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  1. Article ; Online: Preparation of

    Qi, Jinghua / Qi, Xingli / Chen, Hongyuan / Rui, Wen

    Anti-cancer agents in medicinal chemistry

    2024  Volume 24, Issue 2, Page(s) 132–145

    Abstract: Introduction: The increasing number of studies have shown that : Methods: In this study, we aimed to investigate the mechanisms of action of : Results: The results showed that LBAG has a molecular weight of 10-15 kDa and contains Man, Rha, GlcA, ... ...

    Abstract Introduction: The increasing number of studies have shown that
    Methods: In this study, we aimed to investigate the mechanisms of action of
    Results: The results showed that LBAG has a molecular weight of 10-15 kDa and contains Man, Rha, GlcA, Glc, Gal, and Ara18 amino acids. Treatment with LBAG significantly decreased B16 cell proliferation and induced cell cycle arrest at the G0/G phase, accompanied by the accumulation of reactive oxygen species. Western blot analysis revealed that the phosphorylation of P38-MAPK and AKT, as well as the expression of N-acetyl-Lcysteine, were related to cell apoptosis and cell cycle regulation. In mouse xenografts, LBAG inhibited tumor growth through the P38-MAPK and AKT signaling pathways.
    Conclusion: In conclusion, the anti-melanoma activity of LBAG may induce apoptosis in cancer cells through ROSmediated activation of the P38-MAPK and AKT signaling pathways. These findings provide a foundation for further research on the anti-melanoma potential of LBAG.
    MeSH term(s) Male ; Humans ; Animals ; Mice ; Lycium/chemistry ; Lycium/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Melanoma/drug therapy ; Signal Transduction ; Cell Cycle Checkpoints ; Apoptosis
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/0118715206274639231103050807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5583: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: N

    Salami, Sodeeq Aderotimi / Smith, Vincent J / Krause, Rui W M

    RSC advances

    2023  Volume 13, Issue 6, Page(s) 4019–4031

    Abstract: A new simple, efficient, and environmentally friendly protocol is presented for the catalytic synthesis of α-acyloxycarboxamides ... ...

    Abstract A new simple, efficient, and environmentally friendly protocol is presented for the catalytic synthesis of α-acyloxycarboxamides using
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06189a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: BRCA2 deficiency increases sensitivity of medulloblastoma to Olaparib by inhibiting RAD51-mediated DNA damage repair system.

    Yu, J / Zhang, C / Shi, W / Rui, H / Li, H

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2022  Volume 24, Issue 5, Page(s) 919–926

    Abstract: Purpose: BRCA2 defect exists in glioma and regulates drug resistance of glioma to chemotherapy. However, its role in medulloblastoma and the mechanism is not known. To investigate the effects of BRCA2 deficiency combined with Olaparib in medulloblastoma ...

    Abstract Purpose: BRCA2 defect exists in glioma and regulates drug resistance of glioma to chemotherapy. However, its role in medulloblastoma and the mechanism is not known. To investigate the effects of BRCA2 deficiency combined with Olaparib in medulloblastoma and the mechanism.
    Methods: BRCA2 was knocked down by RNAi technology and cell proliferation was detected by CCK-8 assay. Cell apoptosis was determined by FACS analysis when the in vivo role of BRCA2 was explored with xenograft mice model. Western blotting technology was used to explore the mechanism of BRCA2.
    Results: Knockdown of BRCA2 enhanced the inhibitory effect of Olaparib on proliferation of Daoy and LN229 cells. The inhibition rate of Olaparib on Daoy or LN229 cells was 61.1%, 66.03% in shBRCA2 group, while it was 42.9%, 41.1% in shNC group. Overexpression of RAD51 partially reversed the effect of shBRCA2. In Daoy cells, apoptotic rate was 26.9% in Olaparib group and 58.9% in Olaparib/shBRCA2 group. However, it was 33.4% after RAD51 was overexpressed. It was the same in LN229 cells. In xenograft mice model, tumor volume in Olaparib and Olaparib/shBRCA2 group was 376.12 and 84.95mm
    Conclusions: Knockdown of BRCA2 increases the sensitivity of medulloblastoma cells to Olaparib and strengthens the efficacy of Olaparib in vitro and in vivo. Knockdown of BRCA2 causes DNA damage repair by regulating RAD51-mediated signaling pathway in Daoy cells.
    MeSH term(s) Animals ; BRCA2 Protein/genetics ; Cell Line, Tumor ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/genetics ; DNA Damage ; DNA Repair ; Glioma ; Humans ; Medulloblastoma/drug therapy ; Medulloblastoma/genetics ; Mice ; Phthalazines ; Piperazines ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human ; Phthalazines ; Piperazines ; RAD51 protein, human (EC 2.7.7.-) ; Rad51 Recombinase (EC 2.7.7.-) ; olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2022-01-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-021-02742-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
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  4. Article: [Effect of Friday surgery on clinical outcome of elderly patients with hip fracture under multidisciplinary treatment].

    Tian, C W / Zhu, H Y / Zhou, J / Bai, L Y / Wu, W / Qin, S B / Gao, W / Shi, L / Chen, X X / Xie, T / Chen, H / Rui, Y F

    Zhonghua yi xue za zhi

    2023  Volume 103, Issue 19, Page(s) 1496–1503

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Male ; Female ; Humans ; Aged ; Aged, 80 and over ; Retrospective Studies ; Risk Factors ; Hip Fractures/surgery ; Postoperative Complications/epidemiology ; Albumins
    Chemical Substances Albumins
    Language Chinese
    Publishing date 2023-05-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20221024-02216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2011: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Adhesions in the setting of hip arthroscopy.

    Ruzbarsky, Joseph J / Soares, Rui W / Comfort, Spencer M / Arner, Justin W / Philippon, Marc J

    EFORT open reviews

    2023  Volume 8, Issue 11, Page(s) 792–797

    Abstract: With the growing number of primary arthroscopies performed, patients requiring revision hip arthroscopies for various issues is high including postoperative adhesion formation, a source of pain, mechanical symptoms, range of motion limitation, stiffness, ...

    Abstract With the growing number of primary arthroscopies performed, patients requiring revision hip arthroscopies for various issues is high including postoperative adhesion formation, a source of pain, mechanical symptoms, range of motion limitation, stiffness, and microinstability. Adhesions are a consequence of biological pathways that have been stimulated by injury or surgical interventions leading to an increased healing response. Preventative efforts have included surgical adjuncts during/after primary hip arthroscopy, biologic augmentation, and postoperative rehabilitation. Treatment options for adhesion formation includes surgical lysis of adhesions with or without placement of biologic membranes aimed at inhibiting adhesion reformation as well as systemic medications to further reduce the risk. Postoperative rehabilitation exercises have also been demonstrated to prevent adhesions as a result of hip arthroscopy. Ongoing clinical trials are further investigating pathways and prevention of adhesion formation.
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1530/EOR-21-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The circular RNA circATP8B(2) regulates ROS production and antiviral immunity in Drosophila.

    Liang, Weihong / Liu, Wei / Xiong, Xiao-Peng / Li, Jennifer W / Li, Jian-Liang / Perera, Ranjan J / Zhou, Rui

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 113973

    Abstract: We identified and validated a collection of circular RNAs (circRNAs) in Drosophila melanogaster. We show that depletion of the pro-viral circRNA circATP8B(2), but not its linear siblings, compromises viral infection both in cultured Drosophila cells and ... ...

    Abstract We identified and validated a collection of circular RNAs (circRNAs) in Drosophila melanogaster. We show that depletion of the pro-viral circRNA circATP8B(2), but not its linear siblings, compromises viral infection both in cultured Drosophila cells and in vivo. In addition, circATP8B(2) is enriched in the fly gut, and gut-specific depletion of circATP8B(2) attenuates viral replication in an oral infection model. Furthermore, circATP8B(2) depletion results in increased levels of reactive oxygen species (ROS) and enhanced expression of dual oxidase (Duox), which produces ROS. Genetic and pharmacological manipulations of circATP8B(2)-depleted flies that reduce ROS levels rescue the viral replication defects elicited by circATP8B(2) depletion. Mechanistically, circATP8B(2) associates with Duox, and circATP8B(2)-Duox interaction is crucial for circATP8B(2)-mediated modulation of Duox activity. In addition, Gαq, a G protein subunit required for optimal Duox activity, acts downstream of circATP8B(2). We conclude that circATP8B(2) regulates antiviral defense by modulating Duox expression and Duox-dependent ROS production.
    MeSH term(s) Animals ; Reactive Oxygen Species/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Drosophila melanogaster/immunology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Virus Replication ; RNA/metabolism ; RNA/genetics ; NADPH Oxidases/metabolism ; NADPH Oxidases/genetics ; Dual Oxidases/metabolism ; Dual Oxidases/genetics
    Chemical Substances Reactive Oxygen Species ; RNA, Circular ; Drosophila Proteins ; RNA (63231-63-0) ; NADPH Oxidases (EC 1.6.3.-) ; Dual Oxidases (EC 1.11.1.-)
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Calcineurin promotes adaptation to chronic stress through two distinct mechanisms.

    Flynn, Mackenzie J / Harper, Nicholas W / Li, Rui / Zhu, Lihua Julie / Lee, Michael J / Benanti, Jennifer A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Adaptation to environmental stress requires coordination between stress-defense programs and cell cycle progression. The immediate response to many stressors has been well characterized, but how cells survive in challenging environments long-term is ... ...

    Abstract Adaptation to environmental stress requires coordination between stress-defense programs and cell cycle progression. The immediate response to many stressors has been well characterized, but how cells survive in challenging environments long-term is unknown. Here, we investigate the role of the stress-activated phosphatase calcineurin (CN) in adaptation to chronic CaCl
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.19.585797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Phytochemicals from

    Teclegeorgish, Zecarias W / Mokgalaka, Ntebogeng S / Kemboi, Douglas / Krause, Rui W M / Siwe-Noundou, Xavier / Nyemba, Getrude R / Davison, Candace / de la Mare, Jo-Anne / Tembu, Vuyelwa J

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Pterocarpus ... ...

    Abstract Pterocarpus anglonesis
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Novel Algorithm for Streamlining Diagnosis of Advanced Liver Fibrosis in CHB Patients with Concurrent Hepatic Steatosis.

    Xu, Xiaoming / Rui, Fajuan / Ni, Wenjing / Wu, Chao / Shi, Junping / Li, Jie

    Journal of clinical and translational hepatology

    2024  Volume 12, Issue 2, Page(s) 222–226

    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2023.00362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: METTL3/

    Xiong, Jian / Lian, Wenqin / Zhao, Rui / Gao, Kefei

    OncoTargets and therapy

    2024  Volume 17, Page(s) 85–97

    Abstract: Background: Studies increasingly recognize the role of N6-methyladenosine (: Methods: In this study, GEPIA 2.0 database was applied for expression analysis, survival analysis and correlation analysis for OC. Additionally, in vitro and in vivo assays ... ...

    Abstract Background: Studies increasingly recognize the role of N6-methyladenosine (
    Methods: In this study, GEPIA 2.0 database was applied for expression analysis, survival analysis and correlation analysis for OC. Additionally, in vitro and in vivo assays were conducted to explore regulatory mechanisms of METTL3 in OC.
    Results: We found that METTL3 and
    Conclusion: In conclusion, METTL3 was a carcinogenic molecule that promoted the occurrence of OC. The potential mechanism of the carcinogenic effect of METTL3 was realized by enhancing the m6A modification of
    Language English
    Publishing date 2024-02-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S431810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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