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  1. Book ; Online ; E-Book: Vander's renal physiology

    Eaton, Douglas C. / Pooler, John

    2023  

    Abstract: Combining the latest research with a fully integrated teaching approach, Vander's Renal Physiology, Tenth Edition clearly and expertly explains how the kidneys affect other body systems and how they in turn are affected by these systems. There is no ... ...

    Author's details Douglas C. Eaton, John Pooler
    Abstract "Combining the latest research with a fully integrated teaching approach, Vander's Renal Physiology, Tenth Edition clearly and expertly explains how the kidneys affect other body systems and how they in turn are affected by these systems. There is no better way to learn the fundamental principles of the structure, function, and pathologies of the human kidney that are essential for an understanding of clinical medicine, than this time-tested resource"--
    Keywords Kidneys/Physiology
    Subject code 612.463
    Language English
    Size 1 online resource (vii, 220 pages) :, illustrations
    Edition Tenth edition.
    Publisher McGraw-Hill Medical
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-264-27853-5 ; 1-264-27852-7 ; 978-1-264-27853-4 ; 978-1-264-27852-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Vander's renal physiology

    Eaton, Douglas C. / Pooler, John P. / Vander, Arthur J.

    (A Lange medical book)

    2013  

    Author's details Douglas C. Eaton ; John P. Pooler
    Series title A Lange medical book
    Keywords Kidney / physiology ; Kidneys/Physiology
    Subject code 612.463
    Language English
    Size VII, 204 S. : Ill., graph. Darst., 24cm
    Edition 8. ed.
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017615305
    ISBN 0-07-179748-3 ; 978-0-07-179748-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 587 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Vander's renal physiology

    Eaton, Douglas C. / Pooler, John P. / Vander, Arthur J.

    (A Lange medical book)

    2009  

    Title variant Renal physiology
    Author's details Douglas C. Eaton ; John P. Pooler
    Series title A Lange medical book
    Keywords Kidney / physiology ; Kidneys/Physiology
    Subject code 612.463
    Language English
    Size VII, 222 S. : Ill., graph. Darst., 24cm
    Edition 7. ed
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015943138
    ISBN 0-07-161303-X ; 978-0-07-161303-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 2230 order for loan Magazin

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  4. Article ; Online: Regulating ENaC's gate.

    Kleyman, Thomas R / Eaton, Douglas C

    American journal of physiology. Cell physiology

    2019  Volume 318, Issue 1, Page(s) C150–C162

    Abstract: Epithelial ... ...

    Abstract Epithelial Na
    MeSH term(s) Animals ; Epithelial Sodium Channels/chemistry ; Epithelial Sodium Channels/metabolism ; Humans ; Ion Channel Gating ; Membrane Potentials ; Models, Molecular ; Protein Conformation ; Signal Transduction ; Sodium/metabolism ; Structure-Activity Relationship
    Chemical Substances Epithelial Sodium Channels ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00418.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Changing Demographics of NIDDK-Funded Physician-Scientists Doing Kidney Research.

    Abood, Delaney C / King, Spencer A / Eaton, Douglas C / Wall, Susan M

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 9, Page(s) 1337–1344

    Abstract: Background and objectives: Although US physician-scientists have made enormous contributions to biomedical research, this workforce is thought to be getting smaller. However, among kidney researchers, changes have not been fully quantified.: Design, ... ...

    Abstract Background and objectives: Although US physician-scientists have made enormous contributions to biomedical research, this workforce is thought to be getting smaller. However, among kidney researchers, changes have not been fully quantified.
    Design, setting, participants, & measurements: We mined National Institutes of Health RePORTER to explore demographic changes of early-career and established physician and nonphysician principal investigators doing kidney-focused research. We searched for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded K series and R01 awards focused on the kidney that were active between 1990 and 2020 and determined if their emphasis was basic or clinical science. We then used public databases available on the internet to determine if these funded investigators were physicians or nonphysicians, the year in which they received either their MD (physicians) or their terminal graduate degree (nonphysicians), their sex, and whether they received their terminal degree from a US or international institution.
    Results: Kidney-focused R01-funded principal investigators are aging, particularly among physicians. Moreover, the relative representation of physicians among both early-career and established principal investigators is falling, particularly among those doing basic science research. In contrast, the number and relative representation of nonphysician-scientists are increasing. There is also greater representation of women and international graduates among physician and nonphysician R01-funded, kidney-focused NIDDK investigators. However, although there are greater numbers of women physician principal investigators doing both basic as well as clinical research, women physician principal investigators are increasingly more likely to do clinical rather than basic science research.
    Conclusions: The physician-scientist workforce is increasingly made up of women and international medical graduates. However, the physician-scientist workforce is older and represents a smaller proportion of all principal investigators, particularly among those doing basic science research.
    MeSH term(s) Biomedical Research/economics ; Demography ; Female ; Humans ; Male ; National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) ; Nephrology ; Physicians/economics ; Research Personnel/economics ; United States ; Workforce/economics
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.02440221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  6. Article ; Online: Frontiers in renal and epithelial physiology - grand challenges.

    Eaton, Douglas C

    Frontiers in physiology

    2012  Volume 3, Page(s) 2

    Language English
    Publishing date 2012-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X ; 1664-042X
    ISSN (online) 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2012.00002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: Vander's renal physiology

    Eaton, Douglas C. / Pooler, John P. / Vander, Arthur J.

    (Lange physiology series ; A Lange medical book)

    2004  

    Title variant Renal physiology
    Author's details Douglas C. Eaton ; John P. Pooler
    Series title Lange physiology series
    A Lange medical book
    Keywords Kidney / physiology ; Kidneys/Physiology
    Subject code 612.463
    Language English
    Size VII, 214 S. : Ill., graph. Darst., 24cm
    Edition 6. ed
    Publisher McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014073393
    ISBN 0-07-135728-9 ; 978-0-07-135728-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 2937 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A Model for Postdoctoral Education That Promotes Minority and Majority Success in the Biomedical Sciences.

    Eisen, Arri / Eaton, Douglas C

    CBE life sciences education

    2017  Volume 16, Issue 4

    Abstract: How does the United States maintain the highest-quality research and teaching in its professional science workforce and ensure that those in this workforce are effectively trained and representative of national demographics? In the pathway to science ... ...

    Abstract How does the United States maintain the highest-quality research and teaching in its professional science workforce and ensure that those in this workforce are effectively trained and representative of national demographics? In the pathway to science careers, the postdoctoral stage is formative, providing the experiences that define the independent work of one's first faculty position. It is also a stage in which underrepresented minorities (URMs) disproportionately lose interest in pursuing academic careers in science and, models suggest, a point at which interventions to increase proportions of URMs in such careers could be most effective. We present a mixed-methods, case study analysis from 17 years of the Fellowships in Research and Science Teaching (FIRST) postdoctoral program, to our knowledge the largest and longest continuously running science postdoctoral program in the United States. We demonstrate that FIRST fellows, in sharp contrast to postdocs overall, are inclusive of URMs (50% African American; 70% women) and as or more successful in their fellowships and beyond as a comparison group (measured by publication rate, attainment of employment in academic science careers, and eventual research grant support). Analysis of alumni surveys and focus group discussions reveals that FIRST fellows place highest value on the cohort-driven community and the developmental teaching and research training the program provides.
    MeSH term(s) Academic Success ; Biomedical Research/education ; Biomedical Research/manpower ; Career Choice ; Education, Graduate ; Employment ; Fellowships and Scholarships ; Goals ; Humans ; Minority Groups/education ; Models, Educational ; Publications ; Research Support as Topic/economics ; Teaching
    Language English
    Publishing date 2017-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2465176-X
    ISSN 1931-7913 ; 1931-7913
    ISSN (online) 1931-7913
    ISSN 1931-7913
    DOI 10.1187/cbe.17-03-0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: PIP

    Yue, Qiang / Al-Khalili, Otor / Moseley, Auriel / Yoshigi, Masaaki / Wynne, Brandi Michele / Ma, Heping / Eaton, Douglas C

    Biology

    2022  Volume 11, Issue 12

    Abstract: We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5- ...

    Abstract We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11121694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.

    Romero, Cesar A / Lim, Jasmine / Wang, Hong / Wynne, Brandi M / Ma, Peipei / Jing, Yao / Liotta, Dennis C / D'Erasmo, Michael / Traynelis, Stephen F / Eaton, Douglas C / Wall, Susan M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: N-methyl-D-aspartate receptor (NMDAR) are amino acid receptors that are well studied in brain physiology; however, their role in kidney is poorly understood. Nonetheless, NMDAR inhibitors can increase serum K+ and reduce GFR, which suggests ... ...

    Abstract Background: N-methyl-D-aspartate receptor (NMDAR) are amino acid receptors that are well studied in brain physiology; however, their role in kidney is poorly understood. Nonetheless, NMDAR inhibitors can increase serum K+ and reduce GFR, which suggests they have an important physiological role in the kidney. We hypothesized that NMDARs in the distal nephron induce afferent-arteriole vasodilation through the vasodilator mechanism connecting-tubule-glomerular feedback (CNTGF) that involves ENaC activation.
    Methods and results: Using a tubule-specific transcriptome database combined with molecular biology and microscopy techniques, we showed kidney expression of NMDAR subunits along the nephron and specifically in ENaC-positive cells. This receptor is expressed in both male and female mice, with higher abundance in females (p=0.02). Microperfusing NMDAR agonists into the connecting tubule induced afferent-arteriole vasodilation (EC
    Conclusion: NMDARs are expressed along the nephron, including ENaC-positive cells, with higher expression in females. Epithelial NMDAR mediates renal vasodilation through the connecting-tubule-glomerular feedback, by increasing ENaC activity.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.04.569973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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