-4804 |
ISSN | 0022-2623 |
DOI | 10.1021/acs.jmedchem.3c00516 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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